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The map label for this gene is add

Identifier: 93005286

GI number: 93005286

Start: 560229

End: 561227

Strand: Direct

Name: add

Synonym: Pcryo_0456

Alternate gene names: 93005286

Gene position: 560229-561227 (Clockwise)

Preceding gene: 93005285

Following gene: 93005288

Centisome position: 18.31

GC content: 38.74

Gene sequence:

>999_bases
ATGATTGATCTAATAAAAAGACTGCCAAAAGCAGAACTGCATTTACATATTGAAGGCTCGCTCGAGCCTGAGCTTATGTT
TAGATTGGCAAAAAAGAACCAGATAGAGATTCCTTATAAAGACATAGAAGATGTGCGTAATGCTTATAACTTTACCAATC
TGCAGACGTTTTTAGACATCTATTATGCCGGTGCCAATGTCTTGATTACGCAGGATGATTTCTACGATTTGACATGGGAG
TATATTCTCAAATGTGTCGAAGACAATGTCATTCATACAGAGATATTTTTTGATCCGCAGACGCATACGGCAAGAGGCGT
GACGTTTGAGACAGTCATAACAGGCATCAAACGTGCACTGGCTGATGCCAAAGCACAATATGGTATTACTTCTTGTATTA
TCATGTGCTTTTTACGGCATTTATCACAAGAAGAAGCGTTTGAGACGTTAGAGCAAGCATTACCATTTAAAGACGATATT
ATCGGTGTCGGTTTAGATTCTTCAGAATTAGGCAATCCGCCATCGAAGTTTATAGAGGTATTTAAAAAGGCAAAAGAGGA
AGGCTTTAAGTTGGTTGCCCATGCTGGCGAAGAAGCGGATTTCTCTTACATTTATGAAGCGTTAGATTTATTGGATATCA
GTAGAATCGACCATGGCGTGCAATCTATCAAAAGCGCTGAGCTGATGCAGCGTCTAAAAGATGAGCAGATGCCGCTCACC
GTATGCCCGAATTCTAATATCGAGTTGAGAGTATTTAACAATTATAAAGAGCACAACATCAAAGAGCTGCTAGATTATGG
TCTAAATATCACTGTCAATTCAGATGACCCTGCTTATTTTAAAGGCTATATCAATCAGAACTTTATTAATATCAGCGAGA
ATTTGCCACTGACAGAAGACGATATTATCACCTTGGTAAAGAACTCTTTTAGATCGTCATTTATCAGTGATGAGCTAAAG
CAGCAGTATTTAAATAGAGTCGATCAAGCGGTAGGCTAA

Upstream 100 bases:

>100_bases
TTAAAATAAACCCTTACGGCCATCAGCATGAAAGATTACACTAAACACTTATCGCTATATTTAATAAATAACCGATATAC
AACGCCAATACTGGAATATT

Downstream 100 bases:

>100_bases
TGGGATGCCAGTTATATCATAGTATGCCCATTCTTTTTACCAACTCTGGCAGGATGGCACCAGCTTTTGCTGCCAGAGTA
ATATCGACTAGCGTATTTGG

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MIDLIKRLPKAELHLHIEGSLEPELMFRLAKKNQIEIPYKDIEDVRNAYNFTNLQTFLDIYYAGANVLITQDDFYDLTWE
YILKCVEDNVIHTEIFFDPQTHTARGVTFETVITGIKRALADAKAQYGITSCIIMCFLRHLSQEEAFETLEQALPFKDDI
IGVGLDSSELGNPPSKFIEVFKKAKEEGFKLVAHAGEEADFSYIYEALDLLDISRIDHGVQSIKSAELMQRLKDEQMPLT
VCPNSNIELRVFNNYKEHNIKELLDYGLNITVNSDDPAYFKGYINQNFINISENLPLTEDDIITLVKNSFRSSFISDELK
QQYLNRVDQAVG

Sequences:

>Translated_332_residues
MIDLIKRLPKAELHLHIEGSLEPELMFRLAKKNQIEIPYKDIEDVRNAYNFTNLQTFLDIYYAGANVLITQDDFYDLTWE
YILKCVEDNVIHTEIFFDPQTHTARGVTFETVITGIKRALADAKAQYGITSCIIMCFLRHLSQEEAFETLEQALPFKDDI
IGVGLDSSELGNPPSKFIEVFKKAKEEGFKLVAHAGEEADFSYIYEALDLLDISRIDHGVQSIKSAELMQRLKDEQMPLT
VCPNSNIELRVFNNYKEHNIKELLDYGLNITVNSDDPAYFKGYINQNFINISENLPLTEDDIITLVKNSFRSSFISDELK
QQYLNRVDQAVG
>Mature_332_residues
MIDLIKRLPKAELHLHIEGSLEPELMFRLAKKNQIEIPYKDIEDVRNAYNFTNLQTFLDIYYAGANVLITQDDFYDLTWE
YILKCVEDNVIHTEIFFDPQTHTARGVTFETVITGIKRALADAKAQYGITSCIIMCFLRHLSQEEAFETLEQALPFKDDI
IGVGLDSSELGNPPSKFIEVFKKAKEEGFKLVAHAGEEADFSYIYEALDLLDISRIDHGVQSIKSAELMQRLKDEQMPLT
VCPNSNIELRVFNNYKEHNIKELLDYGLNITVNSDDPAYFKGYINQNFINISENLPLTEDDIITLVKNSFRSSFISDELK
QQYLNRVDQAVG

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=346, Percent_Identity=23.121387283237, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1787910, Length=332, Percent_Identity=25.9036144578313, Blast_Score=131, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17538512, Length=342, Percent_Identity=21.6374269005848, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32565969, Length=342, Percent_Identity=21.6374269005848, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324188, Length=339, Percent_Identity=43.6578171091445, Blast_Score=296, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24645260, Length=341, Percent_Identity=24.9266862170088, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_PSYCK (Q1QDL4)

Other databases:

- EMBL:   CP000323
- RefSeq:   YP_579723.1
- ProteinModelPortal:   Q1QDL4
- SMR:   Q1QDL4
- STRING:   Q1QDL4
- GeneID:   4034074
- GenomeReviews:   CP000323_GR
- KEGG:   pcr:Pcryo_0456
- NMPDR:   fig|335284.3.peg.1246
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   YFGGYLN
- PhylomeDB:   Q1QDL4
- ProtClustDB:   CLSK2777524
- BioCyc:   PCRY335284:PCRYO_0456-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 38113; Mature: 38113

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 197-197 BINDING 16-16 BINDING 18-18 BINDING 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLIKRLPKAELHLHIEGSLEPELMFRLAKKNQIEIPYKDIEDVRNAYNFTNLQTFLDI
CCCHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
YYAGANVLITQDDFYDLTWEYILKCVEDNVIHTEIFFDPQTHTARGVTFETVITGIKRAL
HHCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
ADAKAQYGITSCIIMCFLRHLSQEEAFETLEQALPFKDDIIGVGLDSSELGNPPSKFIEV
HHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEECCCCHHHCCCCHHHHHHH
FKKAKEEGFKLVAHAGEEADFSYIYEALDLLDISRIDHGVQSIKSAELMQRLKDEQMPLT
HHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VCPNSNIELRVFNNYKEHNIKELLDYGLNITVNSDDPAYFKGYINQNFINISENLPLTED
ECCCCCEEEEEECCCCCCCHHHHHHCCCEEEECCCCCCHHHHCCCCCEEEECCCCCCCHH
DIITLVKNSFRSSFISDELKQQYLNRVDQAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDLIKRLPKAELHLHIEGSLEPELMFRLAKKNQIEIPYKDIEDVRNAYNFTNLQTFLDI
CCCHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
YYAGANVLITQDDFYDLTWEYILKCVEDNVIHTEIFFDPQTHTARGVTFETVITGIKRAL
HHCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
ADAKAQYGITSCIIMCFLRHLSQEEAFETLEQALPFKDDIIGVGLDSSELGNPPSKFIEV
HHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEECCCCHHHCCCCHHHHHHH
FKKAKEEGFKLVAHAGEEADFSYIYEALDLLDISRIDHGVQSIKSAELMQRLKDEQMPLT
HHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VCPNSNIELRVFNNYKEHNIKELLDYGLNITVNSDDPAYFKGYINQNFINISENLPLTED
ECCCCCEEEEEECCCCCCCHHHHHHCCCEEEECCCCCCHHHHCCCCCEEEECCCCCCCHH
DIITLVKNSFRSSFISDELKQQYLNRVDQAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA