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The map label for this gene is uvrD [H]

Identifier: 89256929

GI number: 89256929

Start: 1584551

End: 1586773

Strand: Reverse

Name: uvrD [H]

Synonym: FTL_1656

Alternate gene names: 89256929

Gene position: 1586773-1584551 (Counterclockwise)

Preceding gene: 89256930

Following gene: 89256928

Centisome position: 83.69

GC content: 33.47

Gene sequence:

>2223_bases
ATGTCTAATTATGACTTTACCTTAGGATTAAATCCAGAGCAGCAAAAAGCTACATTACTAGAGGATCGTAATGCTTTGAT
TCTCGCTGGTGCTGGCAGTGGTAAAACAAAAGTTCTAACATCACGTATAGCTTATCTTTGTCGTGATAAAGGAGTATCTA
TAGAAAATATCCTTGCCGTAACATTCACTAATAAAGCAGCAAAAGAGATTCAGCAGCGTGTAGAAAAGATGCTTGGGATT
TCTACATTTGGAATGTGGATAGGTACTTTTCATGGTATTGCACATAGACTATTGCGTAAGCATGCTCATGAACTTGGCTT
AGATAAGAACTTTAGGATACTTGATCAAGATGAGCAGGCACAACTGGTTAAAAAGGTAATCAATAATCTAGATCTTGATG
ATAAAAAATATCCGCCTAAATTACTGCAGAATTTTATCAATAAACAAAAAGATAAAGCTATCCGTAGTAATAAACTAACA
AAGCAGTATGATGCCAATTATGCGCATATTTATACAGCTTATGAAGAAAGACTTCAGCTTGATAATGCTTTGGATTTTGC
AGATTTGCTTTTACATCTTTATGAGCTTTTTTCTTTTAATCAACAGCTTAGAGAATATTATCAAAACAAATTTAAATATA
TTTTGATTGATGAGTTTCAGGATACTAACCATGTTCAATACATGTGGCTAAAATTACTTATAACTGATAATAACTACATG
ATGGCAGTTGGCGATGATGATCAGTCAATATATGGTTGGCGTGGTGCTGTCGTAGATAATATCCATAATTATGTAAAAGA
TCTCAAAAACGTTGAGATTATAAAACTAGAACAAAACTACCGCTCAACAAAAAATATTCTAAAAGTAGCTAATTCAGTAA
TCAAAAATAATGATAATAGGATGTCAAAGGAGCTGTGGTCAGCAGCTGAAGATGGTGAAAAAGTAGTGCTTTATTGTGCC
GTTAATGAGCGTGATGAGGCAAAATATATTATAGATAAAATTCGCCAGTTGCATAATGATGGAGTTGACTATAGTGATAT
AGCTATCTTATATCGTTCAAACTATCTATCACGTGTTTTAGAGGAAAGTTGTATTTATGCAAGTATTCCATATCGAATTT
ATGGCGGTTTTAGGTTCTTTGATAGAGCAGAGATTAAAGATGCTTTAGCATACTTAAGATTAGCTGTTACAAATAGTGAT
AATTTAGCATTTGAACGAATTATTAACACACCAACACGAGGAATTGGTAATAAGACATTAGAGACAATTAGAAATTATGC
GCAAATTAATTCATTATCATATTGGCAAGCTACTTTAGATGTTATTCAAAAAGAGCTTGTAACTAAAAGAACGGCAAGTT
TACTTTTAAAGTTTATCGAATTAATTAGTGGTATTTCGGCACAAATAAATCAGCATAGCTTAGATAAGCTCTTAGAATCG
GTAATAAATCAAAGTGGTCTTTTAGCATCATATCAAGAAAAAAATAGTGAAAAGGATCGCCAAAAGATTGATAACTTAAA
AGAGTTGATAAGTGCAGCTAAAGATTTTGAACCACAGATAGAGTTACTTGATGATAATACTGACATACTACAAGATTTCT
TGTCATTTGCTGTTCTAGAAGCTGGTGAAATGCAAGCTGATGAAGCTACAGATAGTGTGCAGTTAATGACTATTCATGCT
TCAAAAGGTTTAGAGTTTCGTTATGTGTTTCTAGTTGCTGCAGAAGAAGGGGTTTTTCCACCAAGCTCAATTGTTAACTC
TGAAGAAGTGTTCGATAATACAAGCTCTAAGAAAATGCAAGAGAAGCTTGCTGAAGAGCGTCGCCTTTTTTATGTAGCAG
TAACAAGAGCTATGAGAGCCTTAACTATAAGTTATGCACAAGTACGCAGTATCTTTGGTCGTAGTAGTTTTCAAGTTAAG
TCACGTTTCGTTACAGAGATAGACTCTCAGCATTTGAGTCAGGGTAAACTAGAGTTTACAGCGGCTAAACCTAAAACTAA
ACAAAAAGCAAATTTTGGGATGTCGCCTTTTGATTTTCTTAAATCAAATAATACTACCAATAGTTTTAAACCTGGTGATA
AAGTATTTCATAAGGTTTTTGGCAAAGGAGTATTTATAAAAGCGCAAGCACAAGGGACAAAAGAGTTTTATACTGTAGAT
TTTGGTATAGATGTTGGTCAGAAAATATTGCTAGCAGATATCGCTAATCTGGTTAAGGTCTGA

Upstream 100 bases:

>100_bases
TAACGATTAATGCTACAAACTAATTTGTGAAACTTAGCACTATCTTAATATTTTTTGTTAAAATACTATTTATCTAAATT
ACATAAAATATAAGTTTCTA

Downstream 100 bases:

>100_bases
AATATATAGCCTTAGCGTGTGTATAATTCATTGAGTTTTAAAAATTAATAGGTTCTGTGCACAAAAAACTTAAATTATAT
TGAAAATAGCTAAACTGCTG

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MSNYDFTLGLNPEQQKATLLEDRNALILAGAGSGKTKVLTSRIAYLCRDKGVSIENILAVTFTNKAAKEIQQRVEKMLGI
STFGMWIGTFHGIAHRLLRKHAHELGLDKNFRILDQDEQAQLVKKVINNLDLDDKKYPPKLLQNFINKQKDKAIRSNKLT
KQYDANYAHIYTAYEERLQLDNALDFADLLLHLYELFSFNQQLREYYQNKFKYILIDEFQDTNHVQYMWLKLLITDNNYM
MAVGDDDQSIYGWRGAVVDNIHNYVKDLKNVEIIKLEQNYRSTKNILKVANSVIKNNDNRMSKELWSAAEDGEKVVLYCA
VNERDEAKYIIDKIRQLHNDGVDYSDIAILYRSNYLSRVLEESCIYASIPYRIYGGFRFFDRAEIKDALAYLRLAVTNSD
NLAFERIINTPTRGIGNKTLETIRNYAQINSLSYWQATLDVIQKELVTKRTASLLLKFIELISGISAQINQHSLDKLLES
VINQSGLLASYQEKNSEKDRQKIDNLKELISAAKDFEPQIELLDDNTDILQDFLSFAVLEAGEMQADEATDSVQLMTIHA
SKGLEFRYVFLVAAEEGVFPPSSIVNSEEVFDNTSSKKMQEKLAEERRLFYVAVTRAMRALTISYAQVRSIFGRSSFQVK
SRFVTEIDSQHLSQGKLEFTAAKPKTKQKANFGMSPFDFLKSNNTTNSFKPGDKVFHKVFGKGVFIKAQAQGTKEFYTVD
FGIDVGQKILLADIANLVKV

Sequences:

>Translated_740_residues
MSNYDFTLGLNPEQQKATLLEDRNALILAGAGSGKTKVLTSRIAYLCRDKGVSIENILAVTFTNKAAKEIQQRVEKMLGI
STFGMWIGTFHGIAHRLLRKHAHELGLDKNFRILDQDEQAQLVKKVINNLDLDDKKYPPKLLQNFINKQKDKAIRSNKLT
KQYDANYAHIYTAYEERLQLDNALDFADLLLHLYELFSFNQQLREYYQNKFKYILIDEFQDTNHVQYMWLKLLITDNNYM
MAVGDDDQSIYGWRGAVVDNIHNYVKDLKNVEIIKLEQNYRSTKNILKVANSVIKNNDNRMSKELWSAAEDGEKVVLYCA
VNERDEAKYIIDKIRQLHNDGVDYSDIAILYRSNYLSRVLEESCIYASIPYRIYGGFRFFDRAEIKDALAYLRLAVTNSD
NLAFERIINTPTRGIGNKTLETIRNYAQINSLSYWQATLDVIQKELVTKRTASLLLKFIELISGISAQINQHSLDKLLES
VINQSGLLASYQEKNSEKDRQKIDNLKELISAAKDFEPQIELLDDNTDILQDFLSFAVLEAGEMQADEATDSVQLMTIHA
SKGLEFRYVFLVAAEEGVFPPSSIVNSEEVFDNTSSKKMQEKLAEERRLFYVAVTRAMRALTISYAQVRSIFGRSSFQVK
SRFVTEIDSQHLSQGKLEFTAAKPKTKQKANFGMSPFDFLKSNNTTNSFKPGDKVFHKVFGKGVFIKAQAQGTKEFYTVD
FGIDVGQKILLADIANLVKV
>Mature_739_residues
SNYDFTLGLNPEQQKATLLEDRNALILAGAGSGKTKVLTSRIAYLCRDKGVSIENILAVTFTNKAAKEIQQRVEKMLGIS
TFGMWIGTFHGIAHRLLRKHAHELGLDKNFRILDQDEQAQLVKKVINNLDLDDKKYPPKLLQNFINKQKDKAIRSNKLTK
QYDANYAHIYTAYEERLQLDNALDFADLLLHLYELFSFNQQLREYYQNKFKYILIDEFQDTNHVQYMWLKLLITDNNYMM
AVGDDDQSIYGWRGAVVDNIHNYVKDLKNVEIIKLEQNYRSTKNILKVANSVIKNNDNRMSKELWSAAEDGEKVVLYCAV
NERDEAKYIIDKIRQLHNDGVDYSDIAILYRSNYLSRVLEESCIYASIPYRIYGGFRFFDRAEIKDALAYLRLAVTNSDN
LAFERIINTPTRGIGNKTLETIRNYAQINSLSYWQATLDVIQKELVTKRTASLLLKFIELISGISAQINQHSLDKLLESV
INQSGLLASYQEKNSEKDRQKIDNLKELISAAKDFEPQIELLDDNTDILQDFLSFAVLEAGEMQADEATDSVQLMTIHAS
KGLEFRYVFLVAAEEGVFPPSSIVNSEEVFDNTSSKKMQEKLAEERRLFYVAVTRAMRALTISYAQVRSIFGRSSFQVKS
RFVTEIDSQHLSQGKLEFTAAKPKTKQKANFGMSPFDFLKSNNTTNSFKPGDKVFHKVFGKGVFIKAQAQGTKEFYTVDF
GIDVGQKILLADIANLVKV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=734, Percent_Identity=43.5967302452316, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=654, Percent_Identity=37.0030581039755, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6322369, Length=750, Percent_Identity=28, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324477, Length=684, Percent_Identity=23.3918128654971, Blast_Score=107, Evalue=8e-24,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 84697; Mature: 84565

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYDFTLGLNPEQQKATLLEDRNALILAGAGSGKTKVLTSRIAYLCRDKGVSIENILAV
CCCCCEEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHEEEE
TFTNKAAKEIQQRVEKMLGISTFGMWIGTFHGIAHRLLRKHAHELGLDKNFRILDQDEQA
EECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHH
QLVKKVINNLDLDDKKYPPKLLQNFINKQKDKAIRSNKLTKQYDANYAHIYTAYEERLQL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEHHHHHHHHH
DNALDFADLLLHLYELFSFNQQLREYYQNKFKYILIDEFQDTNHVQYMWLKLLITDNNYM
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEEEECCCEE
MAVGDDDQSIYGWRGAVVDNIHNYVKDLKNVEIIKLEQNYRSTKNILKVANSVIKNNDNR
EEECCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHH
MSKELWSAAEDGEKVVLYCAVNERDEAKYIIDKIRQLHNDGVDYSDIAILYRSNYLSRVL
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EESCIYASIPYRIYGGFRFFDRAEIKDALAYLRLAVTNSDNLAFERIINTPTRGIGNKTL
HHCCEEEECCCEEECCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCCHHHH
ETIRNYAQINSLSYWQATLDVIQKELVTKRTASLLLKFIELISGISAQINQHSLDKLLES
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VINQSGLLASYQEKNSEKDRQKIDNLKELISAAKDFEPQIELLDDNTDILQDFLSFAVLE
HHCCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHH
AGEMQADEATDSVQLMTIHASKGLEFRYVFLVAAEEGVFPPSSIVNSEEVFDNTSSKKMQ
CCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCCCHHHCCCHHHHCCCHHHHHH
EKLAEERRLFYVAVTRAMRALTISYAQVRSIFGRSSFQVKSRFVTEIDSQHLSQGKLEFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEE
AAKPKTKQKANFGMSPFDFLKSNNTTNSFKPGDKVFHKVFGKGVFIKAQAQGTKEFYTVD
ECCCCCHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEEEE
FGIDVGQKILLADIANLVKV
ECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNYDFTLGLNPEQQKATLLEDRNALILAGAGSGKTKVLTSRIAYLCRDKGVSIENILAV
CCCCEEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHEEEE
TFTNKAAKEIQQRVEKMLGISTFGMWIGTFHGIAHRLLRKHAHELGLDKNFRILDQDEQA
EECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHH
QLVKKVINNLDLDDKKYPPKLLQNFINKQKDKAIRSNKLTKQYDANYAHIYTAYEERLQL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEHHHHHHHHH
DNALDFADLLLHLYELFSFNQQLREYYQNKFKYILIDEFQDTNHVQYMWLKLLITDNNYM
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEEEECCCEE
MAVGDDDQSIYGWRGAVVDNIHNYVKDLKNVEIIKLEQNYRSTKNILKVANSVIKNNDNR
EEECCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHH
MSKELWSAAEDGEKVVLYCAVNERDEAKYIIDKIRQLHNDGVDYSDIAILYRSNYLSRVL
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EESCIYASIPYRIYGGFRFFDRAEIKDALAYLRLAVTNSDNLAFERIINTPTRGIGNKTL
HHCCEEEECCCEEECCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCCHHHH
ETIRNYAQINSLSYWQATLDVIQKELVTKRTASLLLKFIELISGISAQINQHSLDKLLES
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VINQSGLLASYQEKNSEKDRQKIDNLKELISAAKDFEPQIELLDDNTDILQDFLSFAVLE
HHCCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHH
AGEMQADEATDSVQLMTIHASKGLEFRYVFLVAAEEGVFPPSSIVNSEEVFDNTSSKKMQ
CCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCCCHHHCCCHHHHCCCHHHHHH
EKLAEERRLFYVAVTRAMRALTISYAQVRSIFGRSSFQVKSRFVTEIDSQHLSQGKLEFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEE
AAKPKTKQKANFGMSPFDFLKSNNTTNSFKPGDKVFHKVFGKGVFIKAQAQGTKEFYTVD
ECCCCCHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEEEE
FGIDVGQKILLADIANLVKV
ECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]