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The map label for this gene is mrdA [H]

Identifier: 93006569

GI number: 93006569

Start: 2160786

End: 2162774

Strand: Direct

Name: mrdA [H]

Synonym: Pcryo_1745

Alternate gene names: 93006569

Gene position: 2160786-2162774 (Clockwise)

Preceding gene: 93006562

Following gene: 93006570

Centisome position: 70.62

GC content: 46.35

Gene sequence:

>1989_bases
ATGAACAAACCGCTCACTCCTGATACCGAACAGGTCAATCGCATTTTTACCAGTCGCATTCTTATTCTTGGATTAATCAT
ATTTGTGGGCTTACTAGGGCTAATAGTACGTTATGGATTTCTGCAAGTTTTTGCTCACGATAAATATACGACCCAAGCAG
ACAACAATCGCATCAAATTGATTTCTGCCCCACCAAGTCGTGGTTATATTTATGATCGCAACGGCGTTATCCTCGCTGAC
AATCAGCCGGTTTTTACCGCTATGCTCAGCCCTGATGAAGTCGAAAACCCTGAGCGTACCTTACAATTACTCGCGCCCAT
CTTTGATTTGACGGATGAAAATATCACCGATATTTTGGCGCGTGTGAGTAAAAGTAAAAATGATCCGGTAACCATCAAGA
TTGACTTAACCGAGGCGCAATTGGCGCAGTTTAGTGAACGCAAACCTTTTTTTCGCGGTGTTAGCATCCAAAGTAAGCTC
ACACGCTCATACCCTTATGATGAACTTTTTGCCCATGTTATTGGCTATGTCGGACGTATTAACGACAAAGAATCGAAGAG
AATCAATAAAGATCGCTATGCCGGTACCGACCTTATCGGTAAGATTGGGATCGAAGATTATTACGAAGATATTTTACTTG
GACAACCCGGTTATCAGTCAGTAGAAACCAACGCGCACGGCAATGTGCTACGTCAACTTGATACTAAGCCACCAATCGCC
GGCAACGACATCACCTTAAGTTTAGATTATGGGTTGCAGGTTGTGGCGCAGCAGCAGCTTGATGGCAGGCGCGGTGCCAT
TGTGGCAATAGACCCCAAAACCGGCGATGTACTAGCCTTTGTCAGTAATCCAAGTTATGACCCAAACCCCTTCATCTCCG
GCATCTCATTTAAAGACTATGATGATCTGCGTGAAGATTTGGATCAGCCGCTTTATAACCGTGCCCTACAAGGCACTTAT
CCACCGGGTTCAACTATCAAGCCCTTTGAAGCCCTAGGCGGTATTCATTATGGTCTACGTAACTGGGAAACCACTATCTA
CGACCCAGGTTATTTTAGCCTGCCAGGTGACTCCCACCGCTTTCGTGATTGGAAAAAAGGTGGTCATGGTACCGTCGATC
TCAAAAAATCCATCGTGATGTCAGTCGATACTTATTATTATAAATTGGCGTATGAGATGGGCATTCAGCGCTTACATGAC
TGGATGGTACGTTTTGGCTTCGGCGAAGAAACTGGCATTGACTTGCCCAATGAAAAATCCGGAATTATGCCTTCACCAAA
ATGGAAAAAAGACACGTACGATAAGGGTTGGTTGCCGGGTGAGACCATCTCTGTCAGTATTGGTCAAGGCTATTTCTTAG
CGACGCCACTACAGATTGCCAATGCAACGGCCATGACAGCGAGTAAAGGTCTTCATATTACTCCGCATCTCTTAAAGAGT
AGCGACGGTGCAGCAGCAGTCGATGTCATCACCAAACCGGATGGCAAGATTGATTATAATGGCAAACCCTCTGATTGGCT
GCGTATGCATGATGCTATGGAGCAAACGGTCAAAGCCGGTACTGGACGCGGTATATACACACCGCGCTATCGTATCGCCG
GTAAAACGGGCACCGCGCAAGTAAAATCCATTGCTCAGGGTAAAAGCTATAACAAATCCGCGCTGGATAAGCGCCACTGG
GATCACGCTTGGTTTAATGGCTTTGCGCCAGTAGAGGATCCACAAATCGCCCTAGCGGTATTGGTCGAAAACGGCGGTGG
CGGTAGTGTCGTTGCTGCGCCTATTGGGCGAGCCTTGTTTGATTATTGGGTATTACAGCGCGACACCAATCCTATTTTGC
CGCCCACTGCTGATCAGCTAAAGGTTATTAAACGGCAAAAAGCATTTGAGAAAGCCATGCGTGATGCGATACGTGAAAAA
GAATACAAAGCACTAGAAGCCGCAAAAGAACAGGCTCAAACCGCTACAACGACAGCGACTTCTGACTAA

Upstream 100 bases:

>100_bases
TCTACATGATATTTGACATGGTCGACTGCTACTTTATAAATACCTCTTTTGATAACTTTTTGATTTATTGTCTCACTGAC
TGTTTGGGTACTGACTTTAT

Downstream 100 bases:

>100_bases
CATATTCAGTATAGAGTAGATAACTAAGCTAATTTTATGAAAAAATCTTCAAGCGCGCGTAAGCCTAGTAAAAACCAAAA
AACCAAATCTACTGCAGCTG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MNKPLTPDTEQVNRIFTSRILILGLIIFVGLLGLIVRYGFLQVFAHDKYTTQADNNRIKLISAPPSRGYIYDRNGVILAD
NQPVFTAMLSPDEVENPERTLQLLAPIFDLTDENITDILARVSKSKNDPVTIKIDLTEAQLAQFSERKPFFRGVSIQSKL
TRSYPYDELFAHVIGYVGRINDKESKRINKDRYAGTDLIGKIGIEDYYEDILLGQPGYQSVETNAHGNVLRQLDTKPPIA
GNDITLSLDYGLQVVAQQQLDGRRGAIVAIDPKTGDVLAFVSNPSYDPNPFISGISFKDYDDLREDLDQPLYNRALQGTY
PPGSTIKPFEALGGIHYGLRNWETTIYDPGYFSLPGDSHRFRDWKKGGHGTVDLKKSIVMSVDTYYYKLAYEMGIQRLHD
WMVRFGFGEETGIDLPNEKSGIMPSPKWKKDTYDKGWLPGETISVSIGQGYFLATPLQIANATAMTASKGLHITPHLLKS
SDGAAAVDVITKPDGKIDYNGKPSDWLRMHDAMEQTVKAGTGRGIYTPRYRIAGKTGTAQVKSIAQGKSYNKSALDKRHW
DHAWFNGFAPVEDPQIALAVLVENGGGGSVVAAPIGRALFDYWVLQRDTNPILPPTADQLKVIKRQKAFEKAMRDAIREK
EYKALEAAKEQAQTATTTATSD

Sequences:

>Translated_662_residues
MNKPLTPDTEQVNRIFTSRILILGLIIFVGLLGLIVRYGFLQVFAHDKYTTQADNNRIKLISAPPSRGYIYDRNGVILAD
NQPVFTAMLSPDEVENPERTLQLLAPIFDLTDENITDILARVSKSKNDPVTIKIDLTEAQLAQFSERKPFFRGVSIQSKL
TRSYPYDELFAHVIGYVGRINDKESKRINKDRYAGTDLIGKIGIEDYYEDILLGQPGYQSVETNAHGNVLRQLDTKPPIA
GNDITLSLDYGLQVVAQQQLDGRRGAIVAIDPKTGDVLAFVSNPSYDPNPFISGISFKDYDDLREDLDQPLYNRALQGTY
PPGSTIKPFEALGGIHYGLRNWETTIYDPGYFSLPGDSHRFRDWKKGGHGTVDLKKSIVMSVDTYYYKLAYEMGIQRLHD
WMVRFGFGEETGIDLPNEKSGIMPSPKWKKDTYDKGWLPGETISVSIGQGYFLATPLQIANATAMTASKGLHITPHLLKS
SDGAAAVDVITKPDGKIDYNGKPSDWLRMHDAMEQTVKAGTGRGIYTPRYRIAGKTGTAQVKSIAQGKSYNKSALDKRHW
DHAWFNGFAPVEDPQIALAVLVENGGGGSVVAAPIGRALFDYWVLQRDTNPILPPTADQLKVIKRQKAFEKAMRDAIREK
EYKALEAAKEQAQTATTTATSD
>Mature_662_residues
MNKPLTPDTEQVNRIFTSRILILGLIIFVGLLGLIVRYGFLQVFAHDKYTTQADNNRIKLISAPPSRGYIYDRNGVILAD
NQPVFTAMLSPDEVENPERTLQLLAPIFDLTDENITDILARVSKSKNDPVTIKIDLTEAQLAQFSERKPFFRGVSIQSKL
TRSYPYDELFAHVIGYVGRINDKESKRINKDRYAGTDLIGKIGIEDYYEDILLGQPGYQSVETNAHGNVLRQLDTKPPIA
GNDITLSLDYGLQVVAQQQLDGRRGAIVAIDPKTGDVLAFVSNPSYDPNPFISGISFKDYDDLREDLDQPLYNRALQGTY
PPGSTIKPFEALGGIHYGLRNWETTIYDPGYFSLPGDSHRFRDWKKGGHGTVDLKKSIVMSVDTYYYKLAYEMGIQRLHD
WMVRFGFGEETGIDLPNEKSGIMPSPKWKKDTYDKGWLPGETISVSIGQGYFLATPLQIANATAMTASKGLHITPHLLKS
SDGAAAVDVITKPDGKIDYNGKPSDWLRMHDAMEQTVKAGTGRGIYTPRYRIAGKTGTAQVKSIAQGKSYNKSALDKRHW
DHAWFNGFAPVEDPQIALAVLVENGGGGSVVAAPIGRALFDYWVLQRDTNPILPPTADQLKVIKRQKAFEKAMRDAIREK
EYKALEAAKEQAQTATTTATSD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=614, Percent_Identity=42.8338762214984, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1786272, Length=639, Percent_Identity=24.7261345852895, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 73681; Mature: 73681

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPLTPDTEQVNRIFTSRILILGLIIFVGLLGLIVRYGFLQVFAHDKYTTQADNNRIKL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEE
ISAPPSRGYIYDRNGVILADNQPVFTAMLSPDEVENPERTLQLLAPIFDLTDENITDILA
EECCCCCCEEECCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
RVSKSKNDPVTIKIDLTEAQLAQFSERKPFFRGVSIQSKLTRSYPYDELFAHVIGYVGRI
HHHCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCC
NDKESKRINKDRYAGTDLIGKIGIEDYYEDILLGQPGYQSVETNAHGNVLRQLDTKPPIA
CCHHHHHCCHHHCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCC
GNDITLSLDYGLQVVAQQQLDGRRGAIVAIDPKTGDVLAFVSNPSYDPNPFISGISFKDY
CCCEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCH
DDLREDLDQPLYNRALQGTYPPGSTIKPFEALGGIHYGLRNWETTIYDPGYFSLPGDSHR
HHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHCCCCEEEECCCEEECCCCCCH
FRDWKKGGHGTVDLKKSIVMSVDTYYYKLAYEMGIQRLHDWMVRFGFGEETGIDLPNEKS
HHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GIMPSPKWKKDTYDKGWLPGETISVSIGQGYFLATPLQIANATAMTASKGLHITPHLLKS
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCHHHHCCHHHHHCCCCEECHHHHCC
SDGAAAVDVITKPDGKIDYNGKPSDWLRMHDAMEQTVKAGTGRGIYTPRYRIAGKTGTAQ
CCCCEEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHH
VKSIAQGKSYNKSALDKRHWDHAWFNGFAPVEDPQIALAVLVENGGGGSVVAAPIGRALF
HHHHHCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCEEEEEEEECCCCCCEEHHHHHHHHH
DYWVLQRDTNPILPPTADQLKVIKRQKAFEKAMRDAIREKEYKALEAAKEQAQTATTTAT
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SD
CC
>Mature Secondary Structure
MNKPLTPDTEQVNRIFTSRILILGLIIFVGLLGLIVRYGFLQVFAHDKYTTQADNNRIKL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEE
ISAPPSRGYIYDRNGVILADNQPVFTAMLSPDEVENPERTLQLLAPIFDLTDENITDILA
EECCCCCCEEECCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
RVSKSKNDPVTIKIDLTEAQLAQFSERKPFFRGVSIQSKLTRSYPYDELFAHVIGYVGRI
HHHCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCC
NDKESKRINKDRYAGTDLIGKIGIEDYYEDILLGQPGYQSVETNAHGNVLRQLDTKPPIA
CCHHHHHCCHHHCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCC
GNDITLSLDYGLQVVAQQQLDGRRGAIVAIDPKTGDVLAFVSNPSYDPNPFISGISFKDY
CCCEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCH
DDLREDLDQPLYNRALQGTYPPGSTIKPFEALGGIHYGLRNWETTIYDPGYFSLPGDSHR
HHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHCCCCEEEECCCEEECCCCCCH
FRDWKKGGHGTVDLKKSIVMSVDTYYYKLAYEMGIQRLHDWMVRFGFGEETGIDLPNEKS
HHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GIMPSPKWKKDTYDKGWLPGETISVSIGQGYFLATPLQIANATAMTASKGLHITPHLLKS
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCHHHHCCHHHHHCCCCEECHHHHCC
SDGAAAVDVITKPDGKIDYNGKPSDWLRMHDAMEQTVKAGTGRGIYTPRYRIAGKTGTAQ
CCCCEEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHH
VKSIAQGKSYNKSALDKRHWDHAWFNGFAPVEDPQIALAVLVENGGGGSVVAAPIGRALF
HHHHHCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCEEEEEEEECCCCCCEEHHHHHHHHH
DYWVLQRDTNPILPPTADQLKVIKRQKAFEKAMRDAIREKEYKALEAAKEQAQTATTTAT
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]