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The map label for this gene is sthA [H]

Identifier: 89256309

GI number: 89256309

Start: 927498

End: 928898

Strand: Reverse

Name: sthA [H]

Synonym: FTL_0960

Alternate gene names: 89256309

Gene position: 928898-927498 (Counterclockwise)

Preceding gene: 89256310

Following gene: 89256308

Centisome position: 48.99

GC content: 34.33

Gene sequence:

>1401_bases
ATGGAATATAATTACGATATTATTATTATAGGCAGTGGTCCTGGTGGTGAAGGGGCTGCGATGAAAGCAACTAGGAACGG
ACAAAAAGTAGCTATCATCGAAGATGACGCTATTGGTGGTGGTTGTAATAACTGGGGAACAATTCCAAGTAAAGCTCTAA
GACAGCTATCACGTGAAGTTTGGTACAACAAGAAGAATTTCGATTTCCCAGAGATGCTTGATACTGCTTATGAAATAGTT
ATCAAACAAAGAGAGATTAAGAGAAATCGTTTCGCTAATAATGAAATTGATGTTTTCTATGGTTTTGCTAGTTTTATCGA
CAAGCATAAAATAAAAATTTCACGTAAAAATGGTTCAACTGAAATCATTACGGCAAAAAAATTCATTCTCTCTACAGGAT
CTCGTCCATATCATCCTGATGATATTGACTTTACTCATCCTAGAATTTTGGATAGTGATAAACTTCTAGAGTTGAAAGAC
AAAAATATCAAATCAATTACTATTTATGGTGCTGGTGTAATTGGTTGTGAATATGCATCCATACTTGGAACACTAGATAT
TCAGGTAAATCTTATCAACACTAGAAATAAACTAATGTCGTTCCTTGATGATGAAATTATCGAAACGCTAACAAATCACT
TTACAATTAATCAAAGAATTAATCTAATACATAATGAAACTTATAAAAGTATCAAAGCAAGAGGAGATAAAGTAGTTACT
ACTCTTAACTCAGGTAGAATTATCGAATCTGATTATGTCTTGTTTGCGCTTGGCCGATCAGGTAATACAAATGGCCTTAA
TTTAGATAAAATTGGAGTTGAGTATGACCCACAAAGAGGTCTTGTTAAGGTTAATGACAATTATCAAACTACTCAAGAGA
ATATCTATGCTGTTGGTGATGTTATAGGTTTTCCTTCACTTGCATCATCTGCTTTTAACCAAGGTAGATTTGCAGCTACG
CATATTATAGATGGCTCTTGTAATGACAAATTAGTCGAGGATATCCCAACAGGGATTTATACCCGCCCTGAGATTAGTTG
TATTGGAAAAACAGAAGAGCAATTAACTGCTGAGAATATTCCATATGAAGTTGGTAGAGCATATTTTAAAGATTTAGCTC
GTGCACAAATTTCAGGAAGTGAAACAGGGATGTTAAAGATACTTTTCCATAAAGAAACTCTAGAGATCCTTGGCATTCAC
TGTTTTGGTCATAGGGTATCTGAGATTATCCATATTGGTCAAGCTATCAAATCAATGCCAGGCAAACACAATACTATCAG
ATACTTTTTGAACACTACATTTAACTACCCTACTATGGCTGAGGCTTATCGTATTGCTGGTATTGACGGTCTTAATAAGC
TTAAACCTAAAAATAAACAATTTGTCCCAGAATACCAATAA

Upstream 100 bases:

>100_bases
AATAATTTAACTAAAACTAATCAATATAAGCTTATACTATGTTATTATTTTGACAATGTGTTTGCTGATTTTTTAAGAAA
ATAGAGTGTGGAGTAAAACC

Downstream 100 bases:

>100_bases
TCCATGTACTACGATATCTATATAATTTACTTGTTTATATTTCTATTTGGTGCTGCTATTGGCAGTTTTTTGAATGTTGT
TATATATCGAGTGCCAAATA

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MEYNYDIIIIGSGPGGEGAAMKATRNGQKVAIIEDDAIGGGCNNWGTIPSKALRQLSREVWYNKKNFDFPEMLDTAYEIV
IKQREIKRNRFANNEIDVFYGFASFIDKHKIKISRKNGSTEIITAKKFILSTGSRPYHPDDIDFTHPRILDSDKLLELKD
KNIKSITIYGAGVIGCEYASILGTLDIQVNLINTRNKLMSFLDDEIIETLTNHFTINQRINLIHNETYKSIKARGDKVVT
TLNSGRIIESDYVLFALGRSGNTNGLNLDKIGVEYDPQRGLVKVNDNYQTTQENIYAVGDVIGFPSLASSAFNQGRFAAT
HIIDGSCNDKLVEDIPTGIYTRPEISCIGKTEEQLTAENIPYEVGRAYFKDLARAQISGSETGMLKILFHKETLEILGIH
CFGHRVSEIIHIGQAIKSMPGKHNTIRYFLNTTFNYPTMAEAYRIAGIDGLNKLKPKNKQFVPEYQ

Sequences:

>Translated_466_residues
MEYNYDIIIIGSGPGGEGAAMKATRNGQKVAIIEDDAIGGGCNNWGTIPSKALRQLSREVWYNKKNFDFPEMLDTAYEIV
IKQREIKRNRFANNEIDVFYGFASFIDKHKIKISRKNGSTEIITAKKFILSTGSRPYHPDDIDFTHPRILDSDKLLELKD
KNIKSITIYGAGVIGCEYASILGTLDIQVNLINTRNKLMSFLDDEIIETLTNHFTINQRINLIHNETYKSIKARGDKVVT
TLNSGRIIESDYVLFALGRSGNTNGLNLDKIGVEYDPQRGLVKVNDNYQTTQENIYAVGDVIGFPSLASSAFNQGRFAAT
HIIDGSCNDKLVEDIPTGIYTRPEISCIGKTEEQLTAENIPYEVGRAYFKDLARAQISGSETGMLKILFHKETLEILGIH
CFGHRVSEIIHIGQAIKSMPGKHNTIRYFLNTTFNYPTMAEAYRIAGIDGLNKLKPKNKQFVPEYQ
>Mature_466_residues
MEYNYDIIIIGSGPGGEGAAMKATRNGQKVAIIEDDAIGGGCNNWGTIPSKALRQLSREVWYNKKNFDFPEMLDTAYEIV
IKQREIKRNRFANNEIDVFYGFASFIDKHKIKISRKNGSTEIITAKKFILSTGSRPYHPDDIDFTHPRILDSDKLLELKD
KNIKSITIYGAGVIGCEYASILGTLDIQVNLINTRNKLMSFLDDEIIETLTNHFTINQRINLIHNETYKSIKARGDKVVT
TLNSGRIIESDYVLFALGRSGNTNGLNLDKIGVEYDPQRGLVKVNDNYQTTQENIYAVGDVIGFPSLASSAFNQGRFAAT
HIIDGSCNDKLVEDIPTGIYTRPEISCIGKTEEQLTAENIPYEVGRAYFKDLARAQISGSETGMLKILFHKETLEILGIH
CFGHRVSEIIHIGQAIKSMPGKHNTIRYFLNTTFNYPTMAEAYRIAGIDGLNKLKPKNKQFVPEYQ

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=468, Percent_Identity=29.9145299145299, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=27.2532188841202, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI22035672, Length=428, Percent_Identity=25.2336448598131, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI33519430, Length=448, Percent_Identity=27.9017857142857, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI33519428, Length=448, Percent_Identity=27.9017857142857, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI33519426, Length=448, Percent_Identity=27.9017857142857, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI148277065, Length=482, Percent_Identity=27.5933609958506, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI148277071, Length=448, Percent_Identity=27.9017857142857, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI291045266, Length=482, Percent_Identity=26.5560165975104, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI291045268, Length=356, Percent_Identity=27.5280898876405, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=53.448275862069, Blast_Score=506, Evalue=1e-145,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=28.7878787878788, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789915, Length=461, Percent_Identity=29.2841648590022, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87081717, Length=443, Percent_Identity=26.410835214447, Blast_Score=119, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=28.2937365010799, Blast_Score=185, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17557007, Length=462, Percent_Identity=26.1904761904762, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=389, Percent_Identity=27.2493573264781, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=347, Percent_Identity=25.6484149855908, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71983419, Length=347, Percent_Identity=25.6484149855908, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321091, Length=483, Percent_Identity=29.6066252587992, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=483, Percent_Identity=26.7080745341615, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6325166, Length=472, Percent_Identity=26.4830508474576, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21358499, Length=475, Percent_Identity=29.6842105263158, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI24640549, Length=490, Percent_Identity=27.3469387755102, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24640553, Length=490, Percent_Identity=27.3469387755102, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24640551, Length=491, Percent_Identity=27.4949083503055, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17737741, Length=492, Percent_Identity=25.4065040650407, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 52299; Mature: 52299

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNYDIIIIGSGPGGEGAAMKATRNGQKVAIIEDDAIGGGCNNWGTIPSKALRQLSREV
CCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
WYNKKNFDFPEMLDTAYEIVIKQREIKRNRFANNEIDVFYGFASFIDKHKIKISRKNGST
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCEEEEEECCCCE
EIITAKKFILSTGSRPYHPDDIDFTHPRILDSDKLLELKDKNIKSITIYGAGVIGCEYAS
EEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCEEHHHHHH
ILGTLDIQVNLINTRNKLMSFLDDEIIETLTNHFTINQRINLIHNETYKSIKARGDKVVT
HHEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCEEECCEEEEEEHHHHHHHHHCCCEEEE
TLNSGRIIESDYVLFALGRSGNTNGLNLDKIGVEYDPQRGLVKVNDNYQTTQENIYAVGD
EECCCEEEECCEEEEEECCCCCCCCEEEEEECCEECCCCCEEEECCCCCCCCCCEEEEHH
VIGFPSLASSAFNQGRFAATHIIDGSCNDKLVEDIPTGIYTRPEISCIGKTEEQLTAENI
HHCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCEEECCCCHHHHHHCCC
PYEVGRAYFKDLARAQISGSETGMLKILFHKETLEILGIHCFGHRVSEIIHIGQAIKSMP
CHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEHEEEHHHHHHHHHHHHHHHHHHHCC
GKHNTIRYFLNTTFNYPTMAEAYRIAGIDGLNKLKPKNKQFVPEYQ
CCCCEEEEEEECCCCCCCHHHHHEECCCCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEYNYDIIIIGSGPGGEGAAMKATRNGQKVAIIEDDAIGGGCNNWGTIPSKALRQLSREV
CCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
WYNKKNFDFPEMLDTAYEIVIKQREIKRNRFANNEIDVFYGFASFIDKHKIKISRKNGST
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCEEEEEECCCCE
EIITAKKFILSTGSRPYHPDDIDFTHPRILDSDKLLELKDKNIKSITIYGAGVIGCEYAS
EEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCEEHHHHHH
ILGTLDIQVNLINTRNKLMSFLDDEIIETLTNHFTINQRINLIHNETYKSIKARGDKVVT
HHEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCEEECCEEEEEEHHHHHHHHHCCCEEEE
TLNSGRIIESDYVLFALGRSGNTNGLNLDKIGVEYDPQRGLVKVNDNYQTTQENIYAVGD
EECCCEEEECCEEEEEECCCCCCCCEEEEEECCEECCCCCEEEECCCCCCCCCCEEEEHH
VIGFPSLASSAFNQGRFAATHIIDGSCNDKLVEDIPTGIYTRPEISCIGKTEEQLTAENI
HHCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCEEECCCCHHHHHHCCC
PYEVGRAYFKDLARAQISGSETGMLKILFHKETLEILGIHCFGHRVSEIIHIGQAIKSMP
CHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEHEEEHHHHHHHHHHHHHHHHHHHCC
GKHNTIRYFLNTTFNYPTMAEAYRIAGIDGLNKLKPKNKQFVPEYQ
CCCCEEEEEEECCCCCCCHHHHHEECCCCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA