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The map label for this gene is tcmA [H]

Identifier: 91787112

GI number: 91787112

Start: 1259379

End: 1260812

Strand: Direct

Name: tcmA [H]

Synonym: Bpro_1215

Alternate gene names: 91787112

Gene position: 1259379-1260812 (Clockwise)

Preceding gene: 91787110

Following gene: 91787113

Centisome position: 24.22

GC content: 67.71

Gene sequence:

>1434_bases
ATGCAAGGCGATAAGCAGTTCCCGGGATTCACGCCCTCCCAGCGGTGGGTGCTGGGCCTGGCCGCGGCCGGCTCGTTCAT
GGCGGTGCTGGACGCGATGGTAGTGACGACTGCGCTGGATACGTTGCGGCACGAGCTGTCGGCCTCGGTAGCGGCGCTGG
AATGGACGGTCAATGCCTATAGTCTCAGCTTCGCGGCGCTGTTGATGACCGGAGCAGCGCTGGGCGACCGATTCGGGCGG
CGGCGTATGTATGTGCTTGGGTTGTTGCTGTTCGCGCTGGCTTCGGCAGCCTGCGCCGCGGCTCCCAGCACCGCCTGGCT
GATCGCGGGGCGGGCGGTGCAGGGCATGGGCGCGGCGCTTGTGATGCCCATTGCGATGGCGTTGCTGGGCGCTGCATTTC
CGCCGCCGCAACGGGCCAGGGCCTTGGGTATTTTCAGCGGCATCACCGGGCTGGCGGTGCTGTCGGGGCCATTGTTCGGC
GGGGCCATCGTACAAGGGCTGGCATGGCAGTGGATTTTCTGGATCAACCTGCCGGTGGCGCTGGCAGTGGCATGGCTGAT
GCTGCTGAAGGTGCCCGAAGGCAAGACTCTGTCGGCGCCGCTGGACTTGCGGGGCGCAGGGCTGATGTCCGCATCACTGT
TGGGGCTGGTTTGGGGTCTGGTCCATGGCAATCGCGCCGGCTGGGGCAGCGCCGAGGTCCTGACTTCGTTGGGAGCGGGC
GCTGTGTTGGGCGCTGCATTCGTGGCGTCGCAACGCGTGAATACCTGGGACGCCATGATTCCGCCGCGCCTGTTTCGCTC
GCCGGTGCTCGCGGCGGGGCTCACCGTCAGCTTGCTGTTGACGGCGTCGCTTTTCGGCACGCTGTTCTTCATGGCGCAGT
TCTTCCAGGTGACCCGGGGCCTGTCACCCCTGTCAGCGGGCGCGAGCATGCTGCCGTGGACGGCCACGCTGTTCCTGGTC
GCGCCGGTGGCGGGTGCGATGATCACGCGCATCGGCGAGCGCGCGCTGGTGGTCGCGGGCCTCGGTATTCAGGCCGGGGG
GATGGCGTGGCTCGCCGTGCTGGTGCGCGCCGACGCGCCCTATACGCTATGGGTGGTGCCGCTCATGATCGCCGGTGCGG
GCATTTCGATGGCCATGCCGGCGGTGCAGAGCGCCGTACTGGCTGAGGTGGCGCCGAGTGACATGGGCAAGGCGGCGGGG
CTTTTCAACACGCTACGTCAATTGGGCGGCGTGATTGGTGTGGCGCTGGTGGTGGCGGTGTTCACGCGAGTTGGCGGCTA
CGGCAGCGCGCAGCAGTTCAGCGCCGGCTTTGCCACGGTGTTGGGAGTTTGTGCGGCACTCTCGCTGGCTGGCGCCGCCG
TGGGCTTACGGTTGAAGGGGCGTGGGCAACGCGCCGCCGCGTCGAACGCCAACGTCCACGGGGCAAAGTCATGA

Upstream 100 bases:

>100_bases
CAGAAAAAATATTTCCGCATCGTTTGTGGCAGTCGCCTCGTCTTTGGCAGTGGAAGCGGTGGCGTTCGGCCTGCCGCCAC
AACCAAAAAGGAAGATACCT

Downstream 100 bases:

>100_bases
AAACGGTGGTCGTGCGCTACCAGGTCAAGCCCGAGGCGGCTTCGCAGAACGAGGAATTGATCCGCCAGGTATTCGTCCAG
CTCGAACGCGAGCGGCCCGC

Product: EmrB/QacA family drug resistance transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MQGDKQFPGFTPSQRWVLGLAAAGSFMAVLDAMVVTTALDTLRHELSASVAALEWTVNAYSLSFAALLMTGAALGDRFGR
RRMYVLGLLLFALASAACAAAPSTAWLIAGRAVQGMGAALVMPIAMALLGAAFPPPQRARALGIFSGITGLAVLSGPLFG
GAIVQGLAWQWIFWINLPVALAVAWLMLLKVPEGKTLSAPLDLRGAGLMSASLLGLVWGLVHGNRAGWGSAEVLTSLGAG
AVLGAAFVASQRVNTWDAMIPPRLFRSPVLAAGLTVSLLLTASLFGTLFFMAQFFQVTRGLSPLSAGASMLPWTATLFLV
APVAGAMITRIGERALVVAGLGIQAGGMAWLAVLVRADAPYTLWVVPLMIAGAGISMAMPAVQSAVLAEVAPSDMGKAAG
LFNTLRQLGGVIGVALVVAVFTRVGGYGSAQQFSAGFATVLGVCAALSLAGAAVGLRLKGRGQRAAASNANVHGAKS

Sequences:

>Translated_477_residues
MQGDKQFPGFTPSQRWVLGLAAAGSFMAVLDAMVVTTALDTLRHELSASVAALEWTVNAYSLSFAALLMTGAALGDRFGR
RRMYVLGLLLFALASAACAAAPSTAWLIAGRAVQGMGAALVMPIAMALLGAAFPPPQRARALGIFSGITGLAVLSGPLFG
GAIVQGLAWQWIFWINLPVALAVAWLMLLKVPEGKTLSAPLDLRGAGLMSASLLGLVWGLVHGNRAGWGSAEVLTSLGAG
AVLGAAFVASQRVNTWDAMIPPRLFRSPVLAAGLTVSLLLTASLFGTLFFMAQFFQVTRGLSPLSAGASMLPWTATLFLV
APVAGAMITRIGERALVVAGLGIQAGGMAWLAVLVRADAPYTLWVVPLMIAGAGISMAMPAVQSAVLAEVAPSDMGKAAG
LFNTLRQLGGVIGVALVVAVFTRVGGYGSAQQFSAGFATVLGVCAALSLAGAAVGLRLKGRGQRAAASNANVHGAKS
>Mature_477_residues
MQGDKQFPGFTPSQRWVLGLAAAGSFMAVLDAMVVTTALDTLRHELSASVAALEWTVNAYSLSFAALLMTGAALGDRFGR
RRMYVLGLLLFALASAACAAAPSTAWLIAGRAVQGMGAALVMPIAMALLGAAFPPPQRARALGIFSGITGLAVLSGPLFG
GAIVQGLAWQWIFWINLPVALAVAWLMLLKVPEGKTLSAPLDLRGAGLMSASLLGLVWGLVHGNRAGWGSAEVLTSLGAG
AVLGAAFVASQRVNTWDAMIPPRLFRSPVLAAGLTVSLLLTASLFGTLFFMAQFFQVTRGLSPLSAGASMLPWTATLFLV
APVAGAMITRIGERALVVAGLGIQAGGMAWLAVLVRADAPYTLWVVPLMIAGAGISMAMPAVQSAVLAEVAPSDMGKAAG
LFNTLRQLGGVIGVALVVAVFTRVGGYGSAQQFSAGFATVLGVCAALSLAGAAVGLRLKGRGQRAAASNANVHGAKS

Specific function: Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=411, Percent_Identity=29.9270072992701, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1790195, Length=479, Percent_Identity=28.39248434238, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789042, Length=434, Percent_Identity=25.3456221198157, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788710, Length=421, Percent_Identity=25.1781472684086, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788392, Length=410, Percent_Identity=27.0731707317073, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790146, Length=151, Percent_Identity=31.1258278145695, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322958, Length=451, Percent_Identity=24.390243902439, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324954, Length=396, Percent_Identity=24.7474747474747, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319770, Length=393, Percent_Identity=23.6641221374046, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321663, Length=149, Percent_Identity=24.8322147651007, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=260, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48738; Mature: 48738

Theoretical pI: Translated: 11.65; Mature: 11.65

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGDKQFPGFTPSQRWVLGLAAAGSFMAVLDAMVVTTALDTLRHELSASVAALEWTVNAY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHH
SLSFAALLMTGAALGDRFGRRRMYVLGLLLFALASAACAAAPSTAWLIAGRAVQGMGAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCHHH
VMPIAMALLGAAFPPPQRARALGIFSGITGLAVLSGPLFGGAIVQGLAWQWIFWINLPVA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LAVAWLMLLKVPEGKTLSAPLDLRGAGLMSASLLGLVWGLVHGNRAGWGSAEVLTSLGAG
HHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCH
AVLGAAFVASQRVNTWDAMIPPRLFRSPVLAAGLTVSLLLTASLFGTLFFMAQFFQVTRG
HHHHHHHHHHCCCCCHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSPLSAGASMLPWTATLFLVAPVAGAMITRIGERALVVAGLGIQAGGMAWLAVLVRADAP
CCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCC
YTLWVVPLMIAGAGISMAMPAVQSAVLAEVAPSDMGKAAGLFNTLRQLGGVIGVALVVAV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTRVGGYGSAQQFSAGFATVLGVCAALSLAGAAVGLRLKGRGQRAAASNANVHGAKS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQGDKQFPGFTPSQRWVLGLAAAGSFMAVLDAMVVTTALDTLRHELSASVAALEWTVNAY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHH
SLSFAALLMTGAALGDRFGRRRMYVLGLLLFALASAACAAAPSTAWLIAGRAVQGMGAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCHHH
VMPIAMALLGAAFPPPQRARALGIFSGITGLAVLSGPLFGGAIVQGLAWQWIFWINLPVA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LAVAWLMLLKVPEGKTLSAPLDLRGAGLMSASLLGLVWGLVHGNRAGWGSAEVLTSLGAG
HHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCH
AVLGAAFVASQRVNTWDAMIPPRLFRSPVLAAGLTVSLLLTASLFGTLFFMAQFFQVTRG
HHHHHHHHHHCCCCCHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSPLSAGASMLPWTATLFLVAPVAGAMITRIGERALVVAGLGIQAGGMAWLAVLVRADAP
CCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCC
YTLWVVPLMIAGAGISMAMPAVQSAVLAEVAPSDMGKAAGLFNTLRQLGGVIGVALVVAV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTRVGGYGSAQQFSAGFATVLGVCAALSLAGAAVGLRLKGRGQRAAASNANVHGAKS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1592819 [H]