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The map label for this gene is tktA [H]

Identifier: 89256469

GI number: 89256469

Start: 1086160

End: 1088151

Strand: Direct

Name: tktA [H]

Synonym: FTL_1145

Alternate gene names: 89256469

Gene position: 1086160-1088151 (Clockwise)

Preceding gene: 89256454

Following gene: 89256470

Centisome position: 57.29

GC content: 37.15

Gene sequence:

>1992_bases
ATGTCTTTATCTATTCCACGCGAGTTTTCAAACGCTATAAGATTTTTATCTATTGATGCAACACTTAAAGCTAAATCAGG
ACATCCTGGAATGCCTATGGGGATGGCTGATATTGCCACAGTGTTATGGACAAAGTTTCTTAAGCACAATCCAAATAATC
CACATTGGATAAATAGAGATAGATTTGTTCTTTCAAATGGGCATGGCTCAATGCTTTTATATTCTCTGTTACATCTGACA
GGTTATGATCTATCTATTGAGGATATTAAAAATTTTAGGCAGTTACACTCAAAAACTCCAGGGCACCCTGAGTATGGCTA
TATGCCAGGAGTTGAGACAACAACTGGTCCATTAGGGCAAGGAGTAGCAAATGCTGTGGGTATGGCTTTAGGTGAAAAGC
TATTATCAGATAGGTATAATACACCTGATTTAAAAGTTATAGATCATCACACTTACGTGTTTTTAGGTGATGGATGTTTG
ATGGAGGGTGTTTCTCATGAAGCATGCTCATTAGCAGGGACTCTAGGTTTAAACAAATTAGTAGCATTTTGGGATGATAA
TAATATTTCGATAGATGGCGATACTAAGGGTTGGTTTAGTGATAATACACCTGAGAGATTTAGGGCGTATGGTTGGCATG
TTATAGAAAATGTTGATGGTCATGAGTTTGTTGCGATTGAAAAAGCTATAAATGAAGCCCATTCTCAGCAGCAAAAACCA
ACTTTAATCTGTTGTAAAACTGTAATTGGTTTTGGCTCACCTGAGAAAGCTGGAACTGCCTCTGTGCATGGTTCGCCTTT
AAGTGATCAAGAAAGAGCCTCAGCTGCTAAAGAGCTTAACTGGGATTATCAAGCTTTTGAAATACCTCAAGATGTTTATA
AATACTGGGATGCTAGGGAAAAAGGACAAGCTTTAGAAGCAAATTGGCAAGGGCAATGGAATTTATTTAAAGACAGTCCT
AAGTTTGACGAATTTGAACGAGTTTTAAGTAAAGAGTTGCCAGTTGGATTAGAAAGCGCTATTAATGACTATATAGCTTC
GCAATTGAGTAATCCTGTCAAAGTGGCAACACGTAAAGCTTCACAAATGGCGCTTGAAGTCTTGTGTAAGAATATGCCTG
AGATGTTTGGTGGATCAGCAGATTTGACAGGATCAAATAATACTAATTGGAGTGGTTCAGTTTGGCTAAATAATACTCAA
GAAGGCGCAAATTATCTTTCTTATGGTGTTAGAGAGTTTGGTATGGCTGCAATAATGAATGGTCTAAGCCTTTATGGTGG
TATCAAACCTTATGGTGGTACATTCTTGGTATTTAGCGATTATTCAAGAAACGCGATAAGAATGTCAGCGTTGATGAAAC
AGCCTGTAGTTCATGTTATGTCGCATGACTCAATTGGTTTGGGAGAAGATGGACCAACTCATCAACCTATAGAACATGTT
CCGAGTTTAAGACTTATACCTAACTTAAGTGTTTGGCGACCTGCTGATACAATTGAAACAATGATAGCATGGAAAGAGGC
TGTAAAATCTAAAGATACGCCAAGTGTAATGGTACTTACACGTCAAAACTTAATGCCAGTAGTGCAAACACAGCATCAGG
TAGCAAATATTGCTAGAGGTGGTTATCTAGTTAAAGATAATCCTGATGCTAAATTAACTATTGTTGCTACTGGCTCTGAA
GTTGAGCTTGCTGTCAAAGTTGCTAATGAATTTGAAAAGAAAGGTATAAAATTAAATGTTGCTTCTATACCGTGTGTAGA
AGTTTTTGCTACTCAAGCTCACGAGTATAAAAAAACAGTAATAAAAGATGATATCCCGGCAGTTTTTGTTGAGATGGCGC
AACCTGATATGTGGTATAAATATATGCCAAAAGCTGGAGGGGAAGTAAAAGGAATCTATAGCTTTGGTGAGTCAGCACCG
GTTGAAGATTTATTTAAACATTTTGGATTTACTGTAGAAAATATTAGCAATATTGTTGCTAAATATGTTTAA

Upstream 100 bases:

>100_bases
GTATATAGATTTCTTGTTTTATGAAAGTCTCTACTGTATCATCATACTAGTTATTTTTTAAAATTGTCAATCATATAATC
AAATATAAGGTTAAATACTA

Downstream 100 bases:

>100_bases
TAAACTTTCGCAAGATAATATCTTAAGGAGATTAAAAATGAGAGTTGCAATTAATGGTTTCGGTAGAATTGGTCGTTTAG
CATTTCGTCAAATGTTTGGT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MSLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRDRFVLSNGHGSMLLYSLLHLT
GYDLSIEDIKNFRQLHSKTPGHPEYGYMPGVETTTGPLGQGVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCL
MEGVSHEACSLAGTLGLNKLVAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHEFVAIEKAINEAHSQQQKP
TLICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDAREKGQALEANWQGQWNLFKDSP
KFDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKASQMALEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQ
EGANYLSYGVREFGMAAIMNGLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGPTHQPIEHV
PSLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARGGYLVKDNPDAKLTIVATGSE
VELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTVIKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAP
VEDLFKHFGFTVENISNIVAKYV

Sequences:

>Translated_663_residues
MSLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRDRFVLSNGHGSMLLYSLLHLT
GYDLSIEDIKNFRQLHSKTPGHPEYGYMPGVETTTGPLGQGVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCL
MEGVSHEACSLAGTLGLNKLVAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHEFVAIEKAINEAHSQQQKP
TLICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDAREKGQALEANWQGQWNLFKDSP
KFDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKASQMALEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQ
EGANYLSYGVREFGMAAIMNGLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGPTHQPIEHV
PSLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARGGYLVKDNPDAKLTIVATGSE
VELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTVIKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAP
VEDLFKHFGFTVENISNIVAKYV
>Mature_662_residues
SLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRDRFVLSNGHGSMLLYSLLHLTG
YDLSIEDIKNFRQLHSKTPGHPEYGYMPGVETTTGPLGQGVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCLM
EGVSHEACSLAGTLGLNKLVAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHEFVAIEKAINEAHSQQQKPT
LICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDAREKGQALEANWQGQWNLFKDSPK
FDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKASQMALEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQE
GANYLSYGVREFGMAAIMNGLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGPTHQPIEHVP
SLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARGGYLVKDNPDAKLTIVATGSEV
ELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTVIKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAPV
EDLFKHFGFTVENISNIVAKYV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=578, Percent_Identity=26.8166089965398, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4507521, Length=578, Percent_Identity=26.8166089965398, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI133778974, Length=586, Percent_Identity=26.4505119453925, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=56.3165905631659, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=55.2671755725191, Blast_Score=753, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=574, Percent_Identity=27.8745644599303, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=46.9448584202683, Blast_Score=569, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=44.4444444444444, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45551847, Length=583, Percent_Identity=26.4150943396226, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45550715, Length=583, Percent_Identity=26.4150943396226, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24666278, Length=577, Percent_Identity=25.4766031195841, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24645119, Length=550, Percent_Identity=25.8181818181818, Blast_Score=137, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73347; Mature: 73216

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRD
CCCCCCHHHHHCEEEEEECEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCC
RFVLSNGHGSMLLYSLLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYMPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
GVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCLMEGVSHEACSLAGTLGLNKL
HHHHHHHHHHHHHHHHCCCCCCCCEEEECEEEEEECCCHHHCCCCHHHHHHHHHCCCCCE
VAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHEFVAIEKAINEAHSQQQKP
EEEECCCEEEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEEHHHHHHHHHHHHHCCC
TLICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDARE
CEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCHHHHHHHCCHH
KGQALEANWQGQWNLFKDSPKFDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKA
CCCEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHH
SQMALEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQEGANYLSYGVREFGMAAIMN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
GLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGPTHQPIEHV
HHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHC
PSLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARG
CCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
GYLVKDNPDAKLTIVATGSEVELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTV
CEEEECCCCCEEEEEEECCCEEEEHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
IKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAPVEDLFKHFGFTVENISNIVA
HHCCCHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHH
KYV
HCC
>Mature Secondary Structure 
SLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRD
CCCCCHHHHHCEEEEEECEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCC
RFVLSNGHGSMLLYSLLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYMPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
GVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCLMEGVSHEACSLAGTLGLNKL
HHHHHHHHHHHHHHHHCCCCCCCCEEEECEEEEEECCCHHHCCCCHHHHHHHHHCCCCCE
VAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHEFVAIEKAINEAHSQQQKP
EEEECCCEEEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEEHHHHHHHHHHHHHCCC
TLICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDARE
CEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCHHHHHHHCCHH
KGQALEANWQGQWNLFKDSPKFDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKA
CCCEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHH
SQMALEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQEGANYLSYGVREFGMAAIMN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
GLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGPTHQPIEHV
HHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHC
PSLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARG
CCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
GYLVKDNPDAKLTIVATGSEVELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTV
CEEEECCCCCEEEEEEECCCEEEEHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
IKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAPVEDLFKHFGFTVENISNIVA
HHCCCHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHH
KYV
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]