Click here to switch to the map view.

The map label for this gene is fadE [H]

Identifier: 89255983

GI number: 89255983

Start: 564922

End: 567162

Strand: Reverse

Name: fadE [H]

Synonym: FTL_0585

Alternate gene names: 89255983

Gene position: 567162-564922 (Counterclockwise)

Preceding gene: 89255984

Following gene: 89255982

Centisome position: 29.91

GC content: 37.62

Gene sequence:

>2241_bases
ATGTTCAATAAAATTTATAAAATAGCCAAAAAAGCCACGCCGACAATTTCGCAAACAGAACAAACAGCTCTTAATGCTGG
CAATAACTGGTTTGAACAAGATATATTCCAAGGTAAACCTGACTTTAATAAACTGCATAGTTTGAAAAAGTTTGAACTAA
CAGCTGAAGAAAAGTCTTTTTTAGCAAATGAAACAACCGAGCTATGTAAACTAATTGATGATTGGAAGATTAATTATCAA
GAAAAAGATTTAAGTGTCGAAGCTTGGGATTTTATCCGTAACAAAGGCTTTTTAGGGCTAGTAATCGGTAAAGAGTACGG
TGGTAAAGGTTTCTCAGCAGCAGCGCACTCAGAAATAGTGATGAAATTAGCAACCAAGAGTGTCACTGCAGCAATTACTG
TGATGGTACCTAACTCACTTGGACCAGGAGAGCTTCTAGTTCATTATGGTACAGATGAGCAAAAAGATCACTATCTACCA
AGATTAGCCTCTGGCCAAGAGATACCATGTTTTGCTTTAACAGGACCAACAGCTGGGTCTGATGCGGCTTCATTACCTGA
CTATGGTGTTGTCTGCCATGAAGAGTTCAATGGTAAAAAAACTCTAGGGATAAAACTAAAAAATATTAATAAACGCTATA
TCACATTAGCTCCTATAGCCACCCTCGTTGGTCTAGCTTTTCAACTACAAGATCCTGATAATCTACTCGGTGATACAGGT
AAAGAAGGCATAACATGCGCACTGCTACCATATAACCATAAAGGCTTAGAAATCGGCAAACGTGGCTTTCCACTAGGGCA
AACATTTATGAATGGCTATATCAAAGCGAAAGATGTATTTATCCCAATTGATTGGATAATTGGCGAACAAAAAATGGCTG
GCGAAGGTTGGCGGATGCTAGTTGAGTGTCTATCTATAGGTAGAGCTATTTCACTACCAGCGTGTGGTACAGCTAACACA
CTAATGTCAGCTGTAATTACCGCAGCATATGCAAGTGTGCGTGAACAATTCAAAGTTCCAATCGCACAATTTGAAGGAGT
CCAAGAAAAACTAGCTCAAACTGCAGGACTTGCATATATTGCTAATGCTACTCGTCAATTCACGGTTGCTGCTGTTGATA
GTGGTCTGCGACCATCTGTATCATCTGCGATTGCAAAATATCACCTAACCGAGATGGGGCGCACAACTATCAACAATGCT
ATGGATATCCATGGTGGTCGAGCAATCATTATGGGACCAAATAACTATCTAGCTATTCCATATATGGCGACACCGATTGG
TATAACTGTTGAGGGTGCCAATATCATGACACGAAATCTAATGATCTTTGGTCAAGGTGCGATGAAGTGCCATCCATATA
TTCGTAACGAGATAGAAAGCCTAATGAATGATGATGAAGAACAATTTACAACTAATTTCAAAAGTCATTTTAAATATATG
GCTTTGAATGGCTCGCGTACTCTTTGGTATGGTTTAAGTGGTGGTTTCACTGCTCCTAGCTACCCTTCTAAATTTAAACG
TTACTATCGCTATATCTCACATATGAGTACTGCTTATTCGTATGTGAATGATATTTCAATAACAGTTTTAGGTGCTGGTC
TAAAACGTAAAGAAAGATTATCTGCCCGTTTGGGAGATATAATGAGTTATCTGTATATGGCTGTAGCTGTATTGAAATAC
TATAAGGACACAGGCGAACCTCAAAGTGATGATATCTATGTTGATTGGAGTATTCAGCACTGTCTATACCAAGCTCAACA
AGCGATGTTAGACTTATTTAGAAATTTCCCAAATAGAATATTTGCTACCAAGATGAAGCTTTTTGTTTTTCCTTATGGTA
AAAAATTCAGAAGACCATCTGACAAGCTTGAAGCACAAATCTGTAATTCATTAGTCAGTAATAGTGATACTAGACAATGG
ATGAAAGATAAATGCTACATACCTAATGACGATAATGATCCTATTGGTAGAGTTGAAAATGCTTATCTTGCATCATTGAC
TACTCAACCTATCAAGAAAAAAATTATTGATGCTATAAAAACTGCTAAGCTACCAAAAGCAAGCTGGCAAAACTCTATAG
ACATAGCCCTAGAGAATAAAATAATCACACAACAAGAGGCAAATATTGCTCATGAGATGCTTACAAAGGTCAATAATATA
ATCCAAACTGATGAGTTTGATGATTATGCTCTAGGGCCTAAAAATGCTCATCTAGAATGGCAAAAAGATACCGACAAGTA
G

Upstream 100 bases:

>100_bases
AATACCGTTGGAAAAATAGATGTAAATGCATTACAAAAAGAATATACTGAAAAGTATGAATAACAGATAATTAAACAGCT
TGCTGCTTAAGGAGCTAAAG

Downstream 100 bases:

>100_bases
TTTACTAATGTCATTCCGCCTAAATAACGGAATCTAAAAAACGATGGATATATTAACATCGGGAGGACAAATATGACAGA
GTTAGAGAAAAAGTTTGAAG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 746; Mature: 746

Protein sequence:

>746_residues
MFNKIYKIAKKATPTISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSFLANETTELCKLIDDWKINYQ
EKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIVMKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLP
RLASGQEIPCFALTGPTAGSDAASLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGEQKMAGEGWRMLVECLSIGRAISLPACGTANT
LMSAVITAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYIANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNA
MDIHGGRAIIMGPNNYLAIPYMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERLSARLGDIMSYLYMAVAVLKY
YKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRIFATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQW
MKDKCYIPNDDNDPIGRVENAYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
IQTDEFDDYALGPKNAHLEWQKDTDK

Sequences:

>Translated_746_residues
MFNKIYKIAKKATPTISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSFLANETTELCKLIDDWKINYQ
EKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIVMKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLP
RLASGQEIPCFALTGPTAGSDAASLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGEQKMAGEGWRMLVECLSIGRAISLPACGTANT
LMSAVITAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYIANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNA
MDIHGGRAIIMGPNNYLAIPYMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERLSARLGDIMSYLYMAVAVLKY
YKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRIFATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQW
MKDKCYIPNDDNDPIGRVENAYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
IQTDEFDDYALGPKNAHLEWQKDTDK
>Mature_746_residues
MFNKIYKIAKKATPTISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSFLANETTELCKLIDDWKINYQ
EKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIVMKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLP
RLASGQEIPCFALTGPTAGSDAASLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGEQKMAGEGWRMLVECLSIGRAISLPACGTANT
LMSAVITAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYIANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNA
MDIHGGRAIIMGPNNYLAIPYMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERLSARLGDIMSYLYMAVAVLKY
YKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRIFATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQW
MKDKCYIPNDDNDPIGRVENAYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
IQTDEFDDYALGPKNAHLEWQKDTDK

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=503, Percent_Identity=26.2425447316103, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4557235, Length=417, Percent_Identity=24.220623501199, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI76496475, Length=378, Percent_Identity=25.1322751322751, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4557233, Length=317, Percent_Identity=28.0757097791798, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI7656849, Length=349, Percent_Identity=24.9283667621776, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI226958414, Length=284, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI4501859, Length=316, Percent_Identity=26.8987341772152, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI226958412, Length=269, Percent_Identity=28.2527881040892, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI87081702, Length=736, Percent_Identity=46.875, Blast_Score=694, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508101, Length=369, Percent_Identity=27.9132791327913, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=260, Percent_Identity=30, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534899, Length=331, Percent_Identity=27.4924471299094, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17570075, Length=365, Percent_Identity=26.8493150684932, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=339, Percent_Identity=27.4336283185841, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71982178, Length=313, Percent_Identity=26.517571884984, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281363737, Length=327, Percent_Identity=27.82874617737, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356377, Length=268, Percent_Identity=27.6119402985075, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24666513, Length=337, Percent_Identity=28.7833827893175, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920834, Length=267, Percent_Identity=29.5880149812734, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355753, Length=368, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: 1.3.99.3

Molecular weight: Translated: 83335; Mature: 83335

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKIYKIAKKATPTISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSF
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCHHEEECHHHHHH
LANETTELCKLIDDWKINYQEKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIV
HHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHH
MKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLPRLASGQEIPCFALTGPTAGS
HHHHHHCEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCC
DAASLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
CCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEEHHHHHHHHHHEEEECCCHHHHCCCC
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGEQKMAGEGWRML
CCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCEEEEEEEEEEEHEEECCHHHCCHHHHHH
VECLSIGRAISLPACGTANTLMSAVITAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYI
HHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCEE
ANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNAMDIHGGRAIIMGPNNYLAIP
ECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCHHHHCCCEEECCCEEEEECCCCEEEEE
YMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
EEECCEEEEEECCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCEEEE
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERL
EECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
SARLGDIMSYLYMAVAVLKYYKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCHHH
FATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQWMKDKCYIPNDDNDPIGRVEN
HHEEEEEEEEECCHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCHHCC
AYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEECHHHHHHHHHHHHHHHHH
IQTDEFDDYALGPKNAHLEWQKDTDK
HCCCCCCCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure
MFNKIYKIAKKATPTISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSF
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCHHEEECHHHHHH
LANETTELCKLIDDWKINYQEKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIV
HHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHH
MKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLPRLASGQEIPCFALTGPTAGS
HHHHHHCEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCC
DAASLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
CCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEEHHHHHHHHHHEEEECCCHHHHCCCC
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGEQKMAGEGWRML
CCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCEEEEEEEEEEEHEEECCHHHCCHHHHHH
VECLSIGRAISLPACGTANTLMSAVITAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYI
HHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCEE
ANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNAMDIHGGRAIIMGPNNYLAIP
ECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCHHHHCCCEEECCCEEEEECCCCEEEEE
YMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
EEECCEEEEEECCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCEEEE
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERL
EECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
SARLGDIMSYLYMAVAVLKYYKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCHHH
FATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQWMKDKCYIPNDDNDPIGRVEN
HHEEEEEEEEECCHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCHHCC
AYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEECHHHHHHHHHHHHHHHHH
IQTDEFDDYALGPKNAHLEWQKDTDK
HCCCCCCCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]