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The map label for this gene is cbh [H]

Identifier: 89256423

GI number: 89256423

Start: 1037417

End: 1038172

Strand: Reverse

Name: cbh [H]

Synonym: FTL_1089

Alternate gene names: 89256423

Gene position: 1038172-1037417 (Counterclockwise)

Preceding gene: 89256424

Following gene: 89256422

Centisome position: 54.76

GC content: 31.22

Gene sequence:

>756_bases
ATGCTTAAGAAAATACTAATAACTCCTTTAATTATACTATCATTTCTACAGTTTAGCTTTGGATGTACTTGGTTTAGCTT
TGAAAATGATAAGGGACATTATTTTATTGGCAGAACTATGGAATGGCCTGGCGATTTAAATACTAAAATCACCTTAGTAC
CAAGAGGATATAAGTTTGGAAACTTTACAACTCACTATGGCTTTGTAGGTATGAGTCATAATGGTAATTTTAGTGATGGT
ATGAATGAATATAGTCTAGCAGTAAGCGCTCTTTGGCTTAGTGGTAGTAAATATCCTGATAAAAAAGATGCTGACTATAA
TATTACTATGCTATTGCCATATGTTTTAGGTAATACCACAACAGTTGCGCAAGCTGTAGAATTCATCAAGAAACACAAGT
TCTACACTTCTGTATTACCAGAGATTTCAGATAAAGTTGAAATTACAGTACATTTTGCGATTAGTGATGCTCAGGGTAAT
TCTGTAGTAGTTGAATTTATAAATGGTAAAACCAAAATTTATGATAATAAAATTAAAGTTCTTACCAATGATCCTGCTTA
TGACGAACAGCTTAAATTACTCAAAAAATATCAAGATCATGAAATTAAAGAAGATAAATTTATCGCTTTTTATTATTCAC
CTCAAGGTCGCTTTGCAAAAATGGTAGCTTTTAATACTACTAAAGCAAATACACCAGATGATTTAACAGCTGTAAATCAT
GCTTGGTCAATGATCAATACTGTAGATATACCATAG

Upstream 100 bases:

>100_bases
TCGATAAGATAACTTTTTAAAAAAATCAAAACATGGCTATATAAATTACTCTATCTATATGTATAATAATCAATAATTAT
CATTTAAAAAAATATTTAAA

Downstream 100 bases:

>100_bases
GGTTATCTATATTGGCGATGGGTAAGCTCTAAGCCACAGTTTACCTCATACTCTGTAGTTGATGACCTTAGCAATCGTGT
TTACTATTTCCGTACTTGGG

Product: choloylglycine hydrolase family protein

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFGNFTTHYGFVGMSHNGNFSDG
MNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTTTVAQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGN
SVVVEFINGKTKIYDNKIKVLTNDPAYDEQLKLLKKYQDHEIKEDKFIAFYYSPQGRFAKMVAFNTTKANTPDDLTAVNH
AWSMINTVDIP

Sequences:

>Translated_251_residues
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFGNFTTHYGFVGMSHNGNFSDG
MNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTTTVAQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGN
SVVVEFINGKTKIYDNKIKVLTNDPAYDEQLKLLKKYQDHEIKEDKFIAFYYSPQGRFAKMVAFNTTKANTPDDLTAVNH
AWSMINTVDIP
>Mature_251_residues
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFGNFTTHYGFVGMSHNGNFSDG
MNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTTTVAQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGN
SVVVEFINGKTKIYDNKIKVLTNDPAYDEQLKLLKKYQDHEIKEDKFIAFYYSPQGRFAKMVAFNTTKANTPDDLTAVNH
AWSMINTVDIP

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 28582; Mature: 28582

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFG
CCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCC
NFTTHYGFVGMSHNGNFSDGMNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTT
CEEEEEEEEEECCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCEEEEEEEEEHHCCCH
TVAQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGNSVVVEFINGKTKIYDNKIKV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEECCCEEEECCEEEE
LTNDPAYDEQLKLLKKYQDHEIKEDKFIAFYYSPQGRFAKMVAFNTTKANTPDDLTAVNH
EECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHH
AWSMINTVDIP
HHHHEEEECCC
>Mature Secondary Structure
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFG
CCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCC
NFTTHYGFVGMSHNGNFSDGMNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTT
CEEEEEEEEEECCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCEEEEEEEEEHHCCCH
TVAQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGNSVVVEFINGKTKIYDNKIKV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEECCCEEEECCEEEE
LTNDPAYDEQLKLLKKYQDHEIKEDKFIAFYYSPQGRFAKMVAFNTTKANTPDDLTAVNH
EECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHH
AWSMINTVDIP
HHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]