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The map label for this gene is cbs [H]

Identifier: 91789216

GI number: 91789216

Start: 3557057

End: 3558031

Strand: Direct

Name: cbs [H]

Synonym: Bpro_3360

Alternate gene names: 91789216

Gene position: 3557057-3558031 (Clockwise)

Preceding gene: 91789215

Following gene: 91789217

Centisome position: 68.4

GC content: 66.97

Gene sequence:

>975_bases
ATGGACGTGCGTGACGGCTTCATCGGCAGCATAGGCAACACACCACTGATCCGGCTGGCAAGGCTGAGCGCCGAGACCGG
CTGCGAGATCCTCGGCAAGGCGGAGTTCCTGAACCCGGGCGGCTCGGTCAAGGACCGCGCGGCGCTCTACATCATCCAGG
ACGCCGAGCGGCGCGGTGCGCTGAAGCCCGGCGGCACGGTGGTGGAAGGCACCGCCGGCAATACCGGCATCGGGCTCGCC
CATATCTGCGCGGCGCGCGGCTACCGCTGCGTGATCGTCATCCCCGAGACGCAGTCGCAGGAAAAGATGGATCTGCTGCG
CGTGCTGGGCGCCGAGGTACGGCCGGTGCCCGCCGTGCCGTACAAGGACCCCAACAACTACCAGAAGATCGCCTCCCGCC
TGGCGCAGGAGATGGACAACGCAATCTGGGCCAACCAGTTCGACAACCTCGTCAACCGCCAGGCCCACTACGAAACCACC
GGGCCGGAGATCTGGCGCGACACGGCCGGCAAGGTGGACGCCTTTACCTGCTCCACCGGCACGGGCGGCACGCTGGCCGG
CGTGGCGCGCTTTCTCAAGGAACAAAACCCTGCTGTGCGCAGCGTGCTGGCCGACCCCTACGGCAGCGCCCTGTACAGCT
TTGTGAAGACCGGCCAGCTCACGGCGGATGGCAACTCCATCACCGAAGGCATTGGCTCCAGCCGCGTGACCGCAAACCTG
GAGGGCACGCCCATCGACGATGCCGTGCGAATCAATGACCAGGACTGCGTCACCATGGTCTACCGCCTGCTGCGCGAAGA
GGGCCTGTTCGTGGGCGGCTCCACGGGCATCAACGTGGCGGCCGCCGCGTGGCTGGCCCGCCAGATGGGACCGGGCCACA
CCATCGTCACCCTGCTGTGCGACCGCGGCGGGCTGTATTCAAGCCGGCTGTTCAATCTCGCCTGGCTGATGGAAAAGGGA
TTGGCGCCGCAGTGA

Upstream 100 bases:

>100_bases
GGATAAGCGGGATGGCACTGCCCGCCGCGATGTTTTCATTGGGAGTATGCTTTACAGAAGACACCCGGCTCGCCCACACC
GGGACACGGAGGTCTGCATC

Downstream 100 bases:

>100_bases
TCCAGTGATTGAGGGAATCAGGGGGGCAAACTCCAATCACCTGAAACATCACCTGAAACGTCTCACCGATGCTCTATATC
TTCCCGGCTGCCAGTTCAAG

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MDVRDGFIGSIGNTPLIRLARLSAETGCEILGKAEFLNPGGSVKDRAALYIIQDAERRGALKPGGTVVEGTAGNTGIGLA
HICAARGYRCVIVIPETQSQEKMDLLRVLGAEVRPVPAVPYKDPNNYQKIASRLAQEMDNAIWANQFDNLVNRQAHYETT
GPEIWRDTAGKVDAFTCSTGTGGTLAGVARFLKEQNPAVRSVLADPYGSALYSFVKTGQLTADGNSITEGIGSSRVTANL
EGTPIDDAVRINDQDCVTMVYRLLREEGLFVGGSTGINVAAAAWLARQMGPGHTIVTLLCDRGGLYSSRLFNLAWLMEKG
LAPQ

Sequences:

>Translated_324_residues
MDVRDGFIGSIGNTPLIRLARLSAETGCEILGKAEFLNPGGSVKDRAALYIIQDAERRGALKPGGTVVEGTAGNTGIGLA
HICAARGYRCVIVIPETQSQEKMDLLRVLGAEVRPVPAVPYKDPNNYQKIASRLAQEMDNAIWANQFDNLVNRQAHYETT
GPEIWRDTAGKVDAFTCSTGTGGTLAGVARFLKEQNPAVRSVLADPYGSALYSFVKTGQLTADGNSITEGIGSSRVTANL
EGTPIDDAVRINDQDCVTMVYRLLREEGLFVGGSTGINVAAAAWLARQMGPGHTIVTLLCDRGGLYSSRLFNLAWLMEKG
LAPQ
>Mature_324_residues
MDVRDGFIGSIGNTPLIRLARLSAETGCEILGKAEFLNPGGSVKDRAALYIIQDAERRGALKPGGTVVEGTAGNTGIGLA
HICAARGYRCVIVIPETQSQEKMDLLRVLGAEVRPVPAVPYKDPNNYQKIASRLAQEMDNAIWANQFDNLVNRQAHYETT
GPEIWRDTAGKVDAFTCSTGTGGTLAGVARFLKEQNPAVRSVLADPYGSALYSFVKTGQLTADGNSITEGIGSSRVTANL
EGTPIDDAVRINDQDCVTMVYRLLREEGLFVGGSTGINVAAAAWLARQMGPGHTIVTLLCDRGGLYSSRLFNLAWLMEKG
LAPQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=318, Percent_Identity=41.8238993710692, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI295821200, Length=318, Percent_Identity=41.8238993710692, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI4557415, Length=318, Percent_Identity=41.8238993710692, Blast_Score=245, Evalue=3e-65,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=38.6885245901639, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=38.0952380952381, Blast_Score=170, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI32566674, Length=290, Percent_Identity=41.7241379310345, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17562970, Length=290, Percent_Identity=41.7241379310345, Blast_Score=200, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=40.1315789473684, Blast_Score=196, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=41.4473684210526, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17561720, Length=280, Percent_Identity=38.2142857142857, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17534315, Length=331, Percent_Identity=35.3474320241692, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=34.3558282208589, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32566672, Length=205, Percent_Identity=38.0487804878049, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71996324, Length=340, Percent_Identity=27.0588235294118, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539800, Length=344, Percent_Identity=24.7093023255814, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539640, Length=342, Percent_Identity=26.0233918128655, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=41.7417417417417, Blast_Score=219, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6321594, Length=332, Percent_Identity=35.5421686746988, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=41.747572815534, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=41.747572815534, Blast_Score=211, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 34659; Mature: 34659

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRDGFIGSIGNTPLIRLARLSAETGCEILGKAEFLNPGGSVKDRAALYIIQDAERRGA
CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCEEECCCCCCCCCEEEEEEECHHHCCC
LKPGGTVVEGTAGNTGIGLAHICAARGYRCVIVIPETQSQEKMDLLRVLGAEVRPVPAVP
CCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCC
YKDPNNYQKIASRLAQEMDNAIWANQFDNLVNRQAHYETTGPEIWRDTAGKVDAFTCSTG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCC
TGGTLAGVARFLKEQNPAVRSVLADPYGSALYSFVKTGQLTADGNSITEGIGSSRVTANL
CCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCEEECCCHHHHCCCCCCEEEEC
EGTPIDDAVRINDQDCVTMVYRLLREEGLFVGGSTGINVAAAAWLARQMGPGHTIVTLLC
CCCCCCCEEEECCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEE
DRGGLYSSRLFNLAWLMEKGLAPQ
CCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDVRDGFIGSIGNTPLIRLARLSAETGCEILGKAEFLNPGGSVKDRAALYIIQDAERRGA
CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCEEECCCCCCCCCEEEEEEECHHHCCC
LKPGGTVVEGTAGNTGIGLAHICAARGYRCVIVIPETQSQEKMDLLRVLGAEVRPVPAVP
CCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCC
YKDPNNYQKIASRLAQEMDNAIWANQFDNLVNRQAHYETTGPEIWRDTAGKVDAFTCSTG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCC
TGGTLAGVARFLKEQNPAVRSVLADPYGSALYSFVKTGQLTADGNSITEGIGSSRVTANL
CCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCEEECCCHHHHCCCCCCEEEEC
EGTPIDDAVRINDQDCVTMVYRLLREEGLFVGGSTGINVAAAAWLARQMGPGHTIVTLLC
CCCCCCCEEEECCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEE
DRGGLYSSRLFNLAWLMEKGLAPQ
CCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]