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The map label for this gene is hisI

Identifier: 92114006

GI number: 92114006

Start: 2141025

End: 2141465

Strand: Direct

Name: hisI

Synonym: Csal_1883

Alternate gene names: 92114006

Gene position: 2141025-2141465 (Clockwise)

Preceding gene: 92114005

Following gene: 92114007

Centisome position: 57.92

GC content: 66.21

Gene sequence:

>441_bases
ATGACACAGCGGTTCAAGCAGCTCGAGACAGCGGCGCAAGGTACTCGCGAAGCCACTCGTGATCTTCTCGATGCCGCGCG
CTGGAACGACGCCGGACTGATCCCGGCGATCGCGCAGCAGCACGACAGTGGCGAGGTTCTGATGATGGCGTGGATGAACC
GCGCCGCCCTGGAAGAAACCCTCGCCACGGGGCGCGTCTGCTACTGGTCACGCTCGCGCGGCAAGCCGTGGCGCAAGGGA
GAGTCGTCGGGTCAGGTCCAGCAGCTGGTCACCGCCCATCTGGATTGCGACGGCGACACCCTGCTGCTCGGCGTCGATCA
GCAAGGTCCGGCCTGTCATACCGGGCGACGCAGTTGCTTCTATGTGGCTCTCGGCGCGGACACCGCGCATGTCGACAGCG
CTCCCCTGGTCGACCCGCACGAACTCTACGGCGAGCGCTGA

Upstream 100 bases:

>100_bases
ATCGAATCGAACGCCAGACCATCGAATTATTGGGACTATGCGCCGACTGCCATCAGGCGGCATCGGCGTAATCCTTTTCC
ACGCAAGCGGTGATGCCCAC

Downstream 100 bases:

>100_bases
GATGCGGCCCGGCAAGCGTCGGCCGCTCACGCGCCTGCCGTTCGCGCTGCTTTCCTGGGGCATGATCGGGTTATTGCGTG
TCTACCAATACGGCATCAGC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MTQRFKQLETAAQGTREATRDLLDAARWNDAGLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPWRKG
ESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFYVALGADTAHVDSAPLVDPHELYGER

Sequences:

>Translated_146_residues
MTQRFKQLETAAQGTREATRDLLDAARWNDAGLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPWRKG
ESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFYVALGADTAHVDSAPLVDPHELYGER
>Mature_145_residues
TQRFKQLETAAQGTREATRDLLDAARWNDAGLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPWRKGE
SSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFYVALGADTAHVDSAPLVDPHELYGER

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=99, Percent_Identity=47.4747474747475, Blast_Score=100, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_CHRSD (Q1QWC3)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_573934.1
- ProteinModelPortal:   Q1QWC3
- SMR:   Q1QWC3
- STRING:   Q1QWC3
- GeneID:   4028246
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_1883
- NMPDR:   fig|290398.4.peg.2108
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   GRRTCFH
- ProtClustDB:   PRK00051
- BioCyc:   CSAL290398:CSAL_1883-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 16081; Mature: 15950

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRFKQLETAAQGTREATRDLLDAARWNDAGLIPAIAQQHDSGEVLMMAWMNRAALEET
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCEEHHHHHHHHHHHHH
LATGRVCYWSRSRGKPWRKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCF
HHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEE
YVALGADTAHVDSAPLVDPHELYGER
EEEECCCCCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure 
TQRFKQLETAAQGTREATRDLLDAARWNDAGLIPAIAQQHDSGEVLMMAWMNRAALEET
CHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCEEHHHHHHHHHHHHH
LATGRVCYWSRSRGKPWRKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCF
HHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEE
YVALGADTAHVDSAPLVDPHELYGER
EEEECCCCCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA