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The map label for this gene is galE [H]

Identifier: 92113845

GI number: 92113845

Start: 1960938

End: 1962059

Strand: Direct

Name: galE [H]

Synonym: Csal_1722

Alternate gene names: 92113845

Gene position: 1960938-1962059 (Clockwise)

Preceding gene: 92113844

Following gene: 92113846

Centisome position: 53.05

GC content: 66.31

Gene sequence:

>1122_bases
ATGACGATTTTAGTGACGGGCGGGGCCGGGTACATCGGCTCGCATATGGTGCTGCGGCTCATCGAAGCCGGCCACGAGGT
GGTCGTGATCGACAACCTCTGCAATGCCTCGCGAGAGTCGCTGGAGCGCGTCTCGCAGTTGACCGGCAAGGAGGTGACCT
TCATCGAGGGCGACATTCGCGATCGTTCGCTGCTGGATTACGTGTTCGCGGACTTCGAGATCAGCGATGTGCTGCATTTC
GCGGGTCTCAAGTCGGTGGGCGAGAGCGTCAGCGAGCCACTGGCGTATTTCGAGAACAACGTGGCGGGCACCATCACGCT
GTGCCAGGCGATGACGGCGGCGGGCGTGTACCGCCTGGTGTTCAGTTCCTCGGCGACGGTGTATGGCGACGCCACGCGCA
TGCCGTTGAGCGAAAACGCGCCTACCGGGCAACCGACCAACGCCTACGGGCATTCCAAGCTGATGGTCGAGGAGGTGCTG
CGCAAGCTGGCGCGGTCCGACCCACGCTGGGCGATCGCCTTGTTGCGCTACTTCAACCCGGTGGGGGCGCACCCCAGTGG
CATGATCGGCGAGGACCCGTCGGGCACGCCCAACAATCTGCTGCCGTTCATCTCGCAGGTGGCGATCGGTCGGCTACCGG
CGCTTTCGGTCTTCGGCGACGACTATCCGACGCCCGATGGCACCGGGGTGCGCGATTACATCCATGTGATGGATCTGGTC
GAGGGACACCTGGCGGCAATGCGCGTGCTGGCGGATCGTGCGGGCGTGAACGTCTGGAACCTGGGCACGGGGCAGGGCTA
CTCGGTACTGGAGATGGTGCGCGCCTTCGAGCATGTCGCCCGGCGCGACGTGCCGTATCGCATCGTGCCGCGTCGCGACG
GCGATATCGCCGCATGCTGGGCCGACGCCTCGCTGGCCGAGCGTGAGCTGGGCTGGCGGGCGCAACGCGGCCTGATGGAC
ATGATCGCCGATACCTGGCGCTGGCAGTCGCGCAACCCCGAAGGCTACCCGCGCAAGCGCATGATCCGGCGCGAGACCGT
CGGGGCCGCGCGTGCCGTGGGCGCCGGCTTGCCCCGTATCTATCTGATAGACACCGCGCGGGCCAACTCCGTGGCGTCGT
AG

Upstream 100 bases:

>100_bases
GTGCGGAGAAGGAGTTCTCGCAGGACATCGTCGTGACGGGATACCTGGCCTGCCTGGAAAGCGGCCTGACGAGTCACCAA
CGCGTGAAAATGGAGGCATG

Downstream 100 bases:

>100_bases
CACTTTCTCTGTCGTCTTTTTTTCTACCGTGTTTGGCCTTGACGCCGGTGCTTCGTGCACCGGCGTTTTTTTATGCCCTC
GCGTCGGCGCGGTGCGAGTG

Product: UDP-galactose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTILVTGGAGYIGSHMVLRLIEAGHEVVVIDNLCNASRESLERVSQLTGKEVTFIEGDIRDRSLLDYVFADFEISDVLHF
AGLKSVGESVSEPLAYFENNVAGTITLCQAMTAAGVYRLVFSSSATVYGDATRMPLSENAPTGQPTNAYGHSKLMVEEVL
RKLARSDPRWAIALLRYFNPVGAHPSGMIGEDPSGTPNNLLPFISQVAIGRLPALSVFGDDYPTPDGTGVRDYIHVMDLV
EGHLAAMRVLADRAGVNVWNLGTGQGYSVLEMVRAFEHVARRDVPYRIVPRRDGDIAACWADASLAERELGWRAQRGLMD
MIADTWRWQSRNPEGYPRKRMIRRETVGAARAVGAGLPRIYLIDTARANSVAS

Sequences:

>Translated_373_residues
MTILVTGGAGYIGSHMVLRLIEAGHEVVVIDNLCNASRESLERVSQLTGKEVTFIEGDIRDRSLLDYVFADFEISDVLHF
AGLKSVGESVSEPLAYFENNVAGTITLCQAMTAAGVYRLVFSSSATVYGDATRMPLSENAPTGQPTNAYGHSKLMVEEVL
RKLARSDPRWAIALLRYFNPVGAHPSGMIGEDPSGTPNNLLPFISQVAIGRLPALSVFGDDYPTPDGTGVRDYIHVMDLV
EGHLAAMRVLADRAGVNVWNLGTGQGYSVLEMVRAFEHVARRDVPYRIVPRRDGDIAACWADASLAERELGWRAQRGLMD
MIADTWRWQSRNPEGYPRKRMIRRETVGAARAVGAGLPRIYLIDTARANSVAS
>Mature_372_residues
TILVTGGAGYIGSHMVLRLIEAGHEVVVIDNLCNASRESLERVSQLTGKEVTFIEGDIRDRSLLDYVFADFEISDVLHFA
GLKSVGESVSEPLAYFENNVAGTITLCQAMTAAGVYRLVFSSSATVYGDATRMPLSENAPTGQPTNAYGHSKLMVEEVLR
KLARSDPRWAIALLRYFNPVGAHPSGMIGEDPSGTPNNLLPFISQVAIGRLPALSVFGDDYPTPDGTGVRDYIHVMDLVE
GHLAAMRVLADRAGVNVWNLGTGQGYSVLEMVRAFEHVARRDVPYRIVPRRDGDIAACWADASLAERELGWRAQRGLMDM
IADTWRWQSRNPEGYPRKRMIRRETVGAARAVGAGLPRIYLIDTARANSVAS

Specific function: By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae [H]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=57.9411764705882, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=57.9411764705882, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=57.9411764705882, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI7657641, Length=277, Percent_Identity=29.2418772563177, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI42516563, Length=315, Percent_Identity=25.3968253968254, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786974, Length=337, Percent_Identity=57.8635014836795, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI48994969, Length=356, Percent_Identity=28.6516853932584, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788353, Length=361, Percent_Identity=26.8698060941828, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=50.4347826086956, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=50.1440922190202, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17568069, Length=340, Percent_Identity=25.5882352941176, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17539532, Length=249, Percent_Identity=25.7028112449799, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=49.8542274052478, Blast_Score=355, Evalue=7e-99,
Organism=Drosophila melanogaster, GI19923002, Length=346, Percent_Identity=55.4913294797688, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI21356223, Length=250, Percent_Identity=28.8, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 40824; Mature: 40693

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVTGGAGYIGSHMVLRLIEAGHEVVVIDNLCNASRESLERVSQLTGKEVTFIEGDIR
CEEEEECCCCHHHHHHHHHHHHCCCCEEEECCHHCHHHHHHHHHHHHCCCEEEEEECCCC
DRSLLDYVFADFEISDVLHFAGLKSVGESVSEPLAYFENNVAGTITLCQAMTAAGVYRLV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FSSSATVYGDATRMPLSENAPTGQPTNAYGHSKLMVEEVLRKLARSDPRWAIALLRYFNP
HCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
VGAHPSGMIGEDPSGTPNNLLPFISQVAIGRLPALSVFGDDYPTPDGTGVRDYIHVMDLV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHCCCCCCCCCCCCCHHHHHHHHHHH
EGHLAAMRVLADRAGVNVWNLGTGQGYSVLEMVRAFEHVARRDVPYRIVPRRDGDIAACW
HHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEE
ADASLAERELGWRAQRGLMDMIADTWRWQSRNPEGYPRKRMIRRETVGAARAVGAGLPRI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
YLIDTARANSVAS
EEEECCCCCCCCC
>Mature Secondary Structure 
TILVTGGAGYIGSHMVLRLIEAGHEVVVIDNLCNASRESLERVSQLTGKEVTFIEGDIR
EEEEECCCCHHHHHHHHHHHHCCCCEEEECCHHCHHHHHHHHHHHHCCCEEEEEECCCC
DRSLLDYVFADFEISDVLHFAGLKSVGESVSEPLAYFENNVAGTITLCQAMTAAGVYRLV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FSSSATVYGDATRMPLSENAPTGQPTNAYGHSKLMVEEVLRKLARSDPRWAIALLRYFNP
HCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
VGAHPSGMIGEDPSGTPNNLLPFISQVAIGRLPALSVFGDDYPTPDGTGVRDYIHVMDLV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHCCCCCCCCCCCCCHHHHHHHHHHH
EGHLAAMRVLADRAGVNVWNLGTGQGYSVLEMVRAFEHVARRDVPYRIVPRRDGDIAACW
HHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEE
ADASLAERELGWRAQRGLMDMIADTWRWQSRNPEGYPRKRMIRRETVGAARAVGAGLPRI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
YLIDTARANSVAS
EEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1956282; 7542800 [H]