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The map label for this gene is silS [H]

Identifier: 93006071

GI number: 93006071

Start: 1513614

End: 1514930

Strand: Reverse

Name: silS [H]

Synonym: Pcryo_1243

Alternate gene names: 93006071

Gene position: 1514930-1513614 (Counterclockwise)

Preceding gene: 93006072

Following gene: 93006070

Centisome position: 49.51

GC content: 40.32

Gene sequence:

>1317_bases
ATGTTCACTATAGAATCCATCGCTAATAAGTTTCGAATCTCCTATTTGTTATTTGCCTTACTGCTTTGCACAACGTTCGT
CAGTATTTTTATGTACGCTGAGATGCGAATCGAACAGGACTTAGTGAAAGGACGTCTTTTACAACAGCTGCAACTTAGTC
AAGAAAAAGAAGGTGAACAGGCGGCTTATACAGCAAATCCTGGTATTAAAATTTATCGTTATGACAGTGCGCCAGAAAAT
TTAAAAGCGATAGCAAACGGAACTGTTCAAGAGATGCAGGTAACCGTGAACAATCAAACGGGCGATACTGAAACGAATCT
TCATTTTTTTGCCCATCAACAAAATGAGCAAAAATATATTTTGACCTACTTAGAAGGGTCCGAGATGGTGATGGAAAACT
ATCCTGTTTTAGCTATCTTTGAAGAGTTAGAGGATATATTTGCAGATGCACTAAAAATTGCGGTTGTTTTGAGTTTGCTC
ATTGCAGCGCTATTCTCTTACTTATCCTCTAAGCAAATCATCAAGCCTTTACTAGATTTAAAGCAAGCCGTAGAAACCGA
TCATCAAAACCTCACTGACTTAACCCATTTACCCTCAGAAGTTGGGGTGTTGGCACGTGCTATCGATGAAAAAAATCATA
AACTAGAGCAATATCTAAAACGTGAGCAGCTATTTACTGGCGATGTCAGTCATGAATTACGCACACCGTTGACCATTATC
ATGGGTGCATCGGAGGTACTAGCCTCACAACTTGAAGAAAATAGTCGCCTGAGCGAATTCGCCAACCGTATTAGTACGAC
CGCCAAAGAAACCTCCGAAATCATCAGCGCTTTATTACTTTTATCGCGCGCGCCTGAACAGCTGGACACACCGCAAACCT
CTATCAACACCATCGCCCTTAATGAAGTGACACGCTTAACATATTTGCTCCGCCATAAACCGGTAACTTGTAAAGTAGTC
GCTGAGCAAGATTACATAGCAAATGTCCGCCCTGAGCTGCTAAAAATGGCATTGGGTAATTTAATAAAAAATGCGTTTCA
ATACACAGATGATGGTGAAGTCATTGTCACTATCGATGCTGAAAAAATTACGGTGACTGATACTGGTCTTGGTATTCCCG
AAATTATGATGCCTTTACTCTATGAGAGATTTGAGCGTCTGAATGACATAAATACCAGCGATCAGGTAGAAGGTAGCGGT
TTGGGTCTTAGCATTGTGCAACGTATCATGACTCATATGAACTGGGAGCTTATGCATCAAGACAATGCTACAGGTGGTAG
TACGTTTAGCATTTATTATAATAAATGCCATATATAA

Upstream 100 bases:

>100_bases
AGTTTGAAAATTCATAATACAATTTAAAGATTGAAGTTTACTATAAGTAGTTACGCCCGTACTTCCCTATCTATTACCTG
ACTCTAAATAAGCACCTGCC

Downstream 100 bases:

>100_bases
GTCTTCACTGTATTTCATGAATCAACCAATCAATATTGTCTTAACGTTTTCTTAATATCCCCTGTTTTATACTGTTTCCA
TAAGAACAGTATGCTAATTT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MFTIESIANKFRISYLLFALLLCTTFVSIFMYAEMRIEQDLVKGRLLQQLQLSQEKEGEQAAYTANPGIKIYRYDSAPEN
LKAIANGTVQEMQVTVNNQTGDTETNLHFFAHQQNEQKYILTYLEGSEMVMENYPVLAIFEELEDIFADALKIAVVLSLL
IAALFSYLSSKQIIKPLLDLKQAVETDHQNLTDLTHLPSEVGVLARAIDEKNHKLEQYLKREQLFTGDVSHELRTPLTII
MGASEVLASQLEENSRLSEFANRISTTAKETSEIISALLLLSRAPEQLDTPQTSINTIALNEVTRLTYLLRHKPVTCKVV
AEQDYIANVRPELLKMALGNLIKNAFQYTDDGEVIVTIDAEKITVTDTGLGIPEIMMPLLYERFERLNDINTSDQVEGSG
LGLSIVQRIMTHMNWELMHQDNATGGSTFSIYYNKCHI

Sequences:

>Translated_438_residues
MFTIESIANKFRISYLLFALLLCTTFVSIFMYAEMRIEQDLVKGRLLQQLQLSQEKEGEQAAYTANPGIKIYRYDSAPEN
LKAIANGTVQEMQVTVNNQTGDTETNLHFFAHQQNEQKYILTYLEGSEMVMENYPVLAIFEELEDIFADALKIAVVLSLL
IAALFSYLSSKQIIKPLLDLKQAVETDHQNLTDLTHLPSEVGVLARAIDEKNHKLEQYLKREQLFTGDVSHELRTPLTII
MGASEVLASQLEENSRLSEFANRISTTAKETSEIISALLLLSRAPEQLDTPQTSINTIALNEVTRLTYLLRHKPVTCKVV
AEQDYIANVRPELLKMALGNLIKNAFQYTDDGEVIVTIDAEKITVTDTGLGIPEIMMPLLYERFERLNDINTSDQVEGSG
LGLSIVQRIMTHMNWELMHQDNATGGSTFSIYYNKCHI
>Mature_438_residues
MFTIESIANKFRISYLLFALLLCTTFVSIFMYAEMRIEQDLVKGRLLQQLQLSQEKEGEQAAYTANPGIKIYRYDSAPEN
LKAIANGTVQEMQVTVNNQTGDTETNLHFFAHQQNEQKYILTYLEGSEMVMENYPVLAIFEELEDIFADALKIAVVLSLL
IAALFSYLSSKQIIKPLLDLKQAVETDHQNLTDLTHLPSEVGVLARAIDEKNHKLEQYLKREQLFTGDVSHELRTPLTII
MGASEVLASQLEENSRLSEFANRISTTAKETSEIISALLLLSRAPEQLDTPQTSINTIALNEVTRLTYLLRHKPVTCKVV
AEQDYIANVRPELLKMALGNLIKNAFQYTDDGEVIVTIDAEKITVTDTGLGIPEIMMPLLYERFERLNDINTSDQVEGSG
LGLSIVQRIMTHMNWELMHQDNATGGSTFSIYYNKCHI

Specific function: Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system silS/silR. May activate silR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=28.2511210762332, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=27.9461279461279, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=27.3858921161826, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=27.4261603375527, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=294, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=306, Percent_Identity=28.1045751633987, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=28.3842794759825, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=27.3648648648649, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=232, Percent_Identity=28.448275862069, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI48994928, Length=252, Percent_Identity=25, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789808, Length=294, Percent_Identity=25.5102040816327, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49480; Mature: 49480

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTIESIANKFRISYLLFALLLCTTFVSIFMYAEMRIEQDLVKGRLLQQLQLSQEKEGEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAYTANPGIKIYRYDSAPENLKAIANGTVQEMQVTVNNQTGDTETNLHFFAHQQNEQKYI
CEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCEEE
LTYLEGSEMVMENYPVLAIFEELEDIFADALKIAVVLSLLIAALFSYLSSKQIIKPLLDL
EEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
KQAVETDHQNLTDLTHLPSEVGVLARAIDEKNHKLEQYLKREQLFTGDVSHELRTPLTII
HHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEE
MGASEVLASQLEENSRLSEFANRISTTAKETSEIISALLLLSRAPEQLDTPQTSINTIAL
ECCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEHH
NEVTRLTYLLRHKPVTCKVVAEQDYIANVRPELLKMALGNLIKNAFQYTDDGEVIVTIDA
HHHHHHHHHHHCCCCEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
EKITVTDTGLGIPEIMMPLLYERFERLNDINTSDQVEGSGLGLSIVQRIMTHMNWELMHQ
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEC
DNATGGSTFSIYYNKCHI
CCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MFTIESIANKFRISYLLFALLLCTTFVSIFMYAEMRIEQDLVKGRLLQQLQLSQEKEGEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAYTANPGIKIYRYDSAPENLKAIANGTVQEMQVTVNNQTGDTETNLHFFAHQQNEQKYI
CEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCEEE
LTYLEGSEMVMENYPVLAIFEELEDIFADALKIAVVLSLLIAALFSYLSSKQIIKPLLDL
EEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
KQAVETDHQNLTDLTHLPSEVGVLARAIDEKNHKLEQYLKREQLFTGDVSHELRTPLTII
HHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEE
MGASEVLASQLEENSRLSEFANRISTTAKETSEIISALLLLSRAPEQLDTPQTSINTIAL
ECCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEHH
NEVTRLTYLLRHKPVTCKVVAEQDYIANVRPELLKMALGNLIKNAFQYTDDGEVIVTIDA
HHHHHHHHHHHCCCCEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
EKITVTDTGLGIPEIMMPLLYERFERLNDINTSDQVEGSGLGLSIVQRIMTHMNWELMHQ
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEC
DNATGGSTFSIYYNKCHI
CCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]