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The map label for this gene is tyrS [H]

Identifier: 89256317

GI number: 89256317

Start: 935670

End: 936860

Strand: Direct

Name: tyrS [H]

Synonym: FTL_0968

Alternate gene names: 89256317

Gene position: 935670-936860 (Clockwise)

Preceding gene: 89256315

Following gene: 89256318

Centisome position: 49.35

GC content: 34.51

Gene sequence:

>1191_bases
ATGTCGAGCATAAAAGAGACTTTAGAAATTATCAAAAGAGGGGCGGATGAGGTCCTAATCGAAGAAGAATTAATCAAAAA
GTTACAAAAACATAAGCCATTAATAATTAAATTTGGTTGCGACCCAACTGCTCCAGATATTCATTTGGGACATACTGTAG
TTATCAATAAGCTAAAGCAATTACAAGATTTGGGACATGAAATTCACTTTTTGATCGGGGATTTTACAGCTCAGATAGGT
GATCCTACAGGTAAAAATGCAACAAGACCGCCATTAACTACCGAAGAAGTTGCGGCAAATGCTGAAACTTATACTAAGCA
AGTATTTAAGATTCTTGATAAAGACAAAACTGTTATTCGTCGTAATGGTGATTGGTTTAACAAAATGTCTGCTAGTGAGA
TGATCAAACTAGCTTCTAAATCAACGGTTGCAAGAATGCTTGAAAGAGATGATTTCTCAAAAAGATATAAAGGCGGACAG
TCGATCTCAATACATGAGTTTTTATATCCATTAGTACAAGGATATGATTCTGTAGCTATGAATGCTGATATTGAGCTTGG
AGGTACAGATCAAAAATTTAACCTACTAATGGGTAGAGAGCTGCAAAAGCAGCAGGGTCAAGAACCACAAGTTATTATCA
CAATGCCACTTTTAGAAGGTTTAGATGGCGTCAAAAAAATGTCTAAATCAAGCCAAAACTATATCGGTATCGAAGAACCA
GCAAATGAAATCTTTGGTAAGATAATGTCAATTTCAGATGAACTTATGTGGCGCTATTATGAATTACTAAGTTTCAAATC
TTTAGAAAATATCGCTAAATTAAAGCAAGATGTTGCAGCTGGAGCTAATCCGCGCGATATTAAGATAGAGCTGGCAAAAG
AGTTAATTGAAAGGTTTCACTCTAAAGAAGATGCTGAGAGTGCGCACCAGGATTTTATTCAAAGATTCCAAAAAAATCAG
ATACCTGATGATATAAATGTTGTAGAATTAAACCAAGAGCTACCGATAGCAAACTTATTAAAAGAAGCAGGCTTAGTTGC
AAGTACTTCTGAAGCTAATCGTATGATTCAGCAAGGTGCTGTTAAAATAGATGGTGAAAAGCTTAGTGATGCTAAGATTA
TTTTTGCTAAAGGAACAAATAATGTTTTCCAAGTAGGAAAACGTAAATTTGCAAAAATTATTATAAAATGA

Upstream 100 bases:

>100_bases
TTTTTACTTTCTAATAAGTATAAGGTTTTATTGGTTCTATAAAAGAGTTTTGTGTTATAATTTTGCTTTATTGAGAGAAA
TTTTTAATATTATAAATATA

Downstream 100 bases:

>100_bases
GGGGTTGTAAGATGGATAAGTTTTTATCAATATTTGTTGGCGTATTAATCATAGTAACTATTGTAACTATATTTATTCAC
CTGTTTCCTATAGCTATAAA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSSIKETLEIIKRGADEVLIEEELIKKLQKHKPLIIKFGCDPTAPDIHLGHTVVINKLKQLQDLGHEIHFLIGDFTAQIG
DPTGKNATRPPLTTEEVAANAETYTKQVFKILDKDKTVIRRNGDWFNKMSASEMIKLASKSTVARMLERDDFSKRYKGGQ
SISIHEFLYPLVQGYDSVAMNADIELGGTDQKFNLLMGRELQKQQGQEPQVIITMPLLEGLDGVKKMSKSSQNYIGIEEP
ANEIFGKIMSISDELMWRYYELLSFKSLENIAKLKQDVAAGANPRDIKIELAKELIERFHSKEDAESAHQDFIQRFQKNQ
IPDDINVVELNQELPIANLLKEAGLVASTSEANRMIQQGAVKIDGEKLSDAKIIFAKGTNNVFQVGKRKFAKIIIK

Sequences:

>Translated_396_residues
MSSIKETLEIIKRGADEVLIEEELIKKLQKHKPLIIKFGCDPTAPDIHLGHTVVINKLKQLQDLGHEIHFLIGDFTAQIG
DPTGKNATRPPLTTEEVAANAETYTKQVFKILDKDKTVIRRNGDWFNKMSASEMIKLASKSTVARMLERDDFSKRYKGGQ
SISIHEFLYPLVQGYDSVAMNADIELGGTDQKFNLLMGRELQKQQGQEPQVIITMPLLEGLDGVKKMSKSSQNYIGIEEP
ANEIFGKIMSISDELMWRYYELLSFKSLENIAKLKQDVAAGANPRDIKIELAKELIERFHSKEDAESAHQDFIQRFQKNQ
IPDDINVVELNQELPIANLLKEAGLVASTSEANRMIQQGAVKIDGEKLSDAKIIFAKGTNNVFQVGKRKFAKIIIK
>Mature_395_residues
SSIKETLEIIKRGADEVLIEEELIKKLQKHKPLIIKFGCDPTAPDIHLGHTVVINKLKQLQDLGHEIHFLIGDFTAQIGD
PTGKNATRPPLTTEEVAANAETYTKQVFKILDKDKTVIRRNGDWFNKMSASEMIKLASKSTVARMLERDDFSKRYKGGQS
ISIHEFLYPLVQGYDSVAMNADIELGGTDQKFNLLMGRELQKQQGQEPQVIITMPLLEGLDGVKKMSKSSQNYIGIEEPA
NEIFGKIMSISDELMWRYYELLSFKSLENIAKLKQDVAAGANPRDIKIELAKELIERFHSKEDAESAHQDFIQRFQKNQI
PDDINVVELNQELPIANLLKEAGLVASTSEANRMIQQGAVKIDGEKLSDAKIIFAKGTNNVFQVGKRKFAKIIIK

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=411, Percent_Identity=25.3041362530414, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1787925, Length=431, Percent_Identity=27.1461716937355, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25145802, Length=367, Percent_Identity=24.7956403269755, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325160, Length=388, Percent_Identity=25, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI20130383, Length=400, Percent_Identity=22.5, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 44594; Mature: 44463

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIKETLEIIKRGADEVLIEEELIKKLQKHKPLIIKFGCDPTAPDIHLGHTVVINKLKQ
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
LQDLGHEIHFLIGDFTAQIGDPTGKNATRPPLTTEEVAANAETYTKQVFKILDKDKTVIR
HHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCEEE
RNGDWFNKMSASEMIKLASKSTVARMLERDDFSKRYKGGQSISIHEFLYPLVQGYDSVAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEHHHHHHHHHHCCCHHEE
NADIELGGTDQKFNLLMGRELQKQQGQEPQVIITMPLLEGLDGVKKMSKSSQNYIGIEEP
CCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHHHHCCCCCCCCCCH
ANEIFGKIMSISDELMWRYYELLSFKSLENIAKLKQDVAAGANPRDIKIELAKELIERFH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SKEDAESAHQDFIQRFQKNQIPDDINVVELNQELPIANLLKEAGLVASTSEANRMIQQGA
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHCC
VKIDGEKLSDAKIIFAKGTNNVFQVGKRKFAKIIIK
EEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSIKETLEIIKRGADEVLIEEELIKKLQKHKPLIIKFGCDPTAPDIHLGHTVVINKLKQ
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
LQDLGHEIHFLIGDFTAQIGDPTGKNATRPPLTTEEVAANAETYTKQVFKILDKDKTVIR
HHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCEEE
RNGDWFNKMSASEMIKLASKSTVARMLERDDFSKRYKGGQSISIHEFLYPLVQGYDSVAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEHHHHHHHHHHCCCHHEE
NADIELGGTDQKFNLLMGRELQKQQGQEPQVIITMPLLEGLDGVKKMSKSSQNYIGIEEP
CCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHHHHCCCCCCCCCCH
ANEIFGKIMSISDELMWRYYELLSFKSLENIAKLKQDVAAGANPRDIKIELAKELIERFH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SKEDAESAHQDFIQRFQKNQIPDDINVVELNQELPIANLLKEAGLVASTSEANRMIQQGA
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHCC
VKIDGEKLSDAKIIFAKGTNNVFQVGKRKFAKIIIK
EEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA