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The map label for this gene is hemB [H]

Identifier: 93006584

GI number: 93006584

Start: 2179346

End: 2180353

Strand: Direct

Name: hemB [H]

Synonym: Pcryo_1760

Alternate gene names: 93006584

Gene position: 2179346-2180353 (Clockwise)

Preceding gene: 93006583

Following gene: 93006586

Centisome position: 71.22

GC content: 46.83

Gene sequence:

>1008_bases
ATGACTTATACTTTTAACCGCCAATTCCCTGAAACTCGCCTACGTCGTTTGCGTTATAACGACAATATACGGGCGATGAT
TCGTGAAGTTGAGCTGCATCCCAAGCACTTTATCGCGCCCGTTTTTGTATTAGAAGGTACTAACGAGCGTCAAAAAATCG
CTAGTATGCCGGGGGTTGAGCGCTTATCGATAGACCTGCTCATTAAGCACGCCAAAGACTTGTTAAGTGAAGGCGTCACG
ACCATCGATATCTTCCCAGTAATTGATAACTCACTAAAAACCCCTGATGGTAGGTCTGCTTATGATGAAAACGCTCTCAC
TGCACGTGCGGTAAAAGCGGTCAAAGATGCTGTGTCAGAGATGGTCGTCATGACCGATGTGGCATTGGACCCTTATACCT
CACACGGTCAAGATGGCTTGCTGGATAACTCAGGCTATGTCGTAAATGATGCAACGGTTGAAGTATTGGTCAAGCAAGCG
CTCGTCCATGCACGTGCTGGCGCTGATATCATCTCACCCAGTGACATGATGGATGGTCGTATCAAAGCCATGCGTGATGC
CTTTGAAGCTGAAGGTTTTGTGAATACCGCTATCATGGCGTATTCAGCAAAATACGCTTCTGCTTATTACGGTCCATTCC
GTGATGCGGTCGGTAGTGCGGGCAATTTAAAAGGTGGGCATAAGAAGCAGTATCAGATGGACTTTGGTAATCGTGCTGAA
GCGCTACACGAAGTTGCCATGGACATTAATGAAGGCGCGGATATGGTGATGATTAAACCGGGTCAGCCATACTTGGATTT
AATCCGTGAAGTCAAAAATACCTTTGGTGTACCAACGTTTGCATACCAAGTCTCTGGTGAATATGCCATGCATATGGCAG
CGATTCAAAACGGCTGGCTCACGGATGCGGTGATTTTAGAATCACTCATTGGCTTCCGCCGTGCAGGTGCCGATGGTATC
TTGACCTATTTTGCATTAGAAGCGGCAAGACAGCTGAATAACGCTTAA

Upstream 100 bases:

>100_bases
ATTGTGTGACGTACCTTTTTAAAAACCTCAATAGAAACCTCATTAAAAATCTCAGTAATTAAAAAAATAACCGTGATTGC
CATTCAGATAAGGAAACAAT

Downstream 100 bases:

>100_bases
TTTCAGCATATTTTTATATATAGTTAATCCACTTTTAAAAGGGTACAGAACTACTGGGTCTAATTATTCGCAGCCTCTGT
CTGCGTAGGCACAGCAAGCA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTYTFNRQFPETRLRRLRYNDNIRAMIREVELHPKHFIAPVFVLEGTNERQKIASMPGVERLSIDLLIKHAKDLLSEGVT
TIDIFPVIDNSLKTPDGRSAYDENALTARAVKAVKDAVSEMVVMTDVALDPYTSHGQDGLLDNSGYVVNDATVEVLVKQA
LVHARAGADIISPSDMMDGRIKAMRDAFEAEGFVNTAIMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAE
ALHEVAMDINEGADMVMIKPGQPYLDLIREVKNTFGVPTFAYQVSGEYAMHMAAIQNGWLTDAVILESLIGFRRAGADGI
LTYFALEAARQLNNA

Sequences:

>Translated_335_residues
MTYTFNRQFPETRLRRLRYNDNIRAMIREVELHPKHFIAPVFVLEGTNERQKIASMPGVERLSIDLLIKHAKDLLSEGVT
TIDIFPVIDNSLKTPDGRSAYDENALTARAVKAVKDAVSEMVVMTDVALDPYTSHGQDGLLDNSGYVVNDATVEVLVKQA
LVHARAGADIISPSDMMDGRIKAMRDAFEAEGFVNTAIMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAE
ALHEVAMDINEGADMVMIKPGQPYLDLIREVKNTFGVPTFAYQVSGEYAMHMAAIQNGWLTDAVILESLIGFRRAGADGI
LTYFALEAARQLNNA
>Mature_334_residues
TYTFNRQFPETRLRRLRYNDNIRAMIREVELHPKHFIAPVFVLEGTNERQKIASMPGVERLSIDLLIKHAKDLLSEGVTT
IDIFPVIDNSLKTPDGRSAYDENALTARAVKAVKDAVSEMVVMTDVALDPYTSHGQDGLLDNSGYVVNDATVEVLVKQAL
VHARAGADIISPSDMMDGRIKAMRDAFEAEGFVNTAIMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAEA
LHEVAMDINEGADMVMIKPGQPYLDLIREVKNTFGVPTFAYQVSGEYAMHMAAIQNGWLTDAVILESLIGFRRAGADGIL
TYFALEAARQLNNA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=329, Percent_Identity=38.2978723404255, Blast_Score=225, Evalue=4e-59,
Organism=Escherichia coli, GI87081728, Length=320, Percent_Identity=44.6875, Blast_Score=243, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321398, Length=315, Percent_Identity=34.2857142857143, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21358291, Length=298, Percent_Identity=38.9261744966443, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36992; Mature: 36860

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTFNRQFPETRLRRLRYNDNIRAMIREVELHPKHFIAPVFVLEGTNERQKIASMPGVE
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCHHHCCEEEEEECCCHHHHHHCCCCCH
RLSIDLLIKHAKDLLSEGVTTIDIFPVIDNSLKTPDGRSAYDENALTARAVKAVKDAVSE
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MVVMTDVALDPYTSHGQDGLLDNSGYVVNDATVEVLVKQALVHARAGADIISPSDMMDGR
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IKAMRDAFEAEGFVNTAIMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAE
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCEEECCCCCHHH
ALHEVAMDINEGADMVMIKPGQPYLDLIREVKNTFGVPTFAYQVSGEYAMHMAAIQNGWL
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCC
TDAVILESLIGFRRAGADGILTYFALEAARQLNNA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TYTFNRQFPETRLRRLRYNDNIRAMIREVELHPKHFIAPVFVLEGTNERQKIASMPGVE
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCHHHCCEEEEEECCCHHHHHHCCCCCH
RLSIDLLIKHAKDLLSEGVTTIDIFPVIDNSLKTPDGRSAYDENALTARAVKAVKDAVSE
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MVVMTDVALDPYTSHGQDGLLDNSGYVVNDATVEVLVKQALVHARAGADIISPSDMMDGR
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IKAMRDAFEAEGFVNTAIMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAE
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCEEECCCCCHHH
ALHEVAMDINEGADMVMIKPGQPYLDLIREVKNTFGVPTFAYQVSGEYAMHMAAIQNGWL
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCC
TDAVILESLIGFRRAGADGILTYFALEAARQLNNA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]