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The map label for this gene is ftsI [H]

Identifier: 89256823

GI number: 89256823

Start: 1467933

End: 1469627

Strand: Reverse

Name: ftsI [H]

Synonym: FTL_1539

Alternate gene names: 89256823

Gene position: 1469627-1467933 (Counterclockwise)

Preceding gene: 89256824

Following gene: 89256822

Centisome position: 77.51

GC content: 35.22

Gene sequence:

>1695_bases
ATGAGTAGTTATCGACCAAAATTCCGGCACTTTGTTGTAATTATTTTACTGTTGCTAAGTTTTATTGTTTTATTTATAAA
GCTTATTTATATGGAAACTATCCAATATCCTAAGCTTAAGCAAGAAGGCGATAATCGTAGTGATAGAAGTATAGATATAA
AAGCATACAGAGGTGTAATCCTCGATAGAAACGGTAATCCTTTGGCGATAAGTACACCTGTTGATACAATTTGGGTTGAT
CCTTTTTATATTAGCGCGGATAGTCCTGAATTAAATAAAGTCATGGATATTTTAAATCTACCTGAAAAAACTAGAGAAAA
GATAAAAAGTCAAGTTAAGGTTAGAGAAGGAAGAAGTGGTTTTGTCTACATTGAGAGAAAGATTCAACCATATTTATCAC
AAAAAGTTAAAGACCTTGATATTACCGGTATTCATGTGATACGAGAGTTTAAACGCTATTATCCAATGGCTGAGGTAGCT
TCTCATATTGTAGGTTTTACTAATGTTGATGGTAAAGGGCAAGAGGGTTTAGAACTTGAGTTTAATAAGTTTTTAAGTGG
TCAAGATGGTTATTTTGAATATAAAAAAGATCTTCATGGTGGGGTTGCTTCTAAGATTGAGGATAAATATGTTGAGCCTA
AGAATGGTCGTAATCTGCAGATAAGTATTGACTCTAGATTGCAATATATTGCGTATAAATATCTCAAAGAAGGGGTTATT
AGGACTAATTCTGAAGCAGGTTCTGTGATAGTTGAAGATATTCATATTGGTGAGATATTAGCAATGGCAAATTACCCTTC
GTATAATCCTAACAGCATGGCTGATGCCTATCCTGATAGGAGAAGAAATAGAGCTATTACAGATGTCTATGAGTTAGGTT
CGGTAATGAAAACTTTTGCAGCAGCGACAGCTCTAACTTATGGTGATAATGTAACTTCAGATGAGCCTGTAATTGATACT
CACCCTGGATTCTATCGTATCGGTAAAAACACCGTAAGAGATGAACGAGATTATGGTGATATTAATCTAAGACATATCTT
AATGAAGTCTAGTAACGTTGGTGTCTCGAAGATGATTTTAGGTTTGACAGAGCCAAGTATATTAGAGTCTTCATTAAGAA
ATTTTGGTTTTGGTAGTAAGACTGGAATAAAACTACCTGGTGAAAGAGATGGTTATGTTCCAACTAAAGATAAGTGGGGT
GATTTCCAACTAGCGACATTATCTTTTGGTTATGGTATGAATGCTACTGATTTGCAGCTAATAGCTGGTGTATCCGCAAT
TGCTAATAATGGTCAATATATCAAGCCAACTATCCTAAAAAGAAGACCTGGAGAAGAGATTGAAACAAGACCTATCATAT
CTGAGAAGAATTCAAAAGAAATGATAAGTATGATGCAGTCTGTTGTTGAAGACCTGGGAGGAACTGGTTCTAAAGCACAA
ATTCCTCTTTATCATGTTGCTGGCAAAACAGGTACAGCTAGAATGCTTTCTGGTGGAAATTATGGAGCAAAATATTTGGC
AAGTTTCGTTGGTATTGTTCCAGCAACTGATCCTAAACTAGCTATAGTTGTGACAATCAAAGATCCTAAAGGAGATCAAT
ATGGTGGCGGTTCTGTAGCCGCGCCAGTTTTTGCTGATGTTGCATTAAATAGCTTGCAAATACTAGGTGTTAAGCTAGAT
AAGATTGAAAATTAA

Upstream 100 bases:

>100_bases
ACTCCTACAGCTGTGGAGAAGTTTGCTCAAAAAGAAAAAATGACCTTGTCAACACGTAAAACAATAGGCTTTTTGAATGA
GCAAAAAGAGGAGTTAAATA

Downstream 100 bases:

>100_bases
ACTCTTTGTTTTTTTATTGTTATAGTATATAATCATCTATTGGTAAACTGTTCCTTTGTGCGGTTTGCTCAATGTTAATT
TAATCAAGACAAATGGAGTA

Product: penicillin binding protein (peptidoglycan synthetase)

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSSYRPKFRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGVILDRNGNPLAISTPVDTIWVD
PFYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSGFVYIERKIQPYLSQKVKDLDITGIHVIREFKRYYPMAEVA
SHIVGFTNVDGKGQEGLELEFNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVI
RTNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFAAATALTYGDNVTSDEPVIDT
HPGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMILGLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWG
DFQLATLSFGYGMNATDLQLIAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQ
IPLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVAAPVFADVALNSLQILGVKLD
KIEN

Sequences:

>Translated_564_residues
MSSYRPKFRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGVILDRNGNPLAISTPVDTIWVD
PFYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSGFVYIERKIQPYLSQKVKDLDITGIHVIREFKRYYPMAEVA
SHIVGFTNVDGKGQEGLELEFNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVI
RTNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFAAATALTYGDNVTSDEPVIDT
HPGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMILGLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWG
DFQLATLSFGYGMNATDLQLIAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQ
IPLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVAAPVFADVALNSLQILGVKLD
KIEN
>Mature_563_residues
SSYRPKFRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGVILDRNGNPLAISTPVDTIWVDP
FYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSGFVYIERKIQPYLSQKVKDLDITGIHVIREFKRYYPMAEVAS
HIVGFTNVDGKGQEGLELEFNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVIR
TNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFAAATALTYGDNVTSDEPVIDTH
PGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMILGLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWGD
FQLATLSFGYGMNATDLQLIAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQI
PLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVAAPVFADVALNSLQILGVKLDK
IEN

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=567, Percent_Identity=38.2716049382716, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1786854, Length=594, Percent_Identity=24.4107744107744, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 62735; Mature: 62604

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSYRPKFRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEEEEEEE
LDRNGNPLAISTPVDTIWVDPFYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSG
EECCCCEEEEECCCCEEEECCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
FVYIERKIQPYLSQKVKDLDITGIHVIREFKRYYPMAEVASHIVGFTNVDGKGQEGLELE
EEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCEEE
FNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVI
HHHHCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCE
RTNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFA
ECCCCCCCEEEEEECHHHEEEECCCCCCCCCCCHHCCCHHHHCCHHHHHHHHHHHHHHHH
AATALTYGDNVTSDEPVIDTHPGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMIL
HHHHHCCCCCCCCCCCEECCCCCEEECCCCHHCCCCCCCCCEEEEEEEECCCCCHHHHHE
GLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWGDFQLATLSFGYGMNATDLQL
ECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHH
IAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQ
HHHHHHHHCCCCEECCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
IPLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVA
EEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCH
APVFADVALNSLQILGVKLDKIEN
HHHHHHHHHCCEEEEEEEHHCCCC
>Mature Secondary Structure 
SSYRPKFRHFVVIILLLLSFIVLFIKLIYMETIQYPKLKQEGDNRSDRSIDIKAYRGVI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEEEEEEE
LDRNGNPLAISTPVDTIWVDPFYISADSPELNKVMDILNLPEKTREKIKSQVKVREGRSG
EECCCCEEEEECCCCEEEECCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
FVYIERKIQPYLSQKVKDLDITGIHVIREFKRYYPMAEVASHIVGFTNVDGKGQEGLELE
EEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCEEE
FNKFLSGQDGYFEYKKDLHGGVASKIEDKYVEPKNGRNLQISIDSRLQYIAYKYLKEGVI
HHHHCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCE
RTNSEAGSVIVEDIHIGEILAMANYPSYNPNSMADAYPDRRRNRAITDVYELGSVMKTFA
ECCCCCCCEEEEEECHHHEEEECCCCCCCCCCCHHCCCHHHHCCHHHHHHHHHHHHHHHH
AATALTYGDNVTSDEPVIDTHPGFYRIGKNTVRDERDYGDINLRHILMKSSNVGVSKMIL
HHHHHCCCCCCCCCCCEECCCCCEEECCCCHHCCCCCCCCCEEEEEEEECCCCCHHHHHE
GLTEPSILESSLRNFGFGSKTGIKLPGERDGYVPTKDKWGDFQLATLSFGYGMNATDLQL
ECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHH
IAGVSAIANNGQYIKPTILKRRPGEEIETRPIISEKNSKEMISMMQSVVEDLGGTGSKAQ
HHHHHHHHCCCCEECCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
IPLYHVAGKTGTARMLSGGNYGAKYLASFVGIVPATDPKLAIVVTIKDPKGDQYGGGSVA
EEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCH
APVFADVALNSLQILGVKLDKIEN
HHHHHHHHHCCEEEEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]