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The map label for this gene is fabF [H]

Identifier: 93007095

GI number: 93007095

Start: 2788772

End: 2790043

Strand: Direct

Name: fabF [H]

Synonym: Pcryo_2271

Alternate gene names: 93007095

Gene position: 2788772-2790043 (Clockwise)

Preceding gene: 93007094

Following gene: 93007096

Centisome position: 91.14

GC content: 48.58

Gene sequence:

>1272_bases
ATGCGCGTTGTCGTGACAGGTATGGGCGCGGTCACGCCATTGGGATTAGATGTCGAAAGCTCGTGGGCAAAACTACTCAA
AGGTGAAAGTGGCATCACAGCTATTAGTCATTTTGACGCATCGGGTTATCGTGCGCAAATCGCAGGCGTGGTCAAAGACT
TCGATCCAAAGCAATATATGAATGCTAAAGACGCACGCCGTTATGATGATTTTATGCATTATGCGGTTGCTGCTTCCTCG
ATGGCGCTACAGCAAGCAGGTTTTATCAATGAAGTAAGCGCTGCTGACGCTCCGGTACAAGGTGTTGATCAAGAGCGCTT
TGGTGTCATTATAGGCTCAGGTATTGGTGGTATTCAAAACATCGAAAATAGCCGTGATACTTTACGTGAAAAAGGTGCCA
GTAAAGTCTCTCCCTTTATCATTCCAGGCTCTATCGTCAATATGGCAGCAGGGCTGGTGGCGATCAAACATACTTTAAAA
GGTCCGAACCTTGCAACGTCCACTGCTTGCACTACAGCAACTCATGCAATCGGTCTGGCAGCGCGCTTAATTGCTTATGG
CGACGCCGATGTGATCCTAGCAGGCGGTAGTGAAAAAGGCTCAAGTCCACTTGGTATCTCAGGTTTTGGTGCCATGCACG
CTCTTTCAACTCGCAATGACGAGCCAACTCGCGCTTCACGCCCATTTGATAAAGACCGTGATGGTTTTGTACTTGGTGAT
GGCGCAGGGGTCATGGTACTAGAAAGTCTTGCTCACGCAAAAGCGCGCGGTGCGACGATACTGGCTGAATTGGTTGGCTT
TGGTATGAGTGATGATGCCAGTCACATTACTGCGCCGCCAGAAGACGGTAGTGGTGCAGCACAAGCGATGCGTAATGCTT
TAAACGATGCTGGTATTGAGCCGTCAGTCATTGGTTACGTAAATGCCCATGGCACTAGCACGCCTGCTGGTGATGTCGCC
GAATCTATCGCCATTGAAACGGTATTTGCCCCTGTAAAAGATAGCATCTTGGTAAGCTCCACCAAATCGATGACCGGTCA
TCTACTTGGCGCTGCGGGCGGCGTTGAAGCCATCTTTACTGTGCTTGCTTTGCAACATCAACAAGTACCGCCAACGATTA
ATTTGGACAATGTTGAGGATAACTGTAATCTGGATTATGTTGCCAACCAATCGCGCCAAGTTGAGAACTTGCAGTATGCC
GTATCCAATAGCTTTGGTTTTGGTGGCACCAATGGTTCATTGATATTTGCCCGCTGGCCACTCAATCATTAA

Upstream 100 bases:

>100_bases
ACTTATCGACCAAGCTACGAATAGTACTGTTAATAACCCTATTGCCACCGCTCAGACAAAAAAACGTCATAAGCCTCCAC
ATTTTGAACGCACTGATGAG

Downstream 100 bases:

>100_bases
GGCGTCAAGCTTATGAGTGAAACCTTGTAACCTTGGTGGCAGATTTACTACGATTGTCTACTTGCAGCCCCTTATCATCC
TTGCGTATGATAAGGGGTAA

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MRVVVTGMGAVTPLGLDVESSWAKLLKGESGITAISHFDASGYRAQIAGVVKDFDPKQYMNAKDARRYDDFMHYAVAASS
MALQQAGFINEVSAADAPVQGVDQERFGVIIGSGIGGIQNIENSRDTLREKGASKVSPFIIPGSIVNMAAGLVAIKHTLK
GPNLATSTACTTATHAIGLAARLIAYGDADVILAGGSEKGSSPLGISGFGAMHALSTRNDEPTRASRPFDKDRDGFVLGD
GAGVMVLESLAHAKARGATILAELVGFGMSDDASHITAPPEDGSGAAQAMRNALNDAGIEPSVIGYVNAHGTSTPAGDVA
ESIAIETVFAPVKDSILVSSTKSMTGHLLGAAGGVEAIFTVLALQHQQVPPTINLDNVEDNCNLDYVANQSRQVENLQYA
VSNSFGFGGTNGSLIFARWPLNH

Sequences:

>Translated_423_residues
MRVVVTGMGAVTPLGLDVESSWAKLLKGESGITAISHFDASGYRAQIAGVVKDFDPKQYMNAKDARRYDDFMHYAVAASS
MALQQAGFINEVSAADAPVQGVDQERFGVIIGSGIGGIQNIENSRDTLREKGASKVSPFIIPGSIVNMAAGLVAIKHTLK
GPNLATSTACTTATHAIGLAARLIAYGDADVILAGGSEKGSSPLGISGFGAMHALSTRNDEPTRASRPFDKDRDGFVLGD
GAGVMVLESLAHAKARGATILAELVGFGMSDDASHITAPPEDGSGAAQAMRNALNDAGIEPSVIGYVNAHGTSTPAGDVA
ESIAIETVFAPVKDSILVSSTKSMTGHLLGAAGGVEAIFTVLALQHQQVPPTINLDNVEDNCNLDYVANQSRQVENLQYA
VSNSFGFGGTNGSLIFARWPLNH
>Mature_423_residues
MRVVVTGMGAVTPLGLDVESSWAKLLKGESGITAISHFDASGYRAQIAGVVKDFDPKQYMNAKDARRYDDFMHYAVAASS
MALQQAGFINEVSAADAPVQGVDQERFGVIIGSGIGGIQNIENSRDTLREKGASKVSPFIIPGSIVNMAAGLVAIKHTLK
GPNLATSTACTTATHAIGLAARLIAYGDADVILAGGSEKGSSPLGISGFGAMHALSTRNDEPTRASRPFDKDRDGFVLGD
GAGVMVLESLAHAKARGATILAELVGFGMSDDASHITAPPEDGSGAAQAMRNALNDAGIEPSVIGYVNAHGTSTPAGDVA
ESIAIETVFAPVKDSILVSSTKSMTGHLLGAAGGVEAIFTVLALQHQQVPPTINLDNVEDNCNLDYVANQSRQVENLQYA
VSNSFGFGGTNGSLIFARWPLNH

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=424, Percent_Identity=45.0471698113208, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI223972627, Length=172, Percent_Identity=49.4186046511628, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI41872631, Length=431, Percent_Identity=26.6821345707657, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787337, Length=417, Percent_Identity=58.0335731414868, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=37.4701670644391, Blast_Score=242, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=37.9716981132075, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=44.1509433962264, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=292, Percent_Identity=28.0821917808219, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=421, Percent_Identity=23.2779097387173, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=39.3258426966292, Blast_Score=308, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=44.8356807511737, Blast_Score=345, Evalue=5e-95,
Organism=Drosophila melanogaster, GI19920632, Length=325, Percent_Identity=27.3846153846154, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221330659, Length=325, Percent_Identity=27.3846153846154, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581345, Length=438, Percent_Identity=24.6575342465753, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43882; Mature: 43882

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVVTGMGAVTPLGLDVESSWAKLLKGESGITAISHFDASGYRAQIAGVVKDFDPKQYM
CEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHC
NAKDARRYDDFMHYAVAASSMALQQAGFINEVSAADAPVQGVDQERFGVIIGSGIGGIQN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEEEECCCCCHHH
IENSRDTLREKGASKVSPFIIPGSIVNMAAGLVAIKHTLKGPNLATSTACTTATHAIGLA
CCCHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
ARLIAYGDADVILAGGSEKGSSPLGISGFGAMHALSTRNDEPTRASRPFDKDRDGFVLGD
HHHHEECCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEC
GAGVMVLESLAHAKARGATILAELVGFGMSDDASHITAPPEDGSGAAQAMRNALNDAGIE
CCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
PSVIGYVNAHGTSTPAGDVAESIAIETVFAPVKDSILVSSTKSMTGHLLGAAGGVEAIFT
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCHHHHHH
VLALQHQQVPPTINLDNVEDNCNLDYVANQSRQVENLQYAVSNSFGFGGTNGSLIFARWP
HHHHHHCCCCCEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEECC
LNH
CCC
>Mature Secondary Structure
MRVVVTGMGAVTPLGLDVESSWAKLLKGESGITAISHFDASGYRAQIAGVVKDFDPKQYM
CEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHC
NAKDARRYDDFMHYAVAASSMALQQAGFINEVSAADAPVQGVDQERFGVIIGSGIGGIQN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEEEECCCCCHHH
IENSRDTLREKGASKVSPFIIPGSIVNMAAGLVAIKHTLKGPNLATSTACTTATHAIGLA
CCCHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
ARLIAYGDADVILAGGSEKGSSPLGISGFGAMHALSTRNDEPTRASRPFDKDRDGFVLGD
HHHHEECCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEC
GAGVMVLESLAHAKARGATILAELVGFGMSDDASHITAPPEDGSGAAQAMRNALNDAGIE
CCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
PSVIGYVNAHGTSTPAGDVAESIAIETVFAPVKDSILVSSTKSMTGHLLGAAGGVEAIFT
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCHHHHHH
VLALQHQQVPPTINLDNVEDNCNLDYVANQSRQVENLQYAVSNSFGFGGTNGSLIFARWP
HHHHHHCCCCCEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEECC
LNH
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]