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The map label for this gene is gor [H]

Identifier: 93006790

GI number: 93006790

Start: 2426174

End: 2427529

Strand: Direct

Name: gor [H]

Synonym: Pcryo_1966

Alternate gene names: 93006790

Gene position: 2426174-2427529 (Clockwise)

Preceding gene: 93006789

Following gene: 93006792

Centisome position: 79.29

GC content: 45.13

Gene sequence:

>1356_bases
ATGACTAAACACTATGATTATATCGCCATTGGCGGCGGTAGCGGCGGCATTGCTTCGATTAATCGAGCCGCGAGCTATGG
CAAAAAATGTGCCATTATCGAAGCCAACCAATTAGGCGGCACCTGCGTGAACTTGGGCTGCGTACCCAAAAAAGTGATGT
GGTATGGCGCACAAGTTGCTGGAGCCATTCATAAGTATGCGCCAGATTATGGCTTTGACGTTGAGCTAAAAGGCTTTGAC
TTTCAAAAACTGGTACAGAGCCGTCAACAATATATTCAAAATATTCACCGCGCTTATGACAATAACTTGGCAAAAAACGG
TGTAGAAGTAATCAAAGGCTTTGCCAAATTTGTTGATAATCATACCGTAGAAGTGAATGGCGAGCTTATTACCGCTGACC
ATATTTTGATTGCTACAGGCGGTCATCCTATCAAGCCAAATATCAAAGGCGCAGAACATGGCATCGATTCTGATGGTTTT
TTTGCCTTAAATCATTTGCCAAAACGAGTCGCTATCGTTGGAGCGGGATATATCGCCGTTGAGATCGCTGGTGTGATGAA
TAGTCTCGGCGCTGAGGTACACTTGTATGTCCGTCAGCACTCGCCACTGCGCTCGTTTGATCACACCATTGTGGAGACTT
TGCTGATAGAGATGGAGCAAGATGGCATTCAATTGCATACCAATACCACGCTCACTGAAGTTGTTAAAAATGACGATAGT
AGCCTGACTTTGTGTACCACAGATGGTGCTCTTGATACCGTAGACTGCTTGATTTGGGCGATTGGTCGCGCGCCTTCGAC
GGACAATATCAATTTGCAAGTGACGGGCGTGGAAACGACCGAGTTTGGTAAAATCATAGTCGATAAATTCCAAAACACCA
ATGTTAAAGGGATTTATGCGGTAGGCGATATTATCGAAAACAGTGTTGATTTGACGCCAGTGGCTATCGCAGCAGGTCGT
CGCTTGTCAGAGCGCTTGTTTAATAACAAACCTGATGAGCATCTAAACTATGAGCTGATACCGACGGTTATCTTTACCCA
CCCTCCTATCGGCACCATTGGTTTGTCTGAAATCGATGCCGTAAATCAATTTGGTAAAGACAATATTAAATGCTATACCT
CCACCTTTACGGATATGTATAGTGCGGTGACTAAGCATCGCCAAAAGTCTACAATGAAGCTGATATGTTTAGGCGAGGAA
GAAAAAGTCATTGGCTTGCACGGTATCGGCTTTGGCGTGGATGAAATGATTCAGGGCTTTGCGGTAGCGATCAAAATGGG
CGCAACCAAAGCTGACTTTGATAATACCGTCGCCATTCATCCCACTGGCTCAGAAGAGTTTGTGACGATGCGCTAG

Upstream 100 bases:

>100_bases
CGTCGTCCCATCGTATAGATGATGGACTGCTCTTAGCTAGGCACTGTTTTCAATTAACGTTCAAAATTACATTAACAACC
CCTTAATAAAGAGACTCAAT

Downstream 100 bases:

>100_bases
CAATGAACCGGGTAATATTAGTAATAGCCTTATCTATTATATAAAAAGGATGCCGTTTGGGCATCCTTTTTTATTATCAG
CAACCAATAGAAGTGCTTAT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTKHYDYIAIGGGSGGIASINRAASYGKKCAIIEANQLGGTCVNLGCVPKKVMWYGAQVAGAIHKYAPDYGFDVELKGFD
FQKLVQSRQQYIQNIHRAYDNNLAKNGVEVIKGFAKFVDNHTVEVNGELITADHILIATGGHPIKPNIKGAEHGIDSDGF
FALNHLPKRVAIVGAGYIAVEIAGVMNSLGAEVHLYVRQHSPLRSFDHTIVETLLIEMEQDGIQLHTNTTLTEVVKNDDS
SLTLCTTDGALDTVDCLIWAIGRAPSTDNINLQVTGVETTEFGKIIVDKFQNTNVKGIYAVGDIIENSVDLTPVAIAAGR
RLSERLFNNKPDEHLNYELIPTVIFTHPPIGTIGLSEIDAVNQFGKDNIKCYTSTFTDMYSAVTKHRQKSTMKLICLGEE
EKVIGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Sequences:

>Translated_451_residues
MTKHYDYIAIGGGSGGIASINRAASYGKKCAIIEANQLGGTCVNLGCVPKKVMWYGAQVAGAIHKYAPDYGFDVELKGFD
FQKLVQSRQQYIQNIHRAYDNNLAKNGVEVIKGFAKFVDNHTVEVNGELITADHILIATGGHPIKPNIKGAEHGIDSDGF
FALNHLPKRVAIVGAGYIAVEIAGVMNSLGAEVHLYVRQHSPLRSFDHTIVETLLIEMEQDGIQLHTNTTLTEVVKNDDS
SLTLCTTDGALDTVDCLIWAIGRAPSTDNINLQVTGVETTEFGKIIVDKFQNTNVKGIYAVGDIIENSVDLTPVAIAAGR
RLSERLFNNKPDEHLNYELIPTVIFTHPPIGTIGLSEIDAVNQFGKDNIKCYTSTFTDMYSAVTKHRQKSTMKLICLGEE
EKVIGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
>Mature_450_residues
TKHYDYIAIGGGSGGIASINRAASYGKKCAIIEANQLGGTCVNLGCVPKKVMWYGAQVAGAIHKYAPDYGFDVELKGFDF
QKLVQSRQQYIQNIHRAYDNNLAKNGVEVIKGFAKFVDNHTVEVNGELITADHILIATGGHPIKPNIKGAEHGIDSDGFF
ALNHLPKRVAIVGAGYIAVEIAGVMNSLGAEVHLYVRQHSPLRSFDHTIVETLLIEMEQDGIQLHTNTTLTEVVKNDDSS
LTLCTTDGALDTVDCLIWAIGRAPSTDNINLQVTGVETTEFGKIIVDKFQNTNVKGIYAVGDIIENSVDLTPVAIAAGRR
LSERLFNNKPDEHLNYELIPTVIFTHPPIGTIGLSEIDAVNQFGKDNIKCYTSTFTDMYSAVTKHRQKSTMKLICLGEEE
KVIGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=51.7391304347826, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=37.3417721518987, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=34.70715835141, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI33519430, Length=461, Percent_Identity=34.70715835141, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI33519428, Length=461, Percent_Identity=34.70715835141, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI33519426, Length=461, Percent_Identity=34.70715835141, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI148277065, Length=463, Percent_Identity=34.5572354211663, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI291045266, Length=436, Percent_Identity=33.7155963302752, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI291045268, Length=434, Percent_Identity=31.5668202764977, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=27.741935483871, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=69.179600886918, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=28.1879194630872, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=27.7533039647577, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=25.1655629139073, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=54.5454545454545, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=54.5454545454545, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=33.8983050847458, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=34.7916666666667, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=28.2937365010799, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17559934, Length=194, Percent_Identity=25.2577319587629, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=48.2832618025751, Blast_Score=408, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=27.1186440677966, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=466, Percent_Identity=24.4635193133047, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=39.6588486140725, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=39.6588486140725, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=39.6588486140725, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=35.3813559322034, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=27.061310782241, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49068; Mature: 48937

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYIAIGGGSGGIASINRAASYGKKCAIIEANQLGGTCVNLGCVPKKVMWYGAQVA
CCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
GAIHKYAPDYGFDVELKGFDFQKLVQSRQQYIQNIHRAYDNNLAKNGVEVIKGFAKFVDN
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
HTVEVNGELITADHILIATGGHPIKPNIKGAEHGIDSDGFFALNHLPKRVAIVGAGYIAV
CEEEECCEEEEECEEEEEECCCCCCCCCCCHHCCCCCCCEEEECCCCCEEEEEECCHHEE
EIAGVMNSLGAEVHLYVRQHSPLRSFDHTIVETLLIEMEQDGIQLHTNTTLTEVVKNDDS
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCC
SLTLCTTDGALDTVDCLIWAIGRAPSTDNINLQVTGVETTEFGKIIVDKFQNTNVKGIYA
CEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHCHHHHHHCCCCCCCEEEE
VGDIIENSVDLTPVAIAAGRRLSERLFNNKPDEHLNYELIPTVIFTHPPIGTIGLSEIDA
EHHHHHCCCCCCCHHHHHCHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHH
VNQFGKDNIKCYTSTFTDMYSAVTKHRQKSTMKLICLGEEEKVIGLHGIGFGVDEMIQGF
HHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHH
AVAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEEECCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure 
TKHYDYIAIGGGSGGIASINRAASYGKKCAIIEANQLGGTCVNLGCVPKKVMWYGAQVA
CCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
GAIHKYAPDYGFDVELKGFDFQKLVQSRQQYIQNIHRAYDNNLAKNGVEVIKGFAKFVDN
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
HTVEVNGELITADHILIATGGHPIKPNIKGAEHGIDSDGFFALNHLPKRVAIVGAGYIAV
CEEEECCEEEEECEEEEEECCCCCCCCCCCHHCCCCCCCEEEECCCCCEEEEEECCHHEE
EIAGVMNSLGAEVHLYVRQHSPLRSFDHTIVETLLIEMEQDGIQLHTNTTLTEVVKNDDS
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCC
SLTLCTTDGALDTVDCLIWAIGRAPSTDNINLQVTGVETTEFGKIIVDKFQNTNVKGIYA
CEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHCHHHHHHCCCCCCCEEEE
VGDIIENSVDLTPVAIAAGRRLSERLFNNKPDEHLNYELIPTVIFTHPPIGTIGLSEIDA
EHHHHHCCCCCCCHHHHHCHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHH
VNQFGKDNIKCYTSTFTDMYSAVTKHRQKSTMKLICLGEEEKVIGLHGIGFGVDEMIQGF
HHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHH
AVAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEEECCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]