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The map label for this gene is iolA1 [H]

Identifier: 89256350

GI number: 89256350

Start: 972468

End: 972929

Strand: Direct

Name: iolA1 [H]

Synonym: FTL_1009

Alternate gene names: 89256350

Gene position: 972468-972929 (Clockwise)

Preceding gene: 89256349

Following gene: 89256351

Centisome position: 51.29

GC content: 37.88

Gene sequence:

>462_bases
ATGAGTATTTTAAAAGAGCTAGATTTAGGTTTACAAGCATATATCACTAACGATACTAATAACGTTATAGAAACTTTAAA
TCCTGCAACTGGTGAGCTATTAGCTAAAGTTAGAAACCAAAGTGTAACTACTGTGCAGGAGGCTATAGTAAAAGCTACAG
AAGTTGCTAAGCAATGGCGACAAGTTCCTGCACCTAAAAGAGGCGAGTTGGTTAGACTTATCGGTGAGGAATTACATAGA
AACAAAGATCATCTAGGTAGTCTAGTATCTCTTGAGATGGGTAAATCTAAACAAGAGGGTGATGGTGAAGTCCAGGAAAT
GATAGATATGGCAGATTTTGCTGTAGGACAATCGCGTATGCTTTATGGAATGATGATGAATTCTGAGCGCCATAATCATA
GAATGTATGAGCAATGGCATCCACTAGGTGTTGTTGGAGTTATCTCGGCTTTTAACAAATGA

Upstream 100 bases:

>100_bases
CAAGAATCAATATGCCTAAAAGATTTTTATAATAATAGATTTGGTCAATATTACAAAAAATCTGGACTATTAATACAAGC
AGATTAATATAGGGGGGAGC

Downstream 100 bases:

>100_bases
ATTCTCAGAGGAATTACAGCAGACACTAAAAAGATGTGTTGATCTAATGCCACAGCAATTGCTGAATAATCCAGAAAATT
TACTATTATCTGGTGTAAGC

Product: aldehyde dehydrogenase

Products: NA

Alternate protein names: MMSA dehydrogenase 1; MMSDH 1; MSDH 1; Malonate semialdehyde dehydrogenase [acetylating] 1; MSA dehydrogenase 1 [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MSILKELDLGLQAYITNDTNNVIETLNPATGELLAKVRNQSVTTVQEAIVKATEVAKQWRQVPAPKRGELVRLIGEELHR
NKDHLGSLVSLEMGKSKQEGDGEVQEMIDMADFAVGQSRMLYGMMMNSERHNHRMYEQWHPLGVVGVISAFNK

Sequences:

>Translated_153_residues
MSILKELDLGLQAYITNDTNNVIETLNPATGELLAKVRNQSVTTVQEAIVKATEVAKQWRQVPAPKRGELVRLIGEELHR
NKDHLGSLVSLEMGKSKQEGDGEVQEMIDMADFAVGQSRMLYGMMMNSERHNHRMYEQWHPLGVVGVISAFNK
>Mature_152_residues
SILKELDLGLQAYITNDTNNVIETLNPATGELLAKVRNQSVTTVQEAIVKATEVAKQWRQVPAPKRGELVRLIGEELHRN
KDHLGSLVSLEMGKSKQEGDGEVQEMIDMADFAVGQSRMLYGMMMNSERHNHRMYEQWHPLGVVGVISAFNK

Specific function: Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family. IolA subfamily [H]

Homologues:

Organism=Homo sapiens, GI310128099, Length=131, Percent_Identity=54.1984732824427, Blast_Score=144, Evalue=2e-35,
Organism=Homo sapiens, GI310128101, Length=131, Percent_Identity=54.1984732824427, Blast_Score=144, Evalue=3e-35,
Organism=Homo sapiens, GI310128087, Length=131, Percent_Identity=54.1984732824427, Blast_Score=143, Evalue=7e-35,
Organism=Homo sapiens, GI310128093, Length=131, Percent_Identity=54.1984732824427, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI188035924, Length=131, Percent_Identity=54.1984732824427, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI310128103, Length=131, Percent_Identity=54.1984732824427, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI310128091, Length=131, Percent_Identity=41.9847328244275, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1789015, Length=137, Percent_Identity=26.2773722627737, Blast_Score=60, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115534176, Length=134, Percent_Identity=50, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17534119, Length=152, Percent_Identity=29.6052631578947, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319478, Length=134, Percent_Identity=29.8507462686567, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666674, Length=130, Percent_Identity=56.1538461538462, Blast_Score=149, Evalue=5e-37,
Organism=Drosophila melanogaster, GI281362580, Length=139, Percent_Identity=25.8992805755396, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62472918, Length=139, Percent_Identity=25.8992805755396, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62472926, Length=139, Percent_Identity=25.8992805755396, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62472936, Length=139, Percent_Identity=25.8992805755396, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356737, Length=139, Percent_Identity=25.8992805755396, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR010061 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.27; =1.2.1.18 [H]

Molecular weight: Translated: 17188; Mature: 17057

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILKELDLGLQAYITNDTNNVIETLNPATGELLAKVRNQSVTTVQEAIVKATEVAKQWR
CCHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QVPAPKRGELVRLIGEELHRNKDHLGSLVSLEMGKSKQEGDGEVQEMIDMADFAVGQSRM
HCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHH
LYGMMMNSERHNHRMYEQWHPLGVVGVISAFNK
HHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SILKELDLGLQAYITNDTNNVIETLNPATGELLAKVRNQSVTTVQEAIVKATEVAKQWR
CHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QVPAPKRGELVRLIGEELHRNKDHLGSLVSLEMGKSKQEGDGEVQEMIDMADFAVGQSRM
HCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHH
LYGMMMNSERHNHRMYEQWHPLGVVGVISAFNK
HHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA