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The map label for this gene is cbh [H]

Identifier: 89256099

GI number: 89256099

Start: 700348

End: 701301

Strand: Reverse

Name: cbh [H]

Synonym: FTL_0710

Alternate gene names: 89256099

Gene position: 701301-700348 (Counterclockwise)

Preceding gene: 89256102

Following gene: 89256097

Centisome position: 36.99

GC content: 31.13

Gene sequence:

>954_bases
ATGGAGTGGGGATTTAATTGGAGCTGGCAACTCATTTATATACCCAAAGGAACAAAACACTATCTAAGTGCACCAAGTAA
TTTAAACTTAGCTAAAATTAGCTATGCCTCTAAATACTCAATAATTGCTACTGGGCTTGTCAATGCTAATCAAGAATTTT
TAGTTGATGGCCAGAATGATCAAGGTCTTAGTATTAGTGCAAACTATATGCCAGGATTTGCCGAATATCAAAAAGTAACC
AATACAGATAAAAAATATGCCTCTATAAATCAAATTAGTACATTAATCTTAAGCGAGTATGCCAATGTAGAGCAAGTCAA
ACAAGCTCTACAACAATACAAAGTCTGGTCAGATAAAAGTACTATGATTAATGGAGTTGCGCCACAATTACACTTTTTAA
TTACTGATAGAAATGGTAAAGGGCTAGTTGTTGAATATATAAAAGGAGAAGTAAAATTATATGATGTCAATTCAAATGTC
AAAGTAATGACAAATGCTCCTACTTATGATTGGCATCTTATAAACTTGCGAAATTACTTAAATTTAAGTAATCAAACAAC
AACTAGAGTGAAAATAAGTGATGCTATAGATCCTTCACAAAACAAAGATATCCAAGATATAAACTCACTTGGTCAGGGTA
ATGGCTTTTTAGGCTTACCTGGAGACTATTCGCCACCATCAAGATTTATCAAGACGGCAATACTTAGATATTATGCTAAT
AATAAATGTGATAATAATGAAAATCTTGTCACTAAAGTTACCCATATCCTTAATAACGTTGATATAACTAAGGGAACAGT
TACTGAAAAGCTTGGAAATCAGACAATGTTTGATCATACTGCATTTACAGTAATAAAAGACCTTAACAATAATAAGCTTT
ATATTAAAAGCTATAATTCCCCTAATAATGCTGTGGAAATTGATTTAAATACAAAATACATTAGATCAAAATAA

Upstream 100 bases:

>100_bases
ATTTTGTCTGTTGTAGCGCTTTATTGATGCTAATTTCACAGTCACTTGCATCACTGCTCTGACATTAGTTTAAAATGGTC
AAACCGTTTCTGGTAGAACT

Downstream 100 bases:

>100_bases
TTCTAAGCAGTTTGCTATCGATATAGACAAGTTACCTTATCCAAATAATAATATATCGGCTAATCTTATCACCTAGTTAA
GATCTTTTTTTAGCTAAAAG

Product: choloylglycine hydrolase family protein

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISYASKYSIIATGLVNANQEFLVDGQNDQGLSISANYMPGFAEYQKVT
NTDKKYASINQISTLILSEYANVEQVKQALQQYKVWSDKSTMINGVAPQLHFLITDRNGKGLVVEYIKGEVKLYDVNSNV
KVMTNAPTYDWHLINLRNYLNLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNGFLGLPGDYSPPSRFIKTAILRYYAN
NKCDNNENLVTKVTHILNNVDITKGTVTEKLGNQTMFDHTAFTVIKDLNNNKLYIKSYNSPNNAVEIDLNTKYIRSK

Sequences:

>Translated_317_residues
MEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISYASKYSIIATGLVNANQEFLVDGQNDQGLSISANYMPGFAEYQKVT
NTDKKYASINQISTLILSEYANVEQVKQALQQYKVWSDKSTMINGVAPQLHFLITDRNGKGLVVEYIKGEVKLYDVNSNV
KVMTNAPTYDWHLINLRNYLNLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNGFLGLPGDYSPPSRFIKTAILRYYAN
NKCDNNENLVTKVTHILNNVDITKGTVTEKLGNQTMFDHTAFTVIKDLNNNKLYIKSYNSPNNAVEIDLNTKYIRSK
>Mature_317_residues
MEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISYASKYSIIATGLVNANQEFLVDGQNDQGLSISANYMPGFAEYQKVT
NTDKKYASINQISTLILSEYANVEQVKQALQQYKVWSDKSTMINGVAPQLHFLITDRNGKGLVVEYIKGEVKLYDVNSNV
KVMTNAPTYDWHLINLRNYLNLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNGFLGLPGDYSPPSRFIKTAILRYYAN
NKCDNNENLVTKVTHILNNVDITKGTVTEKLGNQTMFDHTAFTVIKDLNNNKLYIKSYNSPNNAVEIDLNTKYIRSK

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 35818; Mature: 35818

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISYASKYSIIATGLVNANQEFLVDGQND
CCCCCCEEEEEEEECCCCHHHCCCCCCCCEEEEECCCCEEEEEEEEECCCCEEEEECCCC
QGLSISANYMPGFAEYQKVTNTDKKYASINQISTLILSEYANVEQVKQALQQYKVWSDKS
CCCEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
TMINGVAPQLHFLITDRNGKGLVVEYIKGEVKLYDVNSNVKVMTNAPTYDWHLINLRNYL
CEECCCCCEEEEEEECCCCCEEEEEEECCEEEEEEECCCEEEEECCCCCEEEEEEEHHHC
NLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNGFLGLPGDYSPPSRFIKTAILRYYAN
CCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHC
NKCDNNENLVTKVTHILNNVDITKGTVTEKLGNQTMFDHTAFTVIKDLNNNKLYIKSYNS
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCEEHHHHHEEEEEECCCCEEEEEECCC
PNNAVEIDLNTKYIRSK
CCCEEEEEECCCEECCC
>Mature Secondary Structure
MEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISYASKYSIIATGLVNANQEFLVDGQND
CCCCCCEEEEEEEECCCCHHHCCCCCCCCEEEEECCCCEEEEEEEEECCCCEEEEECCCC
QGLSISANYMPGFAEYQKVTNTDKKYASINQISTLILSEYANVEQVKQALQQYKVWSDKS
CCCEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
TMINGVAPQLHFLITDRNGKGLVVEYIKGEVKLYDVNSNVKVMTNAPTYDWHLINLRNYL
CEECCCCCEEEEEEECCCCCEEEEEEECCEEEEEEECCCEEEEECCCCCEEEEEEEHHHC
NLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNGFLGLPGDYSPPSRFIKTAILRYYAN
CCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHC
NKCDNNENLVTKVTHILNNVDITKGTVTEKLGNQTMFDHTAFTVIKDLNNNKLYIKSYNS
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCEEHHHHHEEEEEECCCCEEEEEECCC
PNNAVEIDLNTKYIRSK
CCCEEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]