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The map label for this gene is sdaB [H]

Identifier: 89256638

GI number: 89256638

Start: 1268658

End: 1270031

Strand: Reverse

Name: sdaB [H]

Synonym: FTL_1334

Alternate gene names: 89256638

Gene position: 1270031-1268658 (Counterclockwise)

Preceding gene: 89256639

Following gene: 89256637

Centisome position: 66.98

GC content: 36.03

Gene sequence:

>1374_bases
ATGGAAAGTACGTTTGAACTTTTTTCTATAGGAGTTGGTCCATCTTCATCTCATACTATAGGTCCGATGAGAGCTGGTTG
TGATTTCATAAACTTGTATAAAGATAAACTGCCTCAAACTAAGAGTGTTAAGATTGATTTGTTTGGCTCTCTTGCGCTAA
CTGGGAAGGGTCATAAAACAGATTACGCTGTTGTTTTGGGTGTGATGGGTTTTTTACCAGAATCAGTGGATATTGAATTA
GCAAAAAAACTCTATGATGAATGTTTAAGGAATAAAAAACTTAATTTAGGTCAAGAGTTTGAAATTGATTTTGATTATGA
TAAGGATTTAGTATTTCATTATAATGAGTTTTTGCCAGAACATGCTAATGGCATGCGTTTTTCATTGTTTAATGGTGAAG
AACTACTTTGTGAAAAAGAGTATTTTTCGATTGGTGGTGGTTTTATTGTCGATAAAAAACAAATTAAAAAAGATACTGTT
CCTACAGAGGTTTCATGTGATAAGCCTTATAAATTTTCAACTATGGCTGAGTTAAGAGAGCTTTGTCAGCGTGATGGTAA
AACTATTGATGAGATAATGTTTGAGAATGAAAAGACAGCTTATGGTGAGCAGCAATCATTAGATAAACTAGCCGAGATAT
GGCATGTGATGGAAACCTCAATTGAAAAAGGTTTAACTTGTGCTGAAGCAACATTACCAGGTGGCCTCAAAGTTAGAAAA
AGAGCTCCAAGTATGATTAGAAAGCTCAAGGAACAAAATATTGTCAATACTGACTTTAATTATCTAAATGCTTTTGCGAT
AGCTGTAAATGAACAAAATGCGTGTGGTGAAAGAGTAGTTACAGCACCAACTAATGGTGCTGCTGGTGTTATTCCAGCTG
TGCTTAAATATTATTTACAGACTCATGAGATTGTTAATCAACAAGAGCTCAAAGAGGTAGTGAATAAATACTTATTAGTA
TGTGCTGCTATTGGTATTTTGTATAAATCAGGAGCATCAATTTCAGCTGCTGAAGTGGGTTGCCAAGGAGAGGTGGGTGT
TGCCTGTTCAATGGCAGCTGCTGGCTATTGTGCGCTACTTGGTGGAGACCTTGATTCTATTGAGTCTGCCGCAGAAATTG
GTATGGAGCATAATCTAGGACTTACGTGTGATCCTATTGGTGGTTTAGTACAAATACCATGTATAGAGCGTAATGCTATG
GGTGCTGTCCAAGCTATAAATGCAGCTAAACTTGCATACCTTGATACAGGTGAGAAGCGCTTTGTTGGTTTAGATTATGT
AATTAAAGTTATGTATGAAACTGGTTTAGACATGTCTAGTAAATATAAAGAAACTTCTTTGGGTGGCTTAGCTACTAATG
TTCCAGTATGTTAG

Upstream 100 bases:

>100_bases
AGCTATATGCCTGATTGGAAAGTTAGGGAAAAAAGGCTAAAATAGAGTATAATTATTCCGGGTATCTATCATCAAATTTT
TAACTTTCTGGAGGCATTTT

Downstream 100 bases:

>100_bases
TTAATTCATAATATTGAGATATCTCAGTTTTAAGTTAGTTTGGCAAAATTATACTAATTTAGTATAATTTAGACCGTATG
AGTTCTATAGAAATTTTTTG

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH 2; L-serine deaminase 2; L-SD2 [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MESTFELFSIGVGPSSSHTIGPMRAGCDFINLYKDKLPQTKSVKIDLFGSLALTGKGHKTDYAVVLGVMGFLPESVDIEL
AKKLYDECLRNKKLNLGQEFEIDFDYDKDLVFHYNEFLPEHANGMRFSLFNGEELLCEKEYFSIGGGFIVDKKQIKKDTV
PTEVSCDKPYKFSTMAELRELCQRDGKTIDEIMFENEKTAYGEQQSLDKLAEIWHVMETSIEKGLTCAEATLPGGLKVRK
RAPSMIRKLKEQNIVNTDFNYLNAFAIAVNEQNACGERVVTAPTNGAAGVIPAVLKYYLQTHEIVNQQELKEVVNKYLLV
CAAIGILYKSGASISAAEVGCQGEVGVACSMAAAGYCALLGGDLDSIESAAEIGMEHNLGLTCDPIGGLVQIPCIERNAM
GAVQAINAAKLAYLDTGEKRFVGLDYVIKVMYETGLDMSSKYKETSLGGLATNVPVC

Sequences:

>Translated_457_residues
MESTFELFSIGVGPSSSHTIGPMRAGCDFINLYKDKLPQTKSVKIDLFGSLALTGKGHKTDYAVVLGVMGFLPESVDIEL
AKKLYDECLRNKKLNLGQEFEIDFDYDKDLVFHYNEFLPEHANGMRFSLFNGEELLCEKEYFSIGGGFIVDKKQIKKDTV
PTEVSCDKPYKFSTMAELRELCQRDGKTIDEIMFENEKTAYGEQQSLDKLAEIWHVMETSIEKGLTCAEATLPGGLKVRK
RAPSMIRKLKEQNIVNTDFNYLNAFAIAVNEQNACGERVVTAPTNGAAGVIPAVLKYYLQTHEIVNQQELKEVVNKYLLV
CAAIGILYKSGASISAAEVGCQGEVGVACSMAAAGYCALLGGDLDSIESAAEIGMEHNLGLTCDPIGGLVQIPCIERNAM
GAVQAINAAKLAYLDTGEKRFVGLDYVIKVMYETGLDMSSKYKETSLGGLATNVPVC
>Mature_457_residues
MESTFELFSIGVGPSSSHTIGPMRAGCDFINLYKDKLPQTKSVKIDLFGSLALTGKGHKTDYAVVLGVMGFLPESVDIEL
AKKLYDECLRNKKLNLGQEFEIDFDYDKDLVFHYNEFLPEHANGMRFSLFNGEELLCEKEYFSIGGGFIVDKKQIKKDTV
PTEVSCDKPYKFSTMAELRELCQRDGKTIDEIMFENEKTAYGEQQSLDKLAEIWHVMETSIEKGLTCAEATLPGGLKVRK
RAPSMIRKLKEQNIVNTDFNYLNAFAIAVNEQNACGERVVTAPTNGAAGVIPAVLKYYLQTHEIVNQQELKEVVNKYLLV
CAAIGILYKSGASISAAEVGCQGEVGVACSMAAAGYCALLGGDLDSIESAAEIGMEHNLGLTCDPIGGLVQIPCIERNAM
GAVQAINAAKLAYLDTGEKRFVGLDYVIKVMYETGLDMSSKYKETSLGGLATNVPVC

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1789161, Length=465, Percent_Identity=48.3870967741936, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1788116, Length=461, Percent_Identity=47.5054229934924, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI48994925, Length=464, Percent_Identity=48.2758620689655, Blast_Score=414, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 50010; Mature: 50010

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTFELFSIGVGPSSSHTIGPMRAGCDFINLYKDKLPQTKSVKIDLFGSLALTGKGHKT
CCCCEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCC
DYAVVLGVMGFLPESVDIELAKKLYDECLRNKKLNLGQEFEIDFDYDKDLVFHYNEFLPE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCCC
HANGMRFSLFNGEELLCEKEYFSIGGGFIVDKKQIKKDTVPTEVSCDKPYKFSTMAELRE
CCCCCEEEEECCCHHEEEHHHHHCCCCEEEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
LCQRDGKTIDEIMFENEKTAYGEQQSLDKLAEIWHVMETSIEKGLTCAEATLPGGLKVRK
HHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEHHCCCCCCCHHH
RAPSMIRKLKEQNIVNTDFNYLNAFAIAVNEQNACGERVVTAPTNGAAGVIPAVLKYYLQ
HHHHHHHHHHHCCCCCCCCHHEEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHH
THEIVNQQELKEVVNKYLLVCAAIGILYKSGASISAAEVGCQGEVGVACSMAAAGYCALL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEHHHHHCCHHEE
GGDLDSIESAAEIGMEHNLGLTCDPIGGLVQIPCIERNAMGAVQAINAAKLAYLDTGEKR
CCCHHHHHHHHHHCCCCCCCEEECCCCCEEECCEECCCHHHHHHHHHHHHEEEEECCCCE
FVGLDYVIKVMYETGLDMSSKYKETSLGGLATNVPVC
EECHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MESTFELFSIGVGPSSSHTIGPMRAGCDFINLYKDKLPQTKSVKIDLFGSLALTGKGHKT
CCCCEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCC
DYAVVLGVMGFLPESVDIELAKKLYDECLRNKKLNLGQEFEIDFDYDKDLVFHYNEFLPE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCCC
HANGMRFSLFNGEELLCEKEYFSIGGGFIVDKKQIKKDTVPTEVSCDKPYKFSTMAELRE
CCCCCEEEEECCCHHEEEHHHHHCCCCEEEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
LCQRDGKTIDEIMFENEKTAYGEQQSLDKLAEIWHVMETSIEKGLTCAEATLPGGLKVRK
HHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEHHCCCCCCCHHH
RAPSMIRKLKEQNIVNTDFNYLNAFAIAVNEQNACGERVVTAPTNGAAGVIPAVLKYYLQ
HHHHHHHHHHHCCCCCCCCHHEEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHH
THEIVNQQELKEVVNKYLLVCAAIGILYKSGASISAAEVGCQGEVGVACSMAAAGYCALL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEHHHHHCCHHEE
GGDLDSIESAAEIGMEHNLGLTCDPIGGLVQIPCIERNAMGAVQAINAAKLAYLDTGEKR
CCCHHHHHHHHHHCCCCCCCEEECCCCCEEECCEECCCHHHHHHHHHHHHEEEEECCCCE
FVGLDYVIKVMYETGLDMSSKYKETSLGGLATNVPVC
EECHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8385012; 9278503 [H]