| Definition | Polaromonas sp. JS666 chromosome, complete genome. |
|---|---|
| Accession | NC_007948 |
| Length | 5,200,264 |
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The map label for this gene is lon [H]
Identifier: 91786827
GI number: 91786827
Start: 944780
End: 947158
Strand: Direct
Name: lon [H]
Synonym: Bpro_0925
Alternate gene names: 91786827
Gene position: 944780-947158 (Clockwise)
Preceding gene: 91786825
Following gene: 91786828
Centisome position: 18.17
GC content: 66.96
Gene sequence:
>2379_bases ATGGATGCGCCAGTTCCTGATCAGCCCGCCCTTCCAGACCTTCCAGAAGGGGTGATTGCGCTGGTTCCCATGCGCAATGT CGTGCTGTTTCCGCATGTGCTGGTGCCCATCACCGTCGGGCGCGCCAAATCGGTTGCGGCGGTGCAGCATGCACACCAGA CTGGCGCCGGACTGGGCATCGTGCTGCAGCGGGACGCGGCAATTGACGATCCGGGCCGCGATGCGCTGTATGACGTGGGA ACCATCGCCAAGGTGCTGCAGCACGTTGACGCCGATGAGCAGTTGCAGCACGCCGTCTGCCAGGGCGTGGAGCGCTTTCG CATCGAGGCACTGGTCGAGGGCTACCCGTTTCTGGCCGCCCGTGTGCAGCCCATCCCGGAGCCGGCCGTGATTTCCACGC AAGCTGAAGCGCTGGGGCTGCAATTGCGTGACCGCGCAGTGGAAATTCTGGCACTGCTGCCGGGTGCGCCGGCCGAACTG GCCCACACGCTGCAGTCCGTGCGCTCGCCATCGCACCTGGCGGACATCGTCGCGAGCCTGCTGGATGCCGAGCTGGTCGA AAAGCAGATGCTGCTCGAGACGGAGAGCCCGGAAGACCGGCTGCCGAAGGTGTTGCAGATGCTGGAGCACCGCATCGAGG TGCTGCGCCTGTCGCAGGAGATCGGCGAGCGCACCAAGGAACAGATTGACCTTCACCAGCGCAAATATCTGCTGCGTGAG CAACTCAAGGCCATCCAGAAAGAGCTCGGTGAGAGCGGGGACGACGACGAGGATATCGTGCGCCTCGAAGAGCTCATTGC GAAAGCCGGCATGCCGGACGATGTGCAGGCCCAGGCGCGCAAGGAGCTCGGGCGCCTGCAACGCATGCCGGATGCGTCCG GCGAGTATTCGATGCTGCGCACCTACCTGGAATGGATGACCGAGCTGCCGTGGGCGGCCCCGCCGGCCAATCCGATCGAT CTGGGCGAGGCGCGCCGGATCCTCGAAGCCGACCACTACGGGCTGGACCGCATCAAGCAGCGCATTGTCGAGTTTCTGGC GGTGCAAAAGCTCAACCCGCAGGGGCGCGCGCCCATCCTGTGTTTCGTCGGGCCACCCGGTGTGGGCAAGACCTCGCTCG GCCAGAGCATTGCGCGCGCGCTGGGGCGGCCGTTCGTGCGGATGTCGCTGGGTGGCGTGCATGACGAAGCCGAGATCCGC GGCCACCGCCGCACCTACATCGGCGCCATGCCGGGCATCATTGTGCAGAGCCTGCGCAAGGCCGGCGCACGCCATTGCGT GATGATGCTGGACGAGGTTGACAAGCTGTCGCCCAGTGCCCAGGGCGACCCGTCGGCCGCGCTGCTCGAGGTGCTGGACC CGGAGCAGAACGCCACCTTCCGCGACAACTACCTGGGGCTTCCTTTCGATCTGAGCCGTGTGGTCTTCATCGCCACGGCG AACGTGATTGACCAGGTGCCCGCGCCGATGCGTGACCGCATGGAGGTGATCGACCTGCCGGGCTACACGCAGGAAGAAAA GCTGCAGATTGCGCAGCGTTACCTGGTGCAGCGCCAGCGCGAGGCCAACGGCCTGCGCGGCGACCAGTGCGAACTGACAC CGGCTGCGCTGCAGGCGATTGTGGCCGACTACACGCGTGAGGCCGGGGTGCGCCAGCTCGAGCGCGAGATCGGGCGCGTC ATGCGCCATGCCGCAGTGCAGATCGCCGATGGTTCCACGCCGCAGGTGCGCGTCGATGCGGCCGACCTGGATGCGCTCCT CGGCGCCACGAAGTTCGAACACGAAACCGCGTTGCGCAGCAGCGTGCCGGGTGTGGCCACCGGGCTGGCGTGGACGCCGG CCGGCGGGGACATCCTGTTCATCGAGGCAACCCGCGTGGCCGGCTCGGGCCGCCTGATCCTGACCGGTCAGCTGGGCGAT GTGATGAAGGAAAGCGCCCAGGCCGCCCTGACGCTGGTGAAGTCCTGTGCCACTGCGCTGCACCTGTCGGCCAACGCCTT CGATGACATCGACGTGCACGTGCATGTGCCGGCCGGGGCGATTCCCAAGGACGGACCCAGCGCAGGGGTGGCGATGTTCA TCGCCCTGGCCTCCCTGTTCGCCAACCGTGTGGTGCGCCACGATGTGGCCATGACCGGCGAAATCAGCCTGCGCGGCCTG GTGCTGCCGGTGGGCGGCGTCAAGGAAAAAGTGCTGGCCGCGCAGCGTGCCGGCGTGCACACCGTGCTGCTGCCGCAGCG CAACGAGAAGGACCTGCGCGACGTGCCCGAGGCCAGCCGCCAGAACCTGACCTTCGTCTGGCTGAACAATGTGGATGACG CCATCCGCGTGGCACTGGGCGACGCCGCCACCCGAGGCGCCGGGTTCGAGCTGGTGTGA
Upstream 100 bases:
>100_bases CGGGGTTTGCCATGCCGCGTACACGCTTGGTACACAAGCGGCCGTCCGCGGTACTTGCCGCGGGGGCTTCCCGCTCAGCC AGTTCATCGGGTGACATGCC
Downstream 100 bases:
>100_bases GGGCGGCACCATGCCCTGGACCGCGCAGCGCTATCCGGTGTCGATGCGCAATCTCCCGGAGCCGGTACGCGTCAAGGCGA TCGAAATTGCCAATGCGCTG
Product: ATP-dependent protease La
Products: NA
Alternate protein names: ATP-dependent protease La [H]
Number of amino acids: Translated: 792; Mature: 792
Protein sequence:
>792_residues MDAPVPDQPALPDLPEGVIALVPMRNVVLFPHVLVPITVGRAKSVAAVQHAHQTGAGLGIVLQRDAAIDDPGRDALYDVG TIAKVLQHVDADEQLQHAVCQGVERFRIEALVEGYPFLAARVQPIPEPAVISTQAEALGLQLRDRAVEILALLPGAPAEL AHTLQSVRSPSHLADIVASLLDAELVEKQMLLETESPEDRLPKVLQMLEHRIEVLRLSQEIGERTKEQIDLHQRKYLLRE QLKAIQKELGESGDDDEDIVRLEELIAKAGMPDDVQAQARKELGRLQRMPDASGEYSMLRTYLEWMTELPWAAPPANPID LGEARRILEADHYGLDRIKQRIVEFLAVQKLNPQGRAPILCFVGPPGVGKTSLGQSIARALGRPFVRMSLGGVHDEAEIR GHRRTYIGAMPGIIVQSLRKAGARHCVMMLDEVDKLSPSAQGDPSAALLEVLDPEQNATFRDNYLGLPFDLSRVVFIATA NVIDQVPAPMRDRMEVIDLPGYTQEEKLQIAQRYLVQRQREANGLRGDQCELTPAALQAIVADYTREAGVRQLEREIGRV MRHAAVQIADGSTPQVRVDAADLDALLGATKFEHETALRSSVPGVATGLAWTPAGGDILFIEATRVAGSGRLILTGQLGD VMKESAQAALTLVKSCATALHLSANAFDDIDVHVHVPAGAIPKDGPSAGVAMFIALASLFANRVVRHDVAMTGEISLRGL VLPVGGVKEKVLAAQRAGVHTVLLPQRNEKDLRDVPEASRQNLTFVWLNNVDDAIRVALGDAATRGAGFELV
Sequences:
>Translated_792_residues MDAPVPDQPALPDLPEGVIALVPMRNVVLFPHVLVPITVGRAKSVAAVQHAHQTGAGLGIVLQRDAAIDDPGRDALYDVG TIAKVLQHVDADEQLQHAVCQGVERFRIEALVEGYPFLAARVQPIPEPAVISTQAEALGLQLRDRAVEILALLPGAPAEL AHTLQSVRSPSHLADIVASLLDAELVEKQMLLETESPEDRLPKVLQMLEHRIEVLRLSQEIGERTKEQIDLHQRKYLLRE QLKAIQKELGESGDDDEDIVRLEELIAKAGMPDDVQAQARKELGRLQRMPDASGEYSMLRTYLEWMTELPWAAPPANPID LGEARRILEADHYGLDRIKQRIVEFLAVQKLNPQGRAPILCFVGPPGVGKTSLGQSIARALGRPFVRMSLGGVHDEAEIR GHRRTYIGAMPGIIVQSLRKAGARHCVMMLDEVDKLSPSAQGDPSAALLEVLDPEQNATFRDNYLGLPFDLSRVVFIATA NVIDQVPAPMRDRMEVIDLPGYTQEEKLQIAQRYLVQRQREANGLRGDQCELTPAALQAIVADYTREAGVRQLEREIGRV MRHAAVQIADGSTPQVRVDAADLDALLGATKFEHETALRSSVPGVATGLAWTPAGGDILFIEATRVAGSGRLILTGQLGD VMKESAQAALTLVKSCATALHLSANAFDDIDVHVHVPAGAIPKDGPSAGVAMFIALASLFANRVVRHDVAMTGEISLRGL VLPVGGVKEKVLAAQRAGVHTVLLPQRNEKDLRDVPEASRQNLTFVWLNNVDDAIRVALGDAATRGAGFELV >Mature_792_residues MDAPVPDQPALPDLPEGVIALVPMRNVVLFPHVLVPITVGRAKSVAAVQHAHQTGAGLGIVLQRDAAIDDPGRDALYDVG TIAKVLQHVDADEQLQHAVCQGVERFRIEALVEGYPFLAARVQPIPEPAVISTQAEALGLQLRDRAVEILALLPGAPAEL AHTLQSVRSPSHLADIVASLLDAELVEKQMLLETESPEDRLPKVLQMLEHRIEVLRLSQEIGERTKEQIDLHQRKYLLRE QLKAIQKELGESGDDDEDIVRLEELIAKAGMPDDVQAQARKELGRLQRMPDASGEYSMLRTYLEWMTELPWAAPPANPID LGEARRILEADHYGLDRIKQRIVEFLAVQKLNPQGRAPILCFVGPPGVGKTSLGQSIARALGRPFVRMSLGGVHDEAEIR GHRRTYIGAMPGIIVQSLRKAGARHCVMMLDEVDKLSPSAQGDPSAALLEVLDPEQNATFRDNYLGLPFDLSRVVFIATA NVIDQVPAPMRDRMEVIDLPGYTQEEKLQIAQRYLVQRQREANGLRGDQCELTPAALQAIVADYTREAGVRQLEREIGRV MRHAAVQIADGSTPQVRVDAADLDALLGATKFEHETALRSSVPGVATGLAWTPAGGDILFIEATRVAGSGRLILTGQLGD VMKESAQAALTLVKSCATALHLSANAFDDIDVHVHVPAGAIPKDGPSAGVAMFIALASLFANRVVRHDVAMTGEISLRGL VLPVGGVKEKVLAAQRAGVHTVLLPQRNEKDLRDVPEASRQNLTFVWLNNVDDAIRVALGDAATRGAGFELV
Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced
COG id: COG0466
COG function: function code O; ATP-dependent Lon protease, bacterial type
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Lon domain [H]
Homologues:
Organism=Homo sapiens, GI31377667, Length=824, Percent_Identity=41.2621359223301, Blast_Score=580, Evalue=1e-165, Organism=Homo sapiens, GI21396489, Length=846, Percent_Identity=38.5342789598109, Blast_Score=531, Evalue=1e-150, Organism=Escherichia coli, GI1786643, Length=762, Percent_Identity=44.3569553805774, Blast_Score=655, Evalue=0.0, Organism=Caenorhabditis elegans, GI17505831, Length=697, Percent_Identity=39.454806312769, Blast_Score=488, Evalue=1e-138, Organism=Caenorhabditis elegans, GI17556486, Length=530, Percent_Identity=43.2075471698113, Blast_Score=449, Evalue=1e-126, Organism=Saccharomyces cerevisiae, GI6319449, Length=672, Percent_Identity=37.9464285714286, Blast_Score=466, Evalue=1e-132, Organism=Drosophila melanogaster, GI24666867, Length=687, Percent_Identity=41.7758369723435, Blast_Score=526, Evalue=1e-149, Organism=Drosophila melanogaster, GI221513036, Length=687, Percent_Identity=41.7758369723435, Blast_Score=526, Evalue=1e-149,
Paralogues:
None
Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR008269 - InterPro: IPR004815 - InterPro: IPR003111 - InterPro: IPR008268 - InterPro: IPR001984 - InterPro: IPR015947 - InterPro: IPR020568 [H]
Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]
EC number: =3.4.21.53 [H]
Molecular weight: Translated: 86029; Mature: 86029
Theoretical pI: Translated: 5.30; Mature: 5.30
Prosite motif: PS01046 LON_SER
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDAPVPDQPALPDLPEGVIALVPMRNVVLFPHVLVPITVGRAKSVAAVQHAHQTGAGLGI CCCCCCCCCCCCCCCCCCEEEECCCCHHHHCHHHEEEECCCCHHHHHHHHHHHCCCCEEE VLQRDAAIDDPGRDALYDVGTIAKVLQHVDADEQLQHAVCQGVERFRIEALVEGYPFLAA EEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH RVQPIPEPAVISTQAEALGLQLRDRAVEILALLPGAPAELAHTLQSVRSPSHLADIVASL HCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHH LDAELVEKQMLLETESPEDRLPKVLQMLEHRIEVLRLSQEIGERTKEQIDLHQRKYLLRE HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH QLKAIQKELGESGDDDEDIVRLEELIAKAGMPDDVQAQARKELGRLQRMPDASGEYSMLR HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH TYLEWMTELPWAAPPANPIDLGEARRILEADHYGLDRIKQRIVEFLAVQKLNPQGRAPIL HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEE CFVGPPGVGKTSLGQSIARALGRPFVRMSLGGVHDEAEIRGHRRTYIGAMPGIIVQSLRK EEECCCCCCHHHHHHHHHHHHCCCEEEHHCCCCCCHHHHCCCHHHHHHCCHHHHHHHHHH AGARHCVMMLDEVDKLSPSAQGDPSAALLEVLDPEQNATFRDNYLGLPFDLSRVVFIATA HCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH NVIDQVPAPMRDRMEVIDLPGYTQEEKLQIAQRYLVQRQREANGLRGDQCELTPAALQAI HHHHHCCCCHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH VADYTREAGVRQLEREIGRVMRHAAVQIADGSTPQVRVDAADLDALLGATKFEHETALRS HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEHHHHHHHHCCHHHHHHHHHHH SVPGVATGLAWTPAGGDILFIEATRVAGSGRLILTGQLGDVMKESAQAALTLVKSCATAL CCCCHHHCCEECCCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH HLSANAFDDIDVHVHVPAGAIPKDGPSAGVAMFIALASLFANRVVRHDVAMTGEISLRGL HCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEE VLPVGGVKEKVLAAQRAGVHTVLLPQRNEKDLRDVPEASRQNLTFVWLNNVDDAIRVALG EEECCCHHHHHHHHHHCCCEEEECCCCCCCHHHHCCHHHHCCEEEEEECCCCHHHHHHHC DAATRGAGFELV CHHCCCCCCCCC >Mature Secondary Structure MDAPVPDQPALPDLPEGVIALVPMRNVVLFPHVLVPITVGRAKSVAAVQHAHQTGAGLGI CCCCCCCCCCCCCCCCCCEEEECCCCHHHHCHHHEEEECCCCHHHHHHHHHHHCCCCEEE VLQRDAAIDDPGRDALYDVGTIAKVLQHVDADEQLQHAVCQGVERFRIEALVEGYPFLAA EEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH RVQPIPEPAVISTQAEALGLQLRDRAVEILALLPGAPAELAHTLQSVRSPSHLADIVASL HCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHH LDAELVEKQMLLETESPEDRLPKVLQMLEHRIEVLRLSQEIGERTKEQIDLHQRKYLLRE HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH QLKAIQKELGESGDDDEDIVRLEELIAKAGMPDDVQAQARKELGRLQRMPDASGEYSMLR HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH TYLEWMTELPWAAPPANPIDLGEARRILEADHYGLDRIKQRIVEFLAVQKLNPQGRAPIL HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEE CFVGPPGVGKTSLGQSIARALGRPFVRMSLGGVHDEAEIRGHRRTYIGAMPGIIVQSLRK EEECCCCCCHHHHHHHHHHHHCCCEEEHHCCCCCCHHHHCCCHHHHHHCCHHHHHHHHHH AGARHCVMMLDEVDKLSPSAQGDPSAALLEVLDPEQNATFRDNYLGLPFDLSRVVFIATA HCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH NVIDQVPAPMRDRMEVIDLPGYTQEEKLQIAQRYLVQRQREANGLRGDQCELTPAALQAI HHHHHCCCCHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH VADYTREAGVRQLEREIGRVMRHAAVQIADGSTPQVRVDAADLDALLGATKFEHETALRS HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEHHHHHHHHCCHHHHHHHHHHH SVPGVATGLAWTPAGGDILFIEATRVAGSGRLILTGQLGDVMKESAQAALTLVKSCATAL CCCCHHHCCEECCCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH HLSANAFDDIDVHVHVPAGAIPKDGPSAGVAMFIALASLFANRVVRHDVAMTGEISLRGL HCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEE VLPVGGVKEKVLAAQRAGVHTVLLPQRNEKDLRDVPEASRQNLTFVWLNNVDDAIRVALG EEECCCHHHHHHHHHHCCCEEEECCCCCCCHHHHCCHHHHCCEEEEEECCCCHHHHHHHC DAATRGAGFELV CHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA