Click here to switch to the map view.

The map label for this gene is cysM [H]

Identifier: 92113760

GI number: 92113760

Start: 1860075

End: 1860971

Strand: Direct

Name: cysM [H]

Synonym: Csal_1636

Alternate gene names: 92113760

Gene position: 1860075-1860971 (Clockwise)

Preceding gene: 92113758

Following gene: 92113761

Centisome position: 50.32

GC content: 67.34

Gene sequence:

>897_bases
ATGCAATTCCCCACTCTCGCGGATGCGGTCGGTCACACGCCGCTGGTGCGTTTGACGCGGCTTCAGGCAGGGCGCAACAA
CACGCTACTGGCCAAGCTGGAAGGCAACAACCCGGCCGGTTCGGTCAAGGATCGACCGGCCCTGTCGATGCTCGGCGAGG
CCGAGGCGCGTGGCGAGATCCGCCCTGGCGATACCCTGATCGAAGCGACCTCGGGCAACACCGGGATCGCGCTGGCCATG
GCGGCGGCGGTCAAGGGCTACCGCATGGTGCTGATCATGCCGGAAAGCGCCTCCAGCGAGCGCAAGCAGGCCATGGCGGC
TTACGGCGCGCAGTTGATTGAGGTGACCAAGGAGGCGGGCATGGAAGGCGCCCGCGACCTGGCCGACGAGATGATCGCGC
GCGGCGAGGGGAAACCGCTCAACCAGTTCGCCAATCCGGACAACCCGTTGTCGCACTATCGCACCACCGGCCCGGAAATC
TGGGAACAGACCGGCGGCCGGATAACGCATTTCGTCAGCTCGATGGGCACCACCGGCACCATCATGGGCACGTCGCGCTA
CCTCAAGGAGCAGCGTGCCGACATTCAGATCGTCGGCCTGCAGCCTGCCGACGGTGCGAGCATCGCCGGCATCCGCCGCT
GGCCGCGCGAATACCTGCCGAGCATCTTCGATGCCTCGCGGGTCGATGTCACGCTGGATATCGGCCAGCAGGAAGCCGAG
GAGCACATGCGCCTGCTCGCCCGCAAGGAGGGCATCCTGGCGGGCGTCTCCTCCGGCGGCGCGCTGGCGGGGGCGCTGCG
GATCGCCGAGCAGGTGGAAAACGCGGTGATCGTGTTCATCGTCTGCGACCGTGGCGACCGTTACCTGTCCACCGGCCTGT
TCGCCCCGGAGCGCTGA

Upstream 100 bases:

>100_bases
TAATCAGGGGCATCGAACACCCGACGGATGAGTGCCGAAACGCCGTGTGCCGGTCACGCGAGACGTAACGGCGTTCGTCG
TGCCAGTAAAGGATGAACCC

Downstream 100 bases:

>100_bases
GATGGCGATGCTGGGCAAACGGCGTCCACCGCGCACCGCCAACGAACGCGTGCGTCGGGAGCGCGGGTCGGCAACACGGC
GCGACGACGCGACTGCCGAC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQFPTLADAVGHTPLVRLTRLQAGRNNTLLAKLEGNNPAGSVKDRPALSMLGEAEARGEIRPGDTLIEATSGNTGIALAM
AAAVKGYRMVLIMPESASSERKQAMAAYGAQLIEVTKEAGMEGARDLADEMIARGEGKPLNQFANPDNPLSHYRTTGPEI
WEQTGGRITHFVSSMGTTGTIMGTSRYLKEQRADIQIVGLQPADGASIAGIRRWPREYLPSIFDASRVDVTLDIGQQEAE
EHMRLLARKEGILAGVSSGGALAGALRIAEQVENAVIVFIVCDRGDRYLSTGLFAPER

Sequences:

>Translated_298_residues
MQFPTLADAVGHTPLVRLTRLQAGRNNTLLAKLEGNNPAGSVKDRPALSMLGEAEARGEIRPGDTLIEATSGNTGIALAM
AAAVKGYRMVLIMPESASSERKQAMAAYGAQLIEVTKEAGMEGARDLADEMIARGEGKPLNQFANPDNPLSHYRTTGPEI
WEQTGGRITHFVSSMGTTGTIMGTSRYLKEQRADIQIVGLQPADGASIAGIRRWPREYLPSIFDASRVDVTLDIGQQEAE
EHMRLLARKEGILAGVSSGGALAGALRIAEQVENAVIVFIVCDRGDRYLSTGLFAPER
>Mature_298_residues
MQFPTLADAVGHTPLVRLTRLQAGRNNTLLAKLEGNNPAGSVKDRPALSMLGEAEARGEIRPGDTLIEATSGNTGIALAM
AAAVKGYRMVLIMPESASSERKQAMAAYGAQLIEVTKEAGMEGARDLADEMIARGEGKPLNQFANPDNPLSHYRTTGPEI
WEQTGGRITHFVSSMGTTGTIMGTSRYLKEQRADIQIVGLQPADGASIAGIRRWPREYLPSIFDASRVDVTLDIGQQEAE
EHMRLLARKEGILAGVSSGGALAGALRIAEQVENAVIVFIVCDRGDRYLSTGLFAPER

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=35.9872611464968, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=35.9872611464968, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=35.9872611464968, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=68.7074829931973, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=44.2622950819672, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=39, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=38.7959866220736, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI115535073, Length=296, Percent_Identity=40.8783783783784, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=39.2491467576792, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=37.123745819398, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=285, Percent_Identity=37.1929824561403, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17534315, Length=314, Percent_Identity=34.0764331210191, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=34.7417840375587, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321594, Length=317, Percent_Identity=36.5930599369085, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=31.5789473684211, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=36.9774919614148, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=36.9774919614148, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31944; Mature: 31944

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFPTLADAVGHTPLVRLTRLQAGRNNTLLAKLEGNNPAGSVKDRPALSMLGEAEARGEI
CCCCCHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
RPGDTLIEATSGNTGIALAMAAAVKGYRMVLIMPESASSERKQAMAAYGAQLIEVTKEAG
CCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
MEGARDLADEMIARGEGKPLNQFANPDNPLSHYRTTGPEIWEQTGGRITHFVSSMGTTGT
CCHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHCCCCHHHHHHCCCHHHHHHHHCCCCEE
IMGTSRYLKEQRADIQIVGLQPADGASIAGIRRWPREYLPSIFDASRVDVTLDIGQQEAE
EECHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCHHHHHHHHHCCCCEEEEEECCHHHHH
EHMRLLARKEGILAGVSSGGALAGALRIAEQVENAVIVFIVCDRGDRYLSTGLFAPER
HHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCHHCCCCCCCC
>Mature Secondary Structure
MQFPTLADAVGHTPLVRLTRLQAGRNNTLLAKLEGNNPAGSVKDRPALSMLGEAEARGEI
CCCCCHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
RPGDTLIEATSGNTGIALAMAAAVKGYRMVLIMPESASSERKQAMAAYGAQLIEVTKEAG
CCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
MEGARDLADEMIARGEGKPLNQFANPDNPLSHYRTTGPEIWEQTGGRITHFVSSMGTTGT
CCHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHCCCCHHHHHHCCCHHHHHHHHCCCCEE
IMGTSRYLKEQRADIQIVGLQPADGASIAGIRRWPREYLPSIFDASRVDVTLDIGQQEAE
EECHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCHHHHHHHHHCCCCEEEEEECCHHHHH
EHMRLLARKEGILAGVSSGGALAGALRIAEQVENAVIVFIVCDRGDRYLSTGLFAPER
HHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]