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The map label for this gene is ilvG [H]

Identifier: 91788679

GI number: 91788679

Start: 2961907

End: 2963619

Strand: Reverse

Name: ilvG [H]

Synonym: Bpro_2817

Alternate gene names: 91788679

Gene position: 2963619-2961907 (Counterclockwise)

Preceding gene: 91788680

Following gene: 91788671

Centisome position: 56.99

GC content: 63.51

Gene sequence:

>1713_bases
ATGACTACACAACTTGCGGGCCACCTTCTCGTTGACTGCCTGATTGCCCAGGGCGTTACCCATGCGTTTGGCGTTCCCGG
TGAAAGCTACCTCGCCGTCCTTGATGGCTTGCATGCACGCCAGGGCCAGATTGAATTCATCACCTGCCGCCAGGAAGGCG
GTGCTGCCTTCATGGCCGAGGCGCACGGCAAGCTCACCGGCCGGCCGGGCGTTTGCATGGTGACGCGCGGACCGGGTGCT
ACCAACGCTTCCATCGGTGTCCACACCGCGTTTCAGGACTCGACGCCCATGGTGCTGCTGGTGGGCGATGTGGCCAGCGA
CTGCCGCGACCGGGAAGCTTTTCAGGAGGTGGATTACGCCAGCTTTTTCGGGCCGAGCACCAAGGGCTTTGCCAAACGCG
TGGAGCGCATCGACGATGCGGACCGCATTCCGGAGTATGTGGCGCGCGCCTTTGCGACGGCCGTGAACGGCCGGCCCGGC
CCGGTCGTGCTGGTATTGCCTGAAGACATGCTGACGCAGATGACCGGCGCCCAGCCCTTGCCCCGCGTGGAGGCGGTCCA
GGCCTGGAGCGACCCCGGTTCCGTGCGTACGCTGCGCGAGATGCTGCTCCAATCGCAGCGGCCGTTTGTCATTGCCGGAG
GCGGCGGCTGGACGCCGCAGTCGGCGCAGGCACTGCAGCGCTTTGCCGAAAACTGGAAGCTGCCGGTGGGCAACGCCTTT
CGTTTCCAGGACACGTTTGACAACCACCACCCGCAATATGCCGGTGACGTGGGCATCGGCCTGAACCCCAAACTGGCAGC
GCGTATCAAGGCCAGCGACCTCATCATCGCCATCGGCCCGCGCCTGGGGGAAATGACGACCGGCAATTACACCTTGCTGG
AGGCACCTCGGCCCCGGCAGAAGCTGGTGCACATCCACTCCAGCGCCGAAGAACTCAACCGCGTCTACCAGGCCGACCTG
GCCATCAACGCCACCATGAATGCCGCTGCGCGCTCGCTGGAGGTGCTAACGGCACCAGCCGAGTTGCCCTGGGAGGCCTG
GACCGCATCGGCCAACAACGATTACCTGGCCAACCTGCAAACCCAGGAAGGGCAAAAGCTGCCCGGCGATATCGACATGG
CGGCCATCGTCGGCCTGTTGCAAAAGCATTTGCCGCAAGATGCGGTACTGACCAATGGCGCGGGCAACTTTGCCAGCTGG
GTGCACCGGTTTTTCAAACACCACGGGCTGGTCAAAGGGAACAAGACGCAACTGGCGCCCACTGTGGGCGCCATGGGCTA
TGGCGTGCCGGCCGGCATCGCGGCCAATATCGTCTCGGGCCGAACGGCCTTCACCATTGCCGGGGACGGTGACTTCCTGA
TGAATGGCCAGGAGCTGGCGACAGCCGTTCAGCACGGCGCCAAAAGCATCATCGTGCTGCTCAACAACGGCATGTACGGC
ACCATTCGCATGCACCAGGAAAAGACGTATCCGCAGCACGTGAGCGGCTCGCGCCTGAACAACCCGGACTTTGCCGCCCT
GGCACGCGCCTACGGTTATGCGGGTGTTCGCATCACGCGGACCGCCGAATTTGAAGCCGAACTGCTGGCCGCGCTGGCGC
GCAAGGAAGGCACGGTGATCGAGGTGACACTGGATCCTGAGGTCATCACCACGCGGGGCACGCTGTCATCGATTACCCAG
GCTGCATTGACTCAGTCGCTGCAAAAATCATAG

Upstream 100 bases:

>100_bases
CGACAGAGGCGAAGCGTCTCGCGAGACGCGGCCTGCAAGGCCTCGCGCAGTACACGAAGTGACAAGCGTGGGGGCAACAC
TCCAGCGCACAATACGCCCC

Downstream 100 bases:

>100_bases
CTATATGTTGAATGCCTAATCGAGGGCGGATTCAAGCTGAAAAGGCTTGAGGAAATGAAAAAGGCCGGGATAGCCCGGCC
TTTTGTCTGGCACGCCAGCT

Product: thiamine pyrophosphate enzyme-like protein

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MTTQLAGHLLVDCLIAQGVTHAFGVPGESYLAVLDGLHARQGQIEFITCRQEGGAAFMAEAHGKLTGRPGVCMVTRGPGA
TNASIGVHTAFQDSTPMVLLVGDVASDCRDREAFQEVDYASFFGPSTKGFAKRVERIDDADRIPEYVARAFATAVNGRPG
PVVLVLPEDMLTQMTGAQPLPRVEAVQAWSDPGSVRTLREMLLQSQRPFVIAGGGGWTPQSAQALQRFAENWKLPVGNAF
RFQDTFDNHHPQYAGDVGIGLNPKLAARIKASDLIIAIGPRLGEMTTGNYTLLEAPRPRQKLVHIHSSAEELNRVYQADL
AINATMNAAARSLEVLTAPAELPWEAWTASANNDYLANLQTQEGQKLPGDIDMAAIVGLLQKHLPQDAVLTNGAGNFASW
VHRFFKHHGLVKGNKTQLAPTVGAMGYGVPAGIAANIVSGRTAFTIAGDGDFLMNGQELATAVQHGAKSIIVLLNNGMYG
TIRMHQEKTYPQHVSGSRLNNPDFAALARAYGYAGVRITRTAEFEAELLAALARKEGTVIEVTLDPEVITTRGTLSSITQ
AALTQSLQKS

Sequences:

>Translated_570_residues
MTTQLAGHLLVDCLIAQGVTHAFGVPGESYLAVLDGLHARQGQIEFITCRQEGGAAFMAEAHGKLTGRPGVCMVTRGPGA
TNASIGVHTAFQDSTPMVLLVGDVASDCRDREAFQEVDYASFFGPSTKGFAKRVERIDDADRIPEYVARAFATAVNGRPG
PVVLVLPEDMLTQMTGAQPLPRVEAVQAWSDPGSVRTLREMLLQSQRPFVIAGGGGWTPQSAQALQRFAENWKLPVGNAF
RFQDTFDNHHPQYAGDVGIGLNPKLAARIKASDLIIAIGPRLGEMTTGNYTLLEAPRPRQKLVHIHSSAEELNRVYQADL
AINATMNAAARSLEVLTAPAELPWEAWTASANNDYLANLQTQEGQKLPGDIDMAAIVGLLQKHLPQDAVLTNGAGNFASW
VHRFFKHHGLVKGNKTQLAPTVGAMGYGVPAGIAANIVSGRTAFTIAGDGDFLMNGQELATAVQHGAKSIIVLLNNGMYG
TIRMHQEKTYPQHVSGSRLNNPDFAALARAYGYAGVRITRTAEFEAELLAALARKEGTVIEVTLDPEVITTRGTLSSITQ
AALTQSLQKS
>Mature_569_residues
TTQLAGHLLVDCLIAQGVTHAFGVPGESYLAVLDGLHARQGQIEFITCRQEGGAAFMAEAHGKLTGRPGVCMVTRGPGAT
NASIGVHTAFQDSTPMVLLVGDVASDCRDREAFQEVDYASFFGPSTKGFAKRVERIDDADRIPEYVARAFATAVNGRPGP
VVLVLPEDMLTQMTGAQPLPRVEAVQAWSDPGSVRTLREMLLQSQRPFVIAGGGGWTPQSAQALQRFAENWKLPVGNAFR
FQDTFDNHHPQYAGDVGIGLNPKLAARIKASDLIIAIGPRLGEMTTGNYTLLEAPRPRQKLVHIHSSAEELNRVYQADLA
INATMNAAARSLEVLTAPAELPWEAWTASANNDYLANLQTQEGQKLPGDIDMAAIVGLLQKHLPQDAVLTNGAGNFASWV
HRFFKHHGLVKGNKTQLAPTVGAMGYGVPAGIAANIVSGRTAFTIAGDGDFLMNGQELATAVQHGAKSIIVLLNNGMYGT
IRMHQEKTYPQHVSGSRLNNPDFAALARAYGYAGVRITRTAEFEAELLAALARKEGTVIEVTLDPEVITTRGTLSSITQA
ALTQSLQKS

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=577, Percent_Identity=22.7036395147314, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI21361361, Length=529, Percent_Identity=24.1965973534972, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI87081685, Length=566, Percent_Identity=31.2720848056537, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1790104, Length=547, Percent_Identity=27.7879341864717, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1786717, Length=559, Percent_Identity=27.1914132379249, Blast_Score=152, Evalue=8e-38,
Organism=Escherichia coli, GI1788716, Length=586, Percent_Identity=23.7201365187713, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787096, Length=555, Percent_Identity=23.963963963964, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17531301, Length=565, Percent_Identity=25.8407079646018, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17531299, Length=574, Percent_Identity=25.7839721254355, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17542570, Length=552, Percent_Identity=23.1884057971014, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323755, Length=577, Percent_Identity=27.0363951473137, Blast_Score=203, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320816, Length=576, Percent_Identity=20.4861111111111, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323163, Length=551, Percent_Identity=21.0526315789474, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19922626, Length=598, Percent_Identity=24.0802675585284, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61104; Mature: 60973

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQLAGHLLVDCLIAQGVTHAFGVPGESYLAVLDGLHARQGQIEFITCRQEGGAAFMAE
CCCCHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEE
AHGKLTGRPGVCMVTRGPGATNASIGVHTAFQDSTPMVLLVGDVASDCRDREAFQEVDYA
CCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCHH
SFFGPSTKGFAKRVERIDDADRIPEYVARAFATAVNGRPGPVVLVLPEDMLTQMTGAQPL
HHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCCCCCC
PRVEAVQAWSDPGSVRTLREMLLQSQRPFVIAGGGGWTPQSAQALQRFAENWKLPVGNAF
CCHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEE
RFQDTFDNHHPQYAGDVGIGLNPKLAARIKASDLIIAIGPRLGEMTTGNYTLLEAPRPRQ
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCCCCCCCEEEEECCCCHH
KLVHIHSSAEELNRVYQADLAINATMNAAARSLEVLTAPAELPWEAWTASANNDYLANLQ
HHEEHHCCHHHHHHHHHHHHEEECHHHHHHHHEEEEECCCCCCHHHEECCCCCCEEEECC
TQEGQKLPGDIDMAAIVGLLQKHLPQDAVLTNGAGNFASWVHRFFKHHGLVKGNKTQLAP
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCC
TVGAMGYGVPAGIAANIVSGRTAFTIAGDGDFLMNGQELATAVQHGAKSIIVLLNNGMYG
CHHHCCCCCCCHHHHHHCCCCEEEEEECCCCEEECHHHHHHHHHCCCCEEEEEEECCCEE
TIRMHQEKTYPQHVSGSRLNNPDFAALARAYGYAGVRITRTAEFEAELLAALARKEGTVI
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCEE
EVTLDPEVITTRGTLSSITQAALTQSLQKS
EEEECCCEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTQLAGHLLVDCLIAQGVTHAFGVPGESYLAVLDGLHARQGQIEFITCRQEGGAAFMAE
CCCHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEE
AHGKLTGRPGVCMVTRGPGATNASIGVHTAFQDSTPMVLLVGDVASDCRDREAFQEVDYA
CCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCHH
SFFGPSTKGFAKRVERIDDADRIPEYVARAFATAVNGRPGPVVLVLPEDMLTQMTGAQPL
HHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCCCCCC
PRVEAVQAWSDPGSVRTLREMLLQSQRPFVIAGGGGWTPQSAQALQRFAENWKLPVGNAF
CCHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEE
RFQDTFDNHHPQYAGDVGIGLNPKLAARIKASDLIIAIGPRLGEMTTGNYTLLEAPRPRQ
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCCCCCCCEEEEECCCCHH
KLVHIHSSAEELNRVYQADLAINATMNAAARSLEVLTAPAELPWEAWTASANNDYLANLQ
HHEEHHCCHHHHHHHHHHHHEEECHHHHHHHHEEEEECCCCCCHHHEECCCCCCEEEECC
TQEGQKLPGDIDMAAIVGLLQKHLPQDAVLTNGAGNFASWVHRFFKHHGLVKGNKTQLAP
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCC
TVGAMGYGVPAGIAANIVSGRTAFTIAGDGDFLMNGQELATAVQHGAKSIIVLLNNGMYG
CHHHCCCCCCCHHHHHHCCCCEEEEEECCCCEEECHHHHHHHHHCCCCEEEEEEECCCEE
TIRMHQEKTYPQHVSGSRLNNPDFAALARAYGYAGVRITRTAEFEAELLAALARKEGTVI
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCEE
EVTLDPEVITTRGTLSSITQAALTQSLQKS
EEEECCCEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]