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The map label for this gene is ppx [H]

Identifier: 93005004

GI number: 93005004

Start: 203121

End: 204647

Strand: Direct

Name: ppx [H]

Synonym: Pcryo_0173

Alternate gene names: 93005004

Gene position: 203121-204647 (Clockwise)

Preceding gene: 93005002

Following gene: 93005005

Centisome position: 6.64

GC content: 45.19

Gene sequence:

>1527_bases
ATGCCCAAAGACAACCTAAAAAATCCACCACTCGCAGAAGATGAACTGATGGCAGCCATTGATATTGGCTCCAATAGTTT
TCATTTAGCCATTGCTCGCCTCGATCATGGTGAAGTGCGAAAAGTGGTGTCTATGTCTGAAAAAGTTCAGTTAGCTGCAG
GACTGGATGAGCATAATATTTTGGGTGCAGCAGCGGAGCAGCGCGGTTTAGACTGTCTCAGCCGCTTTGTGGCGCGTCTA
GATTCGGTGCCTCCGGAGCGTATTCGTATTGTTGCGACCAACGCCTTACGCCAAGCCAAAAATGCCAATGATTTTATCAG
CCGTGCCAATAAAATCTTACCCAAGCCTATTGAGATTATCGCGGGACGAGAAGAAGCGCGTTTGATTTATTTAGGAGTCT
CGCATACCAATGCCAGTAGTGACAAGCGTCTGGTTATCGATATTGGTGGCGGCTCAACAGAGTTTATTATTGGCCAAGAG
TTTGATCCATTATTGACCGAGAGCTTACAGATGGGCTGTGTTGCCTTTACGCAGAAGTATTTTGCTAATGGGCAAATTAC
CAAAGAAGCCTTTAACAACGCCATATCGGCTGCGCGCAAAGAAGTACTGGCGATCAATGGGCGCTACCAAAAAGTAGGCT
GGAGCAGCGCCATTGGATCGAGTGGTACGATTAAAGCGGTACGTAACGTCCTTGTTTCAAAAGGCTGGGCAGACGAGCAA
GAGCGCATCACTTATAAAGGTGTTAAAAAGTTAGAAAGATTATTGCTTAAAATTGGCAACGTTGATGACATTGATTTAGA
AGGCGTCAAAGAGCACCGTAAAGCCGTATTTCCAGCAGGCGTTGCGGTATTACGAGCAGTCATGAAGGTGTTGGGCGTAG
ATGCTATTACTTACTCAGATGGCGCGCTACGCGAAGGTGTCATGTACGATATGCTTGGACGATTTGCCAGTGAAGACGTA
CGTGACCGCAGTGTATTGGCACTGATTAAGCGCTATTCAGGCGATAAAAAGCAGGCTAAGCAAGTAGTCAAAACCAGTCG
ACACCTTTTTGGGCAAGTGCAAACTAAACTTGGACTCAGTACGGAAGATGGCGATCTACTCAGGCGAGCTGCATTTTTAC
ATGAGATAGGGCTGGCGATTGCTCATAGTAGCTATCACAAACACAGTGCGTATTTGATGGAACATTCTGATATTCCAGGT
TTTTCACAAGTCGATCAAAAACGTATGGCACAGCTGATGTTAAATCATCGCCGTAAGCTCAAAGCAGATATGTTAGAGCA
AACGTGTACTATCGGCGGTGATCAGCTCGTTTATCTGTGCTTGCTGCTACGTTTGGCAGTACTGGCACATCACAGTCGCA
GTGATTATGAATTACCAACATTAGAATTAAAAGTAGATGATGACAATCATTGGCAAATCATGGTTGGTGATAGCAGCGAG
CACTACGCTTTCTTATTATCTGATTTGCAGACTGAAATAGAACAATTTGCCAAATGGGGCGTCAAACTAAGCGTCATTGA
GGTTTAA

Upstream 100 bases:

>100_bases
TTATATATGGTAGTCCTTACTTTAATCCAACGTACTTTCTATTTTAAAAGCCTAAACCCTTTTAATTATCTTTTGATCTG
ACACGGTAACGACCTTACTT

Downstream 100 bases:

>100_bases
TTTTTTATCAGCTAAAACTGTTAGTAGATTACTTGATTAATGTGGTTAGAAATAACATAACAAAAGCGGTGTTGTCGGTA
ATGTTATGGCATATAAGATG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MPKDNLKNPPLAEDELMAAIDIGSNSFHLAIARLDHGEVRKVVSMSEKVQLAAGLDEHNILGAAAEQRGLDCLSRFVARL
DSVPPERIRIVATNALRQAKNANDFISRANKILPKPIEIIAGREEARLIYLGVSHTNASSDKRLVIDIGGGSTEFIIGQE
FDPLLTESLQMGCVAFTQKYFANGQITKEAFNNAISAARKEVLAINGRYQKVGWSSAIGSSGTIKAVRNVLVSKGWADEQ
ERITYKGVKKLERLLLKIGNVDDIDLEGVKEHRKAVFPAGVAVLRAVMKVLGVDAITYSDGALREGVMYDMLGRFASEDV
RDRSVLALIKRYSGDKKQAKQVVKTSRHLFGQVQTKLGLSTEDGDLLRRAAFLHEIGLAIAHSSYHKHSAYLMEHSDIPG
FSQVDQKRMAQLMLNHRRKLKADMLEQTCTIGGDQLVYLCLLLRLAVLAHHSRSDYELPTLELKVDDDNHWQIMVGDSSE
HYAFLLSDLQTEIEQFAKWGVKLSVIEV

Sequences:

>Translated_508_residues
MPKDNLKNPPLAEDELMAAIDIGSNSFHLAIARLDHGEVRKVVSMSEKVQLAAGLDEHNILGAAAEQRGLDCLSRFVARL
DSVPPERIRIVATNALRQAKNANDFISRANKILPKPIEIIAGREEARLIYLGVSHTNASSDKRLVIDIGGGSTEFIIGQE
FDPLLTESLQMGCVAFTQKYFANGQITKEAFNNAISAARKEVLAINGRYQKVGWSSAIGSSGTIKAVRNVLVSKGWADEQ
ERITYKGVKKLERLLLKIGNVDDIDLEGVKEHRKAVFPAGVAVLRAVMKVLGVDAITYSDGALREGVMYDMLGRFASEDV
RDRSVLALIKRYSGDKKQAKQVVKTSRHLFGQVQTKLGLSTEDGDLLRRAAFLHEIGLAIAHSSYHKHSAYLMEHSDIPG
FSQVDQKRMAQLMLNHRRKLKADMLEQTCTIGGDQLVYLCLLLRLAVLAHHSRSDYELPTLELKVDDDNHWQIMVGDSSE
HYAFLLSDLQTEIEQFAKWGVKLSVIEV
>Mature_507_residues
PKDNLKNPPLAEDELMAAIDIGSNSFHLAIARLDHGEVRKVVSMSEKVQLAAGLDEHNILGAAAEQRGLDCLSRFVARLD
SVPPERIRIVATNALRQAKNANDFISRANKILPKPIEIIAGREEARLIYLGVSHTNASSDKRLVIDIGGGSTEFIIGQEF
DPLLTESLQMGCVAFTQKYFANGQITKEAFNNAISAARKEVLAINGRYQKVGWSSAIGSSGTIKAVRNVLVSKGWADEQE
RITYKGVKKLERLLLKIGNVDDIDLEGVKEHRKAVFPAGVAVLRAVMKVLGVDAITYSDGALREGVMYDMLGRFASEDVR
DRSVLALIKRYSGDKKQAKQVVKTSRHLFGQVQTKLGLSTEDGDLLRRAAFLHEIGLAIAHSSYHKHSAYLMEHSDIPGF
SQVDQKRMAQLMLNHRRKLKADMLEQTCTIGGDQLVYLCLLLRLAVLAHHSRSDYELPTLELKVDDDNHWQIMVGDSSEH
YAFLLSDLQTEIEQFAKWGVKLSVIEV

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=494, Percent_Identity=43.3198380566802, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI48994966, Length=453, Percent_Identity=37.9690949227373, Blast_Score=333, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56362; Mature: 56230

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKDNLKNPPLAEDELMAAIDIGSNSFHLAIARLDHGEVRKVVSMSEKVQLAAGLDEHNI
CCCCCCCCCCCCHHHEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCH
LGAAAEQRGLDCLSRFVARLDSVPPERIRIVATNALRQAKNANDFISRANKILPKPIEII
HCHHHHHCCHHHHHHHHHHHHCCCHHHEEEEEHHHHHHHCCHHHHHHHHHHCCCCCHHHH
AGREEARLIYLGVSHTNASSDKRLVIDIGGGSTEFIIGQEFDPLLTESLQMGCVAFTQKY
CCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
FANGQITKEAFNNAISAARKEVLAINGRYQKVGWSSAIGSSGTIKAVRNVLVSKGWADEQ
HCCCCEEHHHHHHHHHHHHHHHEEECCCEEECCCHHCCCCCCHHHHHHHHHHHCCCCCHH
ERITYKGVKKLERLLLKIGNVDDIDLEGVKEHRKAVFPAGVAVLRAVMKVLGVDAITYSD
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEECC
GALREGVMYDMLGRFASEDVRDRSVLALIKRYSGDKKQAKQVVKTSRHLFGQVQTKLGLS
CHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TEDGDLLRRAAFLHEIGLAIAHSSYHKHSAYLMEHSDIPGFSQVDQKRMAQLMLNHRRKL
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KADMLEQTCTIGGDQLVYLCLLLRLAVLAHHSRSDYELPTLELKVDDDNHWQIMVGDSSE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCCC
HYAFLLSDLQTEIEQFAKWGVKLSVIEV
CHHHHHHHHHHHHHHHHHCCCEEEEEEC
>Mature Secondary Structure 
PKDNLKNPPLAEDELMAAIDIGSNSFHLAIARLDHGEVRKVVSMSEKVQLAAGLDEHNI
CCCCCCCCCCCHHHEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCH
LGAAAEQRGLDCLSRFVARLDSVPPERIRIVATNALRQAKNANDFISRANKILPKPIEII
HCHHHHHCCHHHHHHHHHHHHCCCHHHEEEEEHHHHHHHCCHHHHHHHHHHCCCCCHHHH
AGREEARLIYLGVSHTNASSDKRLVIDIGGGSTEFIIGQEFDPLLTESLQMGCVAFTQKY
CCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
FANGQITKEAFNNAISAARKEVLAINGRYQKVGWSSAIGSSGTIKAVRNVLVSKGWADEQ
HCCCCEEHHHHHHHHHHHHHHHEEECCCEEECCCHHCCCCCCHHHHHHHHHHHCCCCCHH
ERITYKGVKKLERLLLKIGNVDDIDLEGVKEHRKAVFPAGVAVLRAVMKVLGVDAITYSD
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEECC
GALREGVMYDMLGRFASEDVRDRSVLALIKRYSGDKKQAKQVVKTSRHLFGQVQTKLGLS
CHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TEDGDLLRRAAFLHEIGLAIAHSSYHKHSAYLMEHSDIPGFSQVDQKRMAQLMLNHRRKL
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KADMLEQTCTIGGDQLVYLCLLLRLAVLAHHSRSDYELPTLELKVDDDNHWQIMVGDSSE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCCC
HYAFLLSDLQTEIEQFAKWGVKLSVIEV
CHHHHHHHHHHHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]