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The map label for this gene is ntpA [H]

Identifier: 91786769

GI number: 91786769

Start: 891021

End: 891467

Strand: Direct

Name: ntpA [H]

Synonym: Bpro_0867

Alternate gene names: 91786769

Gene position: 891021-891467 (Clockwise)

Preceding gene: 91786768

Following gene: 91786770

Centisome position: 17.13

GC content: 63.09

Gene sequence:

>447_bases
ATGAAGCGCTTCAAGATTCCCGAGTCGGTGCTGGTCGTCATCCATACGCCGCAGCTCGATGTGCTGTTGCTGGAGCGAGC
CGACCATCCGGGCTTCTGGCAGAGCGTCACCGGCTCCAAAGACACGGTGGACGAACCGCTTTTGCAGACGGCGCTGCGCG
AGGTGAGGGAAGAAACCGGCATCGTCGCCGCACCCGCGCAATTTCGCGACTGGGCGCTCTCCAACAGTTACGAGATTTAC
CCGGCCTGGCGCCACCGTTACGCGCCAGGGGTGACGCACAATACCGAGCATGTGTTCGGCTTGTGCGTGCCCGAGACCTG
CGCTGTGACCCTCCATCCGCGCGAGCACACAGCCTGGCAGTGGTTGCCGTACCGGGCCGCCGCCGATCTCTGTTTTTCAC
CCTCAAACGCCGAAGCGCTCCTGTTCCTGCCACGCTTCATGGCTTGA

Upstream 100 bases:

>100_bases
CTGCGGCCCGGCTGAGCCGGTTCCGCGGCCCCTGCTTGAAGGGGGTGCCGTCACCACGCTTGCTCGTTGCGCCTCGGGGG
CCGTCGGTGTTTGAGGAGCC

Downstream 100 bases:

>100_bases
CGCGGACCCGGCCGCGCGGTTGGTCTTGTCGTTCTACTTCACGCCGGGGCCGGTGCGCTGCCCGCATCTGGGTCGCAGCC
GATTGGCAAATGCAGGGCAG

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKRFKIPESVLVVIHTPQLDVLLLERADHPGFWQSVTGSKDTVDEPLLQTALREVREETGIVAAPAQFRDWALSNSYEIY
PAWRHRYAPGVTHNTEHVFGLCVPETCAVTLHPREHTAWQWLPYRAAADLCFSPSNAEALLFLPRFMA

Sequences:

>Translated_148_residues
MKRFKIPESVLVVIHTPQLDVLLLERADHPGFWQSVTGSKDTVDEPLLQTALREVREETGIVAAPAQFRDWALSNSYEIY
PAWRHRYAPGVTHNTEHVFGLCVPETCAVTLHPREHTAWQWLPYRAAADLCFSPSNAEALLFLPRFMA
>Mature_148_residues
MKRFKIPESVLVVIHTPQLDVLLLERADHPGFWQSVTGSKDTVDEPLLQTALREVREETGIVAAPAQFRDWALSNSYEIY
PAWRHRYAPGVTHNTEHVFGLCVPETCAVTLHPREHTAWQWLPYRAAADLCFSPSNAEALLFLPRFMA

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=142, Percent_Identity=45.0704225352113, Blast_Score=96, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 16865; Mature: 16865

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFKIPESVLVVIHTPQLDVLLLERADHPGFWQSVTGSKDTVDEPLLQTALREVREETG
CCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
IVAAPAQFRDWALSNSYEIYPAWRHRYAPGVTHNTEHVFGLCVPETCAVTLHPREHTAWQ
EEECCHHHHCEECCCCEEEEECHHHCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCEE
WLPYRAAADLCFSPSNAEALLFLPRFMA
EECCHHHHHEEECCCCCCEEEECCCCCC
>Mature Secondary Structure
MKRFKIPESVLVVIHTPQLDVLLLERADHPGFWQSVTGSKDTVDEPLLQTALREVREETG
CCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
IVAAPAQFRDWALSNSYEIYPAWRHRYAPGVTHNTEHVFGLCVPETCAVTLHPREHTAWQ
EEECCHHHHCEECCCCEEEEECHHHCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCEE
WLPYRAAADLCFSPSNAEALLFLPRFMA
EECCHHHHHEEECCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]