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The map label for this gene is lldD [H]

Identifier: 89256319

GI number: 89256319

Start: 938212

End: 939381

Strand: Direct

Name: lldD [H]

Synonym: FTL_0970

Alternate gene names: 89256319

Gene position: 938212-939381 (Clockwise)

Preceding gene: 89256318

Following gene: 89256320

Centisome position: 49.48

GC content: 32.39

Gene sequence:

>1170_bases
ATGGCTTGCAAATATAGGAAAATTGCTATGAAAATAAATAATATTTATGATATTACAGATATGCATAAAGCAGCTAAAAA
GAGATTGCCAAGAGTTTTTTTAGACTATATTGATAGCGGCTCATATCAGCAACAAACAGTCTATGAGAATGAGCAAGCGT
TTAGAAAAATTAGAATAAATCAAAGCGCATTTAAAGATTGTAGTCAGAGAAACCAAACTATAGAGATATTTGGTTTCAAA
TCTAGTGTTCCATTTGCAATAGCACCAACAGGCTTAGCTGGGATGTTTTGGCCGAAAGGTGAAATAGCATTAGCCTTAGC
TGCTGAAAAATTAGATATTGCATATACAATGAGTACTATGGCTATTTGTTCTTTAGAAACGGTAGCAAAAGAAGCTAATA
ATCATTTTTGGTTTCAACTCTATCTTATGAAAGATAGAGGATTTACTAAGTCGTTACTTGAAAGAGCAAAGGCTTGTGGT
TGTCAGACAATTTTTGTTAATGCTGATTTACCAGTAAGTGGTATTAGATATAGTGATATGCGTAATGGTTTATCAATTCC
TCCTAAATTTGGAATTAGGGATATAATTAATATTACAGCTAAACAAAGTTGGGTTTGGGGATATTTATTAAGTAAATACA
AACAGTTTGGTAATTTAAGTGGTCATATTCCAACTGGTGCTAAAGGGATGAAAAGTGTTACAGATTTTATGGACTCACAA
TTTGATCAAAGTGTCACTTGGAAGGATATAGAGTGGTTAAGAAATATTTGGGATGGTAATTTGATAATAAAAGGTCTTTT
AAATACACAAGGTGCTGAAAATGCAGTAAAGGTTGGTGCTGATGGTATTGTTGTATCTAATCATGGAGGAAGACAACTTG
ATGGTGTGTTACCAACTATAGAAGCTTTGCCAGCAATATCTGATAAAGTAAAAGGTGATATAAAAATAATTTTAGACAGT
GGTATTAGATCGGATCAAGATATCATAAAAGCTTTAGCCTTAGGTGCGGATTTTACTTTGGTTGGTAGACCATTTCTATA
TGGATTGTCAGCATTCGGTCAAAAAGGTGTAGAAAAAGTTTATGACATACTCAAAAAAGAGATAGATAATACTATGGCAT
TAGCAGGAATTTCAGATTTAAATAATATTTCAACTGATGTTGTAGTTTAG

Upstream 100 bases:

>100_bases
GATGTCTCTAAAATCTTGGCTATATGATGGCATTTTTATTAGACATTATAACATTTCTACAAATATCTTTTTCTACAAAT
ATCTTTCGGATTAACTATAT

Downstream 100 bases:

>100_bases
TAAATTAGACAGGTAAATTATTATGCAAATAATAACTGTAAGTGAGTATTTAAGAACAAGATTAAGTGAGTTAGGAATAA
AAGATATAATAGGTGTTGCT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MACKYRKIAMKINNIYDITDMHKAAKKRLPRVFLDYIDSGSYQQQTVYENEQAFRKIRINQSAFKDCSQRNQTIEIFGFK
SSVPFAIAPTGLAGMFWPKGEIALALAAEKLDIAYTMSTMAICSLETVAKEANNHFWFQLYLMKDRGFTKSLLERAKACG
CQTIFVNADLPVSGIRYSDMRNGLSIPPKFGIRDIINITAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQ
FDQSVTWKDIEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHGGRQLDGVLPTIEALPAISDKVKGDIKIILDS
GIRSDQDIIKALALGADFTLVGRPFLYGLSAFGQKGVEKVYDILKKEIDNTMALAGISDLNNISTDVVV

Sequences:

>Translated_389_residues
MACKYRKIAMKINNIYDITDMHKAAKKRLPRVFLDYIDSGSYQQQTVYENEQAFRKIRINQSAFKDCSQRNQTIEIFGFK
SSVPFAIAPTGLAGMFWPKGEIALALAAEKLDIAYTMSTMAICSLETVAKEANNHFWFQLYLMKDRGFTKSLLERAKACG
CQTIFVNADLPVSGIRYSDMRNGLSIPPKFGIRDIINITAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQ
FDQSVTWKDIEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHGGRQLDGVLPTIEALPAISDKVKGDIKIILDS
GIRSDQDIIKALALGADFTLVGRPFLYGLSAFGQKGVEKVYDILKKEIDNTMALAGISDLNNISTDVVV
>Mature_388_residues
ACKYRKIAMKINNIYDITDMHKAAKKRLPRVFLDYIDSGSYQQQTVYENEQAFRKIRINQSAFKDCSQRNQTIEIFGFKS
SVPFAIAPTGLAGMFWPKGEIALALAAEKLDIAYTMSTMAICSLETVAKEANNHFWFQLYLMKDRGFTKSLLERAKACGC
QTIFVNADLPVSGIRYSDMRNGLSIPPKFGIRDIINITAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQF
DQSVTWKDIEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHGGRQLDGVLPTIEALPAISDKVKGDIKIILDSG
IRSDQDIIKALALGADFTLVGRPFLYGLSAFGQKGVEKVYDILKKEIDNTMALAGISDLNNISTDVVV

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=372, Percent_Identity=34.6774193548387, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI54234014, Length=372, Percent_Identity=35.4838709677419, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI7705393, Length=372, Percent_Identity=35.4838709677419, Blast_Score=229, Evalue=5e-60,
Organism=Escherichia coli, GI1790033, Length=374, Percent_Identity=41.4438502673797, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI193208036, Length=377, Percent_Identity=32.0954907161804, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32566217, Length=288, Percent_Identity=30.5555555555556, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=388, Percent_Identity=29.8969072164948, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281363140, Length=373, Percent_Identity=36.9973190348526, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI78707190, Length=373, Percent_Identity=36.9973190348526, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI78707188, Length=373, Percent_Identity=36.9973190348526, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 43195; Mature: 43064

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACKYRKIAMKINNIYDITDMHKAAKKRLPRVFLDYIDSGSYQQQTVYENEQAFRKIRIN
CCCCHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
QSAFKDCSQRNQTIEIFGFKSSVPFAIAPTGLAGMFWPKGEIALALAAEKLDIAYTMSTM
HHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
AICSLETVAKEANNHFWFQLYLMKDRGFTKSLLERAKACGCQTIFVNADLPVSGIRYSDM
HHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHH
RNGLSIPPKFGIRDIINITAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQ
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
FDQSVTWKDIEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHGGRQLDGVLPTI
HCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCHHH
EALPAISDKVKGDIKIILDSGIRSDQDIIKALALGADFTLVGRPFLYGLSAFGQKGVEKV
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHH
YDILKKEIDNTMALAGISDLNNISTDVVV
HHHHHHHHCCCEEEECCHHHCCCCCCCCC
>Mature Secondary Structure 
ACKYRKIAMKINNIYDITDMHKAAKKRLPRVFLDYIDSGSYQQQTVYENEQAFRKIRIN
CCCHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
QSAFKDCSQRNQTIEIFGFKSSVPFAIAPTGLAGMFWPKGEIALALAAEKLDIAYTMSTM
HHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
AICSLETVAKEANNHFWFQLYLMKDRGFTKSLLERAKACGCQTIFVNADLPVSGIRYSDM
HHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHH
RNGLSIPPKFGIRDIINITAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQ
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
FDQSVTWKDIEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHGGRQLDGVLPTI
HCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCCHHH
EALPAISDKVKGDIKIILDSGIRSDQDIIKALALGADFTLVGRPFLYGLSAFGQKGVEKV
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHH
YDILKKEIDNTMALAGISDLNNISTDVVV
HHHHHHHHCCCEEEECCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA