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The map label for this gene is capL [H]

Identifier: 89255994

GI number: 89255994

Start: 582479

End: 583789

Strand: Direct

Name: capL [H]

Synonym: FTL_0596

Alternate gene names: 89255994

Gene position: 582479-583789 (Clockwise)

Preceding gene: 89255993

Following gene: 89255995

Centisome position: 30.72

GC content: 35.01

Gene sequence:

>1311_bases
ATGAGTTTATATGAGGATATAGTCGCTAAAAGAGAAAAGGTTTCATTGGTTGGCTTGGGTTATGTTGGTTTACCAATAGC
TATTGCATTTGCAAAAAAAATAGATGTGTTAGGATTTGATATTTGTGAAACAAAAGTTCAACATTATAAGGATGGTTTTG
ATCCAACAAAAGAAGTAGGAGATGAGGCTGTCAGAAATACGACAATGAAATTTAGTTGTGATGAAACAAGTCTTAAAGAG
TGTAAATTTCATATTGTTGCAGTTCCTACACCAGTTAAAGCAGATAAAACTCCTGATTTGACGCCGATTATTAAGGCAAG
TGAGACGGTTGGTAGGAATCTTGTCAAAGGCGCTTATGTTGTGTTTGAATCAACTGTTTATCCTGGTGTTACAGAAGATG
TTTGCGTACCAATACTTGAAAAAGAGTCTGGCTTGAGGTCTGGTGAAGATTTCAAAGTTGGTTACTCTCCTGAGAGGATA
AATCCTGGTGATAAGGTTCATAGGTTAGAAACAATTATCAAAGTAGTATCTGGTATGGATGAAGAGTCTTTAGATACTAT
AGCAAAAGTTTATGAGCTAGTAGTAGACGCAGGAGTTTATAGAGCTAGTAGTATAAAAGTGGCTGAAGCTGCTAAGGTTA
TAGAAAACTCTCAAAGAGATGTTAATATAGCTTTTGTTAATGAGTTATCGATAATATTTAATCAGATGGGTATTGATACT
CTAGAGGTTTTAGCAGCAGCTGCAACTAAATGGAATTTCTTAAACTTTAAGCCTGGTCTTGTTGGTGGACATTGTATTGG
TGTTGACCCATATTACCTAACGTACAAGGCAGCTGAGCTTGGATATTATTCTCAGGTAATATTATCTGGTCGTAGGATAA
ATGATGGTATGGGCAAATTTGTAGTTGAGAATTTAGTCAAAAAACTGATATCTGCAGATATACCTGTTAAGCGAGCTAGA
GTAGCAATTTTCGGCTTTACTTTTAAAGAAGACTGTCCTGACACTAGGAATACTCGAGTTATAGATATGGTAAAAGAGCT
CAACGAGTATGGTATAGAGCCATATATTATAGATCCGGTAGCTGATAAAGAAGAGGCTAAACATGAGTATGGACTTGAGT
TTGATGATCTAAGTAAAATGGTCAATCTAGATGCGATCATTATTGCTGTTAGTCACGAACAGTTTAAAGATATAACAAAG
CAACAGTTTGATAGGCTATATGCGCATAATTCTAGAAAGATTATCTTTGACATCAAAGGTAGTTTAGATAAATCTGAGTT
TGAAAAAGATTATATTTATTGGAGATTGTAG

Upstream 100 bases:

>100_bases
CTATGAGCTATAAAGCTAGAGCTAAGATAGAAAAAGATTTTGATAGAAGTATTGTTGTCAATGCATACTTACAGCAAAAT
TAATAATAAGGGTTTAAATT

Downstream 100 bases:

>100_bases
TGGCTTACGATAATGTTAAATTTCCTCATGTTTCGTTTTTTTTGGTGACTGGAGGTGCGGGCTTTATTGGCTCTAATTTA
TGTGAAGTTTTACTTAGTAA

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSLYEDIVAKREKVSLVGLGYVGLPIAIAFAKKIDVLGFDICETKVQHYKDGFDPTKEVGDEAVRNTTMKFSCDETSLKE
CKFHIVAVPTPVKADKTPDLTPIIKASETVGRNLVKGAYVVFESTVYPGVTEDVCVPILEKESGLRSGEDFKVGYSPERI
NPGDKVHRLETIIKVVSGMDEESLDTIAKVYELVVDAGVYRASSIKVAEAAKVIENSQRDVNIAFVNELSIIFNQMGIDT
LEVLAAAATKWNFLNFKPGLVGGHCIGVDPYYLTYKAAELGYYSQVILSGRRINDGMGKFVVENLVKKLISADIPVKRAR
VAIFGFTFKEDCPDTRNTRVIDMVKELNEYGIEPYIIDPVADKEEAKHEYGLEFDDLSKMVNLDAIIIAVSHEQFKDITK
QQFDRLYAHNSRKIIFDIKGSLDKSEFEKDYIYWRL

Sequences:

>Translated_436_residues
MSLYEDIVAKREKVSLVGLGYVGLPIAIAFAKKIDVLGFDICETKVQHYKDGFDPTKEVGDEAVRNTTMKFSCDETSLKE
CKFHIVAVPTPVKADKTPDLTPIIKASETVGRNLVKGAYVVFESTVYPGVTEDVCVPILEKESGLRSGEDFKVGYSPERI
NPGDKVHRLETIIKVVSGMDEESLDTIAKVYELVVDAGVYRASSIKVAEAAKVIENSQRDVNIAFVNELSIIFNQMGIDT
LEVLAAAATKWNFLNFKPGLVGGHCIGVDPYYLTYKAAELGYYSQVILSGRRINDGMGKFVVENLVKKLISADIPVKRAR
VAIFGFTFKEDCPDTRNTRVIDMVKELNEYGIEPYIIDPVADKEEAKHEYGLEFDDLSKMVNLDAIIIAVSHEQFKDITK
QQFDRLYAHNSRKIIFDIKGSLDKSEFEKDYIYWRL
>Mature_435_residues
SLYEDIVAKREKVSLVGLGYVGLPIAIAFAKKIDVLGFDICETKVQHYKDGFDPTKEVGDEAVRNTTMKFSCDETSLKEC
KFHIVAVPTPVKADKTPDLTPIIKASETVGRNLVKGAYVVFESTVYPGVTEDVCVPILEKESGLRSGEDFKVGYSPERIN
PGDKVHRLETIIKVVSGMDEESLDTIAKVYELVVDAGVYRASSIKVAEAAKVIENSQRDVNIAFVNELSIIFNQMGIDTL
EVLAAAATKWNFLNFKPGLVGGHCIGVDPYYLTYKAAELGYYSQVILSGRRINDGMGKFVVENLVKKLISADIPVKRARV
AIFGFTFKEDCPDTRNTRVIDMVKELNEYGIEPYIIDPVADKEEAKHEYGLEFDDLSKMVNLDAIIIAVSHEQFKDITKQ
QFDRLYAHNSRKIIFDIKGSLDKSEFEKDYIYWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=476, Percent_Identity=24.1596638655462, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI296040438, Length=342, Percent_Identity=24.8538011695906, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI48994968, Length=418, Percent_Identity=30.1435406698565, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17560350, Length=462, Percent_Identity=24.2424242424242, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=24.2424242424242, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48863; Mature: 48731

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLYEDIVAKREKVSLVGLGYVGLPIAIAFAKKIDVLGFDICETKVQHYKDGFDPTKEVG
CCHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHH
DEAVRNTTMKFSCDETSLKECKFHIVAVPTPVKADKTPDLTPIIKASETVGRNLVKGAYV
HHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHCEEE
VFESTVYPGVTEDVCVPILEKESGLRSGEDFKVGYSPERINPGDKVHRLETIIKVVSGMD
EEECCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
EESLDTIAKVYELVVDAGVYRASSIKVAEAAKVIENSQRDVNIAFVNELSIIFNQMGIDT
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCHH
LEVLAAAATKWNFLNFKPGLVGGHCIGVDPYYLTYKAAELGYYSQVILSGRRINDGMGKF
HHHHHHHHHCCCEEECCCCCCCCEEECCCCEEEEEEHHHHCHHHHHHHCCCCCCCHHHHH
VVENLVKKLISADIPVKRARVAIFGFTFKEDCPDTRNTRVIDMVKELNEYGIEPYIIDPV
HHHHHHHHHHHCCCCHHHEEEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCC
ADKEEAKHEYGLEFDDLSKMVNLDAIIIAVSHEQFKDITKQQFDRLYAHNSRKIIFDIKG
CCHHHHHHHCCCCHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEEECC
SLDKSEFEKDYIYWRL
CCCHHHHCCCEEEEEC
>Mature Secondary Structure 
SLYEDIVAKREKVSLVGLGYVGLPIAIAFAKKIDVLGFDICETKVQHYKDGFDPTKEVG
CHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHH
DEAVRNTTMKFSCDETSLKECKFHIVAVPTPVKADKTPDLTPIIKASETVGRNLVKGAYV
HHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHCEEE
VFESTVYPGVTEDVCVPILEKESGLRSGEDFKVGYSPERINPGDKVHRLETIIKVVSGMD
EEECCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
EESLDTIAKVYELVVDAGVYRASSIKVAEAAKVIENSQRDVNIAFVNELSIIFNQMGIDT
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCHH
LEVLAAAATKWNFLNFKPGLVGGHCIGVDPYYLTYKAAELGYYSQVILSGRRINDGMGKF
HHHHHHHHHCCCEEECCCCCCCCEEECCCCEEEEEEHHHHCHHHHHHHCCCCCCCHHHHH
VVENLVKKLISADIPVKRARVAIFGFTFKEDCPDTRNTRVIDMVKELNEYGIEPYIIDPV
HHHHHHHHHHHCCCCHHHEEEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCC
ADKEEAKHEYGLEFDDLSKMVNLDAIIIAVSHEQFKDITKQQFDRLYAHNSRKIIFDIKG
CCHHHHHHHCCCCHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEEECC
SLDKSEFEKDYIYWRL
CCCHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]