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The map label for this gene is tdk

Identifier: 89885871

GI number: 89885871

Start: 149599

End: 150192

Strand: Reverse

Name: tdk

Synonym: Rfer_4385

Alternate gene names: 89885871

Gene position: 150192-149599 (Counterclockwise)

Preceding gene: 89885874

Following gene: 89885870

Centisome position: 58.34

GC content: 64.31

Gene sequence:

>594_bases
ATGTCACAACTCACTTTCATCTTCGCCGCCATGAACGCGGGCAAGTCCACGCTCTTGCTGCAAGCGGCCCACAACTACGT
CGAACGCGGCATGGCCGTCGAGCTCTACACCGCCGCCCTGGACACGCGCGCCGGCTTGGGCGTCATCCGTTCGCGCCTGG
GCATCGAGCGCGGCGCCAGCACCTTCAACGCCGATACCGTGTTCGATCACCGCATCCTTGAGCGCGACACGGCCTGCTTG
TTAATTGATGAGAGCCAGTTCCTGCGGCCCGTGCAGGTCCGCCAGTTGCACCGCCTGGCCCACACCAGCCAAGTGCCCAT
CCGTTGCTACGGCCTTCGCAGCGACTTTTTAGGGCACCCCTTTGCCGGCAGCGCGGCCCTGCTGACACTCGCCGATGAAT
TCGAGGAAGTGCGCGCGGTCTGCGGCTGCGGAAAAAAAGCCACCATGAACGCCCGGCTTGACGCCACCGGCGCGCGGGTC
AGCGCGGGCGAACAAACCCTCATCGGCGGAAATGAACGCTATATCGCAATGTGCCCGCGCTGCTTCTACCTGGACAGCGC
CGGCGAGCAAGATGCTCAAAGCACGGCGGCCTGA

Upstream 100 bases:

>100_bases
TCAGAGGATGCGGAAAATGAAGCGGGGATATTCAAAACTTGCCAAATGAGCGGTATCCGTTATGCTGAATTGATCACCCT
TAAAAACCATTGCACCACCC

Downstream 100 bases:

>100_bases
AGCCACGACCCGCCTGCGCGCACCCCATTTCACAAAATCACAACCTGACGGAGAAACAACCATGACCTCGCTTGATCCCG
GCCGCCACATGCCCCCCTAT

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MSQLTFIFAAMNAGKSTLLLQAAHNYVERGMAVELYTAALDTRAGLGVIRSRLGIERGASTFNADTVFDHRILERDTACL
LIDESQFLRPVQVRQLHRLAHTSQVPIRCYGLRSDFLGHPFAGSAALLTLADEFEEVRAVCGCGKKATMNARLDATGARV
SAGEQTLIGGNERYIAMCPRCFYLDSAGEQDAQSTAA

Sequences:

>Translated_197_residues
MSQLTFIFAAMNAGKSTLLLQAAHNYVERGMAVELYTAALDTRAGLGVIRSRLGIERGASTFNADTVFDHRILERDTACL
LIDESQFLRPVQVRQLHRLAHTSQVPIRCYGLRSDFLGHPFAGSAALLTLADEFEEVRAVCGCGKKATMNARLDATGARV
SAGEQTLIGGNERYIAMCPRCFYLDSAGEQDAQSTAA
>Mature_196_residues
SQLTFIFAAMNAGKSTLLLQAAHNYVERGMAVELYTAALDTRAGLGVIRSRLGIERGASTFNADTVFDHRILERDTACLL
IDESQFLRPVQVRQLHRLAHTSQVPIRCYGLRSDFLGHPFAGSAALLTLADEFEEVRAVCGCGKKATMNARLDATGARVS
AGEQTLIGGNERYIAMCPRCFYLDSAGEQDAQSTAA

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=186, Percent_Identity=45.1612903225806, Blast_Score=171, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_RHOFD (Q21Q74)

Other databases:

- EMBL:   CP000268
- RefSeq:   YP_516069.1
- ProteinModelPortal:   Q21Q74
- SMR:   Q21Q74
- STRING:   Q21Q74
- GeneID:   3959922
- GenomeReviews:   CP000268_GR
- KEGG:   rfr:Rfer_4385
- NMPDR:   fig|338969.3.peg.73
- eggNOG:   COG1435
- HOGENOM:   HBG522108
- OMA:   FRYGAMN
- PhylomeDB:   Q21Q74
- ProtClustDB:   PRK04296
- BioCyc:   RFER338969:RFER_4385-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 21404; Mature: 21272

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 84-84

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLTFIFAAMNAGKSTLLLQAAHNYVERGMAVELYTAALDTRAGLGVIRSRLGIERGAS
CCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEHHHHCCCHHHHHHHHHHHHHCCC
TFNADTVFDHRILERDTACLLIDESQFLRPVQVRQLHRLAHTSQVPIRCYGLRSDFLGHP
CCCCCHHHHHHHHCCCCEEEEECCHHHCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCC
FAGSAALLTLADEFEEVRAVCGCGKKATMNARLDATGARVSAGEQTLIGGNERYIAMCPR
CCCCHHHHHHHHHHHHHHHHHCCCCCCEECCEECCCCCCCCCCCEEEECCCCEEEEECCE
CFYLDSAGEQDAQSTAA
EEEECCCCCCCHHHCCC
>Mature Secondary Structure 
SQLTFIFAAMNAGKSTLLLQAAHNYVERGMAVELYTAALDTRAGLGVIRSRLGIERGAS
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEHHHHCCCHHHHHHHHHHHHHCCC
TFNADTVFDHRILERDTACLLIDESQFLRPVQVRQLHRLAHTSQVPIRCYGLRSDFLGHP
CCCCCHHHHHHHHCCCCEEEEECCHHHCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCC
FAGSAALLTLADEFEEVRAVCGCGKKATMNARLDATGARVSAGEQTLIGGNERYIAMCPR
CCCCHHHHHHHHHHHHHHHHHCCCCCCEECCEECCCCCCCCCCCEEEECCCCEEEEECCE
CFYLDSAGEQDAQSTAA
EEEECCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA