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The map label for this gene is dnaX [H]

Identifier: 91788139

GI number: 91788139

Start: 2360359

End: 2362191

Strand: Direct

Name: dnaX [H]

Synonym: Bpro_2268

Alternate gene names: 91788139

Gene position: 2360359-2362191 (Clockwise)

Preceding gene: 91788138

Following gene: 91788140

Centisome position: 45.39

GC content: 64.65

Gene sequence:

>1833_bases
ATGTCCTATCTAGTTCTTGCCCGCAAATACCGTCCCCGAAATTTCTCTGAAATGGTGGGTCAGTCGCATGTGGTGCAGGC
ACTTGGCAATGCGCTGAGCACGCGGCGCTTGCACCATGCCTATCTCTTCACCGGCACGCGGGGCGTCGGCAAGACCACCG
TGTCGCGCATTCTCGCCAAGTCGCTCAATTGCACGGGTGTCGATGGGCAGGGCGACATTACCGCCGAGCCCTGCGGCGTT
TGCCAGGCATGCATCGACATCGACAGTGGCCGCTTCGTCGACTACACCGAGCTCGATGCAGCATCCAACCGCGGGGTGGA
TGAAATTGCGCAGTTGCTGGAGCAGGCGGTTTACAAGCCGGTGGTGGGCCGCTTCAAGGTCTTCATGATCGACGAGGTTC
ACATGCTGACGAACACGGCGTTCAACGCCATGCTCAAGACGCTGGAGGAACCGCCCGAGTACCTCAAATTTGTGCTCGCC
ACGACCGATCCGCAGAAGGTCCCCGCCACCGTGCTGTCGCGCTGCCTACAGTTCAACCTGCGCCCCATGGCGCCTGAGAC
GGTGCTGGAACACCTGGCCCAGGTGCTGGGCACCGAAAATGTGCCGGCCGAACCACAGGCCTTGCGTCTGCTGGCACGTG
CGGCCCGAGGCTCCATGCGCGATGCGCTGTCGCTGACCGACCAGGCCATTGCCTTTGGTTCGGGCCAGTTGCTGGAGGCC
AGCGTGCGCACCATGCTGGGCAGCGTGGACCGCAGTTATGTGTTTCGCCTGCTGGATGCGCTGGCGCGCGGCGACGGCAA
AACCGTGGTGGAAACCTCCGAAGCCTTGCGACTCAATGGCCTGAGCGCCGCTTCCACGCTCGAAGAGATGACGGCCGTGC
TGCAGCGCATGGCGGTGCTGCAGGCTGTGCCGGACAGGGGGGGCGTTGATGATGCCGACCCCGAAATCGCCGAGACGGCC
CGGCTGGCCCAGACCTTGCCGGCCGACGAAACCCAGTTGCTCTACAGCCTGTGCCTGCATGGCCGCGGCGAGCTGGGTCT
GGCGCCCGACGAATATGCGGGCCTCACCATGGTGCTATTGCGCTTGCTGGCGTTCAAGCCTTCGTCCGCCATGGTGCCAG
CCGTGCAGGCCAGGTCGCCGGCCTCCTCGCTGGGGAGCGCCGCCGAGCCCGCAAAAAAGCCGCAGCCTGAGTCGGCCATT
GCCGGCGCGCGTGCGGTTCCTGAACCGGCGGCGACGGCATCGGTAGCCCAGCCGGTGCCTGTCGCTGTGCCGGAACGCTC
CTCAAGCCAGAACCAGGGGAGAAAAGATGCTCCAGCCCATGTAAATGCTGAGTCTGTTGCTATTAATTCAGAAGCACCGG
TTGGGCTGCCTGGCGTGCCGGCGCCCGCACCGCGGATCTTACCGACCGCGCCCGCACCCCTGGCGACCACGCCGCTGGGC
GATGCATGGAGCCAGACCGTTAATCAGCTGGTGGTGGCCGAATTGGTTGCCGCGCTGACGCGTGAGCTGGCGCTGCAGTC
AGAGCTGCGCAGTCAGGATGAGGGCATGTGGACCCTGCGCGTGGAGCGGGAGTCATTGAACCAGGCCGCCGCCCGCGAGA
AATTGCAGGCTGCGTTGCAACAGGCGCTCGGCGACACGGCCATCAGGCTGACCGTGGAAATAGGCCCCGTGAGTGATACC
CCGGCACGCCGCAATGCTGCCGCGCTGGCGGAGCGTCAGCGGGCCGCCGAAGAGATGATTCAGAACGACCCGTTTGTGCA
GGACATGATTCGGGATTGGGGTGCCAGGATTGTTCCGGGCAGCATCAGGCCCCTTGCCCCCAAGCCGATATGA

Upstream 100 bases:

>100_bases
AAAAACTATCTGCCAAGCCATCGGGGCAAGGGCTGATGCCTGATGCGCGCCGCCTCGGCAGTGTCTACCGCCTCGTTCCG
CGTCAAATTAGAATGGGTGA

Downstream 100 bases:

>100_bases
TAGCCACCCGTTGTAAAGCCGGAATTTAAAGGAAAGAACCATGTTCAACAAAGGACAACTCGCAGGCCTCATGAAACAGG
CGCAGGCGATGCAGGACAAC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MSYLVLARKYRPRNFSEMVGQSHVVQALGNALSTRRLHHAYLFTGTRGVGKTTVSRILAKSLNCTGVDGQGDITAEPCGV
CQACIDIDSGRFVDYTELDAASNRGVDEIAQLLEQAVYKPVVGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLA
TTDPQKVPATVLSRCLQFNLRPMAPETVLEHLAQVLGTENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLLEA
SVRTMLGSVDRSYVFRLLDALARGDGKTVVETSEALRLNGLSAASTLEEMTAVLQRMAVLQAVPDRGGVDDADPEIAETA
RLAQTLPADETQLLYSLCLHGRGELGLAPDEYAGLTMVLLRLLAFKPSSAMVPAVQARSPASSLGSAAEPAKKPQPESAI
AGARAVPEPAATASVAQPVPVAVPERSSSQNQGRKDAPAHVNAESVAINSEAPVGLPGVPAPAPRILPTAPAPLATTPLG
DAWSQTVNQLVVAELVAALTRELALQSELRSQDEGMWTLRVERESLNQAAAREKLQAALQQALGDTAIRLTVEIGPVSDT
PARRNAAALAERQRAAEEMIQNDPFVQDMIRDWGARIVPGSIRPLAPKPI

Sequences:

>Translated_610_residues
MSYLVLARKYRPRNFSEMVGQSHVVQALGNALSTRRLHHAYLFTGTRGVGKTTVSRILAKSLNCTGVDGQGDITAEPCGV
CQACIDIDSGRFVDYTELDAASNRGVDEIAQLLEQAVYKPVVGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLA
TTDPQKVPATVLSRCLQFNLRPMAPETVLEHLAQVLGTENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLLEA
SVRTMLGSVDRSYVFRLLDALARGDGKTVVETSEALRLNGLSAASTLEEMTAVLQRMAVLQAVPDRGGVDDADPEIAETA
RLAQTLPADETQLLYSLCLHGRGELGLAPDEYAGLTMVLLRLLAFKPSSAMVPAVQARSPASSLGSAAEPAKKPQPESAI
AGARAVPEPAATASVAQPVPVAVPERSSSQNQGRKDAPAHVNAESVAINSEAPVGLPGVPAPAPRILPTAPAPLATTPLG
DAWSQTVNQLVVAELVAALTRELALQSELRSQDEGMWTLRVERESLNQAAAREKLQAALQQALGDTAIRLTVEIGPVSDT
PARRNAAALAERQRAAEEMIQNDPFVQDMIRDWGARIVPGSIRPLAPKPI
>Mature_609_residues
SYLVLARKYRPRNFSEMVGQSHVVQALGNALSTRRLHHAYLFTGTRGVGKTTVSRILAKSLNCTGVDGQGDITAEPCGVC
QACIDIDSGRFVDYTELDAASNRGVDEIAQLLEQAVYKPVVGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLAT
TDPQKVPATVLSRCLQFNLRPMAPETVLEHLAQVLGTENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLLEAS
VRTMLGSVDRSYVFRLLDALARGDGKTVVETSEALRLNGLSAASTLEEMTAVLQRMAVLQAVPDRGGVDDADPEIAETAR
LAQTLPADETQLLYSLCLHGRGELGLAPDEYAGLTMVLLRLLAFKPSSAMVPAVQARSPASSLGSAAEPAKKPQPESAIA
GARAVPEPAATASVAQPVPVAVPERSSSQNQGRKDAPAHVNAESVAINSEAPVGLPGVPAPAPRILPTAPAPLATTPLGD
AWSQTVNQLVVAELVAALTRELALQSELRSQDEGMWTLRVERESLNQAAAREKLQAALQQALGDTAIRLTVEIGPVSDTP
ARRNAAALAERQRAAEEMIQNDPFVQDMIRDWGARIVPGSIRPLAPKPI

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=292, Percent_Identity=27.0547945205479, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194306571, Length=295, Percent_Identity=26.7796610169492, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI194306567, Length=295, Percent_Identity=26.7796610169492, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI194306569, Length=204, Percent_Identity=27.9411764705882, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1786676, Length=661, Percent_Identity=39.9394856278366, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1787341, Length=150, Percent_Identity=34, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17541988, Length=225, Percent_Identity=25.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=219, Percent_Identity=26.027397260274, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=299, Percent_Identity=24.0802675585284, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324478, Length=256, Percent_Identity=25, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921076, Length=306, Percent_Identity=23.5294117647059, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17647857, Length=238, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI18859927, Length=298, Percent_Identity=23.489932885906, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65155; Mature: 65024

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLVLARKYRPRNFSEMVGQSHVVQALGNALSTRRLHHAYLFTGTRGVGKTTVSRILAK
CCCEEEEHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
SLNCTGVDGQGDITAEPCGVCQACIDIDSGRFVDYTELDAASNRGVDEIAQLLEQAVYKP
HCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECHHHCCCCCCCCHHHHHHHHHHHHHHH
VVGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPATVLSRCLQFNL
HHHCEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
RPMAPETVLEHLAQVLGTENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLLEA
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHH
SVRTMLGSVDRSYVFRLLDALARGDGKTVVETSEALRLNGLSAASTLEEMTAVLQRMAVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QAVPDRGGVDDADPEIAETARLAQTLPADETQLLYSLCLHGRGELGLAPDEYAGLTMVLL
HHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHH
RLLAFKPSSAMVPAVQARSPASSLGSAAEPAKKPQPESAIAGARAVPEPAATASVAQPVP
HHHHCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCC
VAVPERSSSQNQGRKDAPAHVNAESVAINSEAPVGLPGVPAPAPRILPTAPAPLATTPLG
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DAWSQTVNQLVVAELVAALTRELALQSELRSQDEGMWTLRVERESLNQAAAREKLQAALQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHH
QALGDTAIRLTVEIGPVSDTPARRNAAALAERQRAAEEMIQNDPFVQDMIRDWGARIVPG
HHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCC
SIRPLAPKPI
CCCCCCCCCC
>Mature Secondary Structure 
SYLVLARKYRPRNFSEMVGQSHVVQALGNALSTRRLHHAYLFTGTRGVGKTTVSRILAK
CCEEEEHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
SLNCTGVDGQGDITAEPCGVCQACIDIDSGRFVDYTELDAASNRGVDEIAQLLEQAVYKP
HCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECHHHCCCCCCCCHHHHHHHHHHHHHHH
VVGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPATVLSRCLQFNL
HHHCEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
RPMAPETVLEHLAQVLGTENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLLEA
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHH
SVRTMLGSVDRSYVFRLLDALARGDGKTVVETSEALRLNGLSAASTLEEMTAVLQRMAVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QAVPDRGGVDDADPEIAETARLAQTLPADETQLLYSLCLHGRGELGLAPDEYAGLTMVLL
HHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHH
RLLAFKPSSAMVPAVQARSPASSLGSAAEPAKKPQPESAIAGARAVPEPAATASVAQPVP
HHHHCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCC
VAVPERSSSQNQGRKDAPAHVNAESVAINSEAPVGLPGVPAPAPRILPTAPAPLATTPLG
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DAWSQTVNQLVVAELVAALTRELALQSELRSQDEGMWTLRVERESLNQAAAREKLQAALQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHH
QALGDTAIRLTVEIGPVSDTPARRNAAALAERQRAAEEMIQNDPFVQDMIRDWGARIVPG
HHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCC
SIRPLAPKPI
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]