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The map label for this gene is treA [H]

Identifier: 89256475

GI number: 89256475

Start: 1093524

End: 1094570

Strand: Reverse

Name: treA [H]

Synonym: FTL_1151

Alternate gene names: 89256475

Gene position: 1094570-1093524 (Counterclockwise)

Preceding gene: 89256483

Following gene: 89256474

Centisome position: 57.73

GC content: 29.42

Gene sequence:

>1047_bases
ATGCTAAACTTCATGGAAATAAATAATATGGATAATAATCAAGAACTACTAATCCAACTATCAGGTGAGCTTTTTGAGGC
AGTTCAATTAGAACCTTGTTTTGATGATTCAAAATATTTTGTAGATATGTCACCTAAAAGATCTCCTGAAGTTATCCTTA
AAGATTACAGAAATTCCAAAGATTCTAAAGATTTCGATCTTAAAAATTTTATTCAAGAAAACTTTCACCCACCCATATCA
GAAAAAACTTTTGATAATAAAGAAATAACTCTCCAGCAATACATAAAACAAATGTGGAGTTTTTTATATCAATCATTTGA
TCAACAAAACTATTTAAGTTCTCTTATACCCTTACCAAACTCCTATATAATTCCAGGCGGTAGATTTAGAGAAGTCTATT
ACTGGGACTGTTACTTTACTTGTGAAGGTCTAAGAGTTGATGGTAAGATTCACATGATAAAAGATATTGCTAATAATTTT
GCATACCTTATAGATACACTTGGCTTTGTACCAAATGCAAATAGAAAATATTACCTAACCCGCTCTCAACCTCCTTTATT
TTATTTGATCTTAAATATTTTATATCAAGAACTTGGTATATCTACCATTGAAAAATATCTCCCATTATTAGAAAAAGAAT
ATTCATTTTGGATGACCTCTCAAAGAAATATCAATGGATTAAATAGATATTGGGATAACTCTGACACTCCTAGACCAGAA
TCATATCGAGAAGATATCGAACATGCAAAAAACATAAAAAACAAATCAAAATTTTATCGAAATATTCGCGCTGCTTGTGA
GTCTGGATGGGATTTCTCTAGCCGCTGGTTTGCCAAAGCAGATGATTTTAATACCATCCAAACAACTGATATTTTACCTG
TTGATTTAAATAGTTATTTATATGGATTAGAACATTTACTAGGTAAATGGTTCACAGAATTTTTACAACAAAAAAAAGCT
ACCAAGTATCTAGAATTAGCAAAAAAAGAAAACAACTTATTCAGGATAAATTTTGGAATAACCAAAAAGAATTTTTTTAT
GATCTAA

Upstream 100 bases:

>100_bases
TCTAAAGTAATTAGTGAAATATTTGCACAATTTGGCGGAATAACTGCATTTTATTTTGTACTTATACCAATAATTTTTTT
AGTACTAATAATACCACCAT

Downstream 100 bases:

>100_bases
ATCATGTTAAGAATGAACTTACAGATATTACAAGTCTAGCTGGAATAGCTCCTTTATTCTTAAACATAGCAACAGATCAG
CAAGCACTGAAAGTTGCTAA

Product: trehalase, pseuodgene

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MLNFMEINNMDNNQELLIQLSGELFEAVQLEPCFDDSKYFVDMSPKRSPEVILKDYRNSKDSKDFDLKNFIQENFHPPIS
EKTFDNKEITLQQYIKQMWSFLYQSFDQQNYLSSLIPLPNSYIIPGGRFREVYYWDCYFTCEGLRVDGKIHMIKDIANNF
AYLIDTLGFVPNANRKYYLTRSQPPLFYLILNILYQELGISTIEKYLPLLEKEYSFWMTSQRNINGLNRYWDNSDTPRPE
SYREDIEHAKNIKNKSKFYRNIRAACESGWDFSSRWFAKADDFNTIQTTDILPVDLNSYLYGLEHLLGKWFTEFLQQKKA
TKYLELAKKENNLFRINFGITKKNFFMI

Sequences:

>Translated_348_residues
MLNFMEINNMDNNQELLIQLSGELFEAVQLEPCFDDSKYFVDMSPKRSPEVILKDYRNSKDSKDFDLKNFIQENFHPPIS
EKTFDNKEITLQQYIKQMWSFLYQSFDQQNYLSSLIPLPNSYIIPGGRFREVYYWDCYFTCEGLRVDGKIHMIKDIANNF
AYLIDTLGFVPNANRKYYLTRSQPPLFYLILNILYQELGISTIEKYLPLLEKEYSFWMTSQRNINGLNRYWDNSDTPRPE
SYREDIEHAKNIKNKSKFYRNIRAACESGWDFSSRWFAKADDFNTIQTTDILPVDLNSYLYGLEHLLGKWFTEFLQQKKA
TKYLELAKKENNLFRINFGITKKNFFMI
>Mature_348_residues
MLNFMEINNMDNNQELLIQLSGELFEAVQLEPCFDDSKYFVDMSPKRSPEVILKDYRNSKDSKDFDLKNFIQENFHPPIS
EKTFDNKEITLQQYIKQMWSFLYQSFDQQNYLSSLIPLPNSYIIPGGRFREVYYWDCYFTCEGLRVDGKIHMIKDIANNF
AYLIDTLGFVPNANRKYYLTRSQPPLFYLILNILYQELGISTIEKYLPLLEKEYSFWMTSQRNINGLNRYWDNSDTPRPE
SYREDIEHAKNIKNKSKFYRNIRAACESGWDFSSRWFAKADDFNTIQTTDILPVDLNSYLYGLEHLLGKWFTEFLQQKKA
TKYLELAKKENNLFRINFGITKKNFFMI

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=348, Percent_Identity=32.7586206896552, Blast_Score=167, Evalue=9e-42,
Organism=Escherichia coli, GI1787447, Length=326, Percent_Identity=42.638036809816, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1789936, Length=343, Percent_Identity=40.2332361516035, Blast_Score=248, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17542196, Length=333, Percent_Identity=34.5345345345345, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI25148109, Length=329, Percent_Identity=35.5623100303951, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17565078, Length=315, Percent_Identity=33.015873015873, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25141398, Length=333, Percent_Identity=32.7327327327327, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71987755, Length=219, Percent_Identity=36.5296803652968, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319473, Length=224, Percent_Identity=30.8035714285714, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320204, Length=248, Percent_Identity=29.0322580645161, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656661, Length=355, Percent_Identity=31.830985915493, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI17933716, Length=355, Percent_Identity=31.830985915493, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24656670, Length=355, Percent_Identity=31.830985915493, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24656680, Length=355, Percent_Identity=31.830985915493, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24656675, Length=355, Percent_Identity=31.830985915493, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24656685, Length=328, Percent_Identity=31.0975609756098, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI22024178, Length=368, Percent_Identity=29.0760869565217, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28573474, Length=289, Percent_Identity=29.0657439446367, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45551104, Length=210, Percent_Identity=31.4285714285714, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 41578; Mature: 41578

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00927 TREHALASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNFMEINNMDNNQELLIQLSGELFEAVQLEPCFDDSKYFVDMSPKRSPEVILKDYRNSK
CCCEEECCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCC
DSKDFDLKNFIQENFHPPISEKTFDNKEITLQQYIKQMWSFLYQSFDQQNYLSSLIPLPN
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
SYIIPGGRFREVYYWDCYFTCEGLRVDGKIHMIKDIANNFAYLIDTLGFVPNANRKYYLT
CEECCCCCEEEEEEEEEEEEECCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
RSQPPLFYLILNILYQELGISTIEKYLPLLEKEYSFWMTSQRNINGLNRYWDNSDTPRPE
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCH
SYREDIEHAKNIKNKSKFYRNIRAACESGWDFSSRWFAKADDFNTIQTTDILPVDLNSYL
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCEEECCEEEECHHHHH
YGLEHLLGKWFTEFLQQKKATKYLELAKKENNLFRINFGITKKNFFMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECEECCCEECC
>Mature Secondary Structure
MLNFMEINNMDNNQELLIQLSGELFEAVQLEPCFDDSKYFVDMSPKRSPEVILKDYRNSK
CCCEEECCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCC
DSKDFDLKNFIQENFHPPISEKTFDNKEITLQQYIKQMWSFLYQSFDQQNYLSSLIPLPN
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
SYIIPGGRFREVYYWDCYFTCEGLRVDGKIHMIKDIANNFAYLIDTLGFVPNANRKYYLT
CEECCCCCEEEEEEEEEEEEECCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
RSQPPLFYLILNILYQELGISTIEKYLPLLEKEYSFWMTSQRNINGLNRYWDNSDTPRPE
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCH
SYREDIEHAKNIKNKSKFYRNIRAACESGWDFSSRWFAKADDFNTIQTTDILPVDLNSYL
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCEEECCEEEECHHHHH
YGLEHLLGKWFTEFLQQKKATKYLELAKKENNLFRINFGITKKNFFMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA