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The map label for this gene is trxA [H]

Identifier: 89256009

GI number: 89256009

Start: 602200

End: 602523

Strand: Reverse

Name: trxA [H]

Synonym: FTL_0611

Alternate gene names: 89256009

Gene position: 602523-602200 (Counterclockwise)

Preceding gene: 89256011

Following gene: 89256008

Centisome position: 31.78

GC content: 34.57

Gene sequence:

>324_bases
ATGTCAAAATGTATCGATATATCAGATAGTCAATTTGAAAGTGAATTAGTTAATAGTGATATCCCAGTATTGTTAGATTT
TTGGGCACCATGGTGTGGTCCTTGCAAAATGCTTGCTCCAATACTTGATCAAGTTGCAGAGCACTACGGTGACAAAATCA
AAGTCTGCAAAATAAATATCGATGATAATGAAGAGACAGCGATGAAATTTGGTGTACGTGGTGTACCTACACTTATGGTT
TTCAAAGATGGTGAAAACAAAGAGACTAAAGTTGGTGTAGTACAAAAAACTCAGTTAATCTCAATCGTAGACAAATATCT
ATAA

Upstream 100 bases:

>100_bases
ATTAGTAATTAGTTTAACTTCTTATAAAATTATCAAGTATACAGCAGTGGATTCTGCTTAATCAGTTTTAAAATCAAAAA
ACTTAAAGGAAAGTCAAAGC

Downstream 100 bases:

>100_bases
TTAGTTATATCAACATATTATTTTTATTAAATAGAGAACCCAATGAACTTAAATGAATTAAAGTATAAATCTGTTAATGA
GCTAATGGATATAGCTCAAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSKCIDISDSQFESELVNSDIPVLLDFWAPWCGPCKMLAPILDQVAEHYGDKIKVCKINIDDNEETAMKFGVRGVPTLMV
FKDGENKETKVGVVQKTQLISIVDKYL

Sequences:

>Translated_107_residues
MSKCIDISDSQFESELVNSDIPVLLDFWAPWCGPCKMLAPILDQVAEHYGDKIKVCKINIDDNEETAMKFGVRGVPTLMV
FKDGENKETKVGVVQKTQLISIVDKYL
>Mature_106_residues
SKCIDISDSQFESELVNSDIPVLLDFWAPWCGPCKMLAPILDQVAEHYGDKIKVCKINIDDNEETAMKFGVRGVPTLMVF
KDGENKETKVGVVQKTQLISIVDKYL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=36.4583333333333, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=37.2093023255814, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI5031973, Length=101, Percent_Identity=29.7029702970297, Blast_Score=66, Evalue=6e-12,
Organism=Homo sapiens, GI4758304, Length=106, Percent_Identity=34.9056603773585, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=50.4761904761905, Blast_Score=122, Evalue=4e-30,
Organism=Escherichia coli, GI1788936, Length=117, Percent_Identity=35.042735042735, Blast_Score=92, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=36.4583333333333, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17556044, Length=102, Percent_Identity=35.2941176470588, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554386, Length=103, Percent_Identity=40.7766990291262, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=100, Percent_Identity=35, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=81, Percent_Identity=39.5061728395062, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=81, Percent_Identity=39.5061728395062, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=81, Percent_Identity=39.5061728395062, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=102, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=102, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=97, Percent_Identity=28.8659793814433, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=74, Percent_Identity=39.1891891891892, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=74, Percent_Identity=39.1891891891892, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=99, Percent_Identity=35.3535353535354, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=40, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=36.046511627907, Blast_Score=67, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=79, Percent_Identity=34.1772151898734, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=41.5584415584416, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28573567, Length=82, Percent_Identity=39.0243902439024, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664269, Length=82, Percent_Identity=39.0243902439024, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17647799, Length=80, Percent_Identity=42.5, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664525, Length=80, Percent_Identity=42.5, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921434, Length=85, Percent_Identity=34.1176470588235, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24639068, Length=105, Percent_Identity=29.5238095238095, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12023; Mature: 11892

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKCIDISDSQFESELVNSDIPVLLDFWAPWCGPCKMLAPILDQVAEHYGDKIKVCKINI
CCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEC
DDNEETAMKFGVRGVPTLMVFKDGENKETKVGVVQKTQLISIVDKYL
CCCHHHHHHHCCCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKCIDISDSQFESELVNSDIPVLLDFWAPWCGPCKMLAPILDQVAEHYGDKIKVCKINI
CCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEC
DDNEETAMKFGVRGVPTLMVFKDGENKETKVGVVQKTQLISIVDKYL
CCCHHHHHHHCCCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]