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The map label for this gene is parC [H]

Identifier: 93006981

GI number: 93006981

Start: 2642598

End: 2644913

Strand: Direct

Name: parC [H]

Synonym: Pcryo_2157

Alternate gene names: 93006981

Gene position: 2642598-2644913 (Clockwise)

Preceding gene: 93006975

Following gene: 93006982

Centisome position: 86.36

GC content: 47.32

Gene sequence:

>2316_bases
ATGTCCAATGTTATCGATAACACGCTTGACCCAATCCTTGCAAATGAACCAATGGATACGCGCTCAGTGGCAGAGTTCGC
TGAGCAAGCCTATCTTAATTATGCCATGTACGTCATCATGGATCGGGCGCTGCCAAATATTGCTGATGGTCTAAAGCCTG
TCCAGCGCCGTATTGTTTATGCCATGAGCGAGCTTGGGCTAAAATCGACAGCGAAGGCGAAAAAATCTGCGCGTACAGTC
GGTGACGTATTGGGTAAATATCATCCGCATGGCGACAGCGCTTGTTATGAGGCGATGGTACTGATGGCACAGCCTTTCAG
CTATCGCTATCCGCTGATCACTGGTCAAGGTAACTGGGGTAGCCCTGATGACCCCAAGTCCTTTGCTGCCATGCGTTATA
CCGAAGCCAAAATGTCTGCTTATGCCAATACCTTGCTCGCGGAACTTGGTCAAGGTACAGTTGATTGGCAAGATAACTTC
GATGGTACGATGTTGGAGCCAACCACCCTGCCTGCCCGCCTGCCCAATATTTTATTAAATGGAACAACTGGTATCGCCGT
CGGTATGGCAACGGATATTCCGCCGCATAACCTGAATGAGGTGGTACGCGCGGCGATTCGTCTGCTCAAAAACCCTGAGC
TGTCGGTTAAGCAATTAACTCAATCGATACCAGCGCCTGATTTGCCAACCCCAGCTGAGATCATCACCAGCAAAAAAGAC
TTGCAAGCGATATATGAGACTGGACGTGGCAGCTATAAAATGCGTGCGACCTTTCATATTGATCCGAAAGAGAAAAATCT
TGTTATCATCAATGCCCTTCCTTACCAAGTCTCAGGCAATAAAATTCAAGAGCAAATCGCCAAGCTGATGACCGATAAGA
AGCTGCCTTGGATTGTTGATATTCATGATGAATCAGACCACGAAAATGCCTGCCGTATCGTCTTAGAGCTAAAATCTACC
CGCGTCGACGTGCAGCGCGTCATGAGCCATTTATTTGCCAGTACCGACCTAGAAAGCAATTACCGCGTCAATATGAATAT
GATTGGCCTAAATGGTAAACCGCAGGTTAAAAACCTGAAAGAAATATTGGAAGAATGGCTCGTCTGTCGCCGTTCTGTAG
TCACGCGCCGCTTGCAATATCGCCTTGATAAAATTGATAAGCGCTTACATATCCTCGCAGGTTTGCTGATTGCTTATCTG
AATATCGATGAAGTTATTCGCATCATTCGTGAAGAAGACGACCCAAAATTATCATTAATGCAAGATTATGACCTGACTGA
AATACAAGCCAATGCTATCTTGGATATTCGTTTGCGTCAGTTAGCTAAACTCGAAGAGATTGAGCTGCGGCGCGAGCAAG
ATGAGCTAGCGGCTGAACGCGCCATCATTCAAGAATACTTGGACAATCCAGATAGCCTGACCAATTTGATGATTGATGAG
CTCACCGCCGATATGAAAGAACACGGTAACGAGCGCGTATCGCAATTGGCAGAACGCGAAGAAGCGCAAGCGCTCAAAGA
ATCGGACCTCGTACCAAGCGAGCCTGTCACCGCTATCCTATCGAAAGCGGGCTGGATTCGTGCGGCTAAAGGTCATGACG
TTGATGCTGCTGGCATGGCTTATCGCTCAGGTGATAGCTACCAAGCCCACGTTCGCGCTAAAGCTAATGAGAAGATCTAC
GTGCTCGATAGTACCGGACGCAGCTATAGTATCGATGCGCATAGCCTCGCTTCTGCTCGTGGTCAAGGCGATCCTCTGAC
CAGTGTACTGAAACCACCAGCAGGTGCGACTTTTGAGCAATTGCTCACTGGCGACAATGACCAGCGCATCATCCTTGCCA
GCTCGCAAGGCTATGGTTTTATTAACACCATTGGTAATCTAGATAGCAATCAAAAAGCCGGTAAAAATATCATTAACCTA
GCTGCTGATAGTCGTTTATTACCTATCGCCCGTATTGATGCTCAAACTGAGGTGATTGTAAGCTCTGAGAATAATGGCAT
CCCTGCTAGCGAAAATAGCTCTACTCTCGATCATATCGCTGTGGTCACCAATGCTGGCTATTTATTGATATTTGCGCTTG
ATGATTTGCCTGAACAGGCTCGCGGCAAGGGTAATAAGATGATTAACCTAAAAGGTGATGAGGAAGTGCTTACCATCACG
CCACTCAGTAAACATGACAGCTTAGTCATTACTGCTGGCAAGCGTCATGTGACCTTAAAGCCGATGGACTTAGCAAACTA
TACATCCAAACGCGGTAGTCGTGGCGGTCAGCTGCCAAGAGGCTTTCAGAATGTGACGAGTATTGAGGTTGGGTGA

Upstream 100 bases:

>100_bases
CTTTTTAATTGCACCAATATCCTTTAGGATAGCACTATCCTATTTGCGCGATTGCACCGATTTTTTATACCTATTAAAAC
TGATAAGTGAACCCTATTTT

Downstream 100 bases:

>100_bases
TTTGATTGAACCTTCAAACATGCTAAATAGCTAGCTTACATTTTCGTAGTGTTAGGTGTCATAAACTTCACCCAGCCTAC
GCGATATCGAATATTTTCTT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MSNVIDNTLDPILANEPMDTRSVAEFAEQAYLNYAMYVIMDRALPNIADGLKPVQRRIVYAMSELGLKSTAKAKKSARTV
GDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLITGQGNWGSPDDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNF
DGTMLEPTTLPARLPNILLNGTTGIAVGMATDIPPHNLNEVVRAAIRLLKNPELSVKQLTQSIPAPDLPTPAEIITSKKD
LQAIYETGRGSYKMRATFHIDPKEKNLVIINALPYQVSGNKIQEQIAKLMTDKKLPWIVDIHDESDHENACRIVLELKST
RVDVQRVMSHLFASTDLESNYRVNMNMIGLNGKPQVKNLKEILEEWLVCRRSVVTRRLQYRLDKIDKRLHILAGLLIAYL
NIDEVIRIIREEDDPKLSLMQDYDLTEIQANAILDIRLRQLAKLEEIELRREQDELAAERAIIQEYLDNPDSLTNLMIDE
LTADMKEHGNERVSQLAEREEAQALKESDLVPSEPVTAILSKAGWIRAAKGHDVDAAGMAYRSGDSYQAHVRAKANEKIY
VLDSTGRSYSIDAHSLASARGQGDPLTSVLKPPAGATFEQLLTGDNDQRIILASSQGYGFINTIGNLDSNQKAGKNIINL
AADSRLLPIARIDAQTEVIVSSENNGIPASENSSTLDHIAVVTNAGYLLIFALDDLPEQARGKGNKMINLKGDEEVLTIT
PLSKHDSLVITAGKRHVTLKPMDLANYTSKRGSRGGQLPRGFQNVTSIEVG

Sequences:

>Translated_771_residues
MSNVIDNTLDPILANEPMDTRSVAEFAEQAYLNYAMYVIMDRALPNIADGLKPVQRRIVYAMSELGLKSTAKAKKSARTV
GDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLITGQGNWGSPDDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNF
DGTMLEPTTLPARLPNILLNGTTGIAVGMATDIPPHNLNEVVRAAIRLLKNPELSVKQLTQSIPAPDLPTPAEIITSKKD
LQAIYETGRGSYKMRATFHIDPKEKNLVIINALPYQVSGNKIQEQIAKLMTDKKLPWIVDIHDESDHENACRIVLELKST
RVDVQRVMSHLFASTDLESNYRVNMNMIGLNGKPQVKNLKEILEEWLVCRRSVVTRRLQYRLDKIDKRLHILAGLLIAYL
NIDEVIRIIREEDDPKLSLMQDYDLTEIQANAILDIRLRQLAKLEEIELRREQDELAAERAIIQEYLDNPDSLTNLMIDE
LTADMKEHGNERVSQLAEREEAQALKESDLVPSEPVTAILSKAGWIRAAKGHDVDAAGMAYRSGDSYQAHVRAKANEKIY
VLDSTGRSYSIDAHSLASARGQGDPLTSVLKPPAGATFEQLLTGDNDQRIILASSQGYGFINTIGNLDSNQKAGKNIINL
AADSRLLPIARIDAQTEVIVSSENNGIPASENSSTLDHIAVVTNAGYLLIFALDDLPEQARGKGNKMINLKGDEEVLTIT
PLSKHDSLVITAGKRHVTLKPMDLANYTSKRGSRGGQLPRGFQNVTSIEVG
>Mature_770_residues
SNVIDNTLDPILANEPMDTRSVAEFAEQAYLNYAMYVIMDRALPNIADGLKPVQRRIVYAMSELGLKSTAKAKKSARTVG
DVLGKYHPHGDSACYEAMVLMAQPFSYRYPLITGQGNWGSPDDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNFD
GTMLEPTTLPARLPNILLNGTTGIAVGMATDIPPHNLNEVVRAAIRLLKNPELSVKQLTQSIPAPDLPTPAEIITSKKDL
QAIYETGRGSYKMRATFHIDPKEKNLVIINALPYQVSGNKIQEQIAKLMTDKKLPWIVDIHDESDHENACRIVLELKSTR
VDVQRVMSHLFASTDLESNYRVNMNMIGLNGKPQVKNLKEILEEWLVCRRSVVTRRLQYRLDKIDKRLHILAGLLIAYLN
IDEVIRIIREEDDPKLSLMQDYDLTEIQANAILDIRLRQLAKLEEIELRREQDELAAERAIIQEYLDNPDSLTNLMIDEL
TADMKEHGNERVSQLAEREEAQALKESDLVPSEPVTAILSKAGWIRAAKGHDVDAAGMAYRSGDSYQAHVRAKANEKIYV
LDSTGRSYSIDAHSLASARGQGDPLTSVLKPPAGATFEQLLTGDNDQRIILASSQGYGFINTIGNLDSNQKAGKNIINLA
ADSRLLPIARIDAQTEVIVSSENNGIPASENSSTLDHIAVVTNAGYLLIFALDDLPEQARGKGNKMINLKGDEEVLTITP
LSKHDSLVITAGKRHVTLKPMDLANYTSKRGSRGGQLPRGFQNVTSIEVG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=349, Percent_Identity=24.0687679083095, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI19913406, Length=320, Percent_Identity=25.3125, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1789396, Length=755, Percent_Identity=56.158940397351, Blast_Score=871, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=760, Percent_Identity=34.4736842105263, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=382, Percent_Identity=25.9162303664921, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI212645657, Length=332, Percent_Identity=24.6987951807229, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17535065, Length=452, Percent_Identity=23.2300884955752, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=411, Percent_Identity=25.0608272506083, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136538, Length=179, Percent_Identity=27.9329608938547, Blast_Score=70, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85353; Mature: 85222

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVIDNTLDPILANEPMDTRSVAEFAEQAYLNYAMYVIMDRALPNIADGLKPVQRRIVY
CCCCHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AMSELGLKSTAKAKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLITGQGNWG
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCC
SPDDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNFDGTMLEPTTLPARLPNILLN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCHHCCCEEEE
GTTGIAVGMATDIPPHNLNEVVRAAIRLLKNPELSVKQLTQSIPAPDLPTPAEIITSKKD
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHCCHHH
LQAIYETGRGSYKMRATFHIDPKEKNLVIINALPYQVSGNKIQEQIAKLMTDKKLPWIVD
HHHHHHCCCCCEEEEEEEEECCCCCCEEEEEECCCEECCHHHHHHHHHHHHCCCCCEEEE
IHDESDHENACRIVLELKSTRVDVQRVMSHLFASTDLESNYRVNMNMIGLNGKPQVKNLK
ECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHH
EILEEWLVCRRSVVTRRLQYRLDKIDKRLHILAGLLIAYLNIDEVIRIIREEDDPKLSLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEE
QDYDLTEIQANAILDIRLRQLAKLEEIELRREQDELAAERAIIQEYLDNPDSLTNLMIDE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LTADMKEHGNERVSQLAEREEAQALKESDLVPSEPVTAILSKAGWIRAAKGHDVDAAGMA
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCE
YRSGDSYQAHVRAKANEKIYVLDSTGRSYSIDAHSLASARGQGDPLTSVLKPPAGATFEQ
EECCCCEEEEEEECCCCEEEEEECCCCEEECCHHHHHHCCCCCCCHHHHHCCCCCCCHHH
LLTGDNDQRIILASSQGYGFINTIGNLDSNQKAGKNIINLAADSRLLPIARIDAQTEVIV
HHCCCCCCEEEEECCCCCEEHHHHCCCCCCCHHCCHHEEECCCCCCCEEEEECCCEEEEE
SSENNGIPASENSSTLDHIAVVTNAGYLLIFALDDLPEQARGKGNKMINLKGDEEVLTIT
ECCCCCCCCCCCCCCHHHEEEEECCCEEEEEEECCCCHHHCCCCCEEEEECCCCEEEEEE
PLSKHDSLVITAGKRHVTLKPMDLANYTSKRGSRGGQLPRGFQNVTSIEVG
ECCCCCCEEEEECCCEEEECCCHHHHHHHHCCCCCCCCCCCHHCCCEEECC
>Mature Secondary Structure 
SNVIDNTLDPILANEPMDTRSVAEFAEQAYLNYAMYVIMDRALPNIADGLKPVQRRIVY
CCCHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AMSELGLKSTAKAKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLITGQGNWG
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCC
SPDDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNFDGTMLEPTTLPARLPNILLN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCHHCCCEEEE
GTTGIAVGMATDIPPHNLNEVVRAAIRLLKNPELSVKQLTQSIPAPDLPTPAEIITSKKD
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHCCHHH
LQAIYETGRGSYKMRATFHIDPKEKNLVIINALPYQVSGNKIQEQIAKLMTDKKLPWIVD
HHHHHHCCCCCEEEEEEEEECCCCCCEEEEEECCCEECCHHHHHHHHHHHHCCCCCEEEE
IHDESDHENACRIVLELKSTRVDVQRVMSHLFASTDLESNYRVNMNMIGLNGKPQVKNLK
ECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHH
EILEEWLVCRRSVVTRRLQYRLDKIDKRLHILAGLLIAYLNIDEVIRIIREEDDPKLSLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEE
QDYDLTEIQANAILDIRLRQLAKLEEIELRREQDELAAERAIIQEYLDNPDSLTNLMIDE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LTADMKEHGNERVSQLAEREEAQALKESDLVPSEPVTAILSKAGWIRAAKGHDVDAAGMA
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCE
YRSGDSYQAHVRAKANEKIYVLDSTGRSYSIDAHSLASARGQGDPLTSVLKPPAGATFEQ
EECCCCEEEEEEECCCCEEEEEECCCCEEECCHHHHHHCCCCCCCHHHHHCCCCCCCHHH
LLTGDNDQRIILASSQGYGFINTIGNLDSNQKAGKNIINLAADSRLLPIARIDAQTEVIV
HHCCCCCCEEEEECCCCCEEHHHHCCCCCCCHHCCHHEEECCCCCCCEEEEECCCEEEEE
SSENNGIPASENSSTLDHIAVVTNAGYLLIFALDDLPEQARGKGNKMINLKGDEEVLTIT
ECCCCCCCCCCCCCCHHHEEEEECCCEEEEEEECCCCHHHCCCCCEEEEECCCCEEEEEE
PLSKHDSLVITAGKRHVTLKPMDLANYTSKRGSRGGQLPRGFQNVTSIEVG
ECCCCCCEEEEECCCEEEECCCHHHHHHHHCCCCCCCCCCCHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]