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The map label for this gene is thrS

Identifier: 94985607

GI number: 94985607

Start: 1600759

End: 1602708

Strand: Reverse

Name: thrS

Synonym: Dgeo_1507

Alternate gene names: 94985607

Gene position: 1602708-1600759 (Counterclockwise)

Preceding gene: 94985608

Following gene: 94985605

Centisome position: 64.96

GC content: 63.38

Gene sequence:

>1950_bases
ATGCACGTCACGTTGCCCGACGGAAAACAACTCGACCTTCAGGCGGGTGCGACGGCCCTCGACGTCGCCCGTGCTCTTGG
CCCCCGCCTCGCCCAGGATGCTCTAGCCGCCCTCGTGAACGGTGAACTGATGGACCTGATGACACCGCTGCCTGAAGGCG
CGCAGGTCCGCCTGATCACGAAGAAGAATCCTGGAGACGCAGCCCCTGTCTTTCGTCACTCACTCGGCCATGTGCTGAGC
CAGGCGGTGGGCGAGTTCTATCAGCGCAAGGGTTATCCGCGGGAGGCGGTCAAACGCGGTGTTGGCCCGGCCATCGAGAA
CGGCTTCTATCAGGATTTCGACCTGCCCGAGCCGCTGAAGGAGGAGGATCTCCCTGAGATCGAGGCAATCATGCGCGAGA
TCATCGGGCGTGGCCTCGACATCGTCCGGCAGGACGTGGGGAAGGCGGCGGCACTGAAGCACTTCAGCTACGACCCCTAC
AAGGTCGAACTCATCCAGGAGCTTCCCGAGAATGAGCCGGTCACGTTCTACGCCCAGGGTGACTACGTGGACCTCTGCCG
GGGGCCGCACTTCCCGAACACGGGCAAGCTGCCGGGCGCCTTCAAACTCATGTCCACCAGCGGCGCGTATTGGCGCGGCA
ACGAAAAGAACCCCATTCTCCAGCGCGTCTATGGTGTAGCCTTTGCCACCCAAAAGGAACTGGACGAGTACCTGGAGCGG
CTGGAGGAAGCCCGGCGGCGCGACCACCGCAAGCTGGGCCGCGAGCTGGAACTCTTCCTGATCGACCCCCTCGTCGGCAA
GGGCCTTCCGATGTGGCTGCCCAACGGCACGGTGCTGCGCGAGGAACTCACCCGCTTCCTGCGCGAGCAGCAGTTCCAGC
GGGACTATCAGGGTGTGGTCACGCCCAACATCGGGAACCTCGACCTCTTCCGCACCTCCGGCCACTATCCCTACTACTCG
GACAGCCAGTTTGAACCGCTCAGCGTGGATGAAGAGCAGTACATGCTCAAGCCAATGAACTGCCCCTTCCACATCCGCAT
CTACGCCAGCAAGCCCAGAAGCTACCGCGACCTGCCGGTGCGGCTGGCCGAATTCGGCACGGTGTACCGCTACGAGATGA
GCGGTGAGCTCAACGGCCTGACGCGGGTGCGCGGTTTTACCCAGGACGACGCGCATATTTTCGCCCGTCCGGATCAGCTC
AAAAAGGAATTCCTGGACGTGCTGGACCTGACGGTGCTGGTGCTGAAGACCTTCGGCATGAACGACGTGCGCTTTCGCGT
AGGGGTGCGCGACCCCGCATCTGACAAGTACGTGGGTGATCCGGCCCAGTGGGAGGTGGCCGAGCGCCAGATCATCGAGG
CGGTGGAGGAGGTTGGCCTCCCCTACACGGTCGAACCCGGCGATGCCGCCTTTTACGGTCCCAAGCTCGACTTCGTGGTC
AAGGACGTGCTGGGCCGCGAGTGGCAGCTCGGCACCATTCAGGTGGACTACAACCTGCCCGAACGCTTCGACCTCACCTA
CACGGGAGAAGACGGCCAGGAACACCGCCCGGTGATGATCCACCGCGCGCCCTTCGGGAGCCTGGAGCGCTTCGTAGGGA
TCTTGATCGAGCACTACGGCGGCGACTTCCCGTTCTGGCTGGCGCCCCGGCAGATCATGCTTATTCCGATTGCTGACCGC
CACAACGCCTATGCCCAGACGCTGGCCAACGAGTTCAAGGCAGCGGGCCTACGCGCTGAGGTAGACGACTCCAACAACCG
CATGAACGCCAAGGTCCGCAACGCCGAACTCCACAAGATCCCGGTGATGCTGATCGTGGGGGACCAGGAAGAAGCGCGGC
GCGAGGTGAGTGTGCGCGAACGCACCCCCGAAGGCCACAAGGAACGCAAGGGTGTAGACTTCACCGCGCTGCTGGCCGAG
TTGCAGGAACGCTACCGCACCCGCGCGTAA

Upstream 100 bases:

>100_bases
CGAACTCTCAGCGCCTGAGAAGTCCCCACGCGGCTCTCAGGCGCTTTGCTGGATCTGCGGCCAGACCGGGTTCTCTCTTG
CTGCTTCAAGGAGTCTTCTC

Downstream 100 bases:

>100_bases
GCGGGGAGAGGGGTCAGTCAGAGCGGCTGCCCCCTTCCGCTGCTGCTCAGCGTTGCCCGTCCTGCTTCGCCAGCACCGCC
CCCAGCAGGTCGGGTCTGTC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MHVTLPDGKQLDLQAGATALDVARALGPRLAQDALAALVNGELMDLMTPLPEGAQVRLITKKNPGDAAPVFRHSLGHVLS
QAVGEFYQRKGYPREAVKRGVGPAIENGFYQDFDLPEPLKEEDLPEIEAIMREIIGRGLDIVRQDVGKAAALKHFSYDPY
KVELIQELPENEPVTFYAQGDYVDLCRGPHFPNTGKLPGAFKLMSTSGAYWRGNEKNPILQRVYGVAFATQKELDEYLER
LEEARRRDHRKLGRELELFLIDPLVGKGLPMWLPNGTVLREELTRFLREQQFQRDYQGVVTPNIGNLDLFRTSGHYPYYS
DSQFEPLSVDEEQYMLKPMNCPFHIRIYASKPRSYRDLPVRLAEFGTVYRYEMSGELNGLTRVRGFTQDDAHIFARPDQL
KKEFLDVLDLTVLVLKTFGMNDVRFRVGVRDPASDKYVGDPAQWEVAERQIIEAVEEVGLPYTVEPGDAAFYGPKLDFVV
KDVLGREWQLGTIQVDYNLPERFDLTYTGEDGQEHRPVMIHRAPFGSLERFVGILIEHYGGDFPFWLAPRQIMLIPIADR
HNAYAQTLANEFKAAGLRAEVDDSNNRMNAKVRNAELHKIPVMLIVGDQEEARREVSVRERTPEGHKERKGVDFTALLAE
LQERYRTRA

Sequences:

>Translated_649_residues
MHVTLPDGKQLDLQAGATALDVARALGPRLAQDALAALVNGELMDLMTPLPEGAQVRLITKKNPGDAAPVFRHSLGHVLS
QAVGEFYQRKGYPREAVKRGVGPAIENGFYQDFDLPEPLKEEDLPEIEAIMREIIGRGLDIVRQDVGKAAALKHFSYDPY
KVELIQELPENEPVTFYAQGDYVDLCRGPHFPNTGKLPGAFKLMSTSGAYWRGNEKNPILQRVYGVAFATQKELDEYLER
LEEARRRDHRKLGRELELFLIDPLVGKGLPMWLPNGTVLREELTRFLREQQFQRDYQGVVTPNIGNLDLFRTSGHYPYYS
DSQFEPLSVDEEQYMLKPMNCPFHIRIYASKPRSYRDLPVRLAEFGTVYRYEMSGELNGLTRVRGFTQDDAHIFARPDQL
KKEFLDVLDLTVLVLKTFGMNDVRFRVGVRDPASDKYVGDPAQWEVAERQIIEAVEEVGLPYTVEPGDAAFYGPKLDFVV
KDVLGREWQLGTIQVDYNLPERFDLTYTGEDGQEHRPVMIHRAPFGSLERFVGILIEHYGGDFPFWLAPRQIMLIPIADR
HNAYAQTLANEFKAAGLRAEVDDSNNRMNAKVRNAELHKIPVMLIVGDQEEARREVSVRERTPEGHKERKGVDFTALLAE
LQERYRTRA
>Mature_649_residues
MHVTLPDGKQLDLQAGATALDVARALGPRLAQDALAALVNGELMDLMTPLPEGAQVRLITKKNPGDAAPVFRHSLGHVLS
QAVGEFYQRKGYPREAVKRGVGPAIENGFYQDFDLPEPLKEEDLPEIEAIMREIIGRGLDIVRQDVGKAAALKHFSYDPY
KVELIQELPENEPVTFYAQGDYVDLCRGPHFPNTGKLPGAFKLMSTSGAYWRGNEKNPILQRVYGVAFATQKELDEYLER
LEEARRRDHRKLGRELELFLIDPLVGKGLPMWLPNGTVLREELTRFLREQQFQRDYQGVVTPNIGNLDLFRTSGHYPYYS
DSQFEPLSVDEEQYMLKPMNCPFHIRIYASKPRSYRDLPVRLAEFGTVYRYEMSGELNGLTRVRGFTQDDAHIFARPDQL
KKEFLDVLDLTVLVLKTFGMNDVRFRVGVRDPASDKYVGDPAQWEVAERQIIEAVEEVGLPYTVEPGDAAFYGPKLDFVV
KDVLGREWQLGTIQVDYNLPERFDLTYTGEDGQEHRPVMIHRAPFGSLERFVGILIEHYGGDFPFWLAPRQIMLIPIADR
HNAYAQTLANEFKAAGLRAEVDDSNNRMNAKVRNAELHKIPVMLIVGDQEEARREVSVRERTPEGHKERKGVDFTALLAE
LQERYRTRA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=652, Percent_Identity=39.2638036809816, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI38570111, Length=651, Percent_Identity=38.0952380952381, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI20070344, Length=641, Percent_Identity=37.2854914196568, Blast_Score=407, Evalue=1e-113,
Organism=Escherichia coli, GI1788013, Length=650, Percent_Identity=38.9230769230769, Blast_Score=497, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71984184, Length=625, Percent_Identity=38.08, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71984192, Length=625, Percent_Identity=38.08, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322112, Length=666, Percent_Identity=36.1861861861862, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=39.6946564885496, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24583842, Length=646, Percent_Identity=39.6284829721362, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI28574141, Length=646, Percent_Identity=39.6284829721362, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24583839, Length=646, Percent_Identity=39.6284829721362, Blast_Score=488, Evalue=1e-138,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_DEIGD (Q1IY82)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_604971.1
- ProteinModelPortal:   Q1IY82
- SMR:   Q1IY82
- STRING:   Q1IY82
- GeneID:   4057393
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_1507
- NMPDR:   fig|68909.1.peg.1708
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GRKWQLG
- PhylomeDB:   Q1IY82
- ProtClustDB:   PRK00413
- BioCyc:   DGEO319795:DGEO_1507-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73930; Mature: 73930

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVTLPDGKQLDLQAGATALDVARALGPRLAQDALAALVNGELMDLMTPLPEGAQVRLIT
CEEECCCCCEEEHHCCCHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEE
KKNPGDAAPVFRHSLGHVLSQAVGEFYQRKGYPREAVKRGVGPAIENGFYQDFDLPEPLK
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHCCCCCCCCCCCCCC
EEDLPEIEAIMREIIGRGLDIVRQDVGKAAALKHFSYDPYKVELIQELPENEPVTFYAQG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECC
DYVDLCRGPHFPNTGKLPGAFKLMSTSGAYWRGNEKNPILQRVYGVAFATQKELDEYLER
CEEEECCCCCCCCCCCCCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LEEARRRDHRKLGRELELFLIDPLVGKGLPMWLPNGTVLREELTRFLREQQFQRDYQGVV
HHHHHHHHHHHHCCEEEEEEECHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
TPNIGNLDLFRTSGHYPYYSDSQFEPLSVDEEQYMLKPMNCPFHIRIYASKPRSYRDLPV
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHEECCCCCEEEEEEECCCCCCCCCCH
RLAEFGTVYRYEMSGELNGLTRVRGFTQDDAHIFARPDQLKKEFLDVLDLTVLVLKTFGM
HHHHCCCEEEEEECCCCCCHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCC
NDVRFRVGVRDPASDKYVGDPAQWEVAERQIIEAVEEVGLPYTVEPGDAAFYGPKLDFVV
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEECCCHHHHH
KDVLGREWQLGTIQVDYNLPERFDLTYTGEDGQEHRPVMIHRAPFGSLERFVGILIEHYG
HHHCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHC
GDFPFWLAPRQIMLIPIADRHNAYAQTLANEFKAAGLRAEVDDSNNRMNAKVRNAELHKI
CCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCEEEEE
PVMLIVGDQEEARREVSVRERTPEGHKERKGVDFTALLAELQERYRTRA
EEEEEECCHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHVTLPDGKQLDLQAGATALDVARALGPRLAQDALAALVNGELMDLMTPLPEGAQVRLIT
CEEECCCCCEEEHHCCCHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEE
KKNPGDAAPVFRHSLGHVLSQAVGEFYQRKGYPREAVKRGVGPAIENGFYQDFDLPEPLK
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHCCCCCCCCCCCCCC
EEDLPEIEAIMREIIGRGLDIVRQDVGKAAALKHFSYDPYKVELIQELPENEPVTFYAQG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECC
DYVDLCRGPHFPNTGKLPGAFKLMSTSGAYWRGNEKNPILQRVYGVAFATQKELDEYLER
CEEEECCCCCCCCCCCCCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LEEARRRDHRKLGRELELFLIDPLVGKGLPMWLPNGTVLREELTRFLREQQFQRDYQGVV
HHHHHHHHHHHHCCEEEEEEECHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
TPNIGNLDLFRTSGHYPYYSDSQFEPLSVDEEQYMLKPMNCPFHIRIYASKPRSYRDLPV
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHEECCCCCEEEEEEECCCCCCCCCCH
RLAEFGTVYRYEMSGELNGLTRVRGFTQDDAHIFARPDQLKKEFLDVLDLTVLVLKTFGM
HHHHCCCEEEEEECCCCCCHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCC
NDVRFRVGVRDPASDKYVGDPAQWEVAERQIIEAVEEVGLPYTVEPGDAAFYGPKLDFVV
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEECCCHHHHH
KDVLGREWQLGTIQVDYNLPERFDLTYTGEDGQEHRPVMIHRAPFGSLERFVGILIEHYG
HHHCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHC
GDFPFWLAPRQIMLIPIADRHNAYAQTLANEFKAAGLRAEVDDSNNRMNAKVRNAELHKI
CCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCEEEEE
PVMLIVGDQEEARREVSVRERTPEGHKERKGVDFTALLAELQERYRTRA
EEEEEECCHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA