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The map label for this gene is pntAA [H]

Identifier: 91790377

GI number: 91790377

Start: 4807912

End: 4809027

Strand: Reverse

Name: pntAA [H]

Synonym: Bpro_4546

Alternate gene names: 91790377

Gene position: 4809027-4807912 (Counterclockwise)

Preceding gene: 91790378

Following gene: 91790376

Centisome position: 92.48

GC content: 66.85

Gene sequence:

>1116_bases
ATGCTGATTGGGGTACCTGCCGAAATCACGGCCGGAGAGACTCGCGTTGCCATCACGCCGGAAACGGCCAAAAAGCTCAA
GGCTCAGGGGCACACCGTTCGCGTCCAGTCCGGCGCCGGCGTCGCCGCCAGCGTTCCAGACGATGCCTACACCGCGGTGG
GGGTCGAGATCACCGACGCCGCGGGTGCCTATGCGGCGGACATCGTGCTCAAGGTGCGCTGCCCGGTGGACGGCGAAATG
GCGCATGCCAAGGCCGGCGGCGTGTTGGTCGGCATGCTCAACCCCTTTGATGCGACCGGCCTGCAGCGGCTGGCCGCCGC
GGGGCTGACCTCCTTTGCCCTGGAAGCGGCGCCGCGCACCAGCCGGGCCCAAAGCATGGACGTGCTGTCTTCGCAGGCCA
ACATTGCCGGCTACAAGGCCGTGATGATGGCGGCTGAACAGTACCAGCGGTTTTTTCCCATGCTGATGACCGCGGCCGGC
ACGGTCAAGGCGGCTCGCGTGGTGATCCTGGGCGTCGGTGTCGCCGGGCTGCAGGCGATTGCCACGGCCAAGCGCCTGGG
CGCCGTGATCGAGGCCAGCGACGTGCGCCCCAGCGTGAAAGAACAGGTCGAGTCACTCGGCGCCAAATTCATCGACGTTC
CCTATGAAACCGACGAGGAACGCGAGGCCGCCGTCGGCGTGGGCGGCTATGCCAAACCCATGCCGCCCAGCTGGCTGGAG
CGGCAAAAGGCCGAAGTGGCCAAACGCGTGGCCCAGGCCGACGTGGTCATCACCACCGCCCTGATTCCAGGCCGCCCCGC
CCCCGTGCTGGTGACCGAAGAGATGGTCAAAGCCATGAAGCCCGGCAGCGTGATCGTCGATCTGGCAGCGCCGCAGGGCG
GCAACTGCCCGCTGACCGAGCCCGGCCAGACCGTCATCAAGCACGGCGTCACGCTGGTTGGCCAGACCAATGTGCCGGCA
CTCGTGGCGGCCGACGCCAGCGCGCTCTACGCCCGCAACCTGATCGACTTCCTCAAGCTCATCATCACGAAAGAGGGCGC
CCTGAATGTCGACCTGGAAGACGACATCGTGGCGGCCTGCCTGATGACGCAGGGCGGTGAAGTCAAGCGCAAGTAG

Upstream 100 bases:

>100_bases
TCATGTAAGCTTGCCGACAGGTTTAAATTCCCTGTCAGGCTCCTGGGTGAGCTGAAGTAAATAATCGCGCCAAAAAAACT
AATCCACTGAGGAGAGACCC

Downstream 100 bases:

>100_bases
GCTCTGGCGGCAACGCCAGCAAGAAACAAAACCATTTCGGAATCAATCGGGCCAGCCGGGCCACACCAGTCTCAAGCCCG
CTACCGCTACCGCCACCTCA

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MLIGVPAEITAGETRVAITPETAKKLKAQGHTVRVQSGAGVAASVPDDAYTAVGVEITDAAGAYAADIVLKVRCPVDGEM
AHAKAGGVLVGMLNPFDATGLQRLAAAGLTSFALEAAPRTSRAQSMDVLSSQANIAGYKAVMMAAEQYQRFFPMLMTAAG
TVKAARVVILGVGVAGLQAIATAKRLGAVIEASDVRPSVKEQVESLGAKFIDVPYETDEEREAAVGVGGYAKPMPPSWLE
RQKAEVAKRVAQADVVITTALIPGRPAPVLVTEEMVKAMKPGSVIVDLAAPQGGNCPLTEPGQTVIKHGVTLVGQTNVPA
LVAADASALYARNLIDFLKLIITKEGALNVDLEDDIVAACLMTQGGEVKRK

Sequences:

>Translated_371_residues
MLIGVPAEITAGETRVAITPETAKKLKAQGHTVRVQSGAGVAASVPDDAYTAVGVEITDAAGAYAADIVLKVRCPVDGEM
AHAKAGGVLVGMLNPFDATGLQRLAAAGLTSFALEAAPRTSRAQSMDVLSSQANIAGYKAVMMAAEQYQRFFPMLMTAAG
TVKAARVVILGVGVAGLQAIATAKRLGAVIEASDVRPSVKEQVESLGAKFIDVPYETDEEREAAVGVGGYAKPMPPSWLE
RQKAEVAKRVAQADVVITTALIPGRPAPVLVTEEMVKAMKPGSVIVDLAAPQGGNCPLTEPGQTVIKHGVTLVGQTNVPA
LVAADASALYARNLIDFLKLIITKEGALNVDLEDDIVAACLMTQGGEVKRK
>Mature_371_residues
MLIGVPAEITAGETRVAITPETAKKLKAQGHTVRVQSGAGVAASVPDDAYTAVGVEITDAAGAYAADIVLKVRCPVDGEM
AHAKAGGVLVGMLNPFDATGLQRLAAAGLTSFALEAAPRTSRAQSMDVLSSQANIAGYKAVMMAAEQYQRFFPMLMTAAG
TVKAARVVILGVGVAGLQAIATAKRLGAVIEASDVRPSVKEQVESLGAKFIDVPYETDEEREAAVGVGGYAKPMPPSWLE
RQKAEVAKRVAQADVVITTALIPGRPAPVLVTEEMVKAMKPGSVIVDLAAPQGGNCPLTEPGQTVIKHGVTLVGQTNVPA
LVAADASALYARNLIDFLKLIITKEGALNVDLEDDIVAACLMTQGGEVKRK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=363, Percent_Identity=41.3223140495868, Blast_Score=261, Evalue=6e-70,
Organism=Homo sapiens, GI122939153, Length=363, Percent_Identity=41.3223140495868, Blast_Score=261, Evalue=6e-70,
Organism=Escherichia coli, GI1787887, Length=371, Percent_Identity=45.0134770889488, Blast_Score=304, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17550456, Length=368, Percent_Identity=42.6630434782609, Blast_Score=293, Evalue=9e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38432; Mature: 38432

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGVPAEITAGETRVAITPETAKKLKAQGHTVRVQSGAGVAASVPDDAYTAVGVEITDA
CEEECCCCCCCCCEEEEECHHHHHHHHCCCCEEEEECCCCEEECCCCCCEEEEEEEEECC
AGAYAADIVLKVRCPVDGEMAHAKAGGVLVGMLNPFDATGLQRLAAAGLTSFALEAAPRT
CCCEEEEEEEEEECCCCCCCHHCCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHCCCCC
SRAQSMDVLSSQANIAGYKAVMMAAEQYQRFFPMLMTAAGTVKAARVVILGVGVAGLQAI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPSVKEQVESLGAKFIDVPYETDEEREAAVGVGGYAKPMPPSWLE
HHHHHHHHEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHH
RQKAEVAKRVAQADVVITTALIPGRPAPVLVTEEMVKAMKPGSVIVDLAAPQGGNCPLTE
HHHHHHHHHHHHCCEEEEEEECCCCCCCEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCC
PGQTVIKHGVTLVGQTNVPALVAADASALYARNLIDFLKLIITKEGALNVDLEDDIVAAC
CCHHHHHCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHH
LMTQGGEVKRK
HHCCCCCCCCC
>Mature Secondary Structure
MLIGVPAEITAGETRVAITPETAKKLKAQGHTVRVQSGAGVAASVPDDAYTAVGVEITDA
CEEECCCCCCCCCEEEEECHHHHHHHHCCCCEEEEECCCCEEECCCCCCEEEEEEEEECC
AGAYAADIVLKVRCPVDGEMAHAKAGGVLVGMLNPFDATGLQRLAAAGLTSFALEAAPRT
CCCEEEEEEEEEECCCCCCCHHCCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHCCCCC
SRAQSMDVLSSQANIAGYKAVMMAAEQYQRFFPMLMTAAGTVKAARVVILGVGVAGLQAI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPSVKEQVESLGAKFIDVPYETDEEREAAVGVGGYAKPMPPSWLE
HHHHHHHHEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHH
RQKAEVAKRVAQADVVITTALIPGRPAPVLVTEEMVKAMKPGSVIVDLAAPQGGNCPLTE
HHHHHHHHHHHHCCEEEEEEECCCCCCCEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCC
PGQTVIKHGVTLVGQTNVPALVAADASALYARNLIDFLKLIITKEGALNVDLEDDIVAAC
CCHHHHHCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHH
LMTQGGEVKRK
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]