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The map label for this gene is rnhA [H]

Identifier: 89256214

GI number: 89256214

Start: 835373

End: 835831

Strand: Direct

Name: rnhA [H]

Synonym: FTL_0854

Alternate gene names: 89256214

Gene position: 835373-835831 (Clockwise)

Preceding gene: 89256213

Following gene: 89256215

Centisome position: 44.06

GC content: 37.04

Gene sequence:

>459_bases
ATGGAAATTTTCAAAAAGAAAAATAGGGTCATTGCCTACACAGATGGTGCTTGTAAAGGCAATCCTGGAATTGGCGGCTG
GGGAGCTATCCTTAGTTATAATGGTGTAGATAAAGAGATATATGGTAGTGAAAAAGATACTACAAATAATAGAATGGAGC
TAATGGCCGCAATCAAAACGCTCCAAGCGCTTAAAAGAAAGTGTGATATAACAATTTATACTGATTCTAAATATCTTCAA
AATGGTATTAATGAATGGTTAGCAAATTGGAAAGCTAATGGTTGGAAAACAGCAGCCAAGAAAGAAGTCAAAAATAAAGA
TCTCTGGCAAGAGCTTGATAGTCTGACAAATAAGCATAATGTAACATGGGGCTGGGTAAAGGGTCACAGTGGTAATGCTG
GCAATGAAAAGGCGGATGAGTTAGCAAACAAAGCTATTGCTGAGCTAATAGGGAAATAA

Upstream 100 bases:

>100_bases
AAAGATAATTATTTTAGGGTTGACCCTTTGAATGTCAGCGAACTTGTTGATAAACCATTAAAGGCTAAAGTCTATAGTGG
TGGTTGCGCTAGGGAAATAT

Downstream 100 bases:

>100_bases
AATGAAAGATCTTGAAAATCGTGCTAATAAAAAAATTTTAGTTCTATATACTGGTGGTACTATAGGTATGGTTAGTACTG
AACAAGGCTATGATGTCAAA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MEIFKKKNRVIAYTDGACKGNPGIGGWGAILSYNGVDKEIYGSEKDTTNNRMELMAAIKTLQALKRKCDITIYTDSKYLQ
NGINEWLANWKANGWKTAAKKEVKNKDLWQELDSLTNKHNVTWGWVKGHSGNAGNEKADELANKAIAELIGK

Sequences:

>Translated_152_residues
MEIFKKKNRVIAYTDGACKGNPGIGGWGAILSYNGVDKEIYGSEKDTTNNRMELMAAIKTLQALKRKCDITIYTDSKYLQ
NGINEWLANWKANGWKTAAKKEVKNKDLWQELDSLTNKHNVTWGWVKGHSGNAGNEKADELANKAIAELIGK
>Mature_152_residues
MEIFKKKNRVIAYTDGACKGNPGIGGWGAILSYNGVDKEIYGSEKDTTNNRMELMAAIKTLQALKRKCDITIYTDSKYLQ
NGINEWLANWKANGWKTAAKKEVKNKDLWQELDSLTNKHNVTWGWVKGHSGNAGNEKADELANKAIAELIGK

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=144, Percent_Identity=41.6666666666667, Blast_Score=95, Evalue=3e-20,
Organism=Escherichia coli, GI1786408, Length=137, Percent_Identity=55.4744525547445, Blast_Score=165, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI115532542, Length=151, Percent_Identity=40.3973509933775, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17505482, Length=130, Percent_Identity=36.1538461538462, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45552509, Length=148, Percent_Identity=38.5135135135135, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137476, Length=148, Percent_Identity=38.5135135135135, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16976; Mature: 16976

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFKKKNRVIAYTDGACKGNPGIGGWGAILSYNGVDKEIYGSEKDTTNNRMELMAAIKT
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHEECCCCCHHHCCCCCCCCHHHHHHHHHHHH
LQALKRKCDITIYTDSKYLQNGINEWLANWKANGWKTAAKKEVKNKDLWQELDSLTNKHN
HHHHHHHCCEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCC
VTWGWVKGHSGNAGNEKADELANKAIAELIGK
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIFKKKNRVIAYTDGACKGNPGIGGWGAILSYNGVDKEIYGSEKDTTNNRMELMAAIKT
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHEECCCCCHHHCCCCCCCCHHHHHHHHHHHH
LQALKRKCDITIYTDSKYLQNGINEWLANWKANGWKTAAKKEVKNKDLWQELDSLTNKHN
HHHHHHHCCEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCC
VTWGWVKGHSGNAGNEKADELANKAIAELIGK
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA