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The map label for this gene is mscM [H]

Identifier: 89256530

GI number: 89256530

Start: 1158146

End: 1158844

Strand: Reverse

Name: mscM [H]

Synonym: FTL_1209

Alternate gene names: 89256530

Gene position: 1158844-1158146 (Counterclockwise)

Preceding gene: 89256531

Following gene: 89256527

Centisome position: 61.12

GC content: 31.76

Gene sequence:

>699_bases
TTGTTAAATAAATTACCTATTGCCTTTTTAACGGGATTAGGAGCATTATCAGCAGTTCTTATGTTGGTCTTTAAGGATAC
AATATTAGGCTTTGTAACCAATGTTCAAGTTGCCGCTCTTGATTTAGTAAGAGTTGGAGATTGGATTACTATCCCATCTG
CTAATGTTGATGGTACTGTTATGGATGTATCTATTAATACAGTAAAAATCCGTAATTTTGATAAAACTATATCGATGATA
CCAACTTATACACTAACTACTCATAGTGTCCAAAATTGGCGTGGTATGGTAGAAACCGGAGGTCGTCGTATTAAGCGCTC
GATAAATATAGATATAGATACGATAAAATTCTGTGATCAAGAGCTTCTAGAAAGACTAGGCAAAGAAACTCTTTTAGCGG
ATTTTATCAAAGCTAAAGCTAATGAAAAACTTACTAATATTAGTCTATTTCGTGCTTATATTGAAAACTATCTGAGAAAT
CATCCTAAGATACATTTAGGTTTGACATTTTTAATTAGGAAGCTTCAGCCGACACAGTTTGGCTTACCTGTTGAGTTATA
TATATTTACAAATGACACTAACTGGGTTAACTATGAGAAAATTCAAGCTGATATTTTTGATTATGTATTTGCTAGTTTAC
ATATGTTTGACTTAAAAGCTTTCCAAGCTATTACTGGTAGAATTAATAATCAATTTTAA

Upstream 100 bases:

>100_bases
GAGAATCTTGCTTATTTTAAAAATCATTCATTACGTAGCTATGCTCAAGTAATCAAGATTATCTTATACATAATAGGCTT
TATCTTAAGTAGTATCGTTA

Downstream 100 bases:

>100_bases
AAAACTTTAGCATTTAGGTAATGTAACGCCAACTTGACCTTGGTATTTACCGCCTTTATCAGCATAAGAAGTTTCACACT
CTTCATCTGACTGAAAAAAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MLNKLPIAFLTGLGALSAVLMLVFKDTILGFVTNVQVAALDLVRVGDWITIPSANVDGTVMDVSINTVKIRNFDKTISMI
PTYTLTTHSVQNWRGMVETGGRRIKRSINIDIDTIKFCDQELLERLGKETLLADFIKAKANEKLTNISLFRAYIENYLRN
HPKIHLGLTFLIRKLQPTQFGLPVELYIFTNDTNWVNYEKIQADIFDYVFASLHMFDLKAFQAITGRINNQF

Sequences:

>Translated_232_residues
MLNKLPIAFLTGLGALSAVLMLVFKDTILGFVTNVQVAALDLVRVGDWITIPSANVDGTVMDVSINTVKIRNFDKTISMI
PTYTLTTHSVQNWRGMVETGGRRIKRSINIDIDTIKFCDQELLERLGKETLLADFIKAKANEKLTNISLFRAYIENYLRN
HPKIHLGLTFLIRKLQPTQFGLPVELYIFTNDTNWVNYEKIQADIFDYVFASLHMFDLKAFQAITGRINNQF
>Mature_232_residues
MLNKLPIAFLTGLGALSAVLMLVFKDTILGFVTNVQVAALDLVRVGDWITIPSANVDGTVMDVSINTVKIRNFDKTISMI
PTYTLTTHSVQNWRGMVETGGRRIKRSINIDIDTIKFCDQELLERLGKETLLADFIKAKANEKLTNISLFRAYIENYLRN
HPKIHLGLTFLIRKLQPTQFGLPVELYIFTNDTNWVNYEKIQADIFDYVFASLHMFDLKAFQAITGRINNQF

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=244, Percent_Identity=44.672131147541, Blast_Score=241, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 26435; Mature: 26435

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKLPIAFLTGLGALSAVLMLVFKDTILGFVTNVQVAALDLVRVGDWITIPSANVDGTV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEECCCCCCCEE
MDVSINTVKIRNFDKTISMIPTYTLTTHSVQNWRGMVETGGRRIKRSINIDIDTIKFCDQ
EEEEEEEEEEECCCHHHHHCCCEEEEECCHHHHHHHHHCCCHHHHHEECCCCHHHHHHHH
ELLERLGKETLLADFIKAKANEKLTNISLFRAYIENYLRNHPKIHLGLTFLIRKLQPTQF
HHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCC
GLPVELYIFTNDTNWVNYEKIQADIFDYVFASLHMFDLKAFQAITGRINNQF
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLNKLPIAFLTGLGALSAVLMLVFKDTILGFVTNVQVAALDLVRVGDWITIPSANVDGTV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEECCCCCCCEE
MDVSINTVKIRNFDKTISMIPTYTLTTHSVQNWRGMVETGGRRIKRSINIDIDTIKFCDQ
EEEEEEEEEEECCCHHHHHCCCEEEEECCHHHHHHHHHCCCHHHHHEECCCCHHHHHHHH
ELLERLGKETLLADFIKAKANEKLTNISLFRAYIENYLRNHPKIHLGLTFLIRKLQPTQF
HHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCC
GLPVELYIFTNDTNWVNYEKIQADIFDYVFASLHMFDLKAFQAITGRINNQF
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]