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The map label for this gene is msrA2 [H]

Identifier: 91788603

GI number: 91788603

Start: 2883145

End: 2883873

Strand: Direct

Name: msrA2 [H]

Synonym: Bpro_2741

Alternate gene names: 91788603

Gene position: 2883145-2883873 (Clockwise)

Preceding gene: 91788602

Following gene: 91788609

Centisome position: 55.44

GC content: 61.18

Gene sequence:

>729_bases
ATGATGATGAACAAATACCTCCTCACCCTTGGCGCAGTCGCACTGGCTGCCTGGGTTTTTGTGGGCGGCGGCATGGGCGT
GAGCTCGGCAGAAGAAAAAGCCGTCAAACTGCCCGCCCCGGCCATGGACATGCCGGCCACCGCACAGGCAGGCCCGCAGG
CGGGCAGCGCCACAGCGGTGTTCGCCGGCGGCTGCTTCTGGGGCGTGCAAGCCGTGTTCCAGCACACCCAGGGCGTCCTC
AACGCCGTATCGGGCTATGCAGGCGGCGAAAAAGCGACCGCCAGCTACGAGATGATCGGCTCAGGCCGTACCGGCCACGC
CGAATCCGTGCAGATCACCTACGACCCGAAAAAGATTTCATACGGCAAGCTGCTGCAGATTTACTTTTCAGTGGCGCACG
ACCCAACAACATTGAACCGCCAGGGCCCGGACAGCGGCACGCAATACCGGTCCGCCGTTTTCTACCAGGACGCCAACCAG
AAAAAAGTGACCGAAAGCTACATCGCCCAGCTGGACGCCGCCAAGGTGTTCCCCAACAAGATCGTGACACAGCTCACGCC
GCTAAACGGCTTCTATCCGGCGGAGGCTTACCACCAGGACTACGCGACCCTGCATCCGAACCAGCCTTACATTGCGCGGT
TTGATTTGCCGAAGATCGCGAACCTGAAAACCGTGATGCCTGAGGTGTATCGGGACAAGCCGGTGCTGGTGTCGCAGGCC
GGCAAGTAG

Upstream 100 bases:

>100_bases
GCCGCTGCGGCGGGCACCTGGGCCACGTGTTTGACGACGGCCCCAAACCCACCGGCCTGCGCTACTGCATCAACGGCCTG
GCCCTTAACTTCAAGGCAGC

Downstream 100 bases:

>100_bases
AGCTGGCTTTAGGCAAAATTGAACAACCAGCTTGAGCCTAGAACCACCTTCCGCGTTTGCGGCCGGTGGACAAAAGTACG
CCCGGCTCCTTATCCAAATT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MMMNKYLLTLGAVALAAWVFVGGGMGVSSAEEKAVKLPAPAMDMPATAQAGPQAGSATAVFAGGCFWGVQAVFQHTQGVL
NAVSGYAGGEKATASYEMIGSGRTGHAESVQITYDPKKISYGKLLQIYFSVAHDPTTLNRQGPDSGTQYRSAVFYQDANQ
KKVTESYIAQLDAAKVFPNKIVTQLTPLNGFYPAEAYHQDYATLHPNQPYIARFDLPKIANLKTVMPEVYRDKPVLVSQA
GK

Sequences:

>Translated_242_residues
MMMNKYLLTLGAVALAAWVFVGGGMGVSSAEEKAVKLPAPAMDMPATAQAGPQAGSATAVFAGGCFWGVQAVFQHTQGVL
NAVSGYAGGEKATASYEMIGSGRTGHAESVQITYDPKKISYGKLLQIYFSVAHDPTTLNRQGPDSGTQYRSAVFYQDANQ
KKVTESYIAQLDAAKVFPNKIVTQLTPLNGFYPAEAYHQDYATLHPNQPYIARFDLPKIANLKTVMPEVYRDKPVLVSQA
GK
>Mature_242_residues
MMMNKYLLTLGAVALAAWVFVGGGMGVSSAEEKAVKLPAPAMDMPATAQAGPQAGSATAVFAGGCFWGVQAVFQHTQGVL
NAVSGYAGGEKATASYEMIGSGRTGHAESVQITYDPKKISYGKLLQIYFSVAHDPTTLNRQGPDSGTQYRSAVFYQDANQ
KKVTESYIAQLDAAKVFPNKIVTQLTPLNGFYPAEAYHQDYATLHPNQPYIARFDLPKIANLKTVMPEVYRDKPVLVSQA
GK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=39.4904458598726, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=39.4904458598726, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=40.3669724770642, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=43.9490445859873, Blast_Score=118, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=37.7622377622378, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=36.969696969697, Blast_Score=108, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24664627, Length=175, Percent_Identity=34.2857142857143, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=35.4609929078014, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24664631, Length=175, Percent_Identity=33.1428571428571, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25978; Mature: 25978

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMNKYLLTLGAVALAAWVFVGGGMGVSSAEEKAVKLPAPAMDMPATAQAGPQAGSATAV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEE
FAGGCFWGVQAVFQHTQGVLNAVSGYAGGEKATASYEMIGSGRTGHAESVQITYDPKKIS
EECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCC
YGKLLQIYFSVAHDPTTLNRQGPDSGTQYRSAVFYQDANQKKVTESYIAQLDAAKVFPNK
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHCHHH
IVTQLTPLNGFYPAEAYHQDYATLHPNQPYIARFDLPKIANLKTVMPEVYRDKPVLVSQA
HHHHHCCCCCCCCCHHHHCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEECC
GK
CC
>Mature Secondary Structure
MMMNKYLLTLGAVALAAWVFVGGGMGVSSAEEKAVKLPAPAMDMPATAQAGPQAGSATAV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEE
FAGGCFWGVQAVFQHTQGVLNAVSGYAGGEKATASYEMIGSGRTGHAESVQITYDPKKIS
EECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCC
YGKLLQIYFSVAHDPTTLNRQGPDSGTQYRSAVFYQDANQKKVTESYIAQLDAAKVFPNK
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHCHHH
IVTQLTPLNGFYPAEAYHQDYATLHPNQPYIARFDLPKIANLKTVMPEVYRDKPVLVSQA
HHHHHCCCCCCCCCHHHHCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEECC
GK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]