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The map label for this gene is proC [H]

Identifier: 93005008

GI number: 93005008

Start: 208179

End: 209012

Strand: Direct

Name: proC [H]

Synonym: Pcryo_0177

Alternate gene names: 93005008

Gene position: 208179-209012 (Clockwise)

Preceding gene: 93005006

Following gene: 93005009

Centisome position: 6.8

GC content: 48.68

Gene sequence:

>834_bases
ATGTCAGTATTAGATAATAAGAAAATCAGCTTTATCGGCGGCGGAAATATGGCGCAGGCTTTGATTAGTGGGCTTGTCAG
CTGCGGCATCAAGCCGAGTTTAATTACCGTTGCTGATCCTAGTAGTGAGGCGCGTGAGCAATTGGCTGCTAAAGGATTGA
ACACGGTTGATCCAACTGCTGATGCAAAAGCTGCCGTTATCGATGCTGACATTGTGGTGCTGGCGGTCAAACCGCAAGTG
ATGAAAGCGGTGGTCAGTAGCTTTGCGGATGTCTTAGACAAACAGCTGGTGATTTCAGTGGCAGCAGGTTTGTCGACTGA
GCTTTTATCTGACATGTTGGGTGGCTGTGAAAATATCGTCCGTGCAATGCCAAATACCCCTGCAATGATTCAAATGGGTG
CAACGGGTCTGTACGGTACTGATAATATTTCTGCTGAACAGAAGCAATTGGCAACGGCGGTCATGGAAGCATCAGGATTG
GTCATGTGGGTCGATAATGAAGAACACATGCATGCGGTAACCGCCGTATCAGGGTCAGCACCAGCGTATATGTTTTACTT
TATTGAAGCTATGGTTGATGGGGCAGTGGCTTTAGGTTTGGATAAAGAGCAGGCCTCCGCGCTTGCCATGCAAACCATGT
TGGGCGCGGCAAAAATGGCAATGGGTAGCGAAGATGCGCCAAGCGAGCTACGTCGTAAAGTGACCTCACCAAACGGCACA
ACCCAAGCCGCCATTGAATCAATGCAAGCCAATGACATTGGTCGTCAAATTGGTGAAGCCATGCAAGCGTGCTATGATCG
CAGCCAAGCCTTGAGTGAAGAGATGAGCAAATAA

Upstream 100 bases:

>100_bases
TTTCCCGAACAGCGCCAGTAGCAGTATGGTAAACTGAGTGTCATTTTACCTATCATTATGTTAGTTTGAATACCTTTGGT
TTTTTGAATAGGAGACATGT

Downstream 100 bases:

>100_bases
TCATCTTTATAATAGAGGTAGTATTTTATAAAATGCGGCCTCTGACTGGTTATAATAAATGCCTGATAATGACATTCGTC
ATCCTCAAACCTGTTAATAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSVLDNKKISFIGGGNMAQALISGLVSCGIKPSLITVADPSSEAREQLAAKGLNTVDPTADAKAAVIDADIVVLAVKPQV
MKAVVSSFADVLDKQLVISVAAGLSTELLSDMLGGCENIVRAMPNTPAMIQMGATGLYGTDNISAEQKQLATAVMEASGL
VMWVDNEEHMHAVTAVSGSAPAYMFYFIEAMVDGAVALGLDKEQASALAMQTMLGAAKMAMGSEDAPSELRRKVTSPNGT
TQAAIESMQANDIGRQIGEAMQACYDRSQALSEEMSK

Sequences:

>Translated_277_residues
MSVLDNKKISFIGGGNMAQALISGLVSCGIKPSLITVADPSSEAREQLAAKGLNTVDPTADAKAAVIDADIVVLAVKPQV
MKAVVSSFADVLDKQLVISVAAGLSTELLSDMLGGCENIVRAMPNTPAMIQMGATGLYGTDNISAEQKQLATAVMEASGL
VMWVDNEEHMHAVTAVSGSAPAYMFYFIEAMVDGAVALGLDKEQASALAMQTMLGAAKMAMGSEDAPSELRRKVTSPNGT
TQAAIESMQANDIGRQIGEAMQACYDRSQALSEEMSK
>Mature_276_residues
SVLDNKKISFIGGGNMAQALISGLVSCGIKPSLITVADPSSEAREQLAAKGLNTVDPTADAKAAVIDADIVVLAVKPQVM
KAVVSSFADVLDKQLVISVAAGLSTELLSDMLGGCENIVRAMPNTPAMIQMGATGLYGTDNISAEQKQLATAVMEASGLV
MWVDNEEHMHAVTAVSGSAPAYMFYFIEAMVDGAVALGLDKEQASALAMQTMLGAAKMAMGSEDAPSELRRKVTSPNGTT
QAAIESMQANDIGRQIGEAMQACYDRSQALSEEMSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=32.8358208955224, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=31.3432835820896, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=31.3432835820896, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=28.8888888888889, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=37.4074074074074, Blast_Score=157, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17569021, Length=271, Percent_Identity=34.6863468634686, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17540664, Length=287, Percent_Identity=33.1010452961672, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=263, Percent_Identity=26.615969581749, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=33.5820895522388, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24648116, Length=287, Percent_Identity=34.4947735191638, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24647700, Length=155, Percent_Identity=33.5483870967742, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28853; Mature: 28722

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLDNKKISFIGGGNMAQALISGLVSCGIKPSLITVADPSSEAREQLAAKGLNTVDPTA
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCC
DAKAAVIDADIVVLAVKPQVMKAVVSSFADVLDKQLVISVAAGLSTELLSDMLGGCENIV
CCCEEEEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RAMPNTPAMIQMGATGLYGTDNISAEQKQLATAVMEASGLVMWVDNEEHMHAVTAVSGSA
HHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHEECCCC
PAYMFYFIEAMVDGAVALGLDKEQASALAMQTMLGAAKMAMGSEDAPSELRRKVTSPNGT
CHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCH
TQAAIESMQANDIGRQIGEAMQACYDRSQALSEEMSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVLDNKKISFIGGGNMAQALISGLVSCGIKPSLITVADPSSEAREQLAAKGLNTVDPTA
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCC
DAKAAVIDADIVVLAVKPQVMKAVVSSFADVLDKQLVISVAAGLSTELLSDMLGGCENIV
CCCEEEEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RAMPNTPAMIQMGATGLYGTDNISAEQKQLATAVMEASGLVMWVDNEEHMHAVTAVSGSA
HHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHEECCCC
PAYMFYFIEAMVDGAVALGLDKEQASALAMQTMLGAAKMAMGSEDAPSELRRKVTSPNGT
CHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCH
TQAAIESMQANDIGRQIGEAMQACYDRSQALSEEMSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]