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The map label for this gene is panB [H]

Identifier: 89256064

GI number: 89256064

Start: 661032

End: 661883

Strand: Reverse

Name: panB [H]

Synonym: FTL_0674

Alternate gene names: 89256064

Gene position: 661883-661032 (Counterclockwise)

Preceding gene: 89256065

Following gene: 89256063

Centisome position: 34.91

GC content: 33.8

Gene sequence:

>852_bases
ATGATGTTTTTAGAGCAATTGTTAATAAATTTTCAAACAAGGAGAAAAGATGAAATGAAATCAGTTTTAGGCTTCAAAAA
AGCTAAAGTAACTCAAGAAAAAATCTCGATGGTAACATGCTATGACTATACTTTAGCTAAAATTATAAACTCAACAGATA
TAGACTGTATCCTCGTTGGCGATAGTGGTGGTATGGTATTACTTGGTAAAAAAAATACTACTTATACAACCCTTGATGAC
ATGCAGTTCATGACTCAAGCGGTAGCTAATGGTGCTACAGATAAATTCATAGTCGCTGATTTACCATTTATGAGTTATCG
CCAATCATTAGAAACAACAATGCAGGCTGTAATGGCACTGATTCAATCAGGAGCTCATGCGATTAAGCTTGAAGGTAGTT
CAGGAAATTTAGATATTATTAAACATATCGTAGATTCTGGTGTTCCAATAATGGGACACATTGGTATGACACCACAATTT
ATAAATAGCTTTGGAGGTTTTAAAGTTCAAGGTAGAACTGAAGAAGCCGCCAAACACTTACTTGAAGAAGCTAAGCTTCT
TGAGCAAGCAGGATGCTTTGGAATAGTTCTAGAATGTATACCAGCAAATATTGCTAAAGATATTACGCAAAATTTAGACA
TCCCAACAATAGGTATTGGTGCTGGTAGCAATACTGATGGTCAGATTTTAGTTCTCCAAGATATGCTTGGCATGAATACT
GACTTTCAACCAAAATTTGTCAAAAAATATATAGATGGCTCAAAGTTATTTTCTGATGCTATAAATACATATGTTAAAGA
AACAAAAGCTAATACTTTTCCTACTAAGGAGCATTGTTATGATTATTGCTGA

Upstream 100 bases:

>100_bases
AATATCAAACACAATCATCATGCCCTATCAGGACCAATAGCTAGAGGAGATAACCTTACGCTACAAAAAGATCTCGATGC
TTTAATTGGTGATGATTTCT

Downstream 100 bases:

>100_bases
TAATATTAAACAATTTCATTCAATAAGAAATAGTCTTATTAAACAACAAAAAATAGGTTTTGTACCTACAATGGGAGCTC
TACACAATGGCCATATAAGT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MMFLEQLLINFQTRRKDEMKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVGDSGGMVLLGKKNTTYTTLDD
MQFMTQAVANGATDKFIVADLPFMSYRQSLETTMQAVMALIQSGAHAIKLEGSSGNLDIIKHIVDSGVPIMGHIGMTPQF
INSFGGFKVQGRTEEAAKHLLEEAKLLEQAGCFGIVLECIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNT
DFQPKFVKKYIDGSKLFSDAINTYVKETKANTFPTKEHCYDYC

Sequences:

>Translated_283_residues
MMFLEQLLINFQTRRKDEMKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVGDSGGMVLLGKKNTTYTTLDD
MQFMTQAVANGATDKFIVADLPFMSYRQSLETTMQAVMALIQSGAHAIKLEGSSGNLDIIKHIVDSGVPIMGHIGMTPQF
INSFGGFKVQGRTEEAAKHLLEEAKLLEQAGCFGIVLECIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNT
DFQPKFVKKYIDGSKLFSDAINTYVKETKANTFPTKEHCYDYC
>Mature_283_residues
MMFLEQLLINFQTRRKDEMKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVGDSGGMVLLGKKNTTYTTLDD
MQFMTQAVANGATDKFIVADLPFMSYRQSLETTMQAVMALIQSGAHAIKLEGSSGNLDIIKHIVDSGVPIMGHIGMTPQF
INSFGGFKVQGRTEEAAKHLLEEAKLLEQAGCFGIVLECIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNT
DFQPKFVKKYIDGSKLFSDAINTYVKETKANTFPTKEHCYDYC

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=256, Percent_Identity=39.0625, Blast_Score=209, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319653, Length=254, Percent_Identity=34.251968503937, Blast_Score=172, Evalue=4e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 31174; Mature: 31174

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFLEQLLINFQTRRKDEMKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVG
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCEEEEEE
DSGGMVLLGKKNTTYTTLDDMQFMTQAVANGATDKFIVADLPFMSYRQSLETTMQAVMAL
CCCCEEEEECCCCCEEEHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
IQSGAHAIKLEGSSGNLDIIKHIVDSGVPIMGHIGMTPQFINSFGGFKVQGRTEEAAKHL
HHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHCCCEEEECCHHHHHHHH
LEEAKLLEQAGCFGIVLECIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEHHHCCCC
DFQPKFVKKYIDGSKLFSDAINTYVKETKANTFPTKEHCYDYC
CCCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC
>Mature Secondary Structure
MMFLEQLLINFQTRRKDEMKSVLGFKKAKVTQEKISMVTCYDYTLAKIINSTDIDCILVG
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCEEEEEE
DSGGMVLLGKKNTTYTTLDDMQFMTQAVANGATDKFIVADLPFMSYRQSLETTMQAVMAL
CCCCEEEEECCCCCEEEHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
IQSGAHAIKLEGSSGNLDIIKHIVDSGVPIMGHIGMTPQFINSFGGFKVQGRTEEAAKHL
HHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHCCCEEEECCHHHHHHHH
LEEAKLLEQAGCFGIVLECIPANIAKDITQNLDIPTIGIGAGSNTDGQILVLQDMLGMNT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEHHHCCCC
DFQPKFVKKYIDGSKLFSDAINTYVKETKANTFPTKEHCYDYC
CCCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA