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The map label for this gene is folE [H]

Identifier: 91786771

GI number: 91786771

Start: 893062

End: 893784

Strand: Direct

Name: folE [H]

Synonym: Bpro_0869

Alternate gene names: 91786771

Gene position: 893062-893784 (Clockwise)

Preceding gene: 91786770

Following gene: 91786772

Centisome position: 17.17

GC content: 58.92

Gene sequence:

>723_bases
ATGCTTATGAAATCCACCACGCACCCCCAGGGGTCCACCGACGAGGGAACGCCCGTATCCGTGAAGATCCGCGAGCGCCT
GCATCAGGCACGCAAGCGTTTTCATGCGAACGACAACATTGCCGCGTTCATTGAACCGGGCGAGCTCGAAAAGCTGCTTG
ACGAAGTTGAAGTCAAGATGCAGACCGTGCTCGACAGCCTGGTGATCGATACCGCCGGCGATCACAACACCAACAACACC
GCGCGCCGCGTCGCCAAGATGTATCTGAACGAGGTGTTCAAGGGCCGTTATGTGCAGCCGCCCACCATCACCGAATTCCC
CAATGCCGAACACCTCAACGAATTGATGATCGTCGGGCCGATCACCGTGCGCAGCGCCTGCTCGCACCACTTCTGCCCGG
TCATCGGCAAGATCTGGATCGGGGTGATGCCCAATGAACACACCAATGTGATCGGCCTGTCCAAATACGCGCGGCTGGCC
GAGTGGGTGATGGGGCGCCCGCAGATCCAGGAAGAGGCCGTGGTGCAGCTGGCCGATCTCATCATGGAGAAAACACAGCC
GGATGGCCTGGCCATCGTGATGGAAGCCAGCCACTACTGCATGGCCTGGCGCGGTGTCAAGGACATGGACAGCAAGATGA
TCAATTCGGTGATGCGCGGCGTATTCCTGAAGGACCCCAACCTGCGCCGTGAATTCCTTGCCCTGATTCCACAGAAAGGA
TGA

Upstream 100 bases:

>100_bases
AAATATATAGCTTCATGCGCTTGTGTCCTGTGGGCTGGGAGCTTAAAACCTTGTAAATTTCGGGACAAGACTGTTTCAGG
ACGGGCTGGTAATATCAGGC

Downstream 100 bases:

>100_bases
TCCCATGTTAGTCCGTTTGCTTTATGCCAGTCGCGCGCTGGACACCCGTCCCGATGCGATTGAGGCCATTCTGACCCAGT
CGCGCCAGTACAACCCGACC

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MLMKSTTHPQGSTDEGTPVSVKIRERLHQARKRFHANDNIAAFIEPGELEKLLDEVEVKMQTVLDSLVIDTAGDHNTNNT
ARRVAKMYLNEVFKGRYVQPPTITEFPNAEHLNELMIVGPITVRSACSHHFCPVIGKIWIGVMPNEHTNVIGLSKYARLA
EWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHYCMAWRGVKDMDSKMINSVMRGVFLKDPNLRREFLALIPQKG

Sequences:

>Translated_240_residues
MLMKSTTHPQGSTDEGTPVSVKIRERLHQARKRFHANDNIAAFIEPGELEKLLDEVEVKMQTVLDSLVIDTAGDHNTNNT
ARRVAKMYLNEVFKGRYVQPPTITEFPNAEHLNELMIVGPITVRSACSHHFCPVIGKIWIGVMPNEHTNVIGLSKYARLA
EWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHYCMAWRGVKDMDSKMINSVMRGVFLKDPNLRREFLALIPQKG
>Mature_240_residues
MLMKSTTHPQGSTDEGTPVSVKIRERLHQARKRFHANDNIAAFIEPGELEKLLDEVEVKMQTVLDSLVIDTAGDHNTNNT
ARRVAKMYLNEVFKGRYVQPPTITEFPNAEHLNELMIVGPITVRSACSHHFCPVIGKIWIGVMPNEHTNVIGLSKYARLA
EWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHYCMAWRGVKDMDSKMINSVMRGVFLKDPNLRREFLALIPQKG

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=127, Percent_Identity=46.4566929133858, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI4503949, Length=127, Percent_Identity=46.4566929133858, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI66932970, Length=102, Percent_Identity=38.2352941176471, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI66932972, Length=88, Percent_Identity=42.0454545454545, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788476, Length=175, Percent_Identity=34.2857142857143, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=130, Percent_Identity=43.8461538461538, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321706, Length=130, Percent_Identity=43.0769230769231, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24656782, Length=130, Percent_Identity=41.5384615384615, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24656796, Length=130, Percent_Identity=41.5384615384615, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24656791, Length=130, Percent_Identity=41.5384615384615, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 27100; Mature: 27100

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMKSTTHPQGSTDEGTPVSVKIRERLHQARKRFHANDNIAAFIEPGELEKLLDEVEVKM
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
QTVLDSLVIDTAGDHNTNNTARRVAKMYLNEVFKGRYVQPPTITEFPNAEHLNELMIVGP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCEEEECC
ITVRSACSHHFCPVIGKIWIGVMPNEHTNVIGLSKYARLAEWVMGRPQIQEEAVVQLADL
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IMEKTQPDGLAIVMEASHYCMAWRGVKDMDSKMINSVMRGVFLKDPNLRREFLALIPQKG
HHHCCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MLMKSTTHPQGSTDEGTPVSVKIRERLHQARKRFHANDNIAAFIEPGELEKLLDEVEVKM
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
QTVLDSLVIDTAGDHNTNNTARRVAKMYLNEVFKGRYVQPPTITEFPNAEHLNELMIVGP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCEEEECC
ITVRSACSHHFCPVIGKIWIGVMPNEHTNVIGLSKYARLAEWVMGRPQIQEEAVVQLADL
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IMEKTQPDGLAIVMEASHYCMAWRGVKDMDSKMINSVMRGVFLKDPNLRREFLALIPQKG
HHHCCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA