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The map label for this gene is trxA [H]

Identifier: 89256545

GI number: 89256545

Start: 1174019

End: 1174345

Strand: Reverse

Name: trxA [H]

Synonym: FTL_1224

Alternate gene names: 89256545

Gene position: 1174345-1174019 (Counterclockwise)

Preceding gene: 89256546

Following gene: 89256544

Centisome position: 61.94

GC content: 31.8

Gene sequence:

>327_bases
ATGACATTGAGTAATGTTATAAAAACAGACGAAGCTAATTTTGACAAACTTATTGATAATACAAATAAAGCTGTTTTGGT
TGATTTCTATGCTGATTGGTGTGGTCCATGTAAGACACTAGCACCTATTCTTGATCAGCTTTCAAAAGATTATACAAAAG
CTGTAATTGTCAAAGTAAATGTGGATGAGAATCAAAATTTAGCTGCAAGATTTGCTATTAGAAGTATTCCAACGTTGATA
GTTTTTAAAAATCGTAAGCAACTTGAGACTTTAATGGGCGTTCATACTGCTTCTCAATTAGAGCAGAAACTAAAAGCATA
TGAGTAA

Upstream 100 bases:

>100_bases
GGCTTATAGTGGTGATGCAAATTCAAATAGCTCTAATCCAGTAGCCGTAACTCAAGACATCAATATTAAAGCAAATGTTA
CATTTATGGAGAAATAGATT

Downstream 100 bases:

>100_bases
ATCTAAAGAAACCGATTCTCAAGGTTTATGCCAATGGTATTTTAAAACGTTTTTTGAAATACCAGTTAAACCAAATAAAT
TTCCTCAAGAATTTGCGATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MTLSNVIKTDEANFDKLIDNTNKAVLVDFYADWCGPCKTLAPILDQLSKDYTKAVIVKVNVDENQNLAARFAIRSIPTLI
VFKNRKQLETLMGVHTASQLEQKLKAYE

Sequences:

>Translated_108_residues
MTLSNVIKTDEANFDKLIDNTNKAVLVDFYADWCGPCKTLAPILDQLSKDYTKAVIVKVNVDENQNLAARFAIRSIPTLI
VFKNRKQLETLMGVHTASQLEQKLKAYE
>Mature_107_residues
TLSNVIKTDEANFDKLIDNTNKAVLVDFYADWCGPCKTLAPILDQLSKDYTKAVIVKVNVDENQNLAARFAIRSIPTLIV
FKNRKQLETLMGVHTASQLEQKLKAYE

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=36.0824742268041, Blast_Score=80, Evalue=3e-16,
Organism=Homo sapiens, GI50592994, Length=74, Percent_Identity=35.1351351351351, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=41.1764705882353, Blast_Score=95, Evalue=1e-21,
Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=36.2745098039216, Blast_Score=79, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17507705, Length=88, Percent_Identity=35.2272727272727, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=89, Percent_Identity=39.3258426966292, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71980562, Length=103, Percent_Identity=34.9514563106796, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980565, Length=96, Percent_Identity=36.4583333333333, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17554386, Length=97, Percent_Identity=41.2371134020619, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17510299, Length=101, Percent_Identity=37.6237623762376, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=90, Percent_Identity=34.4444444444444, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=93, Percent_Identity=37.6344086021505, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=93, Percent_Identity=37.6344086021505, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=93, Percent_Identity=37.6344086021505, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=87, Percent_Identity=35.632183908046, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=40.2298850574713, Blast_Score=81, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=97, Percent_Identity=34.020618556701, Blast_Score=65, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324862, Length=77, Percent_Identity=42.8571428571429, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664269, Length=91, Percent_Identity=45.0549450549451, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24639826, Length=96, Percent_Identity=40.625, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24658597, Length=99, Percent_Identity=37.3737373737374, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17648013, Length=99, Percent_Identity=40.4040404040404, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583090, Length=99, Percent_Identity=40.4040404040404, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17530795, Length=106, Percent_Identity=34.9056603773585, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=93, Percent_Identity=34.4086021505376, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639068, Length=96, Percent_Identity=30.2083333333333, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12202; Mature: 12071

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSNVIKTDEANFDKLIDNTNKAVLVDFYADWCGPCKTLAPILDQLSKDYTKAVIVKVN
CCCCHHHCCCCCCHHHHHCCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHCCEEEEEEEE
VDENQNLAARFAIRSIPTLIVFKNRKQLETLMGVHTASQLEQKLKAYE
CCCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLSNVIKTDEANFDKLIDNTNKAVLVDFYADWCGPCKTLAPILDQLSKDYTKAVIVKVN
CCCHHHCCCCCCHHHHHCCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHCCEEEEEEEE
VDENQNLAARFAIRSIPTLIVFKNRKQLETLMGVHTASQLEQKLKAYE
CCCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3294835 [H]