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The map label for this gene is ndk [H]

Identifier: 93005477

GI number: 93005477

Start: 765606

End: 766037

Strand: Direct

Name: ndk [H]

Synonym: Pcryo_0647

Alternate gene names: 93005477

Gene position: 765606-766037 (Clockwise)

Preceding gene: 93005476

Following gene: 93005478

Centisome position: 25.02

GC content: 44.68

Gene sequence:

>432_bases
ATGGCTAACGAACGTACTCTATCTATCATCAAACCTGACGCAGTCGCTGGCAACAACATTGGCGCTATCTACGATCGTTT
TGAAAAATCAGGTCTAAAAATTGTTGCTGCTAAAATGATGCAACTTGATGATAAAAAAGCGGGCGGTTTTTACGCTGAGC
ACGCTGAGCGTCCATTCTACAACGACCTAGTATCATTTATGACGTCAGGTCCAGTACTGGTATCAGTATTAGAAGGCGAA
AATGCGATCGCTACGCATCGTGATATCATGGGCGCGACTAACCCAAAAGACGCAGCTGAAGGCACTATCCGTGCTGATTT
CGCTAGCAGTATCGATGAAAATGCGGTTCATGGTTCAGATTCAGCTGAATCAGCAGCACGTGAAATCAGCTACTTTTTCA
ATGAAGAAGAAGTGTGTGCACGTACGCGTTAA

Upstream 100 bases:

>100_bases
TGCGTATCCGCATTGGACATGCATAAATGAATTCGCTCAGCGCAGTGATCACAGACAACGTAAATTATTTAACTTCTCAC
TTATTTATTAGGAGCTTTTC

Downstream 100 bases:

>100_bases
TAGCAGTTTTTATTGATAGCCGCTTTTATGCATAATAGCTGTTATGCATAATAACAGTGCTAATTAATAATTAGTGTAGC
GAAACGGCTTATATCTTTTG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MANERTLSIIKPDAVAGNNIGAIYDRFEKSGLKIVAAKMMQLDDKKAGGFYAEHAERPFYNDLVSFMTSGPVLVSVLEGE
NAIATHRDIMGATNPKDAAEGTIRADFASSIDENAVHGSDSAESAAREISYFFNEEEVCARTR

Sequences:

>Translated_143_residues
MANERTLSIIKPDAVAGNNIGAIYDRFEKSGLKIVAAKMMQLDDKKAGGFYAEHAERPFYNDLVSFMTSGPVLVSVLEGE
NAIATHRDIMGATNPKDAAEGTIRADFASSIDENAVHGSDSAESAAREISYFFNEEEVCARTR
>Mature_142_residues
ANERTLSIIKPDAVAGNNIGAIYDRFEKSGLKIVAAKMMQLDDKKAGGFYAEHAERPFYNDLVSFMTSGPVLVSVLEGEN
AIATHRDIMGATNPKDAAEGTIRADFASSIDENAVHGSDSAESAAREISYFFNEEEVCARTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=47.4452554744526, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI4557797, Length=143, Percent_Identity=44.7552447552448, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI38045913, Length=143, Percent_Identity=44.7552447552448, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI66392203, Length=139, Percent_Identity=44.6043165467626, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI66392227, Length=139, Percent_Identity=44.6043165467626, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI66392205, Length=139, Percent_Identity=44.6043165467626, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4505409, Length=139, Percent_Identity=44.6043165467626, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI66392192, Length=139, Percent_Identity=44.6043165467626, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=39.2857142857143, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI37574614, Length=141, Percent_Identity=39.0070921985816, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI7019465, Length=141, Percent_Identity=39.0070921985816, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=38.2352941176471, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=32.5925925925926, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=32.5925925925926, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=30.6569343065693, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=65.034965034965, Blast_Score=197, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=41.726618705036, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=47.4452554744526, Blast_Score=139, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45549037, Length=140, Percent_Identity=44.2857142857143, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18860097, Length=139, Percent_Identity=36.6906474820144, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15508; Mature: 15377

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANERTLSIIKPDAVAGNNIGAIYDRFEKSGLKIVAAKMMQLDDKKAGGFYAEHAERPFY
CCCCCEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHH
NDLVSFMTSGPVLVSVLEGENAIATHRDIMGATNPKDAAEGTIRADFASSIDENAVHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
SAESAAREISYFFNEEEVCARTR
HHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure 
ANERTLSIIKPDAVAGNNIGAIYDRFEKSGLKIVAAKMMQLDDKKAGGFYAEHAERPFY
CCCCEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHH
NDLVSFMTSGPVLVSVLEGENAIATHRDIMGATNPKDAAEGTIRADFASSIDENAVHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
SAESAAREISYFFNEEEVCARTR
HHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA