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The map label for this gene is dctA2 [H]

Identifier: 89256786

GI number: 89256786

Start: 1427426

End: 1428676

Strand: Reverse

Name: dctA2 [H]

Synonym: FTL_1497

Alternate gene names: 89256786

Gene position: 1428676-1427426 (Counterclockwise)

Preceding gene: 89256787

Following gene: 89256783

Centisome position: 75.35

GC content: 33.01

Gene sequence:

>1251_bases
ATGAAAATTTTTCGTCACCTATATGCTCAAGTTTTATTAGGAATATTTATAGGAATATTACTCGGGATTTTTACTCCTAA
CTTTGCAATAGCACTTAAACCTTTTGCAGATGTCTTTGTTAAGCTTATTAAACTTATGATAGCTCCGATTATTTTTCTTA
CCTTAGTTTCTGGTATTGCAGCAATGAATGATCTGAAAACTGTAGGTAAAATAGGTGGAGTGGCATTATTATATTTTTTT
GCAATGACTATTGTAGCTTTAGCAATAGGGATGCTTACAGCAAATATACTTCATCCTGGTTTAGGGCTGAATATTAATCC
TAACTCCTTAGATGCTAGTGCTGCAAAAGCTTACATGGGAGATGTAGAGCATGCTAGTGGAATCAAAGATTTCTTTATGA
GTATTATACCTGATTCGTTTGCAGGTGCTTTCACTGATGGAGATATTTTACAGGTACTTTTCGTATCGATACTATTTGCT
GTTGGATTAGTGATGTATGGTGATTCAGGAAAACCAATACTTGATGGTATTCAAAGTCTATTAAAAGTGTTTTTTAAGAT
AATATATGTAATTATGTACTATTCACCTATAGCGGCATGTACAGCTATTGGCTACACTATTGCAATGTATGGAGCTGGTA
CTTTGATAGGGCTTATAGGCTTATTATTATGTTTTTATATTACTTGTTTGATATTTATAGTAGTTTTTTTAGGAGTTATA
TTAAAGCTGTATTGTGGTATAAATATATTTAAACTACTTGGATATATCAAGACAGAAATACTTATCGTGTTAGGTACTTC
ATCTTCAGAATCAGTTTTGCCAAATTTAATGGAAAAACTAGAAAACCTAGGTTGTGATAAATCAGTTGTAGGTCTAGTGA
TACCAACTGGATATTCATTTAATTTAGATGGTACAGCGATATATTTATCACTAGCTGCGATATTTATAGCACAAGCGTTA
GGTATTGAGCTTACTTTGAGTCAGCAGGTTTTTATGCTGTTAATTATGGTGATTAGTTCAAAAGGGGCAGCTGGAGTTAC
AGGTAGTGGCTTTATCATATTGGCGAGTACTCTTAGTGCTTTAGGTGTTGTTCCTGTTGCGGGTATTGTGATTATCTTAG
GTATAGATAGATTTATGTCAGAAGGGCGCGCTATTACAAATATGATTGGTAATACTATTGGGACGATTATTATATCTAAA
TGGCAGAAGAAATTAGATATTGGTAAATTAAATAGTGAGTTGAGAGGGTAA

Upstream 100 bases:

>100_bases
TCAATCTAATATATTTTCTCTAAATCATATCCAAAGAGTTTACTTAGAATACTAATATAAGCTATAGTTTTATTATGACT
TATAGATTTTAAGGGTCAGT

Downstream 100 bases:

>100_bases
CTTATAGCCTAACAACTCTATCAAAACTTTCCAAAAGCTTAGCATTATGAGTAATAAATATTACAGTCTTATTTTGCATA
AGCTTAGCTAAATTTTCAAA

Product: C4-dicarboxylate transport protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKIFRHLYAQVLLGIFIGILLGIFTPNFAIALKPFADVFVKLIKLMIAPIIFLTLVSGIAAMNDLKTVGKIGGVALLYFF
AMTIVALAIGMLTANILHPGLGLNINPNSLDASAAKAYMGDVEHASGIKDFFMSIIPDSFAGAFTDGDILQVLFVSILFA
VGLVMYGDSGKPILDGIQSLLKVFFKIIYVIMYYSPIAACTAIGYTIAMYGAGTLIGLIGLLLCFYITCLIFIVVFLGVI
LKLYCGINIFKLLGYIKTEILIVLGTSSSESVLPNLMEKLENLGCDKSVVGLVIPTGYSFNLDGTAIYLSLAAIFIAQAL
GIELTLSQQVFMLLIMVISSKGAAGVTGSGFIILASTLSALGVVPVAGIVIILGIDRFMSEGRAITNMIGNTIGTIIISK
WQKKLDIGKLNSELRG

Sequences:

>Translated_416_residues
MKIFRHLYAQVLLGIFIGILLGIFTPNFAIALKPFADVFVKLIKLMIAPIIFLTLVSGIAAMNDLKTVGKIGGVALLYFF
AMTIVALAIGMLTANILHPGLGLNINPNSLDASAAKAYMGDVEHASGIKDFFMSIIPDSFAGAFTDGDILQVLFVSILFA
VGLVMYGDSGKPILDGIQSLLKVFFKIIYVIMYYSPIAACTAIGYTIAMYGAGTLIGLIGLLLCFYITCLIFIVVFLGVI
LKLYCGINIFKLLGYIKTEILIVLGTSSSESVLPNLMEKLENLGCDKSVVGLVIPTGYSFNLDGTAIYLSLAAIFIAQAL
GIELTLSQQVFMLLIMVISSKGAAGVTGSGFIILASTLSALGVVPVAGIVIILGIDRFMSEGRAITNMIGNTIGTIIISK
WQKKLDIGKLNSELRG
>Mature_416_residues
MKIFRHLYAQVLLGIFIGILLGIFTPNFAIALKPFADVFVKLIKLMIAPIIFLTLVSGIAAMNDLKTVGKIGGVALLYFF
AMTIVALAIGMLTANILHPGLGLNINPNSLDASAAKAYMGDVEHASGIKDFFMSIIPDSFAGAFTDGDILQVLFVSILFA
VGLVMYGDSGKPILDGIQSLLKVFFKIIYVIMYYSPIAACTAIGYTIAMYGAGTLIGLIGLLLCFYITCLIFIVVFLGVI
LKLYCGINIFKLLGYIKTEILIVLGTSSSESVLPNLMEKLENLGCDKSVVGLVIPTGYSFNLDGTAIYLSLAAIFIAQAL
GIELTLSQQVFMLLIMVISSKGAAGVTGSGFIILASTLSALGVVPVAGIVIILGIDRFMSEGRAITNMIGNTIGTIIISK
WQKKLDIGKLNSELRG

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=461, Percent_Identity=27.114967462039, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI169790839, Length=420, Percent_Identity=27.8571428571429, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI194239697, Length=475, Percent_Identity=25.0526315789474, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI66773030, Length=458, Percent_Identity=26.2008733624454, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4827012, Length=390, Percent_Identity=27.6923076923077, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI21314632, Length=408, Percent_Identity=26.2254901960784, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI5032093, Length=399, Percent_Identity=25.8145363408521, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=27.807486631016, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223468564, Length=270, Percent_Identity=28.1481481481481, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI223468566, Length=270, Percent_Identity=28.1481481481481, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI301601644, Length=178, Percent_Identity=29.7752808988764, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=53.8647342995169, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1790514, Length=414, Percent_Identity=35.5072463768116, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI1788024, Length=397, Percent_Identity=23.4256926952141, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=384, Percent_Identity=26.8229166666667, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71983099, Length=444, Percent_Identity=24.7747747747748, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=444, Percent_Identity=24.7747747747748, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71996953, Length=445, Percent_Identity=25.6179775280899, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193206505, Length=459, Percent_Identity=22.4400871459695, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI193206654, Length=411, Percent_Identity=23.6009732360097, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=445, Percent_Identity=22.6966292134831, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583025, Length=452, Percent_Identity=24.3362831858407, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17137668, Length=452, Percent_Identity=24.3362831858407, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583023, Length=452, Percent_Identity=24.3362831858407, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281360483, Length=473, Percent_Identity=23.6786469344609, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137666, Length=473, Percent_Identity=23.6786469344609, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360481, Length=473, Percent_Identity=23.6786469344609, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44316; Mature: 44316

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFRHLYAQVLLGIFIGILLGIFTPNFAIALKPFADVFVKLIKLMIAPIIFLTLVSGIA
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNDLKTVGKIGGVALLYFFAMTIVALAIGMLTANILHPGLGLNINPNSLDASAAKAYMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHC
DVEHASGIKDFFMSIIPDSFAGAFTDGDILQVLFVSILFAVGLVMYGDSGKPILDGIQSL
CHHHHCCHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LKVFFKIIYVIMYYSPIAACTAIGYTIAMYGAGTLIGLIGLLLCFYITCLIFIVVFLGVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKLYCGINIFKLLGYIKTEILIVLGTSSSESVLPNLMEKLENLGCDKSVVGLVIPTGYSF
HHHHHCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCEEE
NLDGTAIYLSLAAIFIAQALGIELTLSQQVFMLLIMVISSKGAAGVTGSGFIILASTLSA
CCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LGVVPVAGIVIILGIDRFMSEGRAITNMIGNTIGTIIISKWQKKLDIGKLNSELRG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIFRHLYAQVLLGIFIGILLGIFTPNFAIALKPFADVFVKLIKLMIAPIIFLTLVSGIA
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNDLKTVGKIGGVALLYFFAMTIVALAIGMLTANILHPGLGLNINPNSLDASAAKAYMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHC
DVEHASGIKDFFMSIIPDSFAGAFTDGDILQVLFVSILFAVGLVMYGDSGKPILDGIQSL
CHHHHCCHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LKVFFKIIYVIMYYSPIAACTAIGYTIAMYGAGTLIGLIGLLLCFYITCLIFIVVFLGVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKLYCGINIFKLLGYIKTEILIVLGTSSSESVLPNLMEKLENLGCDKSVVGLVIPTGYSF
HHHHHCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCEEE
NLDGTAIYLSLAAIFIAQALGIELTLSQQVFMLLIMVISSKGAAGVTGSGFIILASTLSA
CCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LGVVPVAGIVIILGIDRFMSEGRAITNMIGNTIGTIIISKWQKKLDIGKLNSELRG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA