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The map label for this gene is gmk [H]

Identifier: 93006827

GI number: 93006827

Start: 2463439

End: 2464065

Strand: Direct

Name: gmk [H]

Synonym: Pcryo_2003

Alternate gene names: 93006827

Gene position: 2463439-2464065 (Clockwise)

Preceding gene: 93006814

Following gene: 93006828

Centisome position: 80.51

GC content: 43.7

Gene sequence:

>627_bases
ATGACAGGTTCATTATTTATTATCACTGCCGCTTCTGGTACAGGCAAGACCTCATTGGTTAAGCAGCTACTTGCCACTAC
CAATGACTTGACTGTCAGTGTTTCACACACCACTCGTGAGCCGCGTCCAGGCGAGATTGACGGTCATCATTATCATTTTA
CTGACGTTAATAAGTTTGTGACTGCCATCAGTGAAAGTCAGTTTTTAGAACATGCCGAAGTGTTTGGCAATTATTATGGC
ACCTCAGAGCAAAGTGTACGCGCGCAACTGGACGCTGGTGTCGATGTAATTTTGGAGATTGATTGGCAAGGCGCGCTGCA
AGTCAAAAAAATCTTTACTGATGCCATCATGATTTTTATTTTACCGCCAAGTATCGCCACTTTACGTCAACGCTTATCAA
CGCGTGGACAGGACAGTATGGAGGTGATAGAGCAGCGTTTGGCTGGTGCTGTTAATGAGATGGCGCAGTACGTCAATTTT
GACTATGTCATTATTAATGACAGTTTTGAGGTTGCTTTAACTGAGCTTAAAGCAATTATCGTTGCCGATAGACAGACTCT
AAAGCGTCAACAGCAGCGTTATCAGCGCACGATTACCAATCTACTTAGCAATACAGTAGACGAGTAA

Upstream 100 bases:

>100_bases
GTCACCATACATGATGGTGTTTTTTATTTTTACCAGCCTTTTATATTAATTCGAATACTTTTATTTATTTATCAAGACAC
AATTCACTAGGACACACTGT

Downstream 100 bases:

>100_bases
ATAAAGCGTTGATATGTCTTAATGCTTTATCTTGAAAATAGTTATCAGCAGACAAGCAAAAAGCAATTACGCCTGCAAGC
AAAAAATGCTATAATGTCTA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTGSLFIITAASGTGKTSLVKQLLATTNDLTVSVSHTTREPRPGEIDGHHYHFTDVNKFVTAISESQFLEHAEVFGNYYG
TSEQSVRAQLDAGVDVILEIDWQGALQVKKIFTDAIMIFILPPSIATLRQRLSTRGQDSMEVIEQRLAGAVNEMAQYVNF
DYVIINDSFEVALTELKAIIVADRQTLKRQQQRYQRTITNLLSNTVDE

Sequences:

>Translated_208_residues
MTGSLFIITAASGTGKTSLVKQLLATTNDLTVSVSHTTREPRPGEIDGHHYHFTDVNKFVTAISESQFLEHAEVFGNYYG
TSEQSVRAQLDAGVDVILEIDWQGALQVKKIFTDAIMIFILPPSIATLRQRLSTRGQDSMEVIEQRLAGAVNEMAQYVNF
DYVIINDSFEVALTELKAIIVADRQTLKRQQQRYQRTITNLLSNTVDE
>Mature_207_residues
TGSLFIITAASGTGKTSLVKQLLATTNDLTVSVSHTTREPRPGEIDGHHYHFTDVNKFVTAISESQFLEHAEVFGNYYGT
SEQSVRAQLDAGVDVILEIDWQGALQVKKIFTDAIMIFILPPSIATLRQRLSTRGQDSMEVIEQRLAGAVNEMAQYVNFD
YVIINDSFEVALTELKAIIVADRQTLKRQQQRYQRTITNLLSNTVDE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=195, Percent_Identity=37.9487179487179, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI226874833, Length=195, Percent_Identity=37.9487179487179, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI4504221, Length=195, Percent_Identity=37.9487179487179, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=30.3370786516854, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI111154074, Length=170, Percent_Identity=33.5294117647059, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI14780902, Length=192, Percent_Identity=26.5625, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21361598, Length=187, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI119943106, Length=148, Percent_Identity=31.0810810810811, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI52630447, Length=181, Percent_Identity=26.5193370165746, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI261862237, Length=149, Percent_Identity=30.8724832214765, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=28.3236994219653, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI119943108, Length=149, Percent_Identity=30.8724832214765, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=28.3236994219653, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=28.3236994219653, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=28.3236994219653, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=204, Percent_Identity=53.921568627451, Blast_Score=227, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=36.1702127659575, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=36.1702127659575, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=27.4725274725275, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=41.7582417582418, Blast_Score=137, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21356141, Length=192, Percent_Identity=38.0208333333333, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI116007136, Length=189, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45554489, Length=189, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI85724806, Length=189, Percent_Identity=28.042328042328, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45554481, Length=189, Percent_Identity=28.042328042328, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24640542, Length=189, Percent_Identity=28.042328042328, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI161077626, Length=189, Percent_Identity=28.042328042328, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330166, Length=124, Percent_Identity=29.8387096774194, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221330164, Length=124, Percent_Identity=29.8387096774194, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221330162, Length=124, Percent_Identity=29.8387096774194, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23269; Mature: 23137

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSLFIITAASGTGKTSLVKQLLATTNDLTVSVSHTTREPRPGEIDGHHYHFTDVNKFV
CCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHH
TAISESQFLEHAEVFGNYYGTSEQSVRAQLDAGVDVILEIDWQGALQVKKIFTDAIMIFI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHEEEE
LPPSIATLRQRLSTRGQDSMEVIEQRLAGAVNEMAQYVNFDYVIINDSFEVALTELKAII
ECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHH
VADRQTLKRQQQRYQRTITNLLSNTVDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGSLFIITAASGTGKTSLVKQLLATTNDLTVSVSHTTREPRPGEIDGHHYHFTDVNKFV
CCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHH
TAISESQFLEHAEVFGNYYGTSEQSVRAQLDAGVDVILEIDWQGALQVKKIFTDAIMIFI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHEEEE
LPPSIATLRQRLSTRGQDSMEVIEQRLAGAVNEMAQYVNFDYVIINDSFEVALTELKAII
ECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHH
VADRQTLKRQQQRYQRTITNLLSNTVDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA