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The map label for this gene is ffh [H]

Identifier: 94985540

GI number: 94985540

Start: 1530194

End: 1531546

Strand: Reverse

Name: ffh [H]

Synonym: Dgeo_1440

Alternate gene names: 94985540

Gene position: 1531546-1530194 (Counterclockwise)

Preceding gene: 94985546

Following gene: 94985532

Centisome position: 62.08

GC content: 63.27

Gene sequence:

>1353_bases
ATGTTTGAGGCGCTCGGCAACAAGTTGCAGGACATTCTCGACCGGATAGGCCGGGAGAGCAAACTCACCGACGCGCAGGT
CAAGGCCGCCATGCGCGAGATTCGCATGGCCCTGCTCGAAGCGGACGTGAACTTCAATGTCGCCAAGGATTTTGTCGCCA
AGGTCAGCGAGAAAGCCGTTGGCCAGGAGGTCGTGGGATCGCTGACTGCTGGGCAGACGGTCGTGAAGCTGGTTCACGAC
GAACTGATCGAGACGCTGGGTGGTGAGGCGCGGCAGCCCACGTTGAAAAACGACGGAAATGTGTGGTTTATGGTCGGCCT
GCAGGGGGCGGGCAAGACGACCAGTGCGGGCAAGCTCGCGGCCTTCTACAAGAGCAAGGGCCGCCGCGTGCTGCTGGTGG
CCGCCGACACCCAGCGTCCCGCCGCGCGTGACCAACTCGAAGTGTTGGCAAAGCAGGTGGGGGTGCCGGTCCTCAAGGTG
AAGGATGGCGAGACGCCGCAGGAAACGAAGCGCCGCCTCGACGAGTACCTCAAGACCGACTACCGCGACCTTGTGATCGT
GGACACGGCGGGCCGCCTCCAAATTGACGAGGCGCTGATGGACCAACTCGCGGCCCTCCAGGCCGAACTTCAACCCACCG
AAACCCTGCTGGTGGTGGACGCGATGACCGGCCAAGAGGCGCTCAACGTGGCCCGCGTGTTTGATGAGCGCGTGCATCTC
TCCGGCCTGATCATCACCAAGATGGATGGTGACGCGCGCGGCGGAGCGGCCTTATCGGCGCGCAGCGTGACGGGCAAGCC
GATCTACTTTGCCGGCGTGAGCGAGAAGCTGACGGGGCTTGAACCCTTCTATCCCGACCGCGTGGCGGGGCGCATTCTCG
GCATGGGCGACGTGCTCGGGCTGATTGAGCGTGCCCAGCAGGCCGATCTCAAGGCGATGGAGGTCAAGAAGCCCGGCGAC
TTCGACCTCGAAGACCTGCTGATCCAGCTGCGCCAGATTCGCAAGATGGGGCCACTTGGCGACCTCCTCAAGCTGATCCC
CGGCATGAGCCGCGCGTTGCCTGAAGGCTTCAACGTAGACGAGAAGCAGATTCAGCGCATCGACGCGATGATCTCCTCAA
TGACGCTGCAAGAGCGCCGGAATCCCAAGATCATCGATGGGCGCCGCCGCAAGCGCATCGCGGCGGGGAGCGGCACCAGT
GTGCAGGACATCAACCGCCTGCTGAAGATGCACGAGCAGATGAAGGAGATGATGAAGCTGCTCCAGCGGCTGAGTGGTCC
CGGTGCCAAAGGCCTGGGCAAGGGCATGAAGCTTCCCAAGACGCCGCCGATGCCGCCGCAGATGAAGCGTTAA

Upstream 100 bases:

>100_bases
GAGGGATCGAACGGGCTTGGGCGTATGCCTGCGGTATGCCTGCGGGGGCAACGCTTCTTCTGCCACAAGCCCGCCCCCTT
CCCCGCGCTAGACTCCTGGC

Downstream 100 bases:

>100_bases
CGTCATCCGCGTTGAGACCCGCGTTGACACCTTCCGGTGTGCTCCCTATACTCAGGCCCGCTGCTTTAGCGCCCCCCGCG
AGCGCAGCGGGTCGTTAGCT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFEALGNKLQDILDRIGRESKLTDAQVKAAMREIRMALLEADVNFNVAKDFVAKVSEKAVGQEVVGSLTAGQTVVKLVHD
ELIETLGGEARQPTLKNDGNVWFMVGLQGAGKTTSAGKLAAFYKSKGRRVLLVAADTQRPAARDQLEVLAKQVGVPVLKV
KDGETPQETKRRLDEYLKTDYRDLVIVDTAGRLQIDEALMDQLAALQAELQPTETLLVVDAMTGQEALNVARVFDERVHL
SGLIITKMDGDARGGAALSARSVTGKPIYFAGVSEKLTGLEPFYPDRVAGRILGMGDVLGLIERAQQADLKAMEVKKPGD
FDLEDLLIQLRQIRKMGPLGDLLKLIPGMSRALPEGFNVDEKQIQRIDAMISSMTLQERRNPKIIDGRRRKRIAAGSGTS
VQDINRLLKMHEQMKEMMKLLQRLSGPGAKGLGKGMKLPKTPPMPPQMKR

Sequences:

>Translated_450_residues
MFEALGNKLQDILDRIGRESKLTDAQVKAAMREIRMALLEADVNFNVAKDFVAKVSEKAVGQEVVGSLTAGQTVVKLVHD
ELIETLGGEARQPTLKNDGNVWFMVGLQGAGKTTSAGKLAAFYKSKGRRVLLVAADTQRPAARDQLEVLAKQVGVPVLKV
KDGETPQETKRRLDEYLKTDYRDLVIVDTAGRLQIDEALMDQLAALQAELQPTETLLVVDAMTGQEALNVARVFDERVHL
SGLIITKMDGDARGGAALSARSVTGKPIYFAGVSEKLTGLEPFYPDRVAGRILGMGDVLGLIERAQQADLKAMEVKKPGD
FDLEDLLIQLRQIRKMGPLGDLLKLIPGMSRALPEGFNVDEKQIQRIDAMISSMTLQERRNPKIIDGRRRKRIAAGSGTS
VQDINRLLKMHEQMKEMMKLLQRLSGPGAKGLGKGMKLPKTPPMPPQMKR
>Mature_450_residues
MFEALGNKLQDILDRIGRESKLTDAQVKAAMREIRMALLEADVNFNVAKDFVAKVSEKAVGQEVVGSLTAGQTVVKLVHD
ELIETLGGEARQPTLKNDGNVWFMVGLQGAGKTTSAGKLAAFYKSKGRRVLLVAADTQRPAARDQLEVLAKQVGVPVLKV
KDGETPQETKRRLDEYLKTDYRDLVIVDTAGRLQIDEALMDQLAALQAELQPTETLLVVDAMTGQEALNVARVFDERVHL
SGLIITKMDGDARGGAALSARSVTGKPIYFAGVSEKLTGLEPFYPDRVAGRILGMGDVLGLIERAQQADLKAMEVKKPGD
FDLEDLLIQLRQIRKMGPLGDLLKLIPGMSRALPEGFNVDEKQIQRIDAMISSMTLQERRNPKIIDGRRRKRIAAGSGTS
VQDINRLLKMHEQMKEMMKLLQRLSGPGAKGLGKGMKLPKTPPMPPQMKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=450, Percent_Identity=32.4444444444444, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI226371618, Length=393, Percent_Identity=33.0788804071247, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI89061728, Length=136, Percent_Identity=36.0294117647059, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI295424842, Length=298, Percent_Identity=26.1744966442953, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI23308697, Length=298, Percent_Identity=26.1744966442953, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=49.4117647058824, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1789874, Length=192, Percent_Identity=38.5416666666667, Blast_Score=126, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17539958, Length=435, Percent_Identity=30.1149425287356, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=288, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325345, Length=441, Percent_Identity=34.4671201814059, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=214, Percent_Identity=28.5046728971963, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17647949, Length=459, Percent_Identity=30.718954248366, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24641198, Length=214, Percent_Identity=29.4392523364486, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49407; Mature: 49407

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEALGNKLQDILDRIGRESKLTDAQVKAAMREIRMALLEADVNFNVAKDFVAKVSEKAV
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GQEVVGSLTAGQTVVKLVHDELIETLGGEARQPTLKNDGNVWFMVGLQGAGKTTSAGKLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
AFYKSKGRRVLLVAADTQRPAARDQLEVLAKQVGVPVLKVKDGETPQETKRRLDEYLKTD
HHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCC
YRDLVIVDTAGRLQIDEALMDQLAALQAELQPTETLLVVDAMTGQEALNVARVFDERVHL
CCCEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
SGLIITKMDGDARGGAALSARSVTGKPIYFAGVSEKLTGLEPFYPDRVAGRILGMGDVLG
CEEEEEECCCCCCCCCEEEECCCCCCCEEEECCCHHHCCCCCCCCHHHHHHHHCHHHHHH
LIERAQQADLKAMEVKKPGDFDLEDLLIQLRQIRKMGPLGDLLKLIPGMSRALPEGFNVD
HHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCCC
EKQIQRIDAMISSMTLQERRNPKIIDGRRRKRIAAGSGTSVQDINRLLKMHEQMKEMMKL
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LQRLSGPGAKGLGKGMKLPKTPPMPPQMKR
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFEALGNKLQDILDRIGRESKLTDAQVKAAMREIRMALLEADVNFNVAKDFVAKVSEKAV
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GQEVVGSLTAGQTVVKLVHDELIETLGGEARQPTLKNDGNVWFMVGLQGAGKTTSAGKLA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
AFYKSKGRRVLLVAADTQRPAARDQLEVLAKQVGVPVLKVKDGETPQETKRRLDEYLKTD
HHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCC
YRDLVIVDTAGRLQIDEALMDQLAALQAELQPTETLLVVDAMTGQEALNVARVFDERVHL
CCCEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
SGLIITKMDGDARGGAALSARSVTGKPIYFAGVSEKLTGLEPFYPDRVAGRILGMGDVLG
CEEEEEECCCCCCCCCEEEECCCCCCCEEEECCCHHHCCCCCCCCHHHHHHHHCHHHHHH
LIERAQQADLKAMEVKKPGDFDLEDLLIQLRQIRKMGPLGDLLKLIPGMSRALPEGFNVD
HHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCCC
EKQIQRIDAMISSMTLQERRNPKIIDGRRRKRIAAGSGTSVQDINRLLKMHEQMKEMMKL
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LQRLSGPGAKGLGKGMKLPKTPPMPPQMKR
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9002524; 9695947; 10426959 [H]