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The map label for this gene is parE [H]

Identifier: 91789025

GI number: 91789025

Start: 3349660

End: 3351639

Strand: Reverse

Name: parE [H]

Synonym: Bpro_3165

Alternate gene names: 91789025

Gene position: 3351639-3349660 (Counterclockwise)

Preceding gene: 91789034

Following gene: 91789024

Centisome position: 64.45

GC content: 61.06

Gene sequence:

>1980_bases
ATGGCCGACAAACTATCTACCGCAAGCAACGAATATTCCGAAGGCTCCATCCGCGTGCTCAAGGGCCTGGAGCCCGTCAA
GCAACGGCCGGGCATGTATACGCGCACCGACAACCCGCTGCACATCATCCAGGAGGTTCTGGACAACTCGGCTGATGAGG
CGCTGGCCGGGTATGGCAAAAAGATCAAGGTCACGCTGCACACCGACGGCTCGGTGAGCGTGGAAGATGACGGCCGCGGC
ATCCCGTTTGGCCTGCACCCGGAAGAAAAAGCACCGGTGGTCGAGCTGGTGTTCACCCGCCTGCATGCCGGCGGCAAGTT
CGACAAGGGCAAGGGCGGCGCTTATAGCTTCTCGGGTGGCCTGCACGGCGTGGGGGTGAGCGTCACCAACGCCTTGTCAA
AACGGCTTGAAGTGATGTCTTACCGCGAAGGCATGGTCGCCCGGCTGGTGTTTTCAGGTGGCGATGTCATTGAAAAACTG
CAGTTGCGCAAGGCTGCTGAAGGCGACCGCAAGTGCGGTACTTCCGTGCGTGCCTGGCCGGACGCCAAATACTTCGAGTC
TGCCGCTCTGCCCATGGCCGAGTTGACGCATTTGCTGCGCAGCAAGGCCGTGTTGATGCCCGGCGTGACTGTCACGCTGA
CCAACGAGAAGACCAAAGAAACGCAGACCTGGGCCTACAAAGGCGGCCTGCGCGACTACCTGATGCAGACCCTCACTGCC
GATCCGGTGATTCCGATGTTTGAAGGCGAGGGCTTTGCCGATGCCTCGCACGACAGTTTTGCCGAGGGTGAGGGCGCCCA
GTGGTGTGTGGCCTTTACCGAAGACGGTCAGCCCATGCGCGAAAGCTACGTCAACCTGATCCCGACCAGTGCCGGCGGTA
CGCACGAGAGCGGGCTGCGCGATGGCTTGTTCACTGCTGTCAAGAGCTTTATCGATTTGCATTCGTTGCTACCCAAGGGC
GTCAAGTTGCTGCCCGAGGATGTGTTTGCCCGGGCCAGCTATGTGCTTTCCGCCAAGGTGCTGGACCCGCAGTTTCAGGG
TCAGATCAAGGAACGCCTGAACTCGCGCGATGCGGTGCGGCTGGTGTCGAGCTTTGTGCGCCCCACGCTGGAGCTGTGGC
TGAACCAGCATGTCGACTACGGAAGAAAGCTGGCCGAACTCGCCATCAAGGCTGCGCAAACCCGCCAGAAGGCTGGCCAG
AAGGTTGAAAAACGCAAGGGCTCCGGCGTGGCCGTGCTGCCGGGCAAGCTGACCGATTGTGAAAGCAAGGACCTGGCACA
CAACGAGGTCTTCCTGGTCGAGGGCGACTCGGCGGGCGGCAGTGCCAAGATGGGGCGCGACAAGGAAAGCCAGGCCATCC
TGCCGCTGCGCGGCAAGGTGCTCAACACCTGGGAGGTCGAGCGTGACCGGCTGTTCGCCAACACGGAAATCCACGATATT
GCCGTGGCCATCGGGGTCGATCCGCATGGCCCCCATGACAAGCCGGACCTGAGCGGCCTGCGCTACGGCAAGGTCTGCAT
CCTCAGCGACGCCGACGTTGACGGCTCGCATATCCAGGTGCTGCTTTTGACCCTCTTTTTTCGCCACTTCCCCAAACTGA
TTGAAGCTGGTAATGTGTATGTGGCGCGCCCGCCGCTGTTTCGGGTGGATGCGCCGGCCCGCGGCAAGAAGCCGGCGTCC
AAGGTGTATGCCCTGGACGAAGGTGAATTGACCGCCATATTGGACAAGTTGCGCAAGGACGGCGTGCGAGAGAACGCCTG
GAGCATCAGCCGCTTCAAGGGGCTGGGCGAAATGAGTGCGGAACAGTTGTGGGAAACCACGCTCAACCCGGACACCCGGC
GCCTATTGCCCGTGCAGTTGGGCAACTTTGATTTTCTGCAAACCGAGAGCCTGATCACCAAGCTGATGGGTAAAGGCGAG
GCTGCGGCGCGGCGCGAACTGATGGAGTTGCACGGCGATGCCGTGGAGATTGATATTTGA

Upstream 100 bases:

>100_bases
CCAGTATATCCGACTCCACTGGAGCTAAGCGGATACCCCTTATATTCATACAGTTACTTTTGCGGCCCGGTCTACAATTG
CCGCAATTTCCTCATCAGCC

Downstream 100 bases:

>100_bases
TGAATTTCCCCCTGAAGTTGTTTTCACTTTTGCACCTGGCATCGGCATCCCGCGCGTTGGCGGGGATGCGGGCGCCGCGT
AGCCCTGCCCGCTGGCGCGC

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MADKLSTASNEYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNSADEALAGYGKKIKVTLHTDGSVSVEDDGRG
IPFGLHPEEKAPVVELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALSKRLEVMSYREGMVARLVFSGGDVIEKL
QLRKAAEGDRKCGTSVRAWPDAKYFESAALPMAELTHLLRSKAVLMPGVTVTLTNEKTKETQTWAYKGGLRDYLMQTLTA
DPVIPMFEGEGFADASHDSFAEGEGAQWCVAFTEDGQPMRESYVNLIPTSAGGTHESGLRDGLFTAVKSFIDLHSLLPKG
VKLLPEDVFARASYVLSAKVLDPQFQGQIKERLNSRDAVRLVSSFVRPTLELWLNQHVDYGRKLAELAIKAAQTRQKAGQ
KVEKRKGSGVAVLPGKLTDCESKDLAHNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVERDRLFANTEIHDI
AVAIGVDPHGPHDKPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGNVYVARPPLFRVDAPARGKKPAS
KVYALDEGELTAILDKLRKDGVRENAWSISRFKGLGEMSAEQLWETTLNPDTRRLLPVQLGNFDFLQTESLITKLMGKGE
AAARRELMELHGDAVEIDI

Sequences:

>Translated_659_residues
MADKLSTASNEYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNSADEALAGYGKKIKVTLHTDGSVSVEDDGRG
IPFGLHPEEKAPVVELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALSKRLEVMSYREGMVARLVFSGGDVIEKL
QLRKAAEGDRKCGTSVRAWPDAKYFESAALPMAELTHLLRSKAVLMPGVTVTLTNEKTKETQTWAYKGGLRDYLMQTLTA
DPVIPMFEGEGFADASHDSFAEGEGAQWCVAFTEDGQPMRESYVNLIPTSAGGTHESGLRDGLFTAVKSFIDLHSLLPKG
VKLLPEDVFARASYVLSAKVLDPQFQGQIKERLNSRDAVRLVSSFVRPTLELWLNQHVDYGRKLAELAIKAAQTRQKAGQ
KVEKRKGSGVAVLPGKLTDCESKDLAHNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVERDRLFANTEIHDI
AVAIGVDPHGPHDKPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGNVYVARPPLFRVDAPARGKKPAS
KVYALDEGELTAILDKLRKDGVRENAWSISRFKGLGEMSAEQLWETTLNPDTRRLLPVQLGNFDFLQTESLITKLMGKGE
AAARRELMELHGDAVEIDI
>Mature_658_residues
ADKLSTASNEYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNSADEALAGYGKKIKVTLHTDGSVSVEDDGRGI
PFGLHPEEKAPVVELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALSKRLEVMSYREGMVARLVFSGGDVIEKLQ
LRKAAEGDRKCGTSVRAWPDAKYFESAALPMAELTHLLRSKAVLMPGVTVTLTNEKTKETQTWAYKGGLRDYLMQTLTAD
PVIPMFEGEGFADASHDSFAEGEGAQWCVAFTEDGQPMRESYVNLIPTSAGGTHESGLRDGLFTAVKSFIDLHSLLPKGV
KLLPEDVFARASYVLSAKVLDPQFQGQIKERLNSRDAVRLVSSFVRPTLELWLNQHVDYGRKLAELAIKAAQTRQKAGQK
VEKRKGSGVAVLPGKLTDCESKDLAHNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVERDRLFANTEIHDIA
VAIGVDPHGPHDKPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGNVYVARPPLFRVDAPARGKKPASK
VYALDEGELTAILDKLRKDGVRENAWSISRFKGLGEMSAEQLWETTLNPDTRRLLPVQLGNFDFLQTESLITKLMGKGEA
AARRELMELHGDAVEIDI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=639, Percent_Identity=25.0391236306729, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI19913406, Length=597, Percent_Identity=24.4556113902848, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1789408, Length=652, Percent_Identity=48.9263803680982, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI48994957, Length=584, Percent_Identity=38.3561643835616, Blast_Score=354, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI17535065, Length=608, Percent_Identity=24.5065789473684, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI212645845, Length=573, Percent_Identity=24.6073298429319, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI212645657, Length=213, Percent_Identity=28.6384976525822, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=357, Percent_Identity=27.4509803921569, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136538, Length=651, Percent_Identity=24.5775729646697, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72168; Mature: 72037

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKLSTASNEYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNSADEALAGYGK
CCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCC
KIKVTLHTDGSVSVEDDGRGIPFGLHPEEKAPVVELVFTRLHAGGKFDKGKGGAYSFSGG
EEEEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCC
LHGVGVSVTNALSKRLEVMSYREGMVARLVFSGGDVIEKLQLRKAAEGDRKCGTSVRAWP
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCHHCCCCCCCCC
DAKYFESAALPMAELTHLLRSKAVLMPGVTVTLTNEKTKETQTWAYKGGLRDYLMQTLTA
CHHHHHHHCCCHHHHHHHHHHCCEECCCEEEEECCCCCCCHHHHHHCCCHHHHHHHHHCC
DPVIPMFEGEGFADASHDSFAEGEGAQWCVAFTEDGQPMRESYVNLIPTSAGGTHESGLR
CCCCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEEECCCCCCCCHHHH
DGLFTAVKSFIDLHSLLPKGVKLLPEDVFARASYVLSAKVLDPQFQGQIKERLNSRDAVR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCHHHHHHHHHHCCCHHHHH
LVSSFVRPTLELWLNQHVDYGRKLAELAIKAAQTRQKAGQKVEKRKGSGVAVLPGKLTDC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
ESKDLAHNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVERDRLFANTEIHDI
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCEECCEECCHHHEEECCCEEEE
AVAIGVDPHGPHDKPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGNVY
EEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
VARPPLFRVDAPARGKKPASKVYALDEGELTAILDKLRKDGVRENAWSISRFKGLGEMSA
EECCCCEEECCCCCCCCCHHHEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHH
EQLWETTLNPDTRRLLPVQLGNFDFLQTESLITKLMGKGEAAARRELMELHGDAVEIDI
HHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure 
ADKLSTASNEYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNSADEALAGYGK
CCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCC
KIKVTLHTDGSVSVEDDGRGIPFGLHPEEKAPVVELVFTRLHAGGKFDKGKGGAYSFSGG
EEEEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCC
LHGVGVSVTNALSKRLEVMSYREGMVARLVFSGGDVIEKLQLRKAAEGDRKCGTSVRAWP
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCHHCCCCCCCCC
DAKYFESAALPMAELTHLLRSKAVLMPGVTVTLTNEKTKETQTWAYKGGLRDYLMQTLTA
CHHHHHHHCCCHHHHHHHHHHCCEECCCEEEEECCCCCCCHHHHHHCCCHHHHHHHHHCC
DPVIPMFEGEGFADASHDSFAEGEGAQWCVAFTEDGQPMRESYVNLIPTSAGGTHESGLR
CCCCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEEECCCCCCCCHHHH
DGLFTAVKSFIDLHSLLPKGVKLLPEDVFARASYVLSAKVLDPQFQGQIKERLNSRDAVR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCHHHHHHHHHHCCCHHHHH
LVSSFVRPTLELWLNQHVDYGRKLAELAIKAAQTRQKAGQKVEKRKGSGVAVLPGKLTDC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
ESKDLAHNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVERDRLFANTEIHDI
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCEECCEECCHHHEEECCCEEEE
AVAIGVDPHGPHDKPDLSGLRYGKVCILSDADVDGSHIQVLLLTLFFRHFPKLIEAGNVY
EEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
VARPPLFRVDAPARGKKPASKVYALDEGELTAILDKLRKDGVRENAWSISRFKGLGEMSA
EECCCCEEECCCCCCCCCHHHEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHH
EQLWETTLNPDTRRLLPVQLGNFDFLQTESLITKLMGKGEAAARRELMELHGDAVEIDI
HHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]