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The map label for this gene is purC [H]

Identifier: 93004991

GI number: 93004991

Start: 190453

End: 191166

Strand: Direct

Name: purC [H]

Synonym: Pcryo_0160

Alternate gene names: 93004991

Gene position: 190453-191166 (Clockwise)

Preceding gene: 93004990

Following gene: 93004993

Centisome position: 6.22

GC content: 43.84

Gene sequence:

>714_bases
ATGCAAAAGCAAGAACTGCTCTATAAAGGCAAAGCCAAATCTGTTTATGAAACAGAAGACAACGACCTGCTGATTTTACA
TTTCCGTGATGACACCTCAGCGCTTGATGGTAAGCGTATTGAACAACTTGCACGCAAAGGCGTGGTTAATAATCGCTTTA
ACGCGTTTATTATGCAAAAGCTTGCTGACGCTGGTATCGAGACGCATTTTGAAAAGCAATTGTCTGATGATGAAGTGTTG
GTCAAGCGTTTGGATATGATTCCGGTTGAATGCGTTGTGCGTAACTTTGCTGCGGGCAGTTTGGTACGTCGTTTAGGGTT
GGAAGAAGGTCAGGCTTTGACGCCACCGACTTACGAGCTATTCTATAAAGATGATGCGCTTGGCGATCCGATGGTTAATG
AGTCAATCTCAATTTCTCTTGGCTGGGCAAATGACGCACAGCTTGTTAAAATGAAAGAGCTGAGTCATCAAGTAAATGAA
GTTTTGACAGCGCTGTTTGATGCTGGTGATTTGATACTAGTAGATTTCAAACTAGAGTTTGGTGTATTTCATGACCGTAT
CGTCTTAGGTGATGAGTTCTCACCAGATGGCTGCCGCATTTGGGATAAAGCCACCAAGAAGAAGCTCGATAAAGACCGCT
TCCGTCAGTCATTAGGTGATGTCATCGAAGCTTATGAAGAAGTGGCAAGCCGTATCGGTGTACCACTGAGCTAA

Upstream 100 bases:

>100_bases
ATGCTTTTATCAATACTAATGTATCTCATTGGTTTTATAAGTTATCAGCGGTCGCTGCGCGTTTTTACCACATAAGCTTG
AACGAACAGGAAACCTCCTA

Downstream 100 bases:

>100_bases
ATGTAGAAAAATTAAAACCGTCAAGACATAAAAAAACTGAGCCATGGCTCAGTTTTTTTTGCACTTAAATTTATTAGCTG
TCTTTGCGAGCGTCTTTGAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQKQELLYKGKAKSVYETEDNDLLILHFRDDTSALDGKRIEQLARKGVVNNRFNAFIMQKLADAGIETHFEKQLSDDEVL
VKRLDMIPVECVVRNFAAGSLVRRLGLEEGQALTPPTYELFYKDDALGDPMVNESISISLGWANDAQLVKMKELSHQVNE
VLTALFDAGDLILVDFKLEFGVFHDRIVLGDEFSPDGCRIWDKATKKKLDKDRFRQSLGDVIEAYEEVASRIGVPLS

Sequences:

>Translated_237_residues
MQKQELLYKGKAKSVYETEDNDLLILHFRDDTSALDGKRIEQLARKGVVNNRFNAFIMQKLADAGIETHFEKQLSDDEVL
VKRLDMIPVECVVRNFAAGSLVRRLGLEEGQALTPPTYELFYKDDALGDPMVNESISISLGWANDAQLVKMKELSHQVNE
VLTALFDAGDLILVDFKLEFGVFHDRIVLGDEFSPDGCRIWDKATKKKLDKDRFRQSLGDVIEAYEEVASRIGVPLS
>Mature_237_residues
MQKQELLYKGKAKSVYETEDNDLLILHFRDDTSALDGKRIEQLARKGVVNNRFNAFIMQKLADAGIETHFEKQLSDDEVL
VKRLDMIPVECVVRNFAAGSLVRRLGLEEGQALTPPTYELFYKDDALGDPMVNESISISLGWANDAQLVKMKELSHQVNE
VLTALFDAGDLILVDFKLEFGVFHDRIVLGDEFSPDGCRIWDKATKKKLDKDRFRQSLGDVIEAYEEVASRIGVPLS

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=244, Percent_Identity=32.7868852459016, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI5453539, Length=244, Percent_Identity=32.7868852459016, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI119220559, Length=251, Percent_Identity=31.4741035856574, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1788820, Length=236, Percent_Identity=65.6779661016949, Blast_Score=321, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17531275, Length=233, Percent_Identity=30.0429184549356, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18860083, Length=222, Percent_Identity=31.981981981982, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24583917, Length=215, Percent_Identity=30.6976744186047, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26810; Mature: 26810

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKQELLYKGKAKSVYETEDNDLLILHFRDDTSALDGKRIEQLARKGVVNNRFNAFIMQK
CCCHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
LADAGIETHFEKQLSDDEVLVKRLDMIPVECVVRNFAAGSLVRRLGLEEGQALTPPTYEL
HHHCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
FYKDDALGDPMVNESISISLGWANDAQLVKMKELSHQVNEVLTALFDAGDLILVDFKLEF
EECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GVFHDRIVLGDEFSPDGCRIWDKATKKKLDKDRFRQSLGDVIEAYEEVASRIGVPLS
CCEECEEEECCCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQKQELLYKGKAKSVYETEDNDLLILHFRDDTSALDGKRIEQLARKGVVNNRFNAFIMQK
CCCHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
LADAGIETHFEKQLSDDEVLVKRLDMIPVECVVRNFAAGSLVRRLGLEEGQALTPPTYEL
HHHCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
FYKDDALGDPMVNESISISLGWANDAQLVKMKELSHQVNEVLTALFDAGDLILVDFKLEF
EECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GVFHDRIVLGDEFSPDGCRIWDKATKKKLDKDRFRQSLGDVIEAYEEVASRIGVPLS
CCEECEEEECCCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA