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The map label for this gene is sbm [H]

Identifier: 91212296

GI number: 91212296

Start: 3238494

End: 3239549

Strand: Direct

Name: sbm [H]

Synonym: UTI89_C3303

Alternate gene names: 91212296

Gene position: 3238494-3239549 (Clockwise)

Preceding gene: 162138380

Following gene: 91212304

Centisome position: 63.93

GC content: 52.75

Gene sequence:

>1056_bases
ATGTCTAACGTGCAGGAGTGGCAACAGCTTGCCAACAAGGAATTGAGCCGTCGGGAGAAAACTGTCGACTCGCTGGTTCA
GCAAACCGCGGAAGGGATCGCCATCAAGCCGCTGTATACCGAAGCCGATCTCGATAATCTGGAGGTGACGGGTACCCTTC
CTGGTTTGCCACCCTACGTTCGTGGCCCGCGTGCCACTATGTATACCGCCCAACCGTGGACCATCCGTCAGTATGCTGGT
TTCTCGACAGCAAAAGAGTCCAACGCTTTTTATCGCCGTAACCTGGCCGCCCACCGAGGCTACGACTCCGATAACCCACG
CGTGGCGGGCGACGTCGGCAAAGCGGGCGTCGCTATCGACACCGGGGAAGATATGAAAGTCCTGTTCGACCAGATCCCGC
TGGATAAAATGTCGGTTTCGATGACCATGAATGGCGCAGTGCTACCAGTACTGGCGTTTTATATCGTCGCCGCAGAAGAG
CAAGGTGTTACATCCGATAAACTGACCGGCACCATTCAGAACGATATCCTCAAAGAGTACCTCTGCCGCAATACCTATAT
TTACCCGCCAAAACCGTCAATGCGTATTATCGCAGACATCATCGCCTGGTGTTCCGGCAACATGCCGCGATTTAATACCA
TCAGTATCAGCAGTTACCACATGGGTGAAGCGGGTGCCAACTGCGTGCAGCAGGTAGCATTTACGCTCGCCGATAGGATT
GAGTACATCAAAGCAGCAATCTCCGCCGGGCTGAAAATTGATGGCTTCGTCCCTCGCCTGTCGTTTTTCTTCGGCATTGG
CATGGATCTGTTTATGAACGCCGCCATGTTGCGTGCGGCACGTTATTTATGGAGCGAAGCGGTCAGTGGATTTGGCGCAC
AGGATCCGTATAACAACGTTATCCGCACCACCATTGATCATTGTGCACATCCTATGTGTCGGGATTATCTGCATCGCTAT
CTGGAAAATGCGTCCGGCGGACATATTCACCACGATCTTAGCCACGTCTTCGACTTACACCGTAATTTAATTGCAACCGG
ATCGATGCTGGGTTAA

Upstream 100 bases:

>100_bases
ACGACGTCTGAATGCATTTTTTTGCTGGCGACAAACCCACGTAAAAAGCTCACCGTAAGCGCAAATACCCTCATTTTGAT
TGCGTTTTACGGAGCAAATA

Downstream 100 bases:

>100_bases
TGGTTTGTCCCGTCACGATCTTCAGCAATATGCTGAAGCATCGTGGCGGTATAACGATGATTTCTGATTGAATAAAGATA
TTCCTGCATATACATCGGCC

Product: hypothetical protein

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSNVQEWQQLANKELSRREKTVDSLVQQTAEGIAIKPLYTEADLDNLEVTGTLPGLPPYVRGPRATMYTAQPWTIRQYAG
FSTAKESNAFYRRNLAAHRGYDSDNPRVAGDVGKAGVAIDTGEDMKVLFDQIPLDKMSVSMTMNGAVLPVLAFYIVAAEE
QGVTSDKLTGTIQNDILKEYLCRNTYIYPPKPSMRIIADIIAWCSGNMPRFNTISISSYHMGEAGANCVQQVAFTLADRI
EYIKAAISAGLKIDGFVPRLSFFFGIGMDLFMNAAMLRAARYLWSEAVSGFGAQDPYNNVIRTTIDHCAHPMCRDYLHRY
LENASGGHIHHDLSHVFDLHRNLIATGSMLG

Sequences:

>Translated_351_residues
MSNVQEWQQLANKELSRREKTVDSLVQQTAEGIAIKPLYTEADLDNLEVTGTLPGLPPYVRGPRATMYTAQPWTIRQYAG
FSTAKESNAFYRRNLAAHRGYDSDNPRVAGDVGKAGVAIDTGEDMKVLFDQIPLDKMSVSMTMNGAVLPVLAFYIVAAEE
QGVTSDKLTGTIQNDILKEYLCRNTYIYPPKPSMRIIADIIAWCSGNMPRFNTISISSYHMGEAGANCVQQVAFTLADRI
EYIKAAISAGLKIDGFVPRLSFFFGIGMDLFMNAAMLRAARYLWSEAVSGFGAQDPYNNVIRTTIDHCAHPMCRDYLHRY
LENASGGHIHHDLSHVFDLHRNLIATGSMLG
>Mature_350_residues
SNVQEWQQLANKELSRREKTVDSLVQQTAEGIAIKPLYTEADLDNLEVTGTLPGLPPYVRGPRATMYTAQPWTIRQYAGF
STAKESNAFYRRNLAAHRGYDSDNPRVAGDVGKAGVAIDTGEDMKVLFDQIPLDKMSVSMTMNGAVLPVLAFYIVAAEEQ
GVTSDKLTGTIQNDILKEYLCRNTYIYPPKPSMRIIADIIAWCSGNMPRFNTISISSYHMGEAGANCVQQVAFTLADRIE
YIKAAISAGLKIDGFVPRLSFFFGIGMDLFMNAAMLRAARYLWSEAVSGFGAQDPYNNVIRTTIDHCAHPMCRDYLHRYL
ENASGGHIHHDLSHVFDLHRNLIATGSMLG

Specific function: Unknown

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=339, Percent_Identity=55.4572271386431, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1789284, Length=343, Percent_Identity=86.8804664723032, Blast_Score=601, Evalue=1e-173,
Organism=Escherichia coli, GI1789287, Length=50, Percent_Identity=92, Blast_Score=105, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25144500, Length=341, Percent_Identity=56.0117302052786, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 38946; Mature: 38815

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVQEWQQLANKELSRREKTVDSLVQQTAEGIAIKPLYTEADLDNLEVTGTLPGLPPYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCCCCC
RGPRATMYTAQPWTIRQYAGFSTAKESNAFYRRNLAAHRGYDSDNPRVAGDVGKAGVAID
CCCCCEEEECCCCCHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEE
TGEDMKVLFDQIPLDKMSVSMTMNGAVLPVLAFYIVAAEEQGVTSDKLTGTIQNDILKEY
CCCHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LCRNTYIYPPKPSMRIIADIIAWCSGNMPRFNTISISSYHMGEAGANCVQQVAFTLADRI
HHCCCEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
EYIKAAISAGLKIDGFVPRLSFFFGIGMDLFMNAAMLRAARYLWSEAVSGFGAQDPYNNV
HHHHHHHHCCCEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
IRTTIDHCAHPMCRDYLHRYLENASGGHIHHDLSHVFDLHRNLIATGSMLG
HHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SNVQEWQQLANKELSRREKTVDSLVQQTAEGIAIKPLYTEADLDNLEVTGTLPGLPPYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCCCCC
RGPRATMYTAQPWTIRQYAGFSTAKESNAFYRRNLAAHRGYDSDNPRVAGDVGKAGVAID
CCCCCEEEECCCCCHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEE
TGEDMKVLFDQIPLDKMSVSMTMNGAVLPVLAFYIVAAEEQGVTSDKLTGTIQNDILKEY
CCCHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LCRNTYIYPPKPSMRIIADIIAWCSGNMPRFNTISISSYHMGEAGANCVQQVAFTLADRI
HHCCCEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
EYIKAAISAGLKIDGFVPRLSFFFGIGMDLFMNAAMLRAARYLWSEAVSGFGAQDPYNNV
HHHHHHHHCCCEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
IRTTIDHCAHPMCRDYLHRYLENASGGHIHHDLSHVFDLHRNLIATGSMLG
HHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]