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The map label for this gene is hutU [H]

Identifier: 94972202

GI number: 94972202

Start: 292077

End: 293774

Strand: Direct

Name: hutU [H]

Synonym: Dgeo_2735

Alternate gene names: 94972202

Gene position: 292077-293774 (Clockwise)

Preceding gene: 94972204

Following gene: 94972201

Centisome position: 50.87

GC content: 67.73

Gene sequence:

>1698_bases
ATGACCCCATCTCTCACGCCCGAAACAGCTCCCGTCATCCGTGCCCCGCGCGGCCCGCAGCGCACTGCGAAGGGCTGGAT
TCAGGAAGCGGCCAAGCGCATGCTGATGAATAACCTCGACCCCGAGGTGGCCGAGCACCCCGAGAATCTCGTCGTGTACG
GCGGACGCGGAAAAGCAGCGCGGAACTGGGAGGCGTTCCACAAGATCGTGGAGACGCTCGACCGGTTAGAGAACGACGAG
ACCCTGCTCATCCAGTCGGGCAAGCCCGTTGCCGTGCTGAGGACGCACGAGTGGGCGCCGCGCGTCATCCTTGCCAACGC
CAATCTGGTGCCGCACTGGGCCAACTGGGAAACCTTCGACCGGCTCGATCAGGCGGGCCTGACCATGTACGGTCAGATGA
CCGCCGGAAGCTGGATCTACATCGGCACCCAAGGCATCCTCCAGGGGACCTATGAGACTTTTGCAGGCGCCGGGAAGAAG
CACTTCGGCGGCAGCCTGAAGGGAACGGTCACCGTCACGGCGGGCCTGGGTGGGATGGGCGGTGCGCAGCCCCTCGCGGT
GAAGCTGGCGGGCGGCGTGAGCATCACAGTCGAGATTGACCCCACCCGCATCCAGAAGCGCCTGGACACCCGGTATCTGG
ACGAGGTGGCGGACAATCTCCAGGACGCGATTGCCCGCGCCGAGCGGTACAAGGCGCAAGGAGTGGCCCGCTCCATCGGC
CTGCTGGGGAACGCCGCCGAAATCCTCCCGCAGCTGGTGGAGCTCAACTGGACACCTGATCTGGTGACCGACCAGACCAG
CGCCCACGACCCGATGTGGGGCTATATCCCGCCCCTCGCCCCCGATGAGGACGCGGACAGGCTGCGTGCCGAGCAGCCGG
AGGTGTACCGCGAGCGGGCGTATGCGGCAATGGCGGGGCACGTCCAGGCCATTCTGGAGCTGCAACAGCGCGGCGCAGTC
GCCTTCGACTACGGCAACAACCTGCGGCAGCGGGCCTTTGAGGCGGGCGTCACGAACGCCTTTGACTATCCCGGCTTCGT
GCCCGCCTTTATCCGCGACTCGTTCTGTGAGGGCCGGGGACCGTTTCGCTGGGTGGCGCTGAGCGGCGACCCCGCGGACA
TCCGCGCCACCGATCAGGCCCTGCTCGACCTTTTCCCCGACGACGAGAGATTGCAATCTTGGCTGACCTACGCCGCCGAT
CAGATCGCCTTCCAGGGCCTGCCCGCGCGCATCTGCTGGCTGGGCTACCGCGAGCGTGACCGGGCCGCCCTCCTGTTCAA
CGAGATGGTGGCCGACGGCCGCCTCAAGGCCCCCATCGTGATCGGGCGCGACCACCTCGACGCGGGCAGTGTCGCCAGCC
CCTACCGGGAGACGGAGGCGATGAAAGACGGCTCGGACGCCGTCTCCGACTGGGCGCTGCTGAATTTCGGCGTCGGGATT
GCCAGCGGTGCCGCATGGATGAGTTTCCACCACGGCGGCGGCGTGGGGATGGGCTTCAGCCAACACAGCGGGCTGGTGGC
GGTGGCCGACGGCACCCCCGAAGCGGCCCAGCGCCTCAGCCGTTGCCTGACCAACGACCCGGCGCTGGGTGTGATCCGCC
ACGCCGACGCCGGATACGAGCAGGCGCTGGAGGTGGCGCGGGAGCGCGGGCTGGATCTGCCGAGTCTGGGGATTGGGGAG
GGGGCTGCACAGTCCTGA

Upstream 100 bases:

>100_bases
TCCGGGATATGCGGAAAGCGGCGTTGTGAGGACGGCGTAGCCGGGGGACGATAGGGGCACGTCACCGCTCATCTCTCGCC
CTCTCCGAAAGGAACTGCCG

Downstream 100 bases:

>100_bases
CCGCCTTTTCAGCCTAAACTGATCAGAAAGGGGGGCAAAAATGACCAGATACTGGAAAGTGGAAGAGGCCAAGGCCAACT
TCTCCCGTCTGCTGCGCGCG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MTPSLTPETAPVIRAPRGPQRTAKGWIQEAAKRMLMNNLDPEVAEHPENLVVYGGRGKAARNWEAFHKIVETLDRLENDE
TLLIQSGKPVAVLRTHEWAPRVILANANLVPHWANWETFDRLDQAGLTMYGQMTAGSWIYIGTQGILQGTYETFAGAGKK
HFGGSLKGTVTVTAGLGGMGGAQPLAVKLAGGVSITVEIDPTRIQKRLDTRYLDEVADNLQDAIARAERYKAQGVARSIG
LLGNAAEILPQLVELNWTPDLVTDQTSAHDPMWGYIPPLAPDEDADRLRAEQPEVYRERAYAAMAGHVQAILELQQRGAV
AFDYGNNLRQRAFEAGVTNAFDYPGFVPAFIRDSFCEGRGPFRWVALSGDPADIRATDQALLDLFPDDERLQSWLTYAAD
QIAFQGLPARICWLGYRERDRAALLFNEMVADGRLKAPIVIGRDHLDAGSVASPYRETEAMKDGSDAVSDWALLNFGVGI
ASGAAWMSFHHGGGVGMGFSQHSGLVAVADGTPEAAQRLSRCLTNDPALGVIRHADAGYEQALEVARERGLDLPSLGIGE
GAAQS

Sequences:

>Translated_565_residues
MTPSLTPETAPVIRAPRGPQRTAKGWIQEAAKRMLMNNLDPEVAEHPENLVVYGGRGKAARNWEAFHKIVETLDRLENDE
TLLIQSGKPVAVLRTHEWAPRVILANANLVPHWANWETFDRLDQAGLTMYGQMTAGSWIYIGTQGILQGTYETFAGAGKK
HFGGSLKGTVTVTAGLGGMGGAQPLAVKLAGGVSITVEIDPTRIQKRLDTRYLDEVADNLQDAIARAERYKAQGVARSIG
LLGNAAEILPQLVELNWTPDLVTDQTSAHDPMWGYIPPLAPDEDADRLRAEQPEVYRERAYAAMAGHVQAILELQQRGAV
AFDYGNNLRQRAFEAGVTNAFDYPGFVPAFIRDSFCEGRGPFRWVALSGDPADIRATDQALLDLFPDDERLQSWLTYAAD
QIAFQGLPARICWLGYRERDRAALLFNEMVADGRLKAPIVIGRDHLDAGSVASPYRETEAMKDGSDAVSDWALLNFGVGI
ASGAAWMSFHHGGGVGMGFSQHSGLVAVADGTPEAAQRLSRCLTNDPALGVIRHADAGYEQALEVARERGLDLPSLGIGE
GAAQS
>Mature_564_residues
TPSLTPETAPVIRAPRGPQRTAKGWIQEAAKRMLMNNLDPEVAEHPENLVVYGGRGKAARNWEAFHKIVETLDRLENDET
LLIQSGKPVAVLRTHEWAPRVILANANLVPHWANWETFDRLDQAGLTMYGQMTAGSWIYIGTQGILQGTYETFAGAGKKH
FGGSLKGTVTVTAGLGGMGGAQPLAVKLAGGVSITVEIDPTRIQKRLDTRYLDEVADNLQDAIARAERYKAQGVARSIGL
LGNAAEILPQLVELNWTPDLVTDQTSAHDPMWGYIPPLAPDEDADRLRAEQPEVYRERAYAAMAGHVQAILELQQRGAVA
FDYGNNLRQRAFEAGVTNAFDYPGFVPAFIRDSFCEGRGPFRWVALSGDPADIRATDQALLDLFPDDERLQSWLTYAADQ
IAFQGLPARICWLGYRERDRAALLFNEMVADGRLKAPIVIGRDHLDAGSVASPYRETEAMKDGSDAVSDWALLNFGVGIA
SGAAWMSFHHGGGVGMGFSQHSGLVAVADGTPEAAQRLSRCLTNDPALGVIRHADAGYEQALEVARERGLDLPSLGIGEG
AAQS

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=561, Percent_Identity=36.0071301247772, Blast_Score=326, Evalue=5e-89,
Organism=Homo sapiens, GI260306182, Length=335, Percent_Identity=35.5223880597015, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71997891, Length=535, Percent_Identity=34.9532710280374, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61346; Mature: 61215

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSLTPETAPVIRAPRGPQRTAKGWIQEAAKRMLMNNLDPEVAEHPENLVVYGGRGKAA
CCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCCC
RNWEAFHKIVETLDRLENDETLLIQSGKPVAVLRTHEWAPRVILANANLVPHWANWETFD
CCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHH
RLDQAGLTMYGQMTAGSWIYIGTQGILQGTYETFAGAGKKHFGGSLKGTVTVTAGLGGMG
HHHHCCCEEEEEECCCCEEEEECHHHHHHHHHHHHCCCCHHCCCCCCEEEEEEECCCCCC
GAQPLAVKLAGGVSITVEIDPTRIQKRLDTRYLDEVADNLQDAIARAERYKAQGVARSIG
CCCCEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGNAAEILPQLVELNWTPDLVTDQTSAHDPMWGYIPPLAPDEDADRLRAEQPEVYRERA
HCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHH
YAAMAGHVQAILELQQRGAVAFDYGNNLRQRAFEAGVTNAFDYPGFVPAFIRDSFCEGRG
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
PFRWVALSGDPADIRATDQALLDLFPDDERLQSWLTYAADQIAFQGLPARICWLGYRERD
CEEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
RAALLFNEMVADGRLKAPIVIGRDHLDAGSVASPYRETEAMKDGSDAVSDWALLNFGVGI
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCH
ASGAAWMSFHHGGGVGMGFSQHSGLVAVADGTPEAAQRLSRCLTNDPALGVIRHADAGYE
HCCHHHEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHH
QALEVARERGLDLPSLGIGEGAAQS
HHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPSLTPETAPVIRAPRGPQRTAKGWIQEAAKRMLMNNLDPEVAEHPENLVVYGGRGKAA
CCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCCC
RNWEAFHKIVETLDRLENDETLLIQSGKPVAVLRTHEWAPRVILANANLVPHWANWETFD
CCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHH
RLDQAGLTMYGQMTAGSWIYIGTQGILQGTYETFAGAGKKHFGGSLKGTVTVTAGLGGMG
HHHHCCCEEEEEECCCCEEEEECHHHHHHHHHHHHCCCCHHCCCCCCEEEEEEECCCCCC
GAQPLAVKLAGGVSITVEIDPTRIQKRLDTRYLDEVADNLQDAIARAERYKAQGVARSIG
CCCCEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGNAAEILPQLVELNWTPDLVTDQTSAHDPMWGYIPPLAPDEDADRLRAEQPEVYRERA
HCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHH
YAAMAGHVQAILELQQRGAVAFDYGNNLRQRAFEAGVTNAFDYPGFVPAFIRDSFCEGRG
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
PFRWVALSGDPADIRATDQALLDLFPDDERLQSWLTYAADQIAFQGLPARICWLGYRERD
CEEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
RAALLFNEMVADGRLKAPIVIGRDHLDAGSVASPYRETEAMKDGSDAVSDWALLNFGVGI
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCH
ASGAAWMSFHHGGGVGMGFSQHSGLVAVADGTPEAAQRLSRCLTNDPALGVIRHADAGYE
HCCHHHEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHH
QALEVARERGLDLPSLGIGEGAAQS
HHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]