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The map label for this gene is bioF [H]

Identifier: 89256540

GI number: 89256540

Start: 1169829

End: 1171070

Strand: Reverse

Name: bioF [H]

Synonym: FTL_1219

Alternate gene names: 89256540

Gene position: 1171070-1169829 (Counterclockwise)

Preceding gene: 89256544

Following gene: 89256539

Centisome position: 61.77

GC content: 29.63

Gene sequence:

>1242_bases
ATGCAAATTACAGAAAACTGGTTTATAAAAAGAGTTAATCGAGCTGAGAAATTTTTAGATTTAAGTTATAGTTGTGCTCG
CAATACTTTCAAAAAATCTGAAAGAAAAAATATTTTATTAACAGATAACAAAACTTACTTAGAGTTTGTTTCATGCTCTT
ATCTAGGTTTACATAATGACAAACAAATAATTGATGCGGTTAAGAAAAGTAAAGCTCTTAAAGCACAAGGTTTTTTGTTT
TCAAGTTCAAGAACAAGGGTAATATCGCAAAATGAGAAATATGCTCTTGATAAACTAAAGGAAGTTTTTGCACCATATTC
GCCAGTATTATTTCAAAATTTACATACAACACACCTTGGAATTATACCTTTATTACTCTCTGGCATATTCCCTAAAATAG
ATCAAGGTAAGCCAATACATTGTATAATTGATAAATATGCTCATCAGTCACTTAAGATTTTAGTAGGAATCATAAAGCAG
TTTTGTGAGGTCGAATTTATAGATAATACAGATATTGATAAACTCTCTTCTAGATTAAAGCAAATTCACCAAGGCAATAA
AATACCATTTATAATGATGGACAGCGTAGGTTCTATGGGAAAAATTTATCCTGTTAAAGAAATTGTAGATTTGGTTAATA
CATATAATGGATATGTTTACTTTGATGATGCACATGGAATGTCAATAATTGGTAAGAATGGTAGTGGATATGTGTTAAAA
GAGCTTGACTATAGACTAAATGATAGAGTATTCATAGCAACTTCATTAACTAAAGCCTTCGGTGGGCAAGGAGGTGTTAT
ACTAATGCCTTATCAAGAGCAAATAGACTTTATTTTACAATATTGTACTACGTACACATTTTCAGGTCCTTTATCAATAC
CTAGCTTAGAAGTAATTAGTAAAAGTTGTGAAATTCATTTATCATCACAAATTGATTTACTCCAGCAGAAACTACACAAT
AACTTAAAATACTTTGACCAAGAAATTAGTAATATTAAATATAACCAACTACGCAATAGTTTTGTACCATTCAGAATTAT
ATACATCGGTAATGAAGACGATGCCATAAAATATTACAAACAATTAAAGGCAGCAGGCATACTTGTGACCTGTGCTATAT
ATCCTGTTGTAGAAAAATCTAATGCTATATTAAGAATTACTTTCTCGGCAAGTCATAAAAATAGTGATATAAAGTTGCTA
GTAAGTAGTTTAAAGAATATCTTAACTGACTATAATGCATGA

Upstream 100 bases:

>100_bases
TAATAAATAAAATAAAAATATTTTGCTATAAAATTTATTTCAAAATGAAATTGATTAATGCATACTTACTGATAAGTAAA
AAATAGTTAAATAAAATATT

Downstream 100 bases:

>100_bases
TAATTTAGACAAATTACTAGTTCACTAATATTTAAGGATATTTAGCGGTAATACTTTTCATGTATGTAAAAATATAGATC
CTAAATATTCCAAACCCTTT

Product: hypothetical protein

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHNDKQIIDAVKKSKALKAQGFLF
SSSRTRVISQNEKYALDKLKEVFAPYSPVLFQNLHTTHLGIIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQ
FCEVEFIDNTDIDKLSSRLKQIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
ELDYRLNDRVFIATSLTKAFGGQGGVILMPYQEQIDFILQYCTTYTFSGPLSIPSLEVISKSCEIHLSSQIDLLQQKLHN
NLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYKQLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLL
VSSLKNILTDYNA

Sequences:

>Translated_413_residues
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHNDKQIIDAVKKSKALKAQGFLF
SSSRTRVISQNEKYALDKLKEVFAPYSPVLFQNLHTTHLGIIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQ
FCEVEFIDNTDIDKLSSRLKQIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
ELDYRLNDRVFIATSLTKAFGGQGGVILMPYQEQIDFILQYCTTYTFSGPLSIPSLEVISKSCEIHLSSQIDLLQQKLHN
NLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYKQLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLL
VSSLKNILTDYNA
>Mature_413_residues
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHNDKQIIDAVKKSKALKAQGFLF
SSSRTRVISQNEKYALDKLKEVFAPYSPVLFQNLHTTHLGIIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQ
FCEVEFIDNTDIDKLSSRLKQIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
ELDYRLNDRVFIATSLTKAFGGQGGVILMPYQEQIDFILQYCTTYTFSGPLSIPSLEVISKSCEIHLSSQIDLLQQKLHN
NLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYKQLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLL
VSSLKNILTDYNA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI83977444, Length=365, Percent_Identity=23.8356164383562, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI83977440, Length=365, Percent_Identity=23.8356164383562, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI83977442, Length=365, Percent_Identity=23.8356164383562, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790046, Length=413, Percent_Identity=26.3922518159806, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1786993, Length=369, Percent_Identity=23.5772357723577, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994529, Length=396, Percent_Identity=25.2525252525253, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24662918, Length=367, Percent_Identity=25.8855585831063, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 47073; Mature: 47073

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHND
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEECCCCC
KQIIDAVKKSKALKAQGFLFSSSRTRVISQNEKYALDKLKEVFAPYSPVLFQNLHTTHLG
HHHHHHHHHHHHHHHCCEEEECCCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHH
IIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQFCEVEFIDNTDIDKLSSRLK
HHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHH
QIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
HHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCEEEE
ELDYRLNDRVFIATSLTKAFGGQGGVILMPYQEQIDFILQYCTTYTFSGPLSIPSLEVIS
ECCCCCCCCEEEEEEHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KSCEIHLSSQIDLLQQKLHNNLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYK
HCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHH
QLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLLVSSLKNILTDYNA
HHHHCCEEEEEEEEHEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHND
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEECCCCC
KQIIDAVKKSKALKAQGFLFSSSRTRVISQNEKYALDKLKEVFAPYSPVLFQNLHTTHLG
HHHHHHHHHHHHHHHCCEEEECCCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHH
IIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQFCEVEFIDNTDIDKLSSRLK
HHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHH
QIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
HHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCEEEE
ELDYRLNDRVFIATSLTKAFGGQGGVILMPYQEQIDFILQYCTTYTFSGPLSIPSLEVIS
ECCCCCCCCEEEEEEHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KSCEIHLSSQIDLLQQKLHNNLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYK
HCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHH
QLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLLVSSLKNILTDYNA
HHHHCCEEEEEEEEHEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA